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Non-hallucinogenic Psychedelic Analog Design:A Promising Direction for Depression Treatment

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Neuroscience Bulletin 2023年第1期39卷 170-172页

作者： Ya-Nan Yin tian-ming gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong Province Key Laboratory of Psychiatric DisordersDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Depression is the most common neuropsychiatric disorder,affecting 350million people worldwide;it has been a leading cause of suicide,causing serious harm to family members and consuming a large amount of social *** onset time of traditional antidepressants is usually 3-4 weeks,and there is no ameliorating effect in nearly one-third of patients with depression.

关键词： consuming patients Depression

The Memory Orchestra:Contribution of Astrocytes

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Neuroscience Bulletin 2023年第3期39卷 409-424页

作者： Yi-Hua Chen Shi-Yang Jin Jian-ming Yang tian-ming gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong Province Key Laboratory of Psychiatric DisordersDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

For decades,memory research has centered on the role of neurons,which do not function in ***,astrocytes play important roles in regulating neuronal recruitment and function at the local and network levels,forming the basis for information processing as well as memory formation and *** this review,we discuss the role of astrocytes in memory functions and their cellular underpinnings at multiple time *** summarize important breakthroughs and controversies in the field as well as potential avenues to further illuminate the role of astrocytes in memory processes.

关键词： Astrocytes Learning and memory GPCR Calcium signal Plasticity

Lithium extraction from hard rock lithium ores(spodumene,lepidolite,zinnwaldite,petalite):Technology,resources,environment and cost

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China Geology 2023年第1期6卷 137-153页

作者： tian-ming gao Na Fan Wu Chen Tao Dai MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral Resources Chinese Academy of Geological SciencesBeijing 100037China Research Center for Strategy of Global Mineral Resources Chinese Geological SurveyBeijing 100037China China Huanqiu Contracting&Engineering Corp. LTD Beijing BranchBeijing 100012China SDU Life Cycle Engineering Department of Green TechnologyUniversity of Southern DenmarkOdense 5230Denmark

Lithium production in China mainly depends on hard rock lithium ores,which has a defect in resources,environment,and economy compared with extracting lithium from *** paper focuses on the research progress of extracting lithium from spodumene,lepidolite,petalite,and zinnwaldite by acid,alkali,salt roasting,and chlorination methods,and analyzes the resource intensity,environmental impact,and production cost of industrial lithium extraction from spodumene and *** is found that the sulfuric acid method has a high lithium recovery rate,but with a complicated process and high energy consumption;alkali and chlorination methods can directly react with lithium ores,reducing energy consumption,but need to optimize reaction conditions and safety of equipment and operation;the salt roasting method has large material flux and high energy consumption,so require adjustment of sulfate ratio to increase the lithium yield and reduce production *** with extracting lithium from brine,extracting lithium from ores,calcination,roasting,purity,and other processes consume more resources and energy;and its environmental impact mainly comes from the pollutants discharged by fossil energy,9.3-60.4 times that of lithium extracted from *** processing cost of lithium extraction from lepidolite by sulfate roasting method is higher than that from spodumene by sulfuric acid due to the consumption of high-value ***,the production costs of both are mainly affected by the price of lithium ores,which is less competitive than that of extracting lithium from ***,the process of extracting lithium from ores should develop appropriate technology,shorten the process flow,save resources and energy,and increase the recovery rate of related elements to reduce environmental impact and improve the added value of by-products and the economy of the process.

关键词： Lithium ore Lithium extraction Comprehensive utilization Acid method Alkali method Salt roasting method Chlorination method Mineral exploration engineering

内侧杏仁核的神经调节素1信号通路调控青春期社会隔离导致的自闭样行为

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Science Bulletin 2024年第10期69卷 1375-1379页

作者：林连虹吴倩云曾恺陈梓瑜王梓萍李伟民张斌高天明刘吉红 Department of Psychiatry Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Southern Medical UniversityGuangzhou 510515China

Autistic spectrum disorder(ASD),characterized by impairments in social interaction and repetitive behaviors,is a complex neurodevelopmental brain disorder that is reportedly increasing in prevalence globally[1].It is ... 详细信息

关键词：社会隔离 impairment prevalence

High success rate of fiberscope-monitored intubation via a supraglottic airway device BlockBuster^(TM)in good device positioning:A prospective observational study

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Chinese Medical Journal 2024年第7期137卷 871-873页

作者： Zhenfa Hu Kai Su Huihui Miao Xue gao Fushan Xue ming tian Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Airway management is closely related to the safety and quality of *** 2015,the Difcult Airway Society suggested that endotracheal intubation should beberoptic bronchoscope(FOB)-guided and blind intubation should be *** supraglottic airway device(SAD)BlockBuster^(TM)with matched tracheal tube(Block-Buster^(TM)tracheal tube,BTT;Tuoren Medical Instrument Co.,Ltd.,Changyuan,Henan,China)is an improved second-generation SAD with intubation function.[1,2]Theberscope-monitored intubation via SAD BlockBuster^(TM)can make the whole process ***,we investigated the feasibility,success rate,and complications of the new intubation technique in a well-positioned SAD BlockBuster^(TM)by sequential case observation.

关键词： intubation airway supra

Effect of Al content in molten steel on interaction between MgO-C refractory and SPHC steel

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Journal of Iron and Steel Research International 2024年第4期31卷 838-848页

作者： Fu-bin gao Fu-ming Wang Xiang Zhang tian-yu Du Xin-hua Wangg School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Handan Iron and Steel Company Hegang GroupHandan 056015HebeiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The effect of Al content in molten steel on the interaction between SPHC steel(0.005-0.068 wt.%Al,and 19×10^(-4)-58×10^(-4)wt.%O)and MgO-C refractory(11.63 wt.%C)was ***-metallic inclusions in the steel were examined at various periods(0,5,15,30,45,and 60 min)as well as the MgO-C interface after 60 min of corrosion at 1600℃.The results show that when MgO-C refractory comes into contact with SPHC steel,the refractory interface consists of three layers arranged from the innermost to the outermost,including the original refractory layer,the dense MgO layer,and the iron infiltration *** carbon in the MgO-C refractories and the Al content in the molten steel undergo a reaction with the MgO in the refractories,resulting in an increase in Mg concentration in the *** Al content in the molten steel from 0.005 to 0.068 wt.%causes a spinel layer to appear at the interface,and the disappearance time of Al_(2)O_(3) inclusions in the steel decreases from 60 to 30 min,while the average MgO content in inclusions ***,controlling the Al content in the molten steel and the smelting duration can help regulate the formation of spinel inclusionsinthe steel.

关键词： MgO-C refractory SPHC steel Inclusion-Spinel Al-killed steel Interfacial reaction

A privacy-preserving vehicle trajectory clustering framework

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Frontiers of Information Technology & Electronic Engineering 2024年第7期25卷 988-1002页

作者： Ran tian Pulun gao Yanxing LIU College of Computer Science&Engineering Northwest Normal UniversityLanzhou 730070China

As one of the essential tools for spatio‒temporal traffic data mining,vehicle trajectory clustering is widely used to mine the behavior patterns of ***,uploading original vehicle trajectory data to the server and clustering carry the risk of privacy ***,one of the current challenges is determining how to perform vehicle trajectory clustering while protecting user *** propose a privacy-preserving vehicle trajectory clustering framework and construct a vehicle trajectory clustering model(IKV)based on the variational autoencoder(VAE)and an improved K-means *** the framework,the client calculates the hidden variables of the vehicle trajectory and uploads the variables to the server;the server uses the hidden variables for clustering analysis and delivers the analysis results to the *** IKV’workflow is as follows:first,we train the VAE with historical vehicle trajectory data(when VAE’s decoder can approximate the original data,the encoder is deployed to the edge computing device);second,the edge device transmits the hidden variables to the server;finally,clustering is performed using improved K-means,which prevents the leakage of the vehicle *** is compared to numerous clustering methods on three *** the nine performance comparison experiments,IKV achieves optimal or sub-optimal performance in six of the ***,in the nine sensitivity analysis experiments,IKV not only demonstrates significant stability in seven experiments but also shows good robustness to hyperparameter *** results validate that the framework proposed in this paper is not only suitable for privacy-conscious production environments,such as carpooling tasks,but also adapts to clustering tasks of different magnitudes due to the low sensitivity to the number of cluster centers.

关键词： Privacy protection Variational autoencoder Improved K-means Vehicle trajectory clustering

Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： gao Chen-yan QIN gao-feng ZHENG ming-cui tian Mei-jing HE Yan-nan WANG Peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

The effects of cool materials,façade orientation,and morphological parameters on energy consumption at the residential neighborhood scale

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Building Simulation 2024年第4期17卷 525-542页

作者： Fusuo Xu Dongdong tian Zhi gao Jianshun Jensen Zhang Department of Mechanical and Aerospace Engineering Syracuse UniversitySyracuseNY13210USA School of Architecture and Urban Planning Nanjing University22 Hankou RoadNanjingJiangsu Province210093China

Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy *** study investigated the impact of radiative properties of materials,façade orientation,and morphological parameters on energy consumption in six typical residential neighborhoods in Nanjing,*** neighborhood energy consumption of 16 application schemes considering the façade orientation factor is compared to determine the best energy-saving *** and annual energy-saving rates,savings in electricity costs,and the price ceiling for materials per unit area are *** results show that for low-rise buildings,using cool materials only on the roof can reduce the annual energy consumption by 1%.When cool or super cool materials are also used on the building façade,the annual energy saving rate can be up to 3.4%and 4.3%,*** cool materials on the south façade of buildings is not recommended due to significant heat loss in *** savings in electricity costs and the price ceiling for materials per unit area,the price of cool and super cool materials should be less than 3.0 and 3.7 RMB/m2,respectively,assuming a lifespan of eight years in Nanjing.

关键词： cool materials building energy saving neighborhood morphology façade orientation