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JAMES GLIMM:MATHEMATICIAN,FRIEND,MENTOR

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Acta Mathematica Scientia 2010年第2期30卷 369-376页

作者： Arthur Jaffe thomas spencer Department of Mathematics Harvard University School of Mathematics Institute for Advanced Study

A description of Jim＇s contributions to mathematics would take us far beyond our expertise. Jim was never content to spend too long in any one area of mathematics. Operator algebras, hyperbolic systems of conservation laws, fluid dynamics, quantum field theory and statistical mechanics and the computational aspects of applied mathematics are just a few of the areas to which Jim has contributed. Here we relate a few impressionistic recollections of personal interactions, together with some ideas about his work in quantum field theory and statistical mechanics. In spite of the non-technical character of these observations, we hope nevertheless that they will provide pleasure for our dear friend and for other readers as well.

关键词： JAMES GLIMM work

Acceptability of an adjunct equine-assisted activities and therapies program for veterans with posttraumatic stress disorder and/or traumatic brain injury

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Journal of Integrative Medicine 2020年第2期18卷 169-173页

作者： Louisa Sylvia Emerson West Allyson M.Blackburn Carina Gupta Eric Bui Tara Mahoney Geraldine Duncan Edward C.Wright Simon Lejeune thomas J.spencer Home Base:A Red Sox Foundation and Massachusetts General Hospital Program Massachusetts General HospitalCharlestownMA 02129USA Harvard Medical School BostonMA 02115USA Dauten Family Center for Bipolar Treatment Innovation Massachusetts General HospitalBostonMA 02114USA Equine Immersion ProgramsTM USA Pediatric Psychopharmacology and Adult ADHD Program Massachusetts General HospitalBostonMA 02114USA

Objective: Equine-assisted activities and therapies(EAATs) have been a growing adjunctive integrative health modality, as they allow participants to practice mindfulness, emotional regulation, and self-mastery or self-esteem building skills. Preliminary evidence suggests that these programs may be helpful in reducing posttraumatic stress disorder(PTSD), anxiety, and depressive symptoms. The current study examines the acceptability of integrating an EAAT program as part of a two-week, intensive clinical program for veterans with PTSD and/or traumatic brain injury(TBI).Methods: A family member or support person could accompany veterans and participate in the *** hundred and six participants(veteran n = 62, family n = 44) left the urban environment in an intensive outpatient program(IOP) to attend a two-day, weekend EAAT in rural New Hampshire. Satisfaction surveys were conducted on the last day of the program and examined using thematic ***: The following themes were reported in the surveys: ability of horses to catalyze emotional rehabilitation, effectiveness of immersion in equine-assisted activities, program’s ability to foster interpersonal relationships and necessity of education about PTSD for staff. Participants also reported enjoying the program as highlighted by qualitative feedback, a mean score of 9.76(standard deviation[SD] = 0.61) as reported by veterans and a mean score of 9.91(SD = 0.29) as reported by family members on a 10-point visual analog scale with higher scores indicating a greater overall ***: These data offer preliminary evidence that an adjunct EAAT program is acceptable for veterans with PTSD and/or TBI participating in an IOP.

关键词： Posttraumatic stress disorder Military personnel Traumatic brain injury Complementary and alternative medicine Equine-assisted therapy

Asynchronous Embryo Transfer in Sheep:Lack of Survival in Progestinized Recipient Ewes

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Journal of Animal Science and Biotechnology 2011年第1期2卷 9-13页

作者： M.Carey Satterfield thomas E.spencer Department of Animal Science Texas A&M UniversityCollege Station

Synchronization of development between the embryo and uterus is required for successful pregnancy establishment. Transfer of early embryos requires synchrony with the recipient uterus of 2 days or less in sheep, because asynchrony of 3 days or more results in failure of pregnancy recognition signaling for maintenance of corpus luteum （CL） and progesterone （P4） production and/or uterine support of the embryo. The objective was to determine if P4 treatment of recipient ewes would obviate the need for pregnancy recognition signaling and maintain a uterine environment conducive to embryo survival after asynchronous transfer, thereby establishing a universal recipient. Embryos （morulae/blastocysts） were recovered on day 6 from super-ovulated donor ewes. Recipient ewes received 25 mg P4 daily from day 6 post-estrus until 60 days after embryo transfer. Embryos were transferred into recipients on day 6,9, 12,18, or 30 post-estrus. The pregnancy rate on day 22 post-transfer was 60% for synchronous transfers to day 6 ewes, 44% and 22% for asynchronous transfers to day 9 and 12 ewes, and 0% for asynchronous transfers to day 18 and 30 ewes. On day 39 posttransfer ,pregnancy rates remained 60% for day 6 ewes,33% for day 9 ewes,and 0% for day 12,18, and 30 ewes. The P4 treatment did extend the window of uterine receptivity to early embryos in ewes by one day ,but did not create a universal recipient. Available results support the idea that a window of uterine receptivity to the conceptus exists in sheep that is independent of pregnancy recognition signaling.

关键词： embryo progesterone sheep transfer uterus

Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with ADHD

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Open Journal of Psychiatry 2014年第2期4卷 147-152页

作者： Paul Hammerness Daniel Geller Gagan Joshi Anna Georgiopoulos Robert Doyle thomas spencer Carter Petty Laura Mahoney Joseph Biederman Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD Massachusetts General Hospital Boston USA

The objective of this study was to examine whether stimulants impact pubertal development in adolescent Attention Deficit Hyperactivity Disorder (ADHD), an understudied subject. Pubertal staging data were collected during a 2-year open study of extended release methylphenidate in adolescents (N = 111) with ADHD. Tanner stages were compared to national estimates. The sample was primarily male, Caucasian, and a mean age of 14.8 years at baseline. The baseline Tanner stage for 70% of subjects was consistent with chronological age. For the majority of subjects who reached 12 - 20 months (N = 25) or 24 months (N = 21) endpoints, the Tanner stage at respective endpoints was consistent with age. We found that progression in Tanner stage was not associated with OROS MPH duration or dose (p > 0.10). Long-term treatment with extended release methylphenidate did not appear to adversely impact pubertal development in this sample of adolescents with ADHD.

关键词： Methylphenidate Puberty Development Adolescents ADHD

TopSTO:a 115-line code for topology optimization of structures under stationary stochastic dynamic loading

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 1081-1100页

作者： Sebastian Pozo Fernando Gomez thomas Golecki Juan Carrion Billie F.spencer Jr. Civil and Environmental Engineering University of Illinois at Urbana-ChampaignUrbana 61801ILUSA College of Science and Engineering Universidad San Francisco de QuitoDiego de Robles y Vía InteroceanicaQuitoEcuador Skidmore Owings&MerrillLLPChicago 60604ILUSA Department of Civil Engineering University of CuencaCuencaEcuador

The use of topology optimization in structural design under dynamic excitation is becoming more prevalent in the *** many such applications utilize frequency or time domain formulations,relatively few consider stochastic dynamic *** paper presents an efficient and compact code called TopSTO for structural topology optimization considering stationary stochastic dynamic loading using a method derived from random vibration *** theory,described in conjunction with the implementation in the provided code,is illustrated for a seismically excited *** work demonstrates the efficiency of the approach in terms of both the computational resources and minimal amount of code *** code is intended to serve as a baseline for understanding the theory and implementation of this topology optimization approach and as a foundation for additional applications and developments.

关键词： topology optimization stochastic dynamics matlab python

High pressure luminescence studies of europium doped GaN

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Journal of Rare Earths 2009年第4期27卷 667-670页

作者： K.Wisniewski W.Jadwisieńczak T.thomas M.spencer Institute of of Experimental Physics Gdańsk University ul.Wita Stwosza 57 Gdańsk 80-952 Poland School of Electrical Engineering and Computer Science Ohio-University Athens OH 45701 USA Second of Electrical and Computer Engineering Cornell University Ithaca NY 14853 USA

We reported on the high pressure luminescence spectra of polycrystalline Eu-doped GaN material synthesized in the reaction between alloys of gallium, bismuth and europium in ammonia atmosphere. The integrated luminescence intensity of the dominant Eu3＋ ion transition （5D0→^7F2） at 622 nm increased approximately one order of rnagnitude whereas its spectral position and line width did not change significantly between ambient and 6.8 GPa pressure, respectively. Moreover, material was characterized with photo- and cathodo-luminescence, and photoluminescence excitation spectra at different temperatures. It was found that the Eu3＋ ions occupying substitutional Ga site created different centers which could be effectively excited with above band gap excitation and from excitons resonantly photoexcited at the I2 bound exciton energy. Furthermore, the less efficient Eu3＋ ions excitation path existed through intrinsic impurities and defeels generating shallow energy levels in the forbidden gap. It was proposed that reduction of the thermal quenching and consequent enhancement of Eu3＋ ion emission intensity resulted from stronger localization of bound exciton on RESI trap induced by applied pressure.

关键词： GaN, Eu^3+ ion high pressure spectroscopy rate earths

Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces

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International Journal of Oral Science 2019年第4期11卷 252-264页

作者： spencer Dunaway Alexandra Rothaus Yuhang Zhang Ana Luisa Kadekaro thomas Andl Claudia DAndl Department of Dermatology College of MedicineUniversity of CincinnatiCincinnatiOHUSA Burnett School of Biomedical Sciences University of Central FloridaOrlandoFLUSA Division of Pharmaceutical Sciences College of PharmacyUniversity of CincinnatiCincinnatiOHUSA

Stem cells are of great interest to the scientific community due to their potential role in regenerative and rejuvenative ***,their role in the aging process and carcinogenesis remains *** DNA replication in stem cells may contribute to the background mutation rate and thereby to cancer,reducing proliferation and establishing a relatively quiescent stem cell compartment has been hypothesized to limit DNA replication-associated *** the other hand,as the main function of stem cells is to provide daughter cells to build and maintain tissues,the idea of a quiescent stem cell compartment appears *** observations in mice have led to the idea of separated stem cell compartments that consist of cells with different proliferative *** epithelia of short-lived rodents appear to lack quiescent stem *** stem cells of different species and different organs(comparative stem cell biology)may allow us to elucidate the evolutionary pressures such as the balance between cancer and longevity that govern stem cell biology(evolutionary stem cell biology).The oral mucosa and its stem cells are an exciting model system to explore the characteristics of quiescent stem cells that have eluded biologists for decades.

关键词： organs elude stem

Granular titanite from the Roter Kamm crater in Namibia:Product of regional metamorphism,not meteorite impact

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Geoscience Frontiers 2022年第3期13卷 156-163页

作者： Aaron J.Cavosie Christopher J.spencer Noreen Evans Kai Rankenburg Robert J.thomas Paul H.Macey Space Science and Technology Centre and The Institute for Geoscience Research School of Earth and Planetary ScienceCurtin UniversityPerthWA 6102Australia Dept.of Geological Sciences and Geological Engineering Queen’s UniversityOntarioCanada John de Laeter Centre Curtin UniversityPerthWA 6102Australia Council for Geoscience BellvilleWestern CapeSouth Africa

Accessory minerals with so-called granular texture have risen in importance as geochronological tools for U-Pb dating of meteorite impact events. Grain-scale recrystallization, typically triggered by a combination of high-strain deformation and post-impact heating, can create a polycrystalline microstructure consisting of neoblasts that expel radiogenic Pb, which are thus ideal for isotopic dating. While granular domains in zircon and monazite from shocked rocks have been demonstrated to preserve impact ages,few U-Pb dating studies have been conducted on granular microstructures in titanite(CaTiSiO;). Here we report the occurrence of granular-textured titanite from ~2020 Ma granite basement rock exposed in the rim of the 4–5 Ma Roter Kamm impact structure in Namibia. Orientation mapping reveals two microstructurally distinct titanite populations: one consisting of strained/deformed grains, and the other consisting of grains that comprise aggregates of strain-free neoblasts. In situ U-Pb geochronology on 37 grains shows that most grains from both titanite populations yield indistinguishable U-Pb dates of ca.1025 Ma, consistent with the observed microstructures forming during the Mesoproterozoic Namaqua Orogeny. Only four grains preserved older age domains, recording ca. 1875 Ma Paleoproterozoic metamorphism. Two significant observations emerge:(1) none of the analyzed titanite grains yield the 2020 Ma igneous crystallization age previously established from zircon in the same sample, and(2) no age-resetting was detected that could be attributed to the 4 to 5 Ma Roter Kamm impact *** the similarity of the neoblastic microstructure to minerals from other sites with an established impact provenance, the granular texture and near-complete Pb-loss in titanite from Roter Kamm granite instead records a Paleo-to Mesoproterozoic polymetamorphic history, rather than Miocene age shockrelated processes. These results highlight the critical importance of grain-scale cont

关键词： Namibia Roter Kamm Titanite EBSD Geochronology

Evolving mantle convection from bottom up to top down

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The Innovation 2022年第6期3卷 13-14页

作者： Ross N.Mitchell Michael Brown thomas M.Gernon Christopher J.spencer State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Laboratory for Crustal Petrology Department of GeologyUniversity of MarylandCollege ParkMD 20742USA School of Ocean and Earth Science University of SouthamptonSouthampton SO224JRUK Department of Geological Sciences and Geological Engineering Queen’s UniversityKingstonON K7L 2N8Canada

When it comes to convection,what goes up must come *** is it,what goes down must come up?The truth is,it *** convection must be mass-balanced,there is no reason that it must be force-balanced:the positive and negative buoyancy forces driving convection up and down,respectively,do not necessarily need to be *** balance,or imbalance,all depends on the top and bottom boundary layers.

关键词： necessarily boundary hough