Antioxidant,Antibacterial and Antitumor Activity of Ethanolic Extract of the Psidium guajava Leaves

作     者：Tatiane Vieira Braga Rosana Goncalves Rodrigues das Dores Camila Soncin Ramos Fernanda Cristina Gontijo Evangelista Leticia Marcia da Silva Tinoco Fernando de Pilla Varotti Maria das Gracas Carvalho Adriano de Paula Sabino 

作者机构：Federal University of Minas GeraisBelo HorizonteBrazil Federal University of Ouro PretoOuro PretoBrazil Federal University of Sao Joao Del ReiDivinopolisBrazil Pitagoras FacultyBelo HorizonteBrazil 

出 版 物：《American Journal of Plant Sciences》 (美国植物学期刊（英文）)

年 卷 期：2014年第5卷第23期

页      面：3492-3500页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq) Fundacao de Amparo a Pesquisa do Estado de Minas Gerais(FAPEMIG)and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)for sponsoring this investigation 

主　　题：Guava Antitumor Medicinal Plants Functional Foods 

摘      要：Psidium guajava L. has extensive use in folk medicine. The aim of this study was to quantify the levels of phenolic, flavonoids, antioxidant activity, leathality assay and antibacterial and antitumoral activities of the extract of P. guajava. In the dry guava extract there were high levels of phenolics (766.08 ± 14.52 mg/g), flavonoids (118.90 ± 5.47 mg/g) and antioxidant activity (87.65%). The LD50 was 185.15 μg/ml. The MIC value was 250 μg/ml for Streptococcus mutans, Streptococcus mitis and Streptococcus oralis. IC50 of the extract tested in the HeLa, RKO and Wi cell lines was 15.6 ± 0.8 μg/ml, 21.2 ± 1.1 μg/ml and 68.9 ± 1.5 μg/ml, respectively. The results of all analyses allow us to conclude that the dry extract of guava leaves has promising activity to be applied topically in the oral cavity or in the development of antitumor formulation or even be used as a functional food.