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Direct-acting antivirals for chronic hepatitis C treatment: The experience of two tertiary university centers in Brazil

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World Journal of Hepatology 2022年第1期14卷 195-208页

作者： Mariana Sandoval Lourenço Patricia Momoyo Y Zitelli Marlone Cunha-silva Arthur Ivan N Oliveira Cláudia P Oliveira tiago Sevá-Pereira Flair JoséCarrilho Mario G Pessoa daniel F Mazo Division of Gastroenterology Department of Internal MedicineSchool of Medical SciencesUniversity of CampinasSao Paulo 13083-878Brazil Division of Clinical Gastroenterology and Hepatology Department of GastroenterologyUniversity of São Paulo School of MedicineSao Paulo 05403-900Brazil

BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent *** interferon-based therapies have been replaced by oral direct-acting antivirals(daA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of daAs for HCV treatment in subjects from two tertiary university centers in *** This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November *** therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of ***,anthropometric,clinical,and laboratory variables were *** were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)*** and serious adverse events(SAEs)were *** the statistical analysis,a P value ofdaclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,P=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,P=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,P=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,P=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,P=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,P=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,P=0.0009).AEs were reported

关键词： Chronic hepatitis C Antiviral agents Hepatitis C virus Sustained virologic response Liver cirrhosis Safety

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Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil

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World Journal of Gastroenterology 2020年第25期26卷 3611-3624页

作者： Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo silva Cézar tiago Nunes Gilaad G Kaplan Cyrla Zaltman Division of Gastroenterology Department of Internal MedicineClementino Fraga Filho HospitalFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Institute for Studies in Public Health Federal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Multidisciplinary Research Laboratory Clementino Fraga Filho HospitalInstitute of Thoracic DiseasesFaculty of MedicineFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of PiauíPiauí64049-550Brazil Almeida Division of GastroenterologyInflammatory Bowel Disease Outpatient ClinicRoberto Santos General Hospital(HGRS)of the Bahia State Department of HealthBahia 40110-060Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicIrmandade Santa Casa da Misericórdia of São PauloSão Paulo 01221020Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of Juiz de ForaMinas Gerais 36036-247Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicFederal District Base HospitalBrasília 70330-150Brazil Gastrointestinal Physiology Institute of Nutritional ScienceNestle Research CenterLausanne 1000Switzerland Departments of Medicine and Community Health Sciences University of CalgaryCalgary T2N4Z6Canada

BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be *** hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated *** To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development *** A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was *** regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),*** This is the first examining environmental exposures as risk factors for inflammatory bowel disease in *** of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.

关键词： Crohn’s disease Ulcerative colitis Risk factors Environmental factors Hygiene hypothesis

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BCG Infection after Bladder Cancer Treatment—3 Clinical Case Reports

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Advances in Infectious Diseases 2015年第4期5卷 218-221页

作者： Joana Alves Angélica Ramos Teresa Carvalho Susana silva Joao tiago Guimaraes António Sarmento Infectious Diseases Department Faculty of MedicineUniversity of PortoCentro Hospitalar Sao Joao EPEPortoPortugal Clinical Pathology Department Centro Hospitalar Sao Joao EPEPortoPortugal EPI Unit Institute of Public Health of University of PortoPortoPortugal Biochemistry Department Faculty of MedicineUniversity of PortoPortoPortugal

Immunotherapy with Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has become an effective and superior alternative to chemotherapy. Intravesical treatment with BCG appears to be relatively safe;however, occasionally BCG infection complicates such treatment. In the present work we describe three patients in whom BCG infection occurred after intravesical BCG therapy. All patients had positive urine culture forMycobacterium tuberculosis complex, using AccuProbe culture identification and then Genotype Mycobacterium MTBC test identified Mycobacterium bovis BCG. The diagnosis is difficult and microbiologic study is usually negative, so high index of suspicion is essential.

关键词： Bacillus Calmette-Guérin Intravesical BCG Therapy BCG Infection Disseminated M.bovis BCG Infection

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Gastric Bypass with Long Pouch and Transit Bipartition for Endoscopic Access to the Remaining Stomach

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Surgical Science 2022年第8期13卷 353-366页

作者： Paulo Reis Esselin de Melo Marcella Giovana Gava-Brandolis Thonya Cruz braga danilo Fossalussa Minari Ricardo Augusto Martins Bueno da Costa Jose Geraldo Moraes Sampaio Neto Louise Flores silva José Humberto Cardoso Resende Hospital Estadual Alberto Rassi Surgical Skills Coordinator Goi&#226nia Brazil UNIFAN Research Coordinator Aparecida de Goi&#226nia Brazil

Introduction: obesity has a complex and multifactorial etiology, difficult treatment and increasing incidence rates in recent decades. The treatment involves clinical and pharmacological approaches and, in case of lack of results, surgical interventions. Roux-en-Y gastric bypass (RYGB) is one of these surgical interventions in which the stomach is divided, creating a small pouch, and the remaining portion of the stomach become excluded and left without endoscopic access. Objective: to evaluate the results of modified RYGB with long pouch and endoscopic access to the remaining stomach. Materials and Methods: prospective clinical trial with sample selected among patients seen at the Alberto Rassi General State Hospital of Goiânia (HGG) and indicated for bariatric and metabolic surgery confirmed by the medical and multidisciplinary team. The study was conducted from January 2020 to August 2021. Clinical history and laboratory test results of the selected patients were collected through consultations with the medical and multidisciplinary team. Results: twelve participants were included in the study. Of these, 11 (91.7%) were women and the mean age was 46.3 years. The weight before surgery was 112.17 kg (92.00 - 150.00) and the Body Mass Index (BMI) was 44.89 (35.06 - 74.39). After 18 months of surgery, the mean weight was 80.77 kg (±11.92) and the mean BMI was 29.46 (±11.00), showing a significant reduction in both (p = 0.003 and p = 0.002, respectively). All patients underwent endoscopic evaluation of the pouch, remaining stomach and duodenum at 12 months postoperatively. The mean percentage of lost excess weight loss was 68.21%. Conclusion: We conclude that the proposed changes in RYGB (GBLP + GIB – Roux-en-Y gastric bypass with long pouch and gastrointestinal bipartition) did not compromise weight loss or control of type 2 diabetes and other comorbidities and proved to be a safe and effective alternative without gastroduodenal exclusion, enabling a better postop

关键词： Obesity Bariatric Surgery Metabolic Surgery Roux-En-Y Gastric Bypass

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Antioxidant,Antibacterial and Antitumor Activity of Ethanolic Extract of the Psidium guajava Leaves

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American Journal of Plant Sciences 2014年第23期5卷 3492-3500页

作者： Tatiane Vieira braga Rosana Goncalves Rodrigues das Dores Camila Soncin Ramos Fernanda Cristina Gontijo Evangelista Leticia Marcia da silva Tinoco Fernando de Pilla Varotti Maria das Gracas Carvalho Adriano de Paula Sabino Federal University of Minas Gerais Belo HorizonteBrazil Federal University of Ouro Preto Ouro PretoBrazil Federal University of Sao Joao Del Rei DivinopolisBrazil Pitagoras Faculty Belo HorizonteBrazil

Psidium guajava L. has extensive use in folk medicine. The aim of this study was to quantify the levels of phenolic, flavonoids, antioxidant activity, leathality assay and antibacterial and antitumoral activities of the extract of P. guajava. In the dry guava extract there were high levels of phenolics (766.08 ± 14.52 mg/g), flavonoids (118.90 ± 5.47 mg/g) and antioxidant activity (87.65%). The LD50 was 185.15 μg/ml. The MIC value was 250 μg/ml for Streptococcus mutans, Streptococcus mitis and Streptococcus oralis. IC50 of the extract tested in the HeLa, RKO and Wi cell lines was 15.6 ± 0.8 μg/ml, 21.2 ± 1.1 μg/ml and 68.9 ± 1.5 μg/ml, respectively. The results of all analyses allow us to conclude that the dry extract of guava leaves has promising activity to be applied topically in the oral cavity or in the development of antitumor formulation or even be used as a functional food.

关键词： Guava Antitumor Medicinal Plants Functional Foods

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Comparison of Experimental Methods to Assess the Competitive Ability of Weed Species

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American Journal of Plant Sciences 2015年第13期6卷 2185-2196页

作者： Leandro Galon Germani Concenco Gismael Francisco Perin Alexandre Ferreira da silva Cesar tiago Forte Felipe de Adelio david Lauri Lourenco Radüz André Luiz Radunz André Andres Siumar Pedro Tironi Samara Emerim Concenco Plant Science Department Federal University of the Southern Border Erechim Brazil Weed Science Embrapa Western Agriculture Dourados Brazil Embrapa Maize and Sorghum Sete Lagoas Brazil Weed Science Embrapa Temperate Agriculture Pelotas Brazil Plant Science Department Federal University of the Southern Border Chapecó Brazil Federal Institute of Santa Catarina at Santa Rosa do Su-SC Santa Rosa do Sul Brazil

Competition between crops and weeds interfere on growth and development with harm to one or both, in different ways. To quantify these differences in competition, additive and replacement series study methods are most often used, each with different characteristics and goals. Therefore, we aimed with this work to study inter-specific competition between plants of soybean and corn against the weeds Bidens pilosa (beggartick) and Digitaria insularis (sourgrass), by two experimental methods of study: additive and replacement series (substitutive) experiments. Initial tests were performed prior to the installation of replacement series experiments to describe the intra-specific competition features for all species. For additive experiments these are unnecessary. To compare the methods of study, there were two sets of trials (an additive and a substitutive) installed under greenhouse, during the growing season 2013/14. Variables analyzed were leaf area and dry weight of shoots of crops and weeds, at 50 days after emergence. The results were analyzed according to the methods used, these being compared. It was found that the additive method supplied results most prone to be applied in the field, while the replacement series (substitutive) method was more appropriate for studies that aimed to provide detailed scientific information regarding the proportions of plants and coefficients describing the behavior of the species community.

关键词： Interference Zea mays Glycine max Weeds

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Immune response to Helicobacter pylori infection and gastric cancer development

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World Journal of Meta-Analysis 2021年第3期9卷 257-276页

作者： Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa braga Maria Luísa Cordeiro Santos Filipe Antônio França da silva Hanna Santos Marques Natália Oliveira e silva Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45031900BahiaBrazil

Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(***)infection is the main risk factor for its *** note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this *** development of an inflammatory process against *** involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial *** process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper *** released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ***,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its *** addition,various repercussions related to some *** virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis.

关键词： Gastric cancer Helicobacter pylori Immune response Virulence factors Polymorphisms

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Comparative Study of Collagen Stimulation Using Semi-Ablative and Non-Ablative Radiofrequency

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Journal of Biosciences and Medicines 2022年第6期10卷 79-89页

作者： Patrícia Froes Meyer Rodrigo Marcel Valentim da silva Eneida De Morais Carreiro Rafaella Rêgo Maia Stephany Luanna Queiroga Farias Ciro dantas Soares Yuri Alexander Afonso Gustavo Felipe Pasqual Silene Bazi Ribeiro Roberto tiago Alves Pinheiro University Centre of Rio Grande do Norte (UNIRN) Natal Brazil Estácio de Sá University Natal Brazil Federal University of Rio Grande do Norte Natal Brazil Potiguar University (UNP) Natal Brazil Campinas State University (UNICAMP) Campinas Brazil Brazilian Society of Plastic Surgery Brazil FSG University Centre of Serra Gaúcha Caxias do Sul Brazil MARC Institute Miami USA

Objective: Comparison between semi-ablative and non-ablative radiofrequency for collagen stimulation. Method: Three volunteers with scheduled surgical procedures of abdominoplasty were selected. After the evaluation, the abdominal area was divided into three quadrants, with the right region receiving monopolar non-ablative radiofrequency (RF) application. In contrast, the left region received fractionated radiofrequency (FRF) application, using three different needle sizes (0.5, 1.5, and 3.0 mm), and the intermediate area was kept as a control. After 24 hours, surgery was performed, and the skin flaps were collected for histological and immunohistochemical analyses. Results: An increase in total collagen and type I collagen was observed in the treated groups. There was also an increase in the expression of COX-2, CD68 positive cells (macrophages), and lymphocyte markers (CD3, CD20, and NK-CD57). Furthermore, it was seen that only the use of 3.0-mm needles kept the channels open in the superficial tissue after 24 hours. There were no significant differences between the modalities. Conclusion: Non-ablative and sub-ablative radiofrequency have positive and effective results for flaccidity, demonstrating the success in collagen production. Furthermore, this study is the first to present channel opening and permanence time, which are important to optimize the action of drug delivery.

关键词： Collagen Flaccidity Radiofrequency Drug Delivery

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Nitrogen Fertilization on Maize Sowing:Plant Growth and Seed Vigor

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American Journal of Plant Sciences 2018年第1期9卷 83-97页

作者： Cristian Troyjack Joao Roberto Pimentel Itala Thaísa Dubal Padilha Ruddy Alvaro Veliz Escalera Lanes Beatriz Acosta Jaques Felipe Koch Manoela Andrade Monteiro Gustavo Henrique Demari Vinicius Jardel Szareski Ivan Ricardo Carvalho Luis Osmar braga Schuch tiago Zanatta Aumonde tiago Pedó Federal University of Pelotas Capao do LeaoBrazil

The management of fertilization in maize plants is a preponderant factor in the search for higher yields and obtaining quality seeds. In this sense, the study of nitrogen (N) management is predominant in improving the efficiency of its application. The objective of this study was to evaluate the growth, partition assimilation and vigor expression of maize seeds submitted at different doses of nitrogen applied at sowing. The treatments were constituted by different doses of nitrogen fertilization at sowing, being: 25%, 50%, 75% and 100% of the recommended dose for the crop, according to the recommendation of nitrogen fertilization. The plants were collected at regular intervals of 21 days after sowing until the end of the growth cycle. For the analysis of growth and partition of dry matter between the organs, the accumulation of dry matter and leaf area was measured. The experimental design was randomized blocks in a 4 × 7 factorial scheme (four N rates at sowing and seven collection times with three replications). The maize plants under the influence of nitrogen fertilization at sowing presented differential growth and distinct responses in the assimilated partition between their structures, with the intensity dependent on the dose used. Plants grown using 75% of the recommended dose of N at sowing had a higher relative growth rate, with more pronounced effects compared to the other doses. The expression of maize seed vigor increases to an increase of 82.5% N at sowing.

关键词： Emergence Speed Net Assimilation Rates Relative Growth Rates Zea mays L. Vigor

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Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1307-1323页

作者： tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle silva Teresa Fiúza Department of Medical Oncology Hospital Professor Doutor Fernando Fonseca EPEAmadora 2720-276Portugal Department of Medical Oncology Centro Hospitalar Barreiro-Montijo EPEBarreiro 2830-003Portugal Department of Medical Oncology Hospital do Espírito Santo deÉvora EPEÉvora 7000-811Portugal Department of Medical Oncology Centro Hospitalar Universitário do Algarve EPEAlgarve 8000-386Portugal Department of Medical Oncology Hospital São Francisco XavierCentro Hospitalar Lisboa Ocidental EPELisboa 1449-005Portugal Department of Medical Oncology Hospital Santo António dos CapuchosCentro Hospital Lisboa Central EPELisboa 1169-050Portugal Department of Medical Oncology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Medical Oncology Centro Hospitalar de Trás-os-Montes e Alto Douro EPEVila Real 5000-508Portugal Department of Medical Oncology Hospital da Senhora da Oliveira EPEGuimarães 4835-044Portugal Department of Medical Oncology Hospital Garcia de Orta EPEAlmada 2805-267Portugal Department of Medical Oncology Hospital da LuzLisboa 1500-650Portugal Department of Medical Oncology Hospital Distrital de Santarém EPESantarém 2005-177Portugal

BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive *** To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC *** This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese *** were compared through non-parametric Mann-Whitney *** operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent *** This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of *** Higher NLR is correlated with longer survival *** LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT a

关键词： Gastric cancer Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel Neutrophil-to-lymphocyte Lymphocyte-to-monocyte Platelet-to-lymphocyte Tumor regression grade

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