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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang Gang Shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang Anton Gao Weiwei Qi Xia Yang ti zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

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高阶矩风险与市场收益:来自中国期权市场的证据

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管理科学学报 2024年第5期27卷 122-140页

作者：周倜王云奇南方科技大学商学院金融系深圳518055 深圳证券交易所博士后工作站深圳518038

基于上证50ETF期权隐含的方差和高阶矩的期限结构,本研究使用偏最小二乘回归的降维方法构造了与中国股票市场收益相关的方差-高阶矩风险因子.实证结果显示,在2015年到2020年的样本期内,该风险因子显著地预测未来1个月以及2周至8周的市... 详细信息

基于上证50ETF期权隐含的方差和高阶矩的期限结构,本研究使用偏最小二乘回归的降维方法构造了与中国股票市场收益相关的方差-高阶矩风险因子.实证结果显示,在2015年到2020年的样本期内,该风险因子显著地预测未来1个月以及2周至8周的市场收益,月度样本内和样本外R^(2)分别达到了10.08%和6.55%.在控制了常见的经济预测变量和期权变量后,该因子的预测能力仍然保持显著.这表明我国股市收益中包含了对偏度和峰度风险的补偿,与含时变高阶矩的资产定价模型相一致.在经济价值方面,方差-高阶矩因子的预测能力可为投资者在市场择时交易中带来可观的收益.结果表明,中国期权市场提供了高阶矩风险的独特信息,这为理解我国股市风险与收益的权衡关系提供了新的角度.

关键词：上证50ETF期权风险中性高阶矩股票收益率可预测性偏最小二乘回归时变高阶矩CAPM

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Ultra-Thin Layer HTaMoO6 Catalyst for the Upgrading of Carbohydrates into 5-Hydroxymethylfurfural

Ultra-Thin Layer HTaMoO6 Catalyst for the Upgrading of Carbo...

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第4届分子科学博士后学术年会

作者： Lei Zhang Bingfeng Chen ti zhou Xiaomeng Cheng Minghua Dong Ye Liu Huizhen Liu Qingling Xu Buxing Han School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesCenter for Carbon Neutral ChemistryInstitute of ChemistryChinese Academy of Sciences Shandong IFT Science & Technology CO LTD.

The conversion of carbohydrates into 5-hydroxymethylfurfural（HMF）, a vital and valuable platform chemical, is sought after in industrial applications but poses significant challenges. In this research, we engineered an ultra-thin layer HTaMoO catalyst using ball-milling/liquid-exfoliation technique, demonstrating its efficiency in catalyzing the transformation of carbohydrates to HMF. In contrast to the conventional method utilizing tetra（n-butylammonium） hydroxide as the intercalation agent, the ball-milling/liquid-exfoliation technique not only reduces catalyst preparation time（within 12 hours） but also enhances the efficient intercalation, leading to the formation of an ultra-thin layer structure. The resulting catalyst exhibits high total acidity, a favorable Br?nsted/Lewis acid ratio, and improved accessibility of active sites due to the thin layer structure post-exfoliation. Compared with bulk LiTaMoO, the ultrathin layer HTaMoO catalyst enables complete fructose dehydration with an HMF yield reaching 89.1% under moderate reaction conditions（120 ℃, 1 hour） and 47.2% yield of HMF is obtained from sucrose at 130 ℃. This work provides a new method to fabricate the solid acid for the transformation of carbohydrates.

关键词： High speed ball-milling Liquid-exfoliation Synergistic catalysis Ultra-thin layer nanosheets 5-hydroxymethylfurfural

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内皮祖细胞在心血管疾病治疗中的作用机制及临床应用前景

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生命的化学 2024年第8期44卷 1449-1457页

作者：钟友斌周倜中山大学中山医学院生物化学与分子生物学系广州510080

心血管疾病(cardiovascular diseases,CVD)是引起死亡的重要因素之一,造成了巨大的经济和医疗负担,探索新的治疗方法和策略显得尤为迫切。在当代医学研究中,内皮祖细胞(endothelial progenitor cells,EPCs)因具有修复受损内皮、促进血... 详细信息

心血管疾病(cardiovascular diseases,CVD)是引起死亡的重要因素之一,造成了巨大的经济和医疗负担,探索新的治疗方法和策略显得尤为迫切。在当代医学研究中,内皮祖细胞(endothelial progenitor cells,EPCs)因具有修复受损内皮、促进血管生成和调节血管功能的能力,作为一种具有潜在治疗价值的细胞类型备受关注。本文首先介绍EPCs的来源、特性和生物学功能,随后重点综述其在CVD治疗中可能的作用机制。此外,本文还总结了EPCs在临床应用中的挑战与机遇,并展望了其在CVD治疗中的潜在应用前景,以期为未来EPCs治疗疾病的相关研究和临床应用提供一定的理论参考。

关键词：内皮祖细胞心血管疾病临床应用

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新媒体环境下营销人才的能力体系研究——基于广深企业招聘信息的社会网络分析

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时代经贸 2024年第5期21卷 113-118页

作者：蒋文锋欧阳峰周倜广州商学院粤港澳大湾区数智商务研究中心广东广州511363

新媒体营销的快速兴起,凸显出新媒体环境下营销人才的供需矛盾,其能力体系不明确,难以适应当前新媒体市场的企业需求。本文运用大数据方法,采集广深两地企业在新媒体营销岗位招聘信息中的文本内容,并采用社会网络分析方法,构建新媒体环... 详细信息

新媒体营销的快速兴起,凸显出新媒体环境下营销人才的供需矛盾,其能力体系不明确,难以适应当前新媒体市场的企业需求。本文运用大数据方法,采集广深两地企业在新媒体营销岗位招聘信息中的文本内容,并采用社会网络分析方法,构建新媒体环境下营销人才的能力体系。研究结果表明,新媒体环境下营销人才的能力体系分为两个层级:一级能力包括数据分析、策划、内容编辑与文案写作、运营与推广等能力,进一步细分得到14个关键的二级能力。相较传统研究方法,大数据社会网络分析方法具有高效率、高代表性和低成本的优势,可以在各专业人才能力体系的构建中广泛使用,其成果为规划专业人才培养方案、建设课程和知识体系、建设实践教学体系提供支持。

关键词：新媒体营销能力体系社会网络分析文本挖掘词频分析

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Influence of varying forms of bionic units on repairing remaining quenching surface of gray cast iron

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Journal of Iron and Steel Research International 2021年第2期28卷 201-210页

作者： Hui Li Li Feng Hong zhou Peng Zhang ti zhou Qi Sui Lu-quan Ren Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationChangchun 130025JilinChina School of Material Science and Engineering Jilin UniversityChangchun 130025JilinChina School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025JilinChina Key Laboratory of Terrain Machinery Bionics Engineering(Jilin University) Ministry of EducationChangchun 130025JilinChina

In order to repair and reuse remaining quenching surface(RQS)divided into severely worn surface(SWun-S)and mildly worn surface(MWun-S)of abandoned gray cast iron guide rail,inspired by the bionic theory,varying forms of bionic units such as spot(Sp-S),striation(St-S),and reticulation(Re-S)were fabricated on RQS of gray cast iron through laser processing ***,the microstructure,phase composition,and microhardness of bionic units and RQS were analyzed by optical microscopy as well as X-ray diffraction instrument and scanning electron microscopy,***,the oil lubrication wear experiment was performed on homemade line reciprocating wear *** results demonstrated that the bionic units had a significant effect on improving wear resistance of RQS of abandoned guide rail due to the microstructure and higher *** addition,the weight loss ratios of MWun-S,Sp-S,St-S,and Re-S samples were decreased by 36.72%,36.78%,62.26%,and 80.39%,respectively,compared with that of SWun-S *** mechanism of wear resistance enhancement was also discussed.

关键词： Repairing Laser bionic unit Remaining quenching surface Gray cast iron

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《口腔修复数字化美学设计流程专家共识》解读

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中国实用口腔科杂志 2024年第4期17卷 414-417页

作者：周倜柳忠豪师晓蕊刘峰滨州医学院附属烟台口腔医院山东烟台264000 北京大学口腔医学院第一门诊部北京100034

在口腔美学修复工作中,数字化美学设计能够通过可视化的手段帮助医生预测并呈现未来的治疗效果,促进医患双方对美学目标达到一致的理解与认知,是实现理想美学修复效果的重要支持。然而,许多临床医生在数字化美学设计方面缺少系统的认识... 详细信息

在口腔美学修复工作中,数字化美学设计能够通过可视化的手段帮助医生预测并呈现未来的治疗效果,促进医患双方对美学目标达到一致的理解与认知,是实现理想美学修复效果的重要支持。然而,许多临床医生在数字化美学设计方面缺少系统的认识,相关流程也缺乏明确的诊疗规范和指南。文章旨在通过分析国内外文献和临床实践经验,详细解读《口腔修复数字化美学设计流程专家共识》的制定过程,阐述其主要内容和主要观点,以期为临床医生提供更全面的指导。

关键词：口腔美学修复数字化美学设计专家共识

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Production of Embryogenic Callus and Plant Regeneration from Elite Guizhou Waxy Maize Inbred Lines

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Agricultural Sciences in China 2011年第4期10卷 490-498页

作者： ZHONG De-yi ZHU You-yin LIU qian zhou ti ZHAO De-gang Guizhou Key Laboratory ofAgro-Bioengineering Guizhou University Guiyang 550025 P.R. China Laboratory of Green Pesticide and Agricultural Biengineering Ministry of Education/Guizhou University Guiyang 550025 P.R.China College of Life Sciences Guizhou University Guiyang 550025 P.R.China

Immature embryos from three elite Guizhou waxy maize inbred lines （W21019, B7, and QCL5036） were evaluated for their ability of forming callus and regeneration into plants. Immature embryos harvested at different physiological stages were used as explants to initiate callus on N6 basal medium with 0-3.5 mg L-1 of 2,4-dichlorophenoxy acetic acid （2,4-D）. The concentration of 2,4-D, physiological age of immature embryos and genotype had a significant effect （P0.05） on the percentage of embryogenic callus formed. The optimum 2,4-D concentration for the initiation of embryogenic callus was varied among the waxy maize genotypes from 2.0 mg L-1 （B7 and QCL5036） to 3.0 mg L-1 （W21019）. The shoots were generated from embryogenic callus which were transferred into the regeneration medium supplemented with 0-2.5 mg L-1 of 6-benzylaminopurine （6-BA）. 6-BA in the medium significantly promoted the regeneration of embryogenic callus. Embryogenic size was also an important factor that affected regeneration capacity. 0.6-0.7 cm was proved to be the best size for regeneration from embryogenic callus and the mean number of shoots per primary callus in all genotypes achieved the highest number. The ability of the plant regeneration was also affected by genotype. W21019 had the highest number of shoots formed per primary embryogenic callus. With the optimum condition, the highest mean number of shoots per primary callus was up to 12.13, 5.73, and 3.33 in line W21019, B7, and QCL5036, respectively. The successful regeneration of the two inbred lines provides a basis for development of genetic transformation to improve priority traits such as enhanced insects and drought tolerance.

关键词： waxy maize immature embryos embryogenic callus regeneration Zea mays L.

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脂质纳米颗粒递送mRNA在疾病防治中的应用

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生物化学与生物物理进展 2024年第10期51卷 2677-2693页

作者：孙伟伦周悌强杨海银李路伟翁郁华张金超黄渊余梁兴杰北京理工大学生命学院、前沿交叉科学研究院、分子医学与生物诊疗重点实验室、医药分子科学与制剂工程重点实验室北京100081 国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室北京100190 河北大学化学与环境科学学院药物化学与分子诊断教育部重点实验室新型药物制剂与辅料全国重点实验室化学生物学重点实验室保定071002

近年来,信使核糖核酸(messenger RNA,mRNA)疗法作为一种革命性的治疗手段,在遗传性疾病、传染病以及癌症治疗领域展现出巨大潜力。然而,mRNA分子的不稳定性和体内递送的低效性仍是限制其广泛应用的关键挑战。本综述聚焦于脂质纳米颗粒(l... 详细信息

近年来,信使核糖核酸(messenger RNA,mRNA)疗法作为一种革命性的治疗手段,在遗传性疾病、传染病以及癌症治疗领域展现出巨大潜力。然而,mRNA分子的不稳定性和体内递送的低效性仍是限制其广泛应用的关键挑战。本综述聚焦于脂质纳米颗粒(lipid nanoparticles,LNPs)作为高效载体在mRNA递送系统中的最新进展与应用,系统地概述了mRNA治疗在疫苗、蛋白质替代疗法和基因编辑治疗中的应用,并基于LNP基础四组分的改造、第五组分的引入、表面改性以及机器学习辅助LNP迭代开发等四个方面,详细介绍了工程化修饰LNP的方式以及在治疗中的应用。

关键词：脂质纳米颗粒 mRNA 工程化靶向性

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The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

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Journal of Molecular Cell Biology 2023年第10期15卷 54-64页

作者： Weiwei Qi Zhenzhen Fang Chuanghua Luo Honghai Hong Yanlan Long Zhiyu Dai Junxi Liu Yongcheng Zeng ti zhou Yong Xia Xia Yang Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Clinical Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510006China Department of Internal Medicine University of Arizona College of MedicinePhoenixAZ 85004USA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD),characterized by hepatic steatosis,is one of the commonest causes of liver *** triglyceride lipase(ATGL)is closely related to lipid turnover and hepatic steatosis as the speed-limited triacylglycerol lipase in liver ***,the expression and regulation of ATGL in NAFLD remain ***,our results showed that ATGL protein levels were decreased in the liver tissues of high-fat diet(HFD)-fed mice,naturally obese mice,and cholangioma/hepatic carcinoma patients with hepatic steatosis,as well as in the oleic acid-induced hepatic steatosis cell model,while ATGL mRNA levels were not *** protein was mainly degraded through the proteasome pathway in ***-transducin repeat containing(BTRC)was upregulated and negatively correlated with the decreased ATGL level in these hepatic steatosis ***,BTRC was identified as the E3 ligase for ATGL through predominant ubiquitination at the lysine 135 ***,adenovirus-mediated knockdown of BTRC ameliorated steatosis in HFD-fed mouse livers and oleic acid-treated liver cells via upregulating the ATGL *** together,BTRC plays a crucial role in hepatic steatosis as a new ATGL E3 ligase and may serve as a potential therapeutic target for treating NAFLD.

关键词： adipose triglyceride lipase(ATGL) beta-transducin repeat containing(BTRC) non-alcoholic fatty liver disease(NAFLD) obesity proteasomal degradation

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