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考虑煤层割理的多分支水平井煤层气开发数值模拟研究

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煤炭学报 2024年第7期49卷 3167-3177页

作者：徐加祥赵洋董丹丹王玫珠杨焦生田丰华辽宁石油化工大学石油天然气工程学院辽宁抚顺113001 中国石油勘探开发研究院非常规研究所北京100083 中石油煤层气有限责任公司勘探开发建设分公司陕西西安710082

开发煤层气的多分支水平井形态多样且在对开发过程中割理的作用认识不清,有必要探究煤层中离散割理分布特征和多分支水平井形态对气井产能的影响。根据煤层中面割理和端割理的发育情况和正交特性,采用随机方法在煤层中分别构建了低密度... 详细信息

开发煤层气的多分支水平井形态多样且在对开发过程中割理的作用认识不清,有必要探究煤层中离散割理分布特征和多分支水平井形态对气井产能的影响。根据煤层中面割理和端割理的发育情况和正交特性,采用随机方法在煤层中分别构建了低密度、中密度和高密度的离散割理系统,并与等长型、纺锤型、交错型和哑铃型4种不同形态的多分支水平井结合,构建出多分支水平井开发煤层气的物理模型。在考虑开发过程中煤层有效应力变化和基质收缩效应的条件下建立了煤层基质和割理系统的应力敏感模型,并采用Langmuir定理计算煤层气的解吸附,建立了一种可压缩煤层气在煤层基质–割理系统–多分支水平井耦合中流动的开发模型,进而研究了多分支水平井形态和割理密度对煤层气开发的影响。结果表明:煤层中的离散割理可以极大地增加多分支水平井在短时间内对煤层的动用范围,但是仅限于与多分支水平井直接联通的割理及周围基质区域,未与多分支水平井联通的部分则需要较长的开发时间,这也是气井在较短的时间获得峰值产量并迅速减产的重要原因;等长型多分支水平井控制的储层范围最大,交错型、哑铃型和纺锤型的控制范围依次减小;在煤层中割理密度相同时,等长型多分支水平井的煤层气峰值日产量和20 a内的累积产量均高于其他3种类型的多分支水平井,可以取得更好的开发效果;增大多分支水平井主次井筒的夹角,等长型多分支水平井开发效果更好,同时纺锤型分支水平井的峰值日产量提高显著;交错型和哑铃型多分支水平井的峰值日产量对分支数量更加敏感,纺锤型多分支水平井的分支数量应不少于8条,而哑铃型多分支井的分支数量不多于6条。

关键词：煤层气多分支水平井煤层割理应力敏感产能分析

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基于压电单晶的宽频带复合棒换能器研究

舰船科学技术 2024年第11期46卷 139-144页

作者：刘一鸣马锐磊田丰华田文强中国船舶集团有限公司第七〇五研究所陕西西安710077

声场为当前水声探测中最重要的、可用的物理场。水声换能器作为声波产生、发射和接收的基本装置,是水声技术发展关注的重点。其中,尺寸小、重量轻、低频、宽带、大功率、抗振动为水声换能器研究和发展的重要方向。为提高复合棒换能器的... 详细信息

声场为当前水声探测中最重要的、可用的物理场。水声换能器作为声波产生、发射和接收的基本装置,是水声技术发展关注的重点。其中,尺寸小、重量轻、低频、宽带、大功率、抗振动为水声换能器研究和发展的重要方向。为提高复合棒换能器的声学性能,以锆钛酸铅(PZT-4)压电陶瓷和铌镁酸铅-钛酸铅(PMN-PT)压电单晶材料分别作为换能器的驱动元件,通过有限元仿真计算、设计加工及试验验证,进行了宽频带复合棒压电单晶换能器的研究,最后对2种换能器进行对比分析,进一步研究宽频带压电单晶换能器在低频、宽带、收发、加速度灵敏度等特性上的优势。研究结果表明,宽频带PMN-PT压电单晶换能器与相似规格的PZT-4压电陶瓷换能器相比,最大发送电压响应高3.4 dB,发送电压响应-6 dB带宽向两端拓展了5.5 kHz;最大接收灵敏度高4 dB,自由场接收灵敏度-6 dB带宽向两端拓展了8.1 kHz;加速度灵敏度更低,抗振动性能更好。

关键词：压电单晶复合棒换能器低频宽带加速度灵敏度

通道压裂中支撑剂团排列方式对裂缝导流能力的影响

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断块油气田 2024年第3期31卷 519-525页

作者：徐加祥赵洋王湘婷王玫珠杨焦生田丰华张艳博辽宁石油化工大学石油天然气工程学院辽宁抚顺113001 中国石油勘探开发研究院北京100083 中石油煤层气有限责任公司勘探开发建设分公司陕西西安710082

高速通道压裂是以支撑剂团支撑裂缝并获得更高裂缝导流能力的新型压裂技术。为了探究支撑剂团排列方式对裂缝整体导流能力的影响,文中在考虑闭合压力作用下支撑剂团和裂缝壁面变形的基础上,建立了一种流体在高速通道和支撑剂团中耦合的... 详细信息

高速通道压裂是以支撑剂团支撑裂缝并获得更高裂缝导流能力的新型压裂技术。为了探究支撑剂团排列方式对裂缝整体导流能力的影响,文中在考虑闭合压力作用下支撑剂团和裂缝壁面变形的基础上,建立了一种流体在高速通道和支撑剂团中耦合的流动模型,并对交错型和正对型支撑剂团排列方式的裂缝整体导流能力进行模拟,分析了支撑剂团半径和间距对裂缝整体导流能力的影响。结果显示:支撑剂团半径的减小和支撑剂团间距的增大均会导致裂缝支撑效果变差,正对型和交错型支撑剂团的半径均不宜小于0.100 m,支撑剂团间距不宜大于0.25 m;相同条件下,交错型支撑剂团填充的裂缝导流能力要比正对型支撑剂团填充的裂缝导流能力平均高53.53%。

关键词：非常规油气通道压裂支撑剂团分布裂缝导流能力

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食用菌栽培学课程教学改革研究

安徽农学通报 2024年第7期30卷 121-123页

作者：田风华王丽艳荆瑞勇徐彦军吴楠秦智贵州大学农学院贵州贵阳550025 黑龙江八一农垦大学生命科学技术学院黑龙江大庆163316 黑龙江八一农垦大学信息与电气工程学院黑龙江大庆163316

本文对食用菌栽培学课程教学改革进行探索。通过以项目带动教学,以信息化手段翻转课堂教学,设定教学目标,合理安排教学内容,优化教学过程和方法,优化考核方式,巧妙引入课程思政和积极开展校企合作推动学生就业等方式进行课程教学改革。... 详细信息

本文对食用菌栽培学课程教学改革进行探索。通过以项目带动教学,以信息化手段翻转课堂教学,设定教学目标,合理安排教学内容,优化教学过程和方法,优化考核方式,巧妙引入课程思政和积极开展校企合作推动学生就业等方式进行课程教学改革。将课程内容设置为包含真菌的生物学特性、食用菌的生理生态、消毒灭菌、菌种生产、常见和特色食用药用菌栽培技术及食用菌病虫害防治等模块,以提高食用菌栽培学的教学效果及学科竞争力,培养高质量人才。

关键词：食用菌栽培方法菌种生产人才培养

Assessment of blood and oxygen delivery to flaps of rhesus using near infrared steady-state spectroscopy

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Chinese Science Bulletin 2002年第21期47卷 1797-1802页

作者： tian fenghua DING Haishu CAI Zhigang WANG Guangzhi ZHAO Fuyun Department of Biomedical Engineering School of MedicineTsinghuaUniversityBeijing 100084China Hospital of Stomatology Peking UniversityBeijing 100081China

Near infrared spectroscopy has been considered as a potentially ideal noninvasive technique for the postoperative monitoring of plastic surgery. In this study, 6 flaps were raised on rhesus monkeys’ forearms. Blood and oxygen delivery to these flaps was monitored following vascular occlusions and inhalation of pure oxygen. Optical fibers were adopted in the probe of the oximeter so that the cutaneous detection could be performed in reflectance mode. Different and repeatable patterns of changes were measured following vascular occlusions on flaps. It is clear that the near infrared spectroscopy is capable of postoperatively monitoring vascular problems in flaps, especially the venous problem. Near infrared spectroscopy showed high sensitivity to detect the dynamic changes in flaps induced by inhalation of pure oxygen in this study. The experimental results indicated that it was potential to assess tissue viability utilizing the dynamic changes induced by some noninvasive stimulation (such as inhaling

关键词： near infrared spectroscopy plastic surgery blood oxy-genation flap.

黑木耳UGP基因家族全基因组鉴定及其与菌丝生长多糖合成的相关性研究

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种子 2024年第4期43卷 69-80页

作者：苏世贤吴媛刘翀江苏燕刘青媛陈孟谈龙茶汪淘徐彦军田风华韦金江郎云龙牟海林徐乾城李伟贵州大学农学院贵阳550025 贵州大学食用菌研究院贵阳550025 贵州省高等学校设施蔬菜工程研究中心贵阳550025 贵州高原蓝梦菇业科技有限公司贵州毕节551700

黑木耳多糖是具有药用价值的生物活性分子,然而黑木耳高多糖的合成分子机理尚未明确。本研究对处于多糖合成途径关键位置的UGP家族基因进行了鉴定,从黑木耳基因组中鉴定出2个AhUGPs基因,并从另外21个食用菌基因组内挖掘出39个UGPs基因,... 详细信息

黑木耳多糖是具有药用价值的生物活性分子,然而黑木耳高多糖的合成分子机理尚未明确。本研究对处于多糖合成途径关键位置的UGP家族基因进行了鉴定,从黑木耳基因组中鉴定出2个AhUGPs基因,并从另外21个食用菌基因组内挖掘出39个UGPs基因,通过生物信息学分析发现,UGP基因家族成员在真菌体内具有较高的保守性,成员数量少但仍发挥着重要作用,木耳属的4个UGPs则表现出了更高的保守性。在对黑木耳AhUGPs的启动子区域分析中发现了较多的光响应元件和激素响应元件,说明AhUGPs较易受到光和激素调节。在对AhUGPs的表征中,发现AhUGP1的表达水平与菌丝生长速度、菌丝生物量、多糖含量都显著相关,相较于AhUGP2,AhUGP1在菌丝生长和多糖合成中的重要性更高。

关键词：黑木耳 UGP基因家族多糖合成菌丝生长

Sorafenib sensitization in tumor therapy by iron overload and AMPK activation

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Nano Research 2024年第7期17卷 6386-6399页

作者： Jun Zhu Shoujie Zhao Yejing Zhu Shouzheng Ma Tenghui Han fenghua Xu Huichen Li Bo Wang Zhixiong Guo Da Chen Yongquan Qu Zhimin tian Junlong Zhao Lei Liu State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi’an 710032China Department of General Surgery The Southern Theater Air Force HospitalGuangzhou 510602China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China Department of Thoracic Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China Department of Neurology Airborne Army HospitalWuhan 430012China Key Laboratory of Modern Teaching Technology(Ministry of Education) Shaanxi Normal UniversityXi’an 710062China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China Department of Pediatrics Tangdu HospitalFourth Military Medical UniversityXi’an 710000China

Sorafenib,as a first-line drug for advanced hepatocellular carcinoma(HCC),could trigger ferroptosis by inhibiting cystine/glutamate ***,low-level intracellular iron and insufficient activation of adenosine monophosphate(AMP)-activated protein kinase(AMPK)confer impaired response to *** this study,a unique sorafenib nanocomposite dexterously modified with Fe-Material of Institut Lavoisier(sora@Fe-MIL)was synthesized to escalate intracellular iron level and activate AMPK,further potentiating the ferroptotic effect of ***,this strategic deployment of sora@Fe-MIL triggered an extensive demise of cancer cells,while manifesting negligible deleterious impact on normal *** prominent ferroptosis biomarkers,glutathione peroxidase 4(GPX4)and solute carrier family 7 member 11(SLC7A11),underwent pronounced downregulation,underscoring the efficacy of this strategy in inducing ***,the bioactivity of AMPK was considerably elevated,and its downstream targets were conspicuously inhibited by the treatment with sora@*** orthotopic HCC animal models,we observed a substantial suppression of primary in situ tumor growth,and ribonucleic acid(RNA)sequencing elucidated an elevated degree of ferroptosis and AMPK activation with the treatment of sora@*** conclusion,we proposed that the meticulously designed strategy for secure and efficacious iron release and AMPK activation could significantly potentiate the ferroptotic impact of sorafenib,thus resuscitating its therapeutic response in HCC patients.

关键词： anti-tumor ferroptosis Fe-Material of Institut Lavoisier(Fe-MIL) sorafenib adenosine monophosphate(AMP)-activated protein kinase(AMPK)

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智能建造背景下人机协作安全研究综述

东南大学学报（自然科学版） 2023年第6期53卷 1053-1064页

作者：夏侯遐迩田丰华李启明东南大学土木工程学院南京211189

为探究施工环境中人类工人与建筑机器人开展人机协作作业的安全保障措施,采用文献计量方法筛选并分析了来自Scopus、Web of Science以及谷歌学术3个数据库的227篇文献,从物理人机交互的角度讨论人机协作安全主题.定量文献分析结果表明,... 详细信息

为探究施工环境中人类工人与建筑机器人开展人机协作作业的安全保障措施,采用文献计量方法筛选并分析了来自Scopus、Web of Science以及谷歌学术3个数据库的227篇文献,从物理人机交互的角度讨论人机协作安全主题.定量文献分析结果表明,当前建造协作机器人的研究热度逐渐上升,且协作机器人是由多学科多技术共同支撑的.综述了建造协作机器人在智能建造背景下人机协作安全在碰撞避免、路径规划与轨迹规划、碰撞感知和柔顺控制三大方面的研究现状.提出了建造协作机器人结构仿生化发展、感知控制能力增强、交互方式智能化发展、建筑领域中人机安全协作方法完善和推广应用实践力度5个未来研究方向和发展建议.

关键词：智能建造协作机器人人机协作建筑机器人

Discussion of the Mode and Mechanism of Oil and Gas Accumulation in the Nanbaxian Pool in the North of the Qaidam Basin

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Petroleum Science 2005年第4期2卷 1-8页

作者： Li Fengjun Luo Qun Chen Shulan Liu Yunhon tian fenghua Basin and Reservoir Research Center China University of Petroleum Beijing 102249 China Beijing Jump Petroleum Techniques Development Co. Ltd Beijing 102249 China Testing Team of the 6th Oil Production Plant in Daqing Oilfield Company Limited Daqing Heilongjiang 163453 China Tarim Research Sub-center of BGP Geophysics Research Institute CNPC Xinjiang 841000 China

Because of the difference ofoil and gas accumulation condition between the hanging wall and the footwall of a fault, there is a peculiar accumulation mechanism that oil and gas mainly exists in the hanging wall of the basement fault, but in the footwall of the shallow detachment fault in the Nanbaxian pool. The oil and gas of the Nanbaxian pool came from the mature Jurassic hydrocarbon source rock of the Yibei depression located at the south of the Nanbaxian pool. Firstly, the oil and gas accumulated in the traps of the hanging wall of the basement fault by way of the unconformity and the basement faults, and turned into some primary deep pools; and then, the shallow detachment fault that formed in the later tectonic movement broke into the deep primary pools, which caused the oil and gas migration upwards along the basement faults and the shallow detachment faults and the evolvement into some secondary oil and gas pools later. The history of the Nanbaxian oil and gas accumulation can be summarized successively as the syndepositional upheaval controlled by faults; single hydrocarbon source rock; unconformities and faults as migration channels; buoyancy, overpressure and tectonic stress as dynamic forces; multistage migration and accumulation of oil and gas; and finally an overlapped double-floor pattern of oil and gas accumulation. The most important explorative targets in the north of the Qaidam Basin are traps connected with the primary pools in the footwall by shallow detachment faults.

关键词： Qaidam Basin Nanbaxian oil and gas pool mechanism of reservoir formation accumulation mode