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Validation of the Danish version of the musculoskeletal tumour society score questionnaire

World Journal of Orthopedics 2019年第1期10卷 23-32页

作者： Casper Kloster Pingel Saebye Johnny Keller thomas Baad-hansen Sarcoma Centre of Aarhus University Hospital Department of Orthopedic Surgery Aarhus University Hospital

BACKGROUND The musculoskeletal tumour society score(MSTS) is a well-known questionnaire for measuring functional outcome in patients with neoplasms in the *** guidelines for cross-cultural translation and validation ensure the equivalence of content between the original and translated versions. The translation and validation provide the possibility to compare different sarcoma populations on an international level. This study is based on the hypothesis that the Danish MSTS questionnaire is a valid tool for measuring the end result after surgery for neoplasms in the *** To validate the Danish version of the upper and lower extremity version of the *** The translation of the MSTS was conducted in accordance with international guidelines. Patients operated for sarcomas and aggressive benign tumors were invited to participate in the study. The psychometric properties of the Danish version of the MSTS were tested in terms of validity and reliability and for the risk of floor or ceiling effect. Spearman's rank coefficient was used to test the validity by comparing with the Toronto Extremity Salvage Score(TESS). The Intraclass Correlation Coefficient(ICC) was used to evaluate inter-rater reliability. Cronbach's alpha was used to test for internal consistency. Spearman's rank coefficient was used to compare the MSTS lower extremity version with the objective test, Timed Up and Go(TUG).RESULTS The upper extremity version demonstrated an ICC of 0.95 in the inter-rater reliability test. The lower extremity version had an ICC of 0.88 in the inter-rater reliability test, respectively. Both MSTS versions showed a ceiling effect. Thevalidity of the MSTS was measured by Spearman's rank correlation coefficient by comparing the MSTS with the TESS and found it to be of 0.80(P < 0.01) and 0.83(P < 0.01) for the upper extremity and lower extremity version, respectively. A Spearman's rank correlation coefficient of-0.26(P < 0.01) was found betwee

关键词： Sarcoma Patient outcome assessment Clinical oncology Surgical oncology Patient satisfaction

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Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism

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World Journal of Gastroenterology 2011年第26期17卷 3117-3125页

作者： Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson thomas VO hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-hansen Genomic Medicine Department of Clinical BiochemistryRigshospitaletUniversity of Copenhagen Department of Basic Animal and Veterinary Sciences Faculty of Life SciencesUniversity of Copenhagen Department of Microbiology University of Lund Department of Gastro-Intestinal Surgery RigshospitaletUniversity of Copenhagen Department of Clinical Physiology RigshospitaletUniversity of Copenhagen

AIM- To investigate if and how the proinflammatory cytokine interferon γ （IFNγ） affects ghrelin expression in mice. METHODS： The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were ex- amined in wild-type mice and mice infected with Helico- bacter pylori （H. pylorO. Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFNγ, alone, mice were given a subcutaneous infusion of IFNγ, for 7 d. Finally, the influ- ence of IFNγ, and somatostatin on the ghrelin promoter was characterized. RESULTS： H. py/ori infection was associated with a 50% reduction in ghrelin expression and plasma concentration. Suppression of ghrelin expression was in- versely correlated with gastric inflammation in achlorh- dyric mouse models. Subcutaneous infusion of IFNγ, suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations. Finally, we showed that the ghrelin promoter operates under the control of soma- tostatin but not under that of IFNγ. CONCLUSION： Gastric infection and inflammation is associated with increased IFNγ, expression and reduced ghrelin expression. IFNγ, does not directly control ghre- lin expression but inhibits it indirectly via somatostatin.

关键词： Ghrelin Interferon-γ Somatostatin Inflam-matory diseases He/icobacterpy/ori

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Is there consensus regarding surgical treatment of bone sarcomas?

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World Journal of Orthopedics 2018年第9期9卷 173-179页

作者： thomas Baad-hansen Sarah Stammose Freund Bodil Hammer Bech Johnny Keller Department of Orthopaedic Oncology Aarhus University Hospital Department of Public Health Aarhus University

AIM To perform an Internet based survey on the surgical management of bone sarcomas in the lower extremity amongst sarcoma surgeons. METHODS All orthopedic surgical members of the Scandinavian Sarcoma Group were invited to participate in an online questionnaire. The questionnaire consisted of a clinical case involving resection of a malignant bone tumor. Several questions were asked, subdivided into categories. Among these, surgical/technical considerations, e.g., choice of implant; choice of antibiotics, dosage, and duration of treatment, choice of antithrombotic drug, initial start-up, dosage, and duration were *** In terms of choice of implant fixation, the majority of surgeons preferred an uncemented prosthesis in younger patients until the age of 50. All participants administer intravenous prophylactic antibiotics for endoprosthetic reconstructive surgery. First choice of antibiotics was cephalosporin. Less common used was glycopeptide, penicillin, or a combination. Duration of prophylactic antibiotics ranged from less than one day to more than four days. All participants used low molecular weight heparins as antithrombotic prophylaxis and 55% of the participants answered that initial treatment was started preoperatively, 3% perioperatively and 42% postoperatively. Duration of the antithrombotic treatment ranged from five days to more than twenty-eight *** The use of resection prosthesis in the treatment of bone sarcomas is a well-established procedure. However, therse is a significant discrepancy in the surgical treatment algorithm between the sarcoma centers. Still the treatment is mainly based on best clinical practice,due to the lack of evidence-based medicine in the surgical management of bone sarcomas.

关键词： Sarcoma Reconstruction Megaprosthesis Antibiotics Antithrombotic prophylaxis

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Reduction and carburization of iron oxides for Fischer–Tropsch synthesis

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Journal of Energy Chemistry 2020年第12期29卷 48-61页

作者： Monia Runge Nielsen Asger Barkholt Moss Anton Simon Bjrnlund Xi Liu Axel Knop-Gericke Alexander YuKlyushin Jan-Dierk Grunwaldt thomas LSheppard Dmitry EDoronkin Anna Zimina thomas Eric Lyck Smitshuysen Christian Danvad Damsgaard Jakob Birkedal Wagner thomas Willum hansen DTU Nanolab Technical University of DenmarkDK-2800Kgs.LyngbyDenmark Department of Physics Technical University of DenmarkDK-2800Kgs.LyngbyDenmark SynCat@Beijing Synfuels China Technology Co.LtdBeijing 101407China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Inorganic Chemistry Fritz Haber Institute of the Max Planck SocietyD-14195 BerlinGermany Research Group Heterogeneous Reactions.Max Planck Institute for Chemical Energy Conversion D-45470 MulheimGermany Research Group Catalysis for Energy Helmholtz-Zentrum Berlin for Materials and Energy(BESSYⅡ)D-12489 BerlinGermany Institute for Chemical Technology and Polymer Chemistry Karlsruhe Institute of TechnologyD-76131 KarlsruheGermany Institute of Catalysis Research and Technology Karlsruhe Institute of TechnologyD-76344 Eggenstein-LeopoldshafenGermany

The activation of iron oxide Fischer–Tropsch Synthesis(FTS) catalysts was investigated during pretreatment: reduction in hydrogen followed by carburization in either CO or syngas mixture, or simultaneously reduction and carburization in syngas. A combination of different complementary in situ techniques was used to gain insight into the behavior of Fe-based FTS catalysts during activation. In situ XRD was used to identify the crystalline structures present during both reduction in hydrogen and carburization. An increase in reduction rate was established when increasing the temperature. A complete reduction was demonstrated in the ETEM and a grain size dependency was proven, i.e. bigger grains need higher temperature in order to reduce. XPS and XAS both indicate the formation of a small amount of carbonaceous species at the surface of the bulk metallic iron during carburization.

关键词： In situ characterization Fischer–Tropsch Catalyst reduction and carburization Iron oxides

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Science and Innovation Diplomacy from a Practitioner's Perspective——A Case-study of “Nordic+” Countries in China

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Innovation and Development Policy 2022年第1期 1-24页

作者： David Bekkers thomas hansen Mika Klemettinen Nannan Lundin Consulate General of the Kingdom of the Netherlands in Shanghai Shanghai 201103China Innovation Centre Denmark in Shanghai Shanghai 200336China Business Finland Shanghai Office Shanghai 310000China Vinnova-Sweden’s Innovation Agency Stockholm 5610158Sweden

Science and innovation diplomacy is at a crossroad-facing the need for enhanced cooperation to tackle global challenges and in a more complex geopolitical *** on“learning-by-doing”and“learningby-experimenting”as well as focusing on future development needs and opportunities,the science and innovation diplomacy practices of“Nordic+”countries,i.e.,Denmark,Finland,Sweden and the Netherlands,in China are presented in the *** common strategic insights can be summarized as:1)a new policy narrative on“co-opetition”,2)a balanced approach and a long-term and future-oriented perspective on“coopetition”and 3)more agile,targeted and impact-oriented instruments and partnerships for“co-opetition”.Concrete suggestions for the future development include:1)a deepened understanding of how science and innovation are inter-connected with strategic and economic interests of countries and continents,2)publicly funded schemes and instruments for engaging Nordic multinationals and deepening science-industry-policy collaborative efforts,3)systematic methods through combining evidence-based and future-oriented analyses and 4)skill-and capacity development for identifying,preventing and mitigating multifaceted risks in *** such contexts,the implementation of EU’s mission-driven innovation and the twin-transition,*** sustainability transition and digital transition,can open up new opportunities for the future cooperation.

关键词： innovation diplomacy science and innovation policy business-driven innovation

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Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep

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Journal of Animal Science and Biotechnology 2018年第2期9卷 306-318页

作者： Yasser Y.Lenis Gregory A.Johnson Xiaoqiu Wang Wendy W.Tang Kathrin A.Dunlap M.Carey Satterfield Guoyao Wu thomas R.hansen Fuller W.Bazer Department of Animal Science Texas A&M UniversityCollege StationTX 77843-2471USA Center for Animal Biotechnology and Genomics Texas A&M UniversityCollege StationTX 77843USA Centauro Research Group School of Veterinary MedicineFaculty of Agrarian ScienceUniversidad de AntioquiaCalle 70 No52-21 MedellínColombia Faculty of Agricultural Sciences Calle 222 No.55-37UDCABogotaColombia Present address:National Institute of Environmental Health Sciences Research Triangle ParkNC 27709USA Animal Reproduction and Biotechnology Laboratory Department of Biomedical SciencesCollege of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsCO 80523USA

Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses(embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine(Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase(ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine(Agm) by arginine decarboxylase(ADC), and Agm is converted to putrescine by agmatinase(AGMAT).Methods: Morpholino antisense oligonucleotides(MAOs) were designed and synthesized to inhibit translational initiation of the m RNAs for ODC1 and ADC, in ovine ***: The morphologies of MAO control, MAO-ODC1, and MAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC(MAO-ODC1:ADC) resulted in two phenotypes of conceptuses; 33% of conceptuses appeared to be morphological y and functional y normal(phenotype a) and 67% of the conceptuses presented an abnormal morphology and functionality(phenotype b). Furthermore, MAO-ODC1:ADC(a) conceptuses had greater tissue concentrations of Agm,putrescine, and spermidine than MAO control conceptuses, while MAO-ODC1:ADC(b) conceptuses only had greater tissue concentrations of Agm. Uterine flushes from ewes with MAO-ODC1:ADC(a) had greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC(b) conceptuses had lower amount of putrescine, spermidine, spermine, alanine, aspartate,glutamine, tyrosine, phenylalanine, isoleucine, leucine, and ***: The double-knockdown of translation of ODC1 and ADC m RNAs was most detrimental to conceptus development and their production of int

关键词： Agmatine Arginine Interferon tau Polyamines Trophectoderm cells

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2015年小企业发展趋势

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网络运维与管理 2015年第4期 28-30页

作者： thomas Neergaard hansen 微软

在与全球各地小型企业主和技术提供商的交流中，我们开诚布公地探讨了各种话题——从本地挑战和不断变化的商业模式，到技术如何支持他们增长、如何创新使其业务更好地面向未来。

关键词：发展趋势小企业商业模式提供商技术

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运用移动网格选择相位实现高效有限差分波形建模

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国外油田工程 2003年第6期19卷 33-36页

作者： thomas Mejer hansen 易继贵王哲杨金富董萍中国石油大港油田研究中心中国石油大港油田采油作业三区

提出一种高效有限差分计算和解释分析地震波场的新方法 ,其基本思想是波场运算只计算移动网格所包含的波前部分 ,解决了全地震波场建模曾存在的两个难点。首先 ,计算量明显减少 ,质量损失较小 ;其次 ,将复杂波场分解为相位进行分析。本... 详细信息

提出一种高效有限差分计算和解释分析地震波场的新方法 ,其基本思想是波场运算只计算移动网格所包含的波前部分 ,解决了全地震波场建模曾存在的两个难点。首先 ,计算量明显减少 ,质量损失较小 ;其次 ,将复杂波场分解为相位进行分析。本方法只要适当修改现有时空域有限差分程序编码就可以实现。网格运动必须在建模之前给出 ,它可以比较精确地从低频有限差分建模或射线追踪中得到。二维试验证明 :在适度牺牲精确度的基础上 ,本方法建模可以减少大量内存需求和计算时间 ,而且可直接扩展到三维波场的计算和分析。

关键词：移动网格相位高效有限差分波形建模地震波场

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Synthetic,Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction

Synthetic,Zwitterionic Sp1 Oligosaccharides Adopt a Helical ...

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中国化学会第三届全国糖化学会议

作者： Qingju Zhang Ana Gimeno Darielys Santana Zhen Wang Yury Valdes-Balbin Laura M.Rodríguez-Noda thomas hansen Li Kong Mengjie Shen Herman S.Overkleeft Vicente Verez-Bencomo Gijsbert A.van der Marel Jesús Jiménez-Barbero Fabrizio Chiodo Jeroen D.C.Codée The National Research Centre for Carbohydrate Synthesis Jiangxi Normal University

The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide（Sp1） is an important anchor point for our immune system to act against streptococcal *** can recognize Sp1 saccharides,and it has been postulated that Sp1 can elicit a T-cell-dependent immune reaction as it can be presented by MHC-II *** unravel the molecular mode of action of this unique polysaccharide we here describe the chemical synthesis of a set of Sp1 fragments,ranging from 3 to 12 monosaccharides in *** outline a unique synthetic approach to overcome the major synthetic challenges associated with the complex Sp1 structure and provide a stereoselective route of synthesis for the oligosaccharide backbone as well as a strategy to introduce the carboxylic acid *** dynamics（MD） simulations together with NMR spectroscopy studies reveal that the oligosaccharides take up helical structures with the nona-and dodecasaccharide completing a full helical *** 3 D structure of the oligosaccharides coincides with the topology required for good interaction with anti-Sp1 antibodies,which has been mapped in detail using *** study has revealed the Sp1 nona-and dodecasaccharides as promising synthetic antigens,displaying all（3 D） structural elements required to mimic the natural polysaccharide and required to unravel the molecular mode of action of these unique zwitterionic polysaccharides.

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Trajectory sampling and finite-size effects in first-principles stopping power calculations

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npj Computational Materials 2023年第1期9卷 238-246页

作者： Alina Kononov thomas W.Hentschel Stephanie B.hansen Andrew D.Baczewski Center for Computing Research Sandia National LaboratoriesAlbuquerqueNMUSA School of Applied&Engineering Physics Cornell UniversityIthacaNYUSA Pulsed Power Sciences Center Sandia National LaboratoriesAlbuquerqueNMUSA

Real-time time-dependent density functional theory(TDDFT)is presently the most accurate available method for computing electronic stopping powers from first ***,obtaining application-relevant results often involves either costly averages over multiple calculations or ad hoc selection of a representative ion *** consider a broadly applicable,quantitative metric for evaluating and optimizing trajectories in this *** methodology enables rigorous analysis of the failure modes of various common trajectory choices in crystalline *** randomly selecting trajectories is common practice in stopping power calculations in solids,we show that nearly 30%of random trajectories in an FCC aluminum crystal will not representatively sample the material over the time and length scales feasibly simulated with TDDFT,and unrepresentative choices incur errors of up to 60%.We also show that finite-size effects depend on ion trajectory via“ouroboros”effects beyond the prevailing plasmon-based interpretation,and we propose a cost-reducing scheme to obtain converged results even when expensive core-electron contributions preclude large *** work helps to mitigate poorly controlled approximations in first-principles stopping power calculations,allowing 1–2 order of magnitude cost reductions for obtaining representatively averaged and converged results.

关键词： size prevailing selecting

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