检索结果-南通市图书馆

Computational prediction of cleavage using proteasomal in vitro digestion and MHC I ligand data

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 816-828页

作者： yu-feng LU hao SHENG Yi ZHANG Zhi-yang LI School of Mathematical Sciences Dalian University of Technology College of Science Hebei University of Science and Technology School of Information Science and Technology Dalian Maritime University

Proteasomes are responsible for the production of the majority of cytotoxic T lymphocyte(CTL) ***,it is important to identify correctly which peptides will be generated by proteasomes from an unknown ***,the pool of proteasome cleavage data used in the prediction algorithms,whether from major histocompatibility complex(MHC) I ligand or in vitro digestion data,is not identical to in vivo proteasomal digestion ***,the accuracy and reliability of these models still need to be *** this paper,three types of proteasomal cleavage data,constitutive proteasome(cCP),immunoproteasome(iCP) in vitro cleavage,and MHC I ligand data,were used for training cleave-site predictive methods based on the kernel-function stabilized matrix method(KSMM).The predictive accuracies of the KSMM+pair coefficients were 75.0%,72.3%,and 83.1% for cCP,iCP,and MHC I ligand data,respectively,which were comparable to the results from support vector machine(SVM).The three proteasomal cleavage methods were combined in turn with MHC I-peptide binding predictions to model MHC I-peptide processing and the presentation *** integrations markedly improved MHC I peptide identification,increasing area under the receiver operator characteristics(ROC) curve(AUC) values from 0.82 to *** results suggested that both MHC I ligand and proteasomal in vitro degradation data can give an exact simulation of in vivo processed *** information extracted from cCP and iCP in vitro cleavage data demonstrated that both cCP and iCP are selective in their usage of peptide bonds for cleavage.

关键词： Cytotoxic T lymphocyte epitopes Kernel function Proteasome Stabilized matrix method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

河北省肉牛养殖高质量发展评价体系构建及测度

引用

河北农业科学 2024年第2期28卷 87-94页

作者：王宇航魏子昊崔姹河北农业大学经济管理学院河北保定071000

为了科学设计指标体系评价及测度肉牛养殖高质量发展水平,从养殖高效、生产安全、绿色发展及福利提升4个维度,构建了肉牛养殖高质量发展评价指标体系;并基于河北省肉牛养殖微观调研数据,采用熵权法对其发展程度进行了研究。结果表明:(1)... 详细信息

为了科学设计指标体系评价及测度肉牛养殖高质量发展水平,从养殖高效、生产安全、绿色发展及福利提升4个维度,构建了肉牛养殖高质量发展评价指标体系;并基于河北省肉牛养殖微观调研数据,采用熵权法对其发展程度进行了研究。结果表明:(1)2019-2022年河北省肉牛养殖高质量发展水平波动上升,且内部发展不平衡。养殖高效维度、生产安全维度是综合得分提升的主要驱动力;福利提升维度是阻碍因素。(2)不同规模养殖户肉牛养殖高质量发展水平差异较大,大规模养殖户的肉牛养殖高质量综合得分最高,小规模养殖户的肉牛养殖高质量综合得分最低。散养、小规模养殖户肉牛养殖高质量发展的主要驱动因素为绿色发展和养殖高效;中规模、大规模养殖户肉牛养殖高质量发展的主要驱动因素为养殖高效和生产安全。(3)劳动生产率、机械化水平与出栏率是养殖高效维度提升的主要驱动力,发病率与死亡率是安全生产维度提升的主要驱动力,种养平衡率与粪污还田能力是绿色发展维度提升的主要驱动力,现代化设备投入水平是福利提升维度的主要驱动因素。头均收益、饲料报酬率、防疫周期、废弃物资源化利用水平和饲养密度是4个维度提升的制约因素。饲料报酬率与肉牛出栏率、防疫周期、种养平衡率和粪污还田能力、现代化设备水平是散养户、小规模养殖户4个维度提升的主要驱动力,平均日增重、死亡率和发病率、废弃物资源化利用水平、饲养密度分别是制约因素;劳动效率、死亡率和发病率、资源利用强度、现代化设备水平是中大规模养殖户4个维度提升的主要驱动力,平均日增重、防疫周期、种养平衡率、饲养密度是制约因素。提出以种养结合为抓手,推进肉牛养殖绿色高效发展;提高肉牛养殖现代化发展水平;引导中小规模养殖户提升养殖高质量发展水平的对策建议。

关键词：河北省肉牛养殖高质量发展熵权法

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chest pain showing precordial ST-segment elevation in a 96-year-old woman with right coronary artery occlusion:A case report

引用

World Journal of Clinical Cases 2021年第8期9卷 1877-1884页

作者： hao-yu Wu Gong Cheng Yi-Wei Cao Department of Cardiology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina Department of Electrocardiology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

BACKGROUND Typically,right coronary artery(RCA)occlusion causes ST-segment elevation in inferior ***,it is rarely observed that RCA occlusion causes STsegment elevation only in precordial *** general,an electrocardiogram is considered to be the most important method for determining the infarct-related artery,and recognizing this is helpful for timely discrimination of the culprit artery for reperfusion *** this case,an elderly woman presented with chest pain showing dynamic changes in precordial ST-segment elevation with RCA *** SUMMARY A 96-year-old woman presented with acute chest pain showing precordial STsegment elevation with dynamic *** injury markers became *** angiography indicated acute total occlusion of the proximal nondominant RCA,mild atherosclerosis of left anterior descending artery and 75%stenosis in the left circumflex coronary *** coronary intervention was conducted for the *** manual thrombus aspiration was performed,and fresh thrombus was aspirated.A 2 mm×15 mm balloon was used to dilate the RCA with an acceptable angiographic *** patient’s chest pain was relieved immediately.A postprocedural electrocardiogram showed alleviation of precordial ST-segment *** diagnosis of acute isolated right ventricular infarction caused by proximal nondominant RCA occlusion was *** indicated normal motion of the left ventricular anterior wall and interventricular septum(ejection fraction of 54%),and the right ventricle was slightly *** patient was asymptomatic during the 9-mo follow-up *** Cardiologists should be conscious that precordial ST-segment elevation may be caused by occlusion of the nondominant RCA.

关键词： Precordial ST-segment elevation Electrocardiogram Isolated right ventricular infarction Right coronary artery occlusion Chest pain Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel double-layer Silastic testicular prosthesis with controlled release of testosterone in vitro, and its effects on castrated rats

引用

Asian Journal of Andrology 2017年第4期19卷 433-438页

作者： Hui-Xing Chen Shi Yang Ye Ning Hai-hao Shao Meng Ma Ru-Hui tian yu-Fei Liu Wei-Qiang Gao Zheng Li Wei-Liang Xia School of Biomedical Engineering & Med-X Research Institute Shanghai Jiao Tong University Shanghai 200030 China Department of Andrology Urologic Medical Center Shanghai General Hospital Shanghai Jiae Tong University Shanghai 200080 China Shanghai Human Sperm Bank Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200135 China Controlled Release Laboratory Shanghai Institute of Planned Parenthood Research Shanghai 200030 China

Testicular prostheses have been used to deal with anorchia for nearly 80 years. Here, we evaluated a novel testicular prosthesis that can controllably release hormones to maintain physiological levels of testosterone in vivo for a long time. Silastic testicular prostheses with controlled release of testosterone （STPT） with different dosages of testosterone undecanoate （TU） were prepared and implanted into castrated Sprague-Dawley rats. TU oil was applied by oral administration to a separate group of castrated rats. Castrated untreated and sham-operated groups were used as controls. Serum samples from every group were collected to measure the levels of testosterone （T）, follicle-stimulating hormone and luteinizing hormone （LH）. Maximum intracavernous penile pressure （ICPmax） was recorded. The prostates and seminal vesicles were weighed and subjected to histology, and a terminal dexynucleotidyl transferase-mediated UTP nick end labeling （TUNEL） assay was used to evaluate apoptosis. Our results revealed that the weights of these tissues and the levels of T and LH showed significant statistical differences in the oral administration and TU replacement groups compared with the castrated group （P 〈 0.05）. Compared with the sham-operated group, the ICPmax, histology and TUNEL staining for apoptosis, showed no significant differences in the hormone replacement groups implanted with medium and high doses of STPT. Our results suggested that this new STPT could release TU stably through its double semi-permeable membranes with excellent biocompatibility. The study provides a new approach for testosterone replacement therapy.

关键词： controlled-release preparations hormone replacement therapy hypogonadism prosthesis Silastic testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Fixed-Point Iterative Method for Discrete Tomography Reconstruction Based on Intelligent Optimization

引用

Computer Modeling in Engineering & Sciences 2023年第1期134卷 731-745页

作者： Luyao Yang hao Chen haocheng yu Jin Qiu Shuxian Zhu School of Electronic and Information Engineering Suzhou University of Science and TechnologySuzhou215009China College of Mechanical Engineering Suzhou University of Science and TechnologySuzhou215009China

Discrete Tomography(DT)is a technology that uses image projection to reconstruct *** reconstruction problem,especially the binary image(0–1matrix)has attracted strong *** this study,a fixed point iterative method of integer programming based on intelligent optimization is proposed to optimize the *** solution process can be divided into two ***,the DT problem is reformulated into a polyhedron judgment problembased on lattice basis ***,the fixed-point iterativemethod of Dang and Ye is used to judge whether an integer point exists in the polyhedron of the previous *** the programs involved in this study are written in *** final experimental data show that this method is obviously better than the branch and bound method in terms of computational efficiency,especially in the case of high *** branch and bound method requires more branch operations and takes a long *** also needs to store a large number of leaf node boundaries and the corresponding consumptionmatrix,which occupies a largememory space.

关键词： Discrete tomography integer programming fixed-point iterative algorithm intelligent optimization lattice basis reduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

引用

International Journal of Ophthalmology(English edition) 2018年第11期11卷 1784-1795页

作者： Xin-Xin Li Wei Wu hao Zhou Jun-Jie Deng Meng-Ya Zhao tian-Wei Qian Chen Yan Xun Xu Su-Qin yu Department of Ophthalmology Shanghai General Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Disease Shanghai 200080 China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080 China Department of Mathematics Eidgenossische Technische Hochschule Zurich Zurich 8092 Switzerland

AIM： To compare the clinical performance of 4 spectraldomain（SD） optical coherence tomography angiography（OCTA） systems： AngioVueTM, AngioPlexTM, Spectralis？ OCTA, AngioScan, and 1 swept-source（SS） OCTA SS OCT AngioTM. METHODS： Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm^2 scan pattern（Spectralis OCTA for 3×3 mm^2 scan only）. Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance（ANOVA） with Bonferroni＇s post-test and Friedman test with Dunn＇s posttest were used to compare ***： The age of the subjects was 28.19±5.55 y（range, 23-49 y）. The spherical equivalent refraction was-2.55±1.84 D（range, 0.00 to-5.25 D）. Significant difference was observed in the evaluation of vessel valid visibility（Angio Vue the highest： 0.111±0.031 for 3×3 mm^2 scan and 0.128±0.020 for 6×6 mm^2 scan）, number of motion artifacts（AngioVue the fewest： 0.778±1.086 for 3×3 mm^2 scan and 0.333±0.620 for 6×6 mm^2 scan） and acquisition time（AngioPlex the shortest： 8.537±1.921 s for 3×3 mm^2 scan and 8.298±1.741 s for 6×6 mm^2 scan; all P〈0.001）. CONCLUSION： There is poor agreement of measurements among systems. AngioVue provides images with the highest vessel valid visibility and the fewest motion artifacts. AngioPlex achieves the shortest acquisition.

关键词： optical coherence tomography angiography devices vessel valid visibility motion artifacts acquisition time

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robust H∞ compensator with constraints for attitude manoeuvres of a quadrotor subject to unknown stochastic input delays

引用

Journal of Control and Decision 2019年第4期6卷 252-278页

作者： Yao yu Qing Wang Changyin Sun hao Liu Key Laboratory of Knowledge Automation for Industrial Processes of Ministry of Education School of Automation and Electrical EngineeringUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China School of Automation Southeast UniversityNanjingPeople’s Republic of China School of Astronautics Beihang UniversityBeijingPeople’s Republic of China

This paper addresses the robust compensator design problem for theattitude tracking of an indoor micro quadrotor subject to unknownstochastic input delays and input constraints. The attitude dynamicsof the micro quadrotor is modelled as a nonlinear system with linear parametric uncertainties, unknown stochastic input delays, inputconstraints and disturbances. Based on the uncertain model and theHanlanay’s inequality, both robust H∞ attitude tracking controllerand suboptimal robust H∞ controller with constraints are developed by constructing an appropriate Lyapunov–Krasvokii functionand presenting standard linear matrix inequalities. The suggestedcontrollers not only achieve the exponential stabilisation of attitudeof the quadrotor but also guarantee the given H∞ ***, both numerical simulation and experimental results are provided to illustrate the effectiveness and merits of the proposedmethods.

关键词： Robust H∞ attitude tracking constraints input delay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于Ventsim的大尹格庄金矿中期通风系统规划研究

引用

世界有色金属 2024年第8期 26-28页

作者：郝宗林于涛董国强甘肃省合作早子沟金矿有限责任公司甘肃甘南州747000 山东国环固废创新科技中心有限公司山东烟台265400 招金矿业股份有限公司山东烟台265400

大尹格庄金矿受高效回采速度及深部资源情况影响,需要及时进行中期通风系统规划以适应深部生产需求。在对中期通风系统进行风量计算和风量分配的基础上,制定通风路线优化方案,借助Ventsim软件建立优化方案的通风系统三维模型,进行了通... 详细信息

大尹格庄金矿受高效回采速度及深部资源情况影响,需要及时进行中期通风系统规划以适应深部生产需求。在对中期通风系统进行风量计算和风量分配的基础上,制定通风路线优化方案,借助Ventsim软件建立优化方案的通风系统三维模型,进行了通风容易期和困难期的通风阻力测算,同时通过模拟软件进行了-676m中段主扇选型,确定了主扇运行工况参数。在完成全部优化方案后,在三维通风模型中对整体通风系统运行情况进行了分析,主要井筒进回风模拟风量与设计风量基本一致,主要井巷风速均符合安全规程要求。通过对优化方案进行工程量估算及其他投资概算分析,便于该矿合理安排规划方案的实施。

关键词：通风系统方案规划 Ventsim 模拟分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

杜鹃素下调JAK2/STAT3通路改善高盐致脑基底动脉炎症和肌张力异常的研究

引用

中国临床药理学杂志 2024年第13期40卷 1898-1902页

作者：侯晓敏陈亮京郝雨萱张明升秦小江山西医科大学基础医学院山西太原030001 山西医科大学公共卫生学院山西太原030001 山西医科大学第二医院全科医学山西太原030001 山西医科大学第一医院全科医学山西太原030001

目的基于Janus激酶2(JAK2)/转录激活子3(STAT3)通路探讨杜鹃素对高盐诱导的小鼠脑基底动脉炎症和肌张力异常的抑制作用及其分子机制。方法用喂养高盐饲料的方法建立高盐模型。将50只C57BL/6J小鼠随机分成正常组(正常饲养)、模型组(高盐... 详细信息

目的基于Janus激酶2(JAK2)/转录激活子3(STAT3)通路探讨杜鹃素对高盐诱导的小鼠脑基底动脉炎症和肌张力异常的抑制作用及其分子机制。方法用喂养高盐饲料的方法建立高盐模型。将50只C57BL/6J小鼠随机分成正常组(正常饲养)、模型组(高盐饲料)、低剂量实验组(高盐饲料+灌胃12.5 mg·kg^(-1)·d^(-1)杜鹃素)、中剂量实验组(高盐饲料+灌胃25 mg·kg^(-1)d^(-1)杜鹃素)、高剂量实验组(高盐饲料+灌胃50 mg·kg^(-1)d^(-1)杜鹃素),每组10只,干预12周。用微血管张力测定仪检测小鼠脑基底动脉对血管收缩剂的收缩反应;用酶联免疫吸附试验(ELISA)法检测炎性细胞因子水平;用蛋白质印迹法检测基底动脉组织JAK2/STAT3通路的相关蛋白表达。结果正常组、模型组和低、中、高剂量实验组脑基底动脉对60 mmol·L^(-1)氯化钾(KCl)的收缩幅度分别为(2.19±0.13)、(2.66±0.11)、(2.52±0.09)、(2.41±0.08)和(2.25±0.10)mN;对10^(-5)mol·L^(-1)血管加压素(AVP)的收缩幅度分别为(1.98±0.09)、(2.46±0.08)、(2.33±0.12)、(2.11±0.10)和(2.05±0.06)mN;对2.5 mmol·L^(-1)氯化钙(CaCl_(2))的收缩幅度分别为(1.77±0.08)、(2.09±0.09)、(2.03±0.08)、(1.94±0.05)和(1.86±0.06)mN;血清中白细胞介素(IL)-1β水平分别为(10.10±3.21)、(47.28±4.78)、(40.16±3.98)、(35.87±4.12)和(20.32±3.17)pg·mL^(-1);肿瘤坏死因子-α(TNF-α)水平分别为(60.26±5.43)、(134.32±4.15)、(110.65±3.56)、(90.79±5.25)和(81.54±6.23)pg·mL^(-1);趋化因子配体3(CCL3)水平分别为(68.93±4.16)、(146.37±5.73)、(128.29±4.38)、(100.25±6.82)和(84.16±3.89)pg·mL^(-1);脑基底动脉组织JAK2表达水平分别为0.52±0.05、1.28±0.07、1.11±0.06、0.88±0.09和0.75±0.04;STAT3表达水平分别为0.58±0.07、1.93±0.10、1.62±0.04、1.34±0.06和0.88±0.09。模型组上述指标与正常组比较,均显著增高,差异均有统计学意义(均P<0.01)。中、高剂量实验组上述指标与模型组比较,均显著降低,差异均有统计学意义(P<0.05,P<0.01)。结论杜鹃素可能通过下调JAK2/STAT3通路改善高盐致小鼠脑基底动脉炎症和肌张力异常。

关键词：杜鹃素 Janus激酶2/转录激活子3 高盐脑基底动脉炎症肌张力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

简析污水生物相对酿酒废水治理监控的指导作用

引用

酿酒 2024年第4期51卷 21-25页

作者：胡浩孟玉刘松董家阳江苏洋河酒厂股份有限公司江苏宿迁223800

生化池系统依靠各种微生物去分解污水中的有机污染物,出水水质的好坏与微生物的活性息息相关。污水生物相观察诊断是监控污水运行的必备检测技术之一,能够及时准确地反映水质的变化和系统运行的好坏。通过对酿酒废水生化池系统中污水生... 详细信息

生化池系统依靠各种微生物去分解污水中的有机污染物,出水水质的好坏与微生物的活性息息相关。污水生物相观察诊断是监控污水运行的必备检测技术之一,能够及时准确地反映水质的变化和系统运行的好坏。通过对酿酒废水生化池系统中污水生物相的长期动态观察,分析指示性微生物的形态、种类、数量和优势度等与污水处理系统运行间的关系,能够及时对工艺系统做出相应优化与调整,指导污水处理厂高效稳定运行。

关键词：生化池污水生物相酿酒废水运行管理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：