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Putative zeatin O-glucosyltransferase OscZOG1 regulates root and shoot development and formation of agronomic traits in rice

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Journal of Integrative Plant Biology 2016年第7期58卷 627-641页

作者： Xiao-Ling Shang Rong-Rong Xie Hua tian,Qing-long wang and Fang-Qing Guo Rong-Rong Xie Hua tian Qing-long wang Fang-Qing Guo The National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research(shanghai) Institute of Plant Physiology&EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China.

As a ubiquitous reaction, glucosylation controls the bioactivity of cytokinins in plant growth and development. Here we show that genetic manipulation of zeatin-O- glucosylation regulates the formation of important agronomic traits in rice by manipulating the expression of OscZOG1 gene, encoding a putative zeatin O-glucosyltransferase. We found that OscZOG~ was preferentially expressed in shoot and root meristematic tissues and nascent organs. The growth of lateral roots was stimulated in the overexpression lines, but inhibited in RNA interference lines. In shoots, knockdown of OscZOG1 expression by RNA interference significantly im- proved tillering, panicle branching, grain number per panicle and seed size, which are important agronomic traits for grain yield. In contrast, constitutive expression of OscZOG1 leads to negative effects on the formation of the grain-yielding traits with a marked increase in the accumulation levels of cis-zeatin O-glucoside （cZOG） in the transgenic rice plants. In this study,our findings demonstrate the feasibility of improving the critical yield-determinant agronomic traits, including tiller number, panicle branches, total grain number per panicle and grain weight by downregulating the expression level of OscZOG1. Our results suggest that modulating the levels of cytokinin glucosylation can function as a fine-tuning switch in regulating the formation of agronomic traits in rice.

关键词： Cis-zeatin O-glucoside (cZOG) cytokinin glucosylation grain-yield traits lateral root panicle development rice

Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia

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Neural Regeneration Research 2022年第7期17卷 1512-1517页

作者： Xiao-Hua wang Wei Jiang Si-Yuan Zhang Bin-Bin Nie Yi Zheng Feng Yan Jian-Feng Lei tian-long wang Department of Anesthesiology Xuanwu HospitalCapital Medical UniversityBeijingChina National Clinical Research Center for Geriatric Disorders BeijingChina Department of Anesthesiology Third Medical Center of People’s Liberation Army General HospitalBeijingChina Daxing Hospital Affiliated to Capital Medical University BeijingChina Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijingChina Neuroprotection Research Laboratory Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Cerebrovascular Research Center Xuanwu HospitalCapital Medical UniversityBeijingChina

Hypothermia is an important protective strategy against global cerebral ischemia following cardiac ***,the mechanisms of hypothermia underlying the changes in different regions and connections of the brain have not been fully *** study aims to identify the metabolic nodes and connection integrity of specific brain regions in rats with global cerebral ischemia that are most affected by hypothermia treatment.18F-fluorodeoxyglucose positron emission tomography was used to quantitatively determine glucose metabolism in different brain regions in a rat model of global cerebral ischemia established at 31–33℃.Diffusion tensor imaging was also used to reconstruct and explore the brain connections *** results showed that,compared with the model rats established at 37–37.5℃,the rat models of global cerebral ischemia established at 31–33℃had smaller hypometabolic regions in the thalamus and primary sensory areas and sustained no obvious thalamic *** selectively preserved the integrity of the anterior forebrain mesocircuit,exhibiting protective effects on the brain during the global cerebral *** study was approved by the Institutional Animal Care and Use Committee at Capital Medical University(approval ***-AD318-97-019)on December 15,2019.

关键词： anterior forebrain mesocircuit cardiac arrest corpus callosum global cerebral ischemia hypometabolic areas hypothermia magnetic resonance imaging positron emission tomography prefrontal cortex rats thalamus

MicroRNA expression in the hippocampal CA1 region under deep hypothermic circulatory arrest

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Neural Regeneration Research 2019年第11期14卷 2003-2010页

作者： Xiao-Hua wang Dong-Xu Yao Xiu-Shu Luan Yu wang Hai-Xia Liu Bei Liu Yang Liu Lei Zhao Xun-Ming Ji tian-long wang Department of Anesthesiology Xuanwu HospitalCapital Medical UniversityBeijingChina Institute of Geriatrics BeijingChina National Clinical Research Center for Geriatric Disorders BeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Cerebrovascular Research Center Xuanwu HospitalCapital Medical UniversityBeijingChina

Using deep hypothermic circulatory arrest, thoracic aorta diseases and complex heart diseases can be subjected to corrective procedures. However, mechanisms underlying brain protection during deep hypothermic circulatory arrest are unclear. After piglet models underwent 60 minutes of deep hypothermic circulatory arrest at 14°C, expression of microRNAs(miRNAs) was analyzed in the hippocampus by microarray. Subsequently, TargetScan 6.2, RNA22 v2.0, miRWalk 2.0, and miRanda were used to predict potential targets, and gene ontology enrichment analysis was carried out to identify functional pathways involved. Quantitative reverse transcription-polymerase chain reaction was conducted to verify miRNA changes. Deep hypothermic circulatory arrest altered the expression of 35 miRNAs. Twenty-two miRNAs were significantly downregulated and thirteen miRNAs were significantly upregulated in the hippocampus after deep hypothermic circulatory arrest. Six out of eight targets among the differentially expressed miRNAs were enriched for neuronal projection(cyclin dependent kinase, CDK16 and SLC1 A2), central nervous system development(FOXO3, TYRO3, and SLC1 A2), ion transmembrane transporter activity(ATP2 B2 and SLC1 A2), and interleukin-6 receptor binding(IL6 R)– these are the key functional pathways involved in cerebral protection during deep hypothermic circulatory arrest. Quantitative reverse transcription-polymerase chain reaction confirmed the results of microarray analysis. Our experimental results illustrate a new role for transcriptional regulation in deep hypothermic circulatory arrest, and provide significant insight for the development of miRNAs to treat brain injuries. All procedures were approved by the Animal Care Committee of Xuanwu Hospital, Capital Medical University, China on March 1, 2017(approval No. XW-INI-AD2017-0112).

关键词： nerve regeneration cerebral protection deep hypothermic circulatory arrest gene ontology enrichment analysis microRNA hippocampus post-transcriptional expression microarray bioinformatics neural regeneration

An overview of Chinese multidisciplinary expert consensus on perioperative brain health in elderly patients

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Chinese Medical Journal 2021年第1期134卷 5-7页

作者： Min Li tian-long wang Dong-Xin wang Department of Anesthesiology Peking University Third HospitalBeijing 100191China Department of Anesthesiology and Operating Theater Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Anesthesiology and Critical Care Medicine Peking University First HospitalBeijing 100034China

Goals for Developing This Consensus The rapidly aging populations in China pose serious challenges for *** and functional decline in elderly patients escalate the risks of cerebral complications which might lead to long-term morbidity and overall reduced quality of life after surgery.[1,2]Therefore,it is imperative to implement perioperative brain protection strategies for geriatric patients.

关键词： patients surgery cerebral

Geriatric Anesthesia-related Morbidity and Mortality in China： Current Status and Trend

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Chinese Medical Journal 2017年第22期130卷 2738-2749页

作者： Yang Liu Wei Xiao Ling-Zhong Meng tian-long wang Department of Anesthesiology and Operating Theatre Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Anesthesiology Yale University School of Medicine New Haven CT 06520 USA

Objective： The population of elderly patients and the amount of geriatric anesthesia have been growing rapidly in China. Thus, understanding the morbidity and mortality associated with geriatric anesthesia in China is critical to the improvement of anesthesia quality and outcome. The aim of the review was to discuss the geriatric anesthesia-related morbidity and mortality in China, as well as to point out the future trend. Data Sources： Articles in this review were all searched from Wanfang, China National Knowledge Infrastructure （CNKI）, VIP, PubMed, and Web of Science databases, based on the reports originated in China from January 2011 to December 2016. Study Selection： A total of 57 studies were selected for further study, including 12 retrospective studies, 35 prospective studies, 3 meta-analyses, 4 reviews, 1 viewpoint, and 2 case reports. Of the total studies, 42 studies were in Chinese while 15 were in English. Results： The mortality and morbidity associated with geriatric anesthesia in China are not yet completely reported. Some factors have been recognized, while some are yet to be identified and confirmed. Several studies addressed postoperative cognitive dysfunction and postoperative delirium, whereas only a few studies can be found on renal complications. Thus, a nationwide registry is essential for geriatric anesthesia-associated adverse outcomes. The mortality associated with geriatric anesthesia in China should be reported promptly. In the future, the perspective of geriatric anesthesia needs to be expanded into perioperative geriatric medicine to improve the perioperative management strategy based on the postoperative outcome-directed concept transformation. Conclusions： Anesthesiologists should evaluate the physiological and medical status and focus on the prevention of potential complications in the perioperative setting with the goal to enhance elderly patients＇ long-term well-being and survival quality.

关键词： Anesthesia China Geriatric Morbidity Mortality

Protective Effect of Low-dose Sevoflurane Inhalation and Propofol Anesthesia on the Myocardium after Carotid Endarterectomy： A Randomized Controlled Trial

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Chinese Medical Journal 2015年第14期128卷 1862-1866页

作者： Qianwang Yan-Hong Li tian-long wang Hua Feng Bing Cai Department of Anesthesiology Xuan Wu Hospital Capital Medical University Beijing 100053 China

Background： Myocardial infarction is an important cause of mortality after carotid endarterectomy （CEA）. Sevoflurane provides myocardial protection to patients undergoing coronary surgery, but whether it also reduces the incidence of myocardial injury in CEA patients is unclear. In this study, we evaluated the cardioprotective effect of low-dose sevoflurane with propofol in patients undergoing CEA. Methods： This was a single-center, prospective, randomized study conducted between November 2011 and December 2013. The study population of 122 patients who underwent CEA were randomly assigned to two groups. Group A （n = 62） received propofol for anesthetic maintenance, and Group B （n = 60） additionally received 0.8% end-tidal sevoflurane. The bispectral index was kept at 40-60. Myocardial injury, defined as cardiac troponin 1 （cTnl） levels 〉0.04 ng/ml, was the primary end-point. Levels ofcTnl were measured before anesthesia, and at 4, 24, and 7211 after surgery. Perioperative hemodynamic parameters and adverse cardiovascular events after surgery were also recorded. Results： Myocardial injury was detected in 18 patients in Group A and 7 in Group B. The difference was statistically signifcant （29.0% vs. 11.7%, P= 0.018）. The hemodynamic parameters were comparable between the groups, as were adverse cardiovascular events （P = 0.619）. Conclusions： Low-dose sevoflurane inhalation along with propofol reduces the incidence of myocardial injury in symptomatic patients after CEA.

关键词： Carotid Endarterectomy Myocardial Injury Propofol Sevoflurane

Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns

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Chinese Medical Journal 2015年第14期128卷 1922-1931页

作者： Wei Xiao Qing-Fang Duan Wen-Ya Fu Xin-Zuo Chi Feng-Ying wang Da-Qing Ma tian-long wang Lei Zhao Department of Anesthesiology Xuan Wu Hospital Capital Medical University Beijing 100053 China Department of Obstetrics and Gynecology Xuan Wu Hospital Capital Medical University Beijing 100053 China Department of Surgery and Cancer Pain Medicine and Intensive Care Faculty of Medicine Chelsea and Westminster Hospital Imperial College London United Kingdom

Background： Hypotension induced by combined spinal epidural anesthesia in parturient with hypertensive disorders of pregnancy （HDP） can easily compromise blood supply to vital organs including uteroplacental perfusion and result in fetal distress. The aim of this study was to investigate whether the goal-directed fluid therapy （GDFT） with LiDCOrapid system can improve well-being of both HDP parturient and their babies. Methods： Fifty-two stable HDP parturient scheduled for elective cesarean delivery were recruited. After loading with 10 ml/kg lactated Ringer＇s solution （LR）, parturient were randomized to the GDFT and control group. In the GDFT group, individualized fluid therapy was guided by increase in stroke volume （ASV） provided via LiDCO rapid system. The control group received the routine fluid therapy. The primary endpoints included maternal hypotension and the doses of vasopressors administered prior to fetal delivery. The secondary endpoints included umbilical blood gas abnormalities and neonatal adverse events. Results： The severity of HDP was similar between two groups. The total LR infusion （P 〈 0.01） and urine output （P 〈 0.05） were higher in the GDFT group than in the control group. Following twice fluid challenge tests, the systolic blood pressure, mean blood pressure, cardiac output and SV in the GDFT group were significantly higher, and the heart rate was lower than in the control group. The incidence of maternal hypotension and doses of phenylephrine used prior to fetal delivery were significantly higher in the control group than in the GDFT group （P 〈 0.01）. There were no differences in the Apgar scores between two groups. In the control group, the mean values of pH in umbilical artery/vein were remarkably decreased （P 〈 0.05）, and the incidences of neonatal hypercapnia and hypoxemia were statistically increased （P 〈 0.05） than in the GDFT group. Conclusions： Dynamic responsiveness guided fluid therapy with the LiDCOrapid system may provide po

关键词： Cesarean Delivery Fluid Therapy Hypertensive Disorders of Pregnancy LiDCOrapid System Parturient

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI Feng wang Tao DUAN Kaijie YANG Bin YANG Chunmei wang Xin tian Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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Optimizing battery deployment: Aging trajectory prediction enabling homogenous performance grouping

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Journal of Energy Chemistry 2025年第1期100卷 565-577页

作者： Shuquan wang Feng Gao Zhan Ma Hao tian Yusen Zhang School of Control Science and Engineering Shandong University Key Lab of Power System Intelligent Dispatch and Control of Ministry of Education Shandong University

As battery deployments in electric vehicles and energy storage systems grow, ensuring homogeneous performance across units is crucial. We propose a multi-derivative imaging fusion(MDIF) model, employing advanced imaging and machine learning to predict battery aging trajectories from minimal initial data, thus facilitating effective performance grouping before deployment. Utilizing a derivative strategy and Gramian Angular Difference Field for dimensional enhancement, the MDIF model uncovers subtle predictive features from discharge curve data after only ten cycles. The architecture includes a parallel convolutional neural network with lateral connections to enhance feature integration and *** on a self-developed dataset, the model achieves an average root-mean-square error of 0.047 Ah and an average mean absolute percentage error of 1.60%, demonstrating high precision and *** robustness is further validated through transfer learning on two publicly available datasets, adapting with minimal retraining. This approach significantly reduces the testing cycles required, lowering both time and costs associated with battery testing. By enabling precise battery behavior predictions with limited data, the MDIF model optimizes battery utilization and deployment strategies, enhancing system efficiency and sustainability.

关键词： Lithium-ion battery Battery prognostics Fusion model Convolutional neural network Transfer learning