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Reduction of epinephrine in the lumbar spinal cord following repetitive blast-induced traumatic brain injury in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： Shigeharu Tsuda Mustafa Golam Jiamei Hou k.vin k.W.Wang Floyd J.thompson Prodip Bose Brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous system after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study was to determine the impact of repeated blast-induced traumatic brain injury on the epinephrine levels in seve ral function-s pecific central nervous system regions in *** three repeated blast injuries at 3-day intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-injury day eight and processed for epinephrine assays using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous system regions,although the epinephrine levels were slightly altered following blast-induced tra u matic brain injury,they were not statistically *** results suggest that blast injury-induced significant downregulation of epinephrine in the lumbar spinal cord could negatively impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord following repetitive mild blast-induced traumatic brain injury.

关键词： balance blood flow cardiovascular system central nervous system epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain injury

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Simplified prediction models for acoustic installation effects of train-mounted equipment

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Railway Engineering Science 2024年第2期32卷 125-143页

作者： David thompson Dong Zhao Giacomo Squicciarini Institute of Sound and Vibration Research University of SouthamptonSouthampton SO171BJUK

Acoustic models of railway vehicles in standstill and pass-by conditions can be used as part of a virtual certification process for new *** each piece of auxiliary equipment,the sound power measured on a test bench is combined with meas-ured or predicted transfer *** is important,however,to allow for installation effects due to shielding by fairings or the train *** the current work.fast-running analytical models are developed to determine these installation *** model for roof-mounted sources tak.s account of diffraction at the corner of the train body or fairing,using a barrier *** equipment mounted under the train,the acoustic propagation from the sides of the source is based on free-field Green’s *** bottom surfaces are assumed to radiate initially into a cavity under the train,which is modelled with a simple diffuse field *** sound emitted from the gaps at the side of the cavity is then assumed to propagate to the receivers according to free-field Green’s *** show good agreement with a 2.5D boundary element model and with *** uncertainty and parametric uncertainty are *** largest variability occurs due to the height and impedance of the ground,especially for a low *** leads to standard deviations of up to 4 dB at low *** the roof-mounted sources,uncertainty over the location of the corner used in the equivalent barrier model can also lead to large standard deviations.

关键词： Train noise Auxiliary equipment Acoustic installation effects Virtual certification Uncertainty

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5F和4F括约肌切开器对于选择性胆总管插管术的效果相同

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 33-34页

作者： Abraham N.S. Williams S.P. thompson k. 程妍 Michael E.DeBak.y VAMC 2002 Holcombe BoulevardHoustonTX 77030United States Dr.

Back.round:Cannulation of the common bile duct(CBD)is the first step in endoscopic retrograde cholangiopancreatography(ERCP).Cannulation difficulty is a k.own risk.factor for post-ERCP complications and may be minimized by the use of a smaller caliber ***:To compare the efficacy of CBD cannulation with a 4 F versus a 5 F ***:A randomized controlled trial,with concealed allocation and ***:Adult patients undergoing their first ERCP at a tertiary referral ***:Patients were randomized to undergo CBD cannulation with either a 4 F or 5 F *** Outcome Measurements:Successful deep cannulation in < 15 attempts was the primary *** outcomes included number of attempts/time to cannulation,incidence of complications within 24 hours,and overall cannulation success(including patients before and after crossover).Analysis was intention to treat and included standard descriptive and inferential ***:A total of 107 patients were randomized:51(4 F)versus 56(5 F).The majority were female(71%)and white(92%).Baseline demographics,presenting symptoms,and laboratory values were similar between *** success in initial cannulation was observed:84.3%(4 F)and 83.9%(5 F).No differences were noted in time to cannulation(5.12 min SD,4.8 for 4 F vs 4.46 min SD,4.13 for 5 F;p = NS),number of attempts to cannulation(6.2 SD,5.2 for 4 F vs 5.7 SD,4.9 for 5 F;p = NS),or *** overall cannulation success was 92.2%(4 F)and 92.9%(5 F).Limitations:Premature termination of the trial resulted in decreased ***:There exists no significant difference in efficacy between 4 F and 5 F *** choice of initial sphincterotome should be dictated by physician preference.

关键词：括约肌切开插管术胆总管内镜下逆行胰胆管造影术术后并发症插管成功率实验室检查结果随机分组

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Harnessing marine microbiomes to develop a sustainable,all-Atlantic bioeconomy

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mLife 2024年第2期3卷 163-166页

作者： Cristiane thompson Alice C.Ortmann Henk.Bolhuis Thulani Mak.alanyane Fabiano thompson Institute of Biology Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroBrazil Fisheries and Oceans Canada Bedford Institute of OceanographyDartmouthNova ScotiaCanada Department of Marine Microbiology and Biogeochemistry Royal Netherlands Institute for Sea Research(NIOZ)The Netherlands Department of Microbiology School of Data Science and Computational ThinkingStellenbosch UniversityStellenboschSouth Africa

Marine microbiomes are integral to the functioning of a healthy ocean and have the potential to be k.y contributors toward an all-Atlantic sustainable blue bioeconomy(Figure 1).New compounds may be developed based on these *** Atlantic Ocean is a biodiversity *** All-Atlantic Ocean Research and Innovation Alliance(AAORIA)Declaration,signed in 2022 in Washington,DC,is a promising mechanism to move forward marine microbiome science,technology,and innovation.

关键词： Atlantic marine ocean

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A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 168-180页

作者： Yi ZHANG Zhiyan QUAN Feiyang LOU Yujiao FANG Garth J.thompson Gao CHEN Xiaotong ZHANG Department of Neurosurgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China k.y Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration Zhejiang UniversityHangzhou310058China Interdisciplinary Institute of Neuroscience and Technology College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou310027China School of Medicine Zhejiang UniversityHangzhou310020China iHuman Institute School of Life Science and TechnologyShanghaiTech UniversityShanghai201210China College of Electrical Engineering Zhejiang UniversityHangzhou310027China

Energy metabolism is fundamental for *** encompasses the utilization of carbohydrates,lipids,and proteins for internal processes,while aberrant energy metabolism is implicated in many *** the present study,using three-dimensional(3D)printing from polycarbonate via fused deposition modeling,we propose a multi-nuclear radiofrequency(RF)coil design with integrated 1H birdcage and interchangeable X-nuclei(^(2)H,^(13)C,^(23)Na,and^(31)P)single-loop coils for magnetic resonance imaging(MRI)/magnetic resonance spectroscopy(MRS).The single-loop coil for each nucleus attaches to an arc brack.t that slides unrestrictedly along the birdcage coil inner surface,enabling convenient switching among various nuclei and animal *** to a commercial 1H birdcage coil,the proposed 1H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio(SNR).For X-nuclei study,prominent peak. in spectroscopy for phantom solutions showed excellent SNR,and the static and dynamic peak. of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.

关键词： Energy metabolism Magnetic resonance imaging(MRI) Magnetic resonance spectroscopy(MRS) Multi-nuclear Radiofrequency coil Three-dimensional(3D)printing

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Robotic-assisted versus laparoscopic repair of type II, III and IV hiatal hernias: A retrospective study comparing adverse outcomes

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 11-15页

作者： Payton k.oik.r Shane Monnett Stephanie thompson Bryan Richmond West Virginia School of Osteopathic Medicine LewisburgWV24901United States Department of Surgery Charleston Area Medical CenterCharlestonWV25304United States

Objective:Robotic-assisted surgery(RAS)is continuing to expand in use in surgical specialties,including foregut *** available data on its use in large hiatal hernia(HH)repair are limited and *** study sought to determine whether there are significant differences in adverse outcomes following HH repair performed with a robotic approach vs.a laparoscopic *** study was limited to outcomes in patients with type II,III,and IV HHs,as these hernias are typically more challenging to ***:A retrospective analysis was performed from data obtained from TriNetX,a large deidentified clinical database,over a 10-year *** patients who underwent type II,III,or IV HH repair were included in the *** with robotic repair was compared to laparoscopic *** were propensity score matched for demographic information and *** ratios,risk.differences(RDs)with 95%confidence intervals(CIs),and t test for each examined adverse outcome were used to estimate the effects of robotic repair *** ***:In total,20,016 patients who met the inclusion criteria were identified;1,515 patients utilized RAS,and 18,501 used *** to matching,there were significant differences in age,sex,comorbidity,and BMI between the two *** 1:1 propensity score matching,analyses of 1,514 well-matched patient pairs revealed no significant differences in demographics or *** who underwent robotic repair were more lik.ly to experience major complications,including venous thromboembolism(RD:0.007,95%CI:0.003,0.011;p?0.002),critical care(RD:0.023,95%CI:0.007,0.039;p?0.004),urinary/renal complications(RD:0.027,95%CI:0.014,0.041;p<0.001),and respiratory complications(RD:0.046,95%CI:0.028,0.064;p<0.001).RAS was associated with a significantly shorter length of stay(32.4±27.5 h vs.35.7±50.1 h,p?0.031),although this finding indicated a reduction in the length of stay of less than 4 *** statist

关键词： Hiatal hernia Robotic-assisted surgery Laparoscopic surgery Adverse outcomes

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Design,Synthesis,and Applications of Mesoporous Covalent Organic Framework.

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CCS Chemistry 2024年第1期6卷 57-68页

作者： Niyati Arora Cassandra Flores Milinda C.Senarathna Christina M.thompson Ronald A.Smaldone Department of Chemistry and Biochemistry University of TexasDallasRichardsonTexas 75080

Covalent organic framework.(COFs)are highly ordered and permanently porous organic polymers that can be classified as two-dimensional or *** tunable design and crystalline order endow a range of pore sizes,shapes,functions,and applications that differentiate them from other *** COF pore sizes and shapes rely on the geometry of the monomers and dynamic covalent chemistry,while the stack.ng of the sheets relies on noncovalent *** tunability allows for post-modification or the incorporation of additional functional groups for the reinforcement by various noncovalent *** limits of mesoporous COFs are still being investigated,with the design rules continuing to *** we report a comprehensive review of mesoporous COFs,explore strategies for large pore reinforcement,highlight structural design and features,elucidate their various functions and applications,discuss fundamental challenges faced that need to be addressed,and predict future directions.

关键词： covalent organic framework. mesoporous supramolecular chemistry polymers pore size

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轨道车辆一系螺旋弹簧振动疲劳失效分析

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振动与冲击 2024年第1期43卷 230-236页

作者：孙文静王嘉豪 thompson David 王腾飞周劲松同济大学铁道与城市轨道交通研究院上海201804 Institute of Sound and Vibration Research University of SouthamptonSouthampton SO171BJUK

轨道车辆服役工况下一系悬挂系统中的金属螺旋弹簧疲劳断裂时有发生,影响列车运行安全性。针对某一系螺旋弹簧疲劳失效故障,考虑轮轨激励与弹簧结构动态特性耦合关系,建立准确提取弹簧载荷的模型,通过结构频域疲劳分析法计算弹簧动应力... 详细信息

轨道车辆服役工况下一系悬挂系统中的金属螺旋弹簧疲劳断裂时有发生,影响列车运行安全性。针对某一系螺旋弹簧疲劳失效故障,考虑轮轨激励与弹簧结构动态特性耦合关系,建立准确提取弹簧载荷的模型,通过结构频域疲劳分析法计算弹簧动应力响应与疲劳寿命。首先考虑螺旋弹簧结构的动态特性,建立包含一系动刚度特性的车辆-轨道耦合精细化动力学模型,然后在轮轨激励下提取服役工况弹簧两端动载荷,最后采用结构频域疲劳分析法计算弹簧动应力响应与疲劳寿命,并与实测动应力结果进行对比验证。结果表明:螺旋弹簧自身动态特性体现在:多阶模态频率下弹簧中部的最大模态变形与簧条1~2圈间的最大模态应力;基于耦合动力学模型,计算得到内簧动应力响应与实测结果一致,在58 Hz的动应力峰值是其它频率动应力峰值的3倍以上;由于内簧一阶固有频率与轮轨系统P2共振频率接近,弹簧内部共振引起簧条1.2圈内侧高应力,该处疲劳寿命最短的分析结果与现场断裂位置吻合,而外簧的最短疲劳寿命约为内簧的3.6倍。因此,同时考虑轮轨激励与螺旋弹簧自身动态特性,使得一系螺旋弹簧固有频率远离轮轨共振频率,可提高弹簧结构的抗疲劳特性。

关键词：轨道车辆螺旋弹簧模态频率动应力振动疲劳

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Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

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Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-Harrison k.zumi Nak.bayashi Ana Espinosa-Ruiz Francesca Robertson Robert Baines Christopher R.L.thompson k.trin Hermann David Alabadí Gerhard Leubner-Metzger Robin S.B.Williams Centre for Biomedical Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de Biología Molecular y Celular de Plantas(CSIC-UPV) 46022 ValenciaSpain Centre for Life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK Syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released by plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighboring *** how allelochemicals function to regulate plant responses may provide valuable new approaches to better control plant *** such allelochemical,Myrigalone A(MyA)produced by Myrica gale,inhibits seed germination and seedling growth through an unk.own ***,we investigate MyA using the tractable modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carboxylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct binding of MyA to ACO within the catalytic *** ***,ablation of ACO mimics the MyA-dependent developmental delay,which is partially restored by exogenous ethylene,and MyA reduces ethylene *** Arabidopsis thaliana,MyA treatment delays seed germination,and this effect is rescued by exogenous *** also mimics the effect of established ACO inhibitors on root and hypocotyl extension,block. ethylenedependent root hair production,and reduces ethylene ***,in silico binding analyses identify a rangeof highlypotentethylene inhibitorsthatblock.ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism by which the allelochemical MyA reduces ethylene biosynthesis and identify a range of ultrapotent inhibitors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carboxylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhibitors structure-activity relationship

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基于无人机多光谱植被指数的生菜全氮含量预测

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光谱学与光谱分析 2024年第8期44卷 2318-2325页

作者：连炳瑞李雅豪张静李长青杨小冬王激清邹国元 thompson Rodney 杨俊刚北京市农林科学院植物营养与资源环境研究所北京100097 河北北方学院农林科技学院河北张家口075000 北京翠湖农业科技有限公司北京100089 河北农业大学资源与环境科学学院河北保定071000 农业农村部农业遥感机理与定量遥感重点实验室北京市农林科学院信息技术研究中心北京100097 University of Almeria Spain 04120

我国露地蔬菜种植规模庞大,生产方式高度集约化,但过量施肥等导致的水氮利用效率低下的问题较为严重。为实现露地蔬菜规模化种植中精准施肥、高效生产的目标,以露地生菜为研究对象,设无氮(N0)、低氮(N1)、高氮(N2)三个处理,通过无人机... 详细信息

我国露地蔬菜种植规模庞大,生产方式高度集约化,但过量施肥等导致的水氮利用效率低下的问题较为严重。为实现露地蔬菜规模化种植中精准施肥、高效生产的目标,以露地生菜为研究对象,设无氮(N0)、低氮(N1)、高氮(N2)三个处理,通过无人机搭载多光谱相机,建立3种多光谱植被指数(NDVI、RVI和SAVI)与生菜叶绿素、生物量、吸氮量、全氮含量数据集,并构建单生育期和多生育期氮素诊断模型。结果表明:(1)在莲座期和结球期,生菜各处理NDVI、RVI和SAVI值表现出随施氮量的增加而增大,但在收获期,N1处理达到最大值。(2)在生菜结球期,NDVI与生菜的产量、吸氮量、叶绿素均存在显著相关性,其中生菜全氮含量与叶绿素在p≤0.01水平下显著相关,相关系数(R)为0.51;综合生菜多生育期,NDVI值与生菜的产量、叶绿素、吸氮量和全氮含量均在p≤0.001水平下达到极显著相关,相关系数分别为0.85、0.82、0.81和0.71。(3)通过相应数据集拟合出指数、线性、对数和幂函数4种模型关系,建立生菜多生育期植株全氮最佳预测模型:全氮=16.52ln(NDVI)+73.514;应用生菜全氮估层模型反演基地生产田块,其平均相对误差为3.22%、RMSE=0.5566、NRMSE=0.0108,说明模型估算效果均较好,通过无人机多光谱遥感对蔬菜氮素诊断具有一定的可行性。

关键词：露地生菜无人机多光谱 NDVI 全氮预测模型

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