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Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

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Journal of Geriatric Cardiology 2022年第9期19卷 705-711页

作者： Danish Iltaf Satti Yan Hiu Athena Lee Keith Sai Kit Leung Jeremy Man Ho Hui thompson ka ming kot Arslan Babar Gauranga Mahalwar Abraham KC Wai Tong Liu Leonardo Roever Gary Tse Jeffrey Shi kai Chan International Health Informatics Study(IHIS)Network Cardiovascular Analytics Group Hong KongChina-UK Collaboration Emergency Medicine Unit Li Ka Shing Fac-ulty of MedicineThe University of Hong KongHong KongChina Aston Medical School Faculty of Health&Life SciencesAston UniversityBirminghamUnited Kingdom Li ka Shing Faculty of Medicine The University of Hong KongHong KongChina Department of Anaesthesia and Pain Service Princess Margaret HospitalLai Chi KokKowloonHong KongChina Department of Medicine Cleveland Clinic FoundationClevelandUSA Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardi-ologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Clinical Research Federal Uni-versity of UberlândiaUberlândiaBrazil Kent and Medway Medical School CanterburyKentUnited Kingdom 不详

OBJECTIVES To assess the effect of vasopressin,steroid and epinephrine(VSE)combination therapy on return of spontan-eous circulation(ROSC)after in-hospital cardiac arrest(IHCA),and test the conclusiveness of evidence using trial sequential ana-lysis(TSA).METHODS The systematic search included PubMed,EMBASE,Scopus,and Cochrane Central Register of Controlled *** controlled trials(RCTs)that included adult patients with IHCA,with at least one group receiving combined VSE therapy were *** was extracted independently by two *** main outcome of interest was *** out-comes included survival to hospital discharge or survival to 30 and 90 days,with good neurological *** We included a total of three RCTs(n=869).Results showed that VSE combination therapy increased ROSC(risk ra-tio=1.41;95%CI:1.25-1.59)as compared to *** demonstrated that the existing evidence is *** was also validated by the alpha-spending adjusted relative risk(1.32[1.16,1.49],P<0.0001).Other outcomes could not be meta-analysed due to differences in timeframe in the included *** VSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ***-ture trials of VSE therapy should evaluate survival to hospital discharge,neurological function and long-term survival.

关键词： resuscitation analysis return

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-Jun Wang ka Wai Wong ka ming Ng Yu Liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compare the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering

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Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

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Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： Jing-Jing Yang Ying-Xin Liu Yan-Fang Wang Bi-Ying Ge Ying Wang Qing-Shan Wang Sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong Sheng-ming Yin Jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(ka)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of ka,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in ka-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

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Preparation, characterization and evaluation of kaempferol phospholipid complex: Improvement of its solubility and biological effect

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Journal of Polyphenols 2024年第2期6卷 56-64页

作者： Dezhi Gao Honghui Zhao Fengmao Zou ming Yang Jing Wang Lina Fang Xu Zhao Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Material Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Pharmacy Shenyang Medical CollegeShenyang 110034China

kaempferol(ka),as one of the flavonoids,has extensive pharmacological ***,the poor solubility of ka severely limits its clinical *** our study,the kaempferol phospholipid complex(ka-PC)has been prepared by solvent evaporation for the enhancement of the bioavailability of ***-PC was verified by scanning electron microscope characterization *** loading,solubility and long-term stability were *** characterization results showed that ka-PC was formed through the intermolecular interaction between ka and *** solubility of ka-PC in water was 189 times higher than that of ka,and the solubility in n-octanol was also significantly ***,pharmacodynamic studies showed that ka-PC can significantly reduce the level of serum uric acid in mice without causing renal *** study expanded the clinical application of ka by preparing ka-PC.

关键词： kaempferol phospholipid complex solubility uric acid-lowering effect

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岩石表层释光暴露年龄及侵蚀速率的相关参数影响分析

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核技术 2024年第1期47卷 9-19页

作者：罗明龚志军郭福生彭花明东华理工大学地球科学学院南昌330013 东华理工大学江西省数字国土重点实验室南昌330013 中国地震局地质研究所地震动力学国家重点实验室北京100029

近十年,岩石表层释光测年方法自提出以来发展迅速,表现出广泛的应用前景和潜力,但该方法相关的参数对暴露年龄和侵蚀速率结果的影响却鲜有研究。本文通过模拟光衰减系数μ、晒退速率σφ_(0)、环境剂量率D及特征饱和剂量D_(0)这些相关... 详细信息

近十年,岩石表层释光测年方法自提出以来发展迅速,表现出广泛的应用前景和潜力,但该方法相关的参数对暴露年龄和侵蚀速率结果的影响却鲜有研究。本文通过模拟光衰减系数μ、晒退速率σφ_(0)、环境剂量率D及特征饱和剂量D_(0)这些相关参数与半饱和深度(量化释光信号晒退深度的指标)之间的关系,分析研究了上述参数对暴露年龄和侵蚀速率的影响,以及在不同参数σφ_(0)及D_(0)下获得暴露年龄和侵蚀速率的极限。结果表明μ和σφ_(0)对释光信号晒退和侵蚀速率的影响非常显著,当增加相同的暴露时间或侵蚀速率时,μ值越小,对应半饱和深度变化的速率更大,而不同σφ_(0)值对应半饱和深度变化的速率相同。浅色透光性(μ值较小)岩石是较为理想的定年材料,野外作业中应优先采集。一般情况下,环境剂量率D和特征饱和剂量D_(0)的大小对暴露年龄和侵蚀速率的值基本不产生影响,故在实际应用中可忽略岩石表面和内部的D值差异。该方法测年范围为10^(-3)~10^(2)ka,获得侵蚀速率范围为10^(-2)~10^(3)mm·ka^(-1)。

关键词：岩石表层释光测年侵蚀速率光衰减参数数值模拟

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20 ka台式8/20μs冲击电流发生器设计

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安全与电磁兼容 2024年第4期 51-57,65页

作者：杨铭苏州泰思特电子科技有限公司

为解决传统8/20μs冲击电流发生器体积庞大、不易转场测试以及气体火花间隙开关触发稳定性较差的问题,通过研究直流高压脉冲电源技术、气体火花开关技术、半导体开关技术,提出了一种20 ka台式8/20μs冲击电流发生器的设计方案。阐述了... 详细信息

为解决传统8/20μs冲击电流发生器体积庞大、不易转场测试以及气体火花间隙开关触发稳定性较差的问题,通过研究直流高压脉冲电源技术、气体火花开关技术、半导体开关技术,提出了一种20 ka台式8/20μs冲击电流发生器的设计方案。阐述了方案的基本组成、工作原理,详细描述了微控制单元(MCU)、直流高压产生电路以及冲击电流产生电路设计。原理样机体积仅为传统设备的1/10左右,脉冲触发成功率100%。系统便捷性、稳定性得到了有效提升,并配套开发了人机交互系统。设计的冲击电流发生器对脉冲功率技术的工程应用具有积极作用。

关键词： 8/20μs 冲击电流半导体开关脉冲功率

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考古遗址所见成都平原史前洪水与治水

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地球环境学报 2024年第2期15卷 193-206页

作者：黄明成都文物考古研究院成都610072

在系统梳理成都平原地区史前考古遗址中所见古洪水证据的基础上,对古洪水发生的规律及背景因素进行分析。现有证据表明:成都平原史前古洪水多发生在宝墩文化晚期及十二桥文化时期,且多集中在4.0 ka BP及3.0 ka BP两个时间节点前后,与长... 详细信息

在系统梳理成都平原地区史前考古遗址中所见古洪水证据的基础上,对古洪水发生的规律及背景因素进行分析。现有证据表明:成都平原史前古洪水多发生在宝墩文化晚期及十二桥文化时期,且多集中在4.0 ka BP及3.0 ka BP两个时间节点前后,与长江、黄河流域古洪水记录具有同步性。一方面可能与成都平原地区的地理水文要素有关;另一方面,4.0 ka BP和3.0 ka BP前后古洪水记录增多可能与4.2 ka BP及2.8 ka BP全球性气候灾变事件有关。通过探讨古蜀先民治水思想及治水技术的发展,认为古蜀先民在与洪水作斗争的过程中治水技术和治水思想也在不断地发展和进步,古蜀文明不断发展的过程也是先民不断治水并总结经验的过程,其治水技术的进步和治水思想的提高最终成就了伟大的都江堰水利工程。

关键词：成都平原史前遗址古洪水治水

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Aromatic and olefinic C–H alkenylation by catalysis with spirocyclic NHC Ru(Ⅳ) pincer complex

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Science China Chemistry 2023年第10期66卷 2791-2796页

作者： Heng Cai Yong-Qiang Tu ka Lu Qi-Long Chen Fu-Min Zhang Xiao-ming Zhang Yuan-Jiang Pan Zhi-Bo Yan State Key Laboratory of Applied Organic Chemistry&College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Zhejiang UniversityHangzhou 310027China

Catalyst innovation lies at the heart of transition-metal-catalyzed reaction development. In this article, we have explored the C(sp2)–H alkenylation activity with novel spirocyclic N-heterocyclic carbene(NHC)-based cyclometalated ruthenium pincer catalyst system, SNRu-X. After screening catalyst and condition, a high valent Ru(Ⅳ) dioxide(X = O_(2)) species has demonstrated superior reactivity in the catalytic alkenylation of aromatic and olefinic C–H bonds with unactivated alkenyl bromides and triflates. This reaction has achieved the easy construction of a wide range of(hetero)aromatic alkenes and dienes, in good to excellent yields with exclusive selectivity. Preliminary mechanistic studies indicate that this reaction may proceed through a single electron transfer(SET) triggered oxidative addition, by doing so, providing valuable complementary to classical alkenylation reactions that are dependent on activated alkenyl precursors.

关键词： transitionmetal catalysis spirocyclic NHC-Ru pincer catalyst C-H alkenylation single electron transfer pathway unactivated alkenyl bromides and triflates

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Effects of biochar on soil water retention curves of compacted clay during wetting and drying

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Biochar 2022年第1期4卷 1117-1130页

作者： James Tsz Fung Wong ka Lai Chow Xun Wen Chen Charles Wang Wai Ng ming Hung Wong Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongSARChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongSARChina Consortium on Health EnvironmentEducation and Research(CHEER)Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongSARChina Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China State Environmental Protection Key Laboratory of Integrated Surface Water Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Compacted clay possesses a low water permeability and has been widely used in geo-environmental facilities such as landfill cover *** studies revealed the potential applications of compacted biochar-amended clay(BAC)as an alternative landfill cover ***,the effects of biochar on the soil water retention curves(SWRCs)of clay at low suction are not *** study can help fill this knowledge gap by measuring the wetting and drying SWRCs of clay and BAC(20%biochar).Soils were compacted in instrumented soil columns and subjected to a wetting and drying cycle,and soil water content and suction were measured along with the soil *** was saturated faster when compared with *** drying,the soil water content of clay at 65 mm depth dropped to almost zero,while about 5%of water was retained in *** showed that biochar increased the soil water retention capacity of compacted clay upon *** showed that biochar-clay composite possesses a higher soil water retention capacity at a low soil suction range(<1000 kPa)compared with clay *** revealed the benefits of using compacted biochar-clay composite as a hydraulic barrier to minimize desiccation-induced cracks and potentially promote its serviceability,especially in arid and semi-arid *** composite is also a carbon sink material that can reduce landfill gas emissions and pollutant leaching.

关键词： Soil amendment Biochar-clay composite Soil carbon Soil suction Soil depth

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Synthesis of zinc-based metal-organic framework as highly efficient photocatalyst for decomposition of organic dyes in aqueous solution

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Rare Metals 2023年第4期42卷 1205-1213页

作者： Geng Tan Yu-Qiong Guo Lu-Yang Zuo ka Zhang Yi-ming Zhang Li-Lei Zhang Jing-Jing Yu Xun Feng Bo Li Li-Ya Wang College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang473061China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934China

In the present work,a zinc-based metal-organic framework{[Zn(ddpd)_(0.5)(bipy)_(0.5)]·H_(2)O]}_(n)(1-Zn)(where ddpd=2,5-di(2',4'-dic arboxylphenyl)-1,4-difluorobenzene,bipy=4,4-bipyridine)was synthesized by a solvothermal *** 1-Zn features a threedimensional(2,4,6)-connected network with{4^2.6^2.8^2}_(2){4^4.6^6.8^5}{6}***,without the assistance of other reagents,complex 1-Zn not only exhibited an exceeded 95%photodegradation efficiency for rhodamine B(Rh B),methyl blue(MB)and methyl orange(MO)within 40 min,but also showed high stability and *** addition,free radical quenching experiments and electron spin resonance(ESR)spectroscopy verified that the main active species in the photodegradation process were·O_(2)^(-)and OH,and a more indepth degradation mechanism was further elucidated by density functional theory(DFT)calculations.

关键词： Zinc Metal-organic frameworks(MOFs) ·O_(2)^(-) ·OH Photodegradation

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