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Nested case-control study of multiple serological indexes and Brighton pediatric early warming score in predicting death of children with sepsis

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World Journal of Clinical Cases 2019年第4期7卷 431-440页

作者： Xiong Xie Ming Li tian-tian Xiong Rui Wang Liang Xiao Department of Pediatrics Third Clinical Hospital China Three Gorges University Gezhouba Central Hospital

BACKGROUND Currently, it is difficult to predict the complications of children at the early stage of sepsis. Brighton pediatric early warning score(PEWS) is a disease risk assessment system that is simple and easy to operate, which has good sensitivity and specificity in disease recognition among children. Because detection indicators vary widely in children, a single indicator is difficult to assess the posttreatment status of children with *** To investigate the relationship between serological markers, Brighton PEWS, and death in children with sepsis after *** A total of 205 children diagnosed with sepsis at our hospital were enrolled. The baseline data, serum scores, and PEWS scores were recorded. In the nested casecontrol study, children who died during the study period were included in an observation group. According to the matching principle, the children who were not dead in the same cohort were included in a control group. The influencing factors of death in children with sepsis after treatment and the value of each evaluation index in predicting the prognosis of children were *** A total of 96 children were enrolled in the study, including 48 each in the observation group and the control group. Multivariate logistic regression analysis indicated that antibacterial treatments within 1 h(P = 0.017), shock(P = 0.044),multiple organ dysfunction syndrome(MODS)(P = 0.027), serum procalcitonin(PCT)(P = 0.047), serum albumin(ALB)(P = 0.024), and PEWS(P = 0.012) were independent risk factors for the death of children with sepsis. The area under the curve of the combination of ALB, PCT, and PEWS to predict the death in children with sepsis was the highest(0.908).CONCLUSION Antibacterial treatments within 1 h, shock, MODS, PCT, ALB, and PEWS are independent risk factors for the death of children with sepsis. The predictive accuracy of the combination of PCT, ALB, and PEWS for the prognosis of children with sepsis is the best.

关键词： Serological indicators Pediatric early warming score Sepsis Nested casecontrol study Systemic inflammatory reaction syndrome

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PKMζ knockdown disrupts post-ischemic long-term potentiation via inhibiting postsynaptic expression of aminomethyl phosphonic acid receptors

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The Journal of Biomedical Research 2015年第3期29卷 241-249页

作者： Nan Cheng Xiaoqiao Hu tian tian Wei Lu Department of Neurobiology Nanjing Medical University

Post-ischemic long-term potentiation （i-LTP） is a pathological form of plasticity that was observed in glutamate receptor-mediated neurotransmission after stroke and may exert a detrimental effect via facilitating excitotoxic damage. The mechanism underlying i-LTP, however, remains less understood. By employing electrophysiological recording and immunofluorescence assay on hippocampal slices and cultured neurons, we found that protein kinase M（（PKMζ）, an atypical protein kinase C isoform, was involved in enhancing aminomethyl phosphonic acid （AMPA） receptor （AMPAR） expression after i-LTP induction. PKMζ knockdown attenuated postsynaptic expression of AMPA receptors and disrupted i-LTP. Consistently, we observed less neuronal death of cultured hippocampal cells with PKMζ knockdown. Meanwhile, these findings indicate that PKMζ plays an important role in i-LTP by regulating postsynaptic expression of AMPA receptors. This work adds new knowledge to the mechanism of i-LTP, and thus is helpful to find the potential target for clinical therapy of ischemic stroke.

关键词： PKMζ i-LTP AMPA receptor oxygen glucose deprivation

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Orientation to learning context modulates retrieval processing for unrecognized words

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Chinese Science Bulletin 2010年第26期55卷 2966-2973页

作者： GUO ChunYan CHEN WenJun tian tian Ken A PALLER Joel L VOSS 'Learning & Cognition'Beijing Key Laboratory Department of Psychology Education Science College Capital Normal University Beijing 100048 China Department of Psychology and Interdepartmental Neuroscience Program Northwestern University Evanston Illinois USA Beckman Institute University of Illinois Urbana-Champaign Urbana Illinois USA Key Laboratory of Mental Health Chinese Academy of Sciences Beijing 100101 China

Explicit memory errors may occur when individuals fail to retrieve information about items previously studied (item memory) or about the learning context (source memory). We examined electrophysiological measures during recognition failure in order to determine the influence of retrieval orientation for item versus source information. Recognition failure was associated with brain potentials distinct from those associated with success. Furthermore, source-memory failures were associated with earlier-onset brain potentials with a more anterior distribution compared to item-memory failures. Neurocognitive processing was thus modulated by retrieval orientation so as to differentially influence neural correlates of successful versus unsuccessful retrieval.

关键词：学习环境检索环境调节词处理取向内存故障内存分配加工调制

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Role of reactive oxygen species in epithelial-mesenchymal transition and apoptosis of human lens epithelial cells

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 1935-1941页

作者： Rui-Hua Jing Cong-Hui Hu tian-tian Qi Bo Ma Department of Ophthalmology the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To investigate the role of reactive oxygen species(ROS)in epithelial–mesenchymal transition(EMT)and apoptosis of human lens epithelial cells(HLECs).METHODS:Flow cytometry was used to assess ROS production after transforming growth factorβ2(TGF-β2)*** of HLECs after H_(2)O_(2) and TGF-β2 interference with or without ROS scavenger N-acetylcysteine(NAC)were assessed by flow *** corresponding protein expression levels of the EMT markerα-smooth muscle actin(α-SMA),the extracellular matrix(ECM),marker fibronectin(Fn),and apoptosis-associated proteins were detected by using Western blotting in the presence of an ROS scavenger(NAC).Wound-healing and Transwell assays were used to assess the migration capability of ***:TGF-β2 stimulates ROS production within 8h in ***,TGF-β2 induced HLECs cell apoptosis,EMT/ECM synthesis protein markers expression,and pro-apoptotic proteins production;nonetheless,NAC treatment prevented these ***,TGF-β2 promoted HLECs cell migration,whereas NAC inhibited cell *** further determined that although ROS initiated apoptosis,it only induced the accumulation of the EMT markerα-SMA protein,but not COL-1 or ***:ROS contribute to TGF-β2-induced EMT/ECM synthesis and cell apoptosis of HLECs;however,ROS alone are not sufficient for EMT/ECM synthesis.

关键词： human lens epithelial cells epithelial-mesenchymal transition transforming growth factorβ2 reactive oxygen species apoptosis

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A cucurbit [8] uril recognized rigid supramolecular polymer with photo-stimulated responsiveness

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Chinese Chemical Letters 2015年第7期26卷 867-871页

作者： tian-tian Cao Xu-Yang Yao Jing Zhang Qiao-Chun Wang Xiang Ma Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology

A rigid supramolecular polymer was constructed in aqueous solution via cucurbit[8]uril （CB[8]） host recognition with a rigid monomer containing an azobenzene unit and two 4,4＇-bipyridin-l-ium （BP） moieties in the two ends, which also exhibited photo-responsiveness owing to the photoinduced trans- cis ~somerization of azobenzene group.

关键词： Supramolecular polymerPhoto-responsivenessHost-guest recognitionCucurbituril

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Surveying ionizing radiations in real time using a smartphone

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Nuclear Science and Techniques 2017年第5期28卷 81-85页

作者： Qing-Yang Wei Ru Bai Zhen-Peng Wang Ru-Tao Yao Yu Gu tian-tian Dai School of Automation and Electrical Engineering Beijing University of Science and Technology School of Medicine and Biological Sciences University at BuffaloState University of New York Department of Radiation Oncology China-Japan Friendship Hospital

Surveying ionizing radiations of the surrounding with a smartphone provides a low-cost and convenient utility for the general public. We developed a smartphone application(App) that uses the built-in camera with a CMOS sensor and a radiation signal extraction *** a calibration through a series of radiation exposures,the App could display radiation dose rate and cumulative dose in real time without requiring covering the camera lens. A smartphone with this App can be used as a fast survey tool for ionizing radiations.

关键词： Ionizing radiation CMOS sensor Smartphone Real time Detection

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Approaches towards the core pentasaccharide in N-linked glycans

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Chinese Chemical Letters 2018年第1期29卷 35-39页

作者： Ning Wang Sheng-Tao Li tian-tian Lu Hideki Nakanishi Xiao-Dong Gao Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of Biotechnology Jiangnan University

All eukaryotic cells share a common core pentasaccharide, Man3GlcNAc2 （M3）, which is found in both dolichol-linked oligosaccharides （DLOs） and N-linked glycoproteins. A pentasaccharide M3 can be elongated and elaborated by various glycosyltransferases and is thus considered as the key intermediate in the in vitro synthetic pathway of N-glycans. In this review, we describe the progresses in the preparation of M3 by chemical and chemoenzymatic methods. We first draw a brief schematic view of the typical N-glycan biological pathway and then focus on the requirements and challenges in obtaining core pentasaccharides. Representative methods and recent reported findings, especially research progress in chemoenzymatic synthesis, are highlighted. In addition, the opportunities in exploiting novel methods for constructing N-glycans, as well as their applications, are discussed.

关键词： N-GlycanPentasaccharideChemoenzymatic synthesisAlg proteinsMannosyltransferase

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Cellulose Acetate Thermoplastics with High Modulus, Dimensicnal Stability and Anti-migration Properties by Using CA-g-PLA as Macromolecular Plasticizer

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Chinese Journal of Polymer Science 2020年第10期38卷 1141-1148,I0008页

作者： Ru-Meng Xu tian-tian Yang Elvira Vidovic Ruo-Nan Jia Jin-Ming Zhang Qin-Yong Mi Jun Zhang CAS Key Laboratory of Engineering Plastis CAS Research/Education Center for Exellence in Molecular SciencesIstute of Chemistry.Chinese Academy of Sciences(CAS)Beijing 100190China University ofChinese Academy ofSciences Bejing 10049 China Faculty ofChemical Engineering and Technology.University ofZagreb Zagreb 1000Croatia

Cellulose diacetate(CDA)can be melt processed to produce numerous and widely-used plastic ***,due to the high glass transition temperature(Tg)of CDA,the addition of up to 30 wt%of micromolecular plasticizers is indispensable,which significantly reduces the dimensional stability and raises safety concerns from the migration of *** this work,a series of CDA-graft poly(lactic acid)(CDA-g-PLA)copolymers were synthesized by ring-opening polymerization of lactide onto the hydroxyI groups of *** resultant CDA-g-PLA copolymers possess adjustable degrees of substitution(DSpua)and side chain length(DPpLa)by controlling the reaction time and feed *** Tgs and thermal flow temperatures(Ts)of CDA-g-PLA strongly depend on DPpA such as the Tgs decrease linearly with the increase of *** CDA-g-PLA copolymers with the DPLA of 3-9 can be directly processed to transparent plastics by melt processing without any external plasticizers,because of their low Tfs of 170-215℃.More *** CDA-g PLA can act as the macromolecular *** obtained CDA/CDA-g-PLA has higher storage modulus,flexural modulus and Young's modulus than the commercial CDA plasticized with triethyl *** addition,the CDA/CDA-g PLA exhibits high dimensional stabilty and anti-migration *** a long term treatment at 80℃ and 60%humidity,the CDA/CDA-g-PLA can retain the initial ***,this work not only proposes a facile method for achieving a direct thermoplastic processing of CDA,but also provides a macromolecular plasticizer for CDA to make lightweight,stable and safer biobased thermoplastics.

关键词： Cellulose diacetate Thermoplastic processing Macromolecular plasticizer Poly(actic acid)

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Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

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Chinese Chemical Letters 2008年第9期19卷 1068-1070页

作者： Wei Zhang tian tian Sun Duo Mei Jun Fei Wang Ying Xia Li Key laboratory of Marine Drugs The Ministry of Education of China School of Pharmacy Ocean University of China Qingdao 266003 China

The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.

关键词： Synthesis Amino acid Schollkopf methodology Culicinins

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CIMBL55:a repository for maize drought resistance alleles

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Stress Biology 2023年第1期3卷 150-153页

作者： tian tian Feng Qin State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Droughts threaten crop yields *** to other major staple cereal crops,maize(Zea mays)is especially sensitive to drought,which can cause dramatic fluctuations in its yield *** maize populations contain many superior alleles that can enhance drought resistance through complex regulatory *** recently de novo assembled the genome of a prominent drought-resistant maize germplasm,CIMBL55,and systematically dissected the genetic basis for its drought resistance on the genome,transcriptome,and epigenome *** analyses revealed 65 favorable drought resistance alleles in ***,we genetically verified the functions of the drought resistance genes ZmABF4,ZmNAC075,and ZmRtn16 and unraveled the function of ZmRtn16 on a molecular level.

关键词： Maize Drought resistance Genome assembly Genetic variants

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