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Reduced non-cpG methylation is a potential epigenetic target after spinal cord injury

Neural Regeneration Research 2023年第11期18卷 2489-2496页

作者： Zhourui Wu chen Li Ran Zhu Yiqiu cao thomas c.chen Liming cheng Key Laboratory of Spine and Spinal cord Injury Repair and Regeneration(Tongji University) Ministry of EducationShanghaiChina Division of Spine Department of OrthopedicsTongji HospitalTongji University School of MedicineShanghaiChina Institute of Spinal and Spinal cord Injury Tongji University School of MedicineShanghaiChina Department of Neurosurgery Keck School of MedicalUniversity of Southern CaliforniaLos AngelesCAUSA

DNA methylation is a critical epigenetic regulator in the occurrence and development of diseases and is closely related to various functional responses in relation to spinal cord *** investigate the role of DNA methylation in spinal cord injury,we constructed a library with reduced-representation bisulfite sequencing data obtained at various time points(day 0-42)after spinal cord injury in *** DNA methylation levels,specifically non-cpG(cHG and cHH)methylation levels,decreased modestly following spinal cord *** post-spinal cord injury were classified as early(day 0-3),intermediate(day7-14),and late(day 28-42)based on similarity and hie rarchical cluste ring of global DNA methylation *** non-cpG methylation level,which included cHG and cHH methylation levels,was markedly reduced despite accounting for a minor proportion of total methylation *** multiple genomic sites,including the 5’untranslated regions,promoter,exon,intron,and 3’untranslated regions,the non-cpG methylation level was markedly decreased following spinal cord injury,whereas the cpG methylation level remained unchanged at these *** one-half of the differentially methylated regions were located in intergenic areas;the other differentially methylated regions in both cpG and non-cpG regions were cluste red in intron regions,where the DNA methylation level was *** function of genes associated with differentially methylated regions in promoter regions was also *** Gene Ontology analysis results,DNA methylation was implicated in a number of essential functional responses to spinal cord injury,including neuronal synaptic connection creation and axon ***,neither cpG methylation nor non-cpG methylation was implicated in the functional response of glial or inflammatory *** summary,our work elucidated the dynamic pattern of DNA methylation in the spinal co rd following injury and identified reduced noncpG meth

关键词： cpG methylation cytosine fraction differentially methylated regions DNA methylation DNA methyltransferases dynamic signatures Gene Ontology non-cpG methylation single-cell RNA-Seq spinal cord injury

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A new localization theory of adaptive machining of near-net-shape blades

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chinese Journal of Aeronautics 2021年第6期34卷 18-32页

作者： Neng WAN Xiaogang SHEN Zhiyong cHANG Zezhong c.chen Department of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Department of Mechanical Industrial and Aerospace EngineeringConcordia UniversityMontrealQuebec H3G IMSCanada

In the fabrication of aero-engine blades,a great deal is gained when massive material removal is avoided at the end of the process,and as little as possible material is left on the blade *** to the uncertainty of pre-process,the billet shapes are ***,the near-net-shape billet doesn’t cover the blade design surface to be ***,blade localization is necessary for these billets before the *** conventional localization methods,the design surface’s location focused on guaranteeing enough material to be ***,because the to-becut surface is in near-net and free-form shape,it is difficult to find a valid localized surface model to generate the tool *** from the localized surface is taken as rigid in previous investigation,it is allowed to deviate from the design surface no more than the tolerance *** term of this principle,the tolerance band is utilized to promote localization ability.A series of optimization models with different priorities is established to avoid the abandonment expensive blade ***,with the experiments performed on the near-net-shape blades,the blade localization theory and the promotion of localization ability are verified.

关键词： Blade localization curvature constraint Machining surface Near-net-shape blade Tolerance constraint

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An automated approach to calculating the maximum diameters of multiple cutters and their paths for sectional milling of centrifugal impellers on a 4_(1/2)-axis cNc machine

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chinese Journal of Aeronautics 2019年第4期32卷 1030-1039页

作者： Baohai WU Zezhong c.chen Ming LUO Dinghua ZHANG Feiyan HAN School of Mechanical Engineering Northwestern Polytechnical University Department of Mechanical Industrial and Aerospace EngineeringConcordia University college of Mechanical Engineering Xi'an University of Science and Technology

Power generators and chemical engineering compressors include heavy and large centrifugal impellers. To produce these impellers in high-speed machining, a 4?-axis milling machine(or a 4-axis machine plus an indexing table) is often used in the industry, which is more rigid than a5-axis milling machine. Since impeller blades are designed with complex B-spline surfaces and impeller channels spaces vary significantly, it is more efficient to use multiple cutters as large as possible to cut a channel in sections and a blade surface in patches, instead of only using a small cutter to machine a whole blade and a channel. Unfortunately, no approach has been established to automatically calculate the largest diameters of cutters and their paths, which include the indexing table angles. To address this problem, an automated and optimization approach is proposed. Based on the structure of a 4?-axis machine, a geometric model for a cutter gouging/interfering the impeller is formulated, and an optimization model of the cutter diameter in terms of the indexing table angle is established at a cutter contact(cc) point on a blade surface. Then, the diameters of the tools,their orientations, and the indexing table angles are optimized, and each tool's paths are generated for machining its corresponding impeller section. As a test, an impeller is efficiently machined with these tools section by section; thus, this approach is valid. It can be directly used in the industry to improve efficiency of machining centrifugal impellers.

关键词： Automated path generation 4_(1/2)-Axis cNc machining centrifugal impeller machining cutter diameter optimization Sectional machining

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Reactive wetting behaviors of Sn/cu systems: A molecular dynamics study

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Nano-Micro Letters 2010年第2期2卷 60-67页

作者： J.Y.Hsieh J.L.chen c.chen H.c.Lin S.S.Yang c.c.Hwang Department of Mechanical Engineering Ming Hsin University of Science and Technology Institute of Precision Mechatronic Engineering Ming Hsin University of Science and Technology Department of Mechanical Engineering Wu Feng Institute of Technology Department of Information Management Meiho Institute of Technology Department of Engineering Science National Cheng Kung University

Influences of temperature and Sn-cu droplet's composition on reactive wettings of cu(100), cu(110), and cu(111) surfaces were analyzed, by using molecular dynamics(MD) calculations. As a result, the spreading on cu(110)(cu(100)) has the fastest(slowest) wetting kinetics. A higher temperature or a diluter cu content in the Sn-cu alloy droplet results in a higher wettability. Moreover, this work has addressed a theory for positioning the interface separating the liquidus and solidus alloys in the spreading film to confirm the hypothesis that the reactive wetting will come to the end when the interface saturates with the temperature-dependent solidus weight fraction of cu.

关键词： Wetting Surface alloying Molecular dynamics Droplet

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Nanoscale strain engineering of graphene and graphene-based devices

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Acta Mechanica Sinica 2016年第3期32卷 497-509页

作者： N.-c.Yeh c.-c.Hsu M.L.Teague J.-Q.Wang D.A.Boyd c.-c.chen Department of Physics Institute for Quantum Information and Matter and Kavli Nanoscience InstituteCalifornia Institute of Technology Department of Physics Fudan University Department of Physics California Institute of Technology

Structural distortions in nano-materials can induce dramatic changes in their electronic properties. This situation is well manifested in graphene, a two-dimensional honeycomb structure of carbon atoms with only one atomic layer thickness. In particular, strained graphene can result in both charging effects and pseudo-magnetic fields, so that controlled strain on a perfect graphene lattice can be tailored to yield desirable electronic properties. Here, we describe the theoretical foundation for strain-engineering of the electronic properties of graphene, and then provide experimental evidence for strain-induced pseudo-magnetic fields and charging effects in monolayer graphene. We further demonstrate the feasibility of nano-scale strain engineering for graphene-based devices by means of theoretical simulations and nano-fabrication technology.

关键词： Graphene Strain-engineering Nanostructures Dirac fermions Pseudo-magnetic field Valleytronics

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The Ductile to Brittle Transition Behavior of the Modified 9cr-1Mo Steel and Its Laser Welds

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材料导报 2004年第8期18卷 121-123页

作者： H.c.Wu R.K.Shiue c.chen DepartmentofMaterialsScienceandEngineering TaiwanUniversityTaipei106ChinaTaiwan DepartmentofMaterialsScienceandEngineering DongHwaUniversityHualien974ChinaTaiwan

The ductile to brittle transition temperature (DBTT) of the modified 9cr-1Mo steel and its laser welds was studied. The increase in grain size of the weld structure ascended the DBTT of the steel significantly. The transformation of retained austenite at martensite interlath boundaries into untempered and/or twinned martensite could also contribute to increased DBTTs of the steel and its welds tempered at 540℃.

关键词： 9cr-1Mo钢激光焊接 DBTT 冲击韧性

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing Yang Jinghui chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4cl1.6from 0.8 to 1.35 mA *** resultant LicoO2/Li5.4PS4.4cl1.4I0.2/Li battery shows excellent cycling stability at 1 c,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LicoO2/Li5.4PS4.4cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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construction of 3D porous cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： chen chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous cu_(1.81)S/nitrogen-doped carbon frameworks(cu_(1.81)S/Nc)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/c cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

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Fabrication of carbon-supported Al2O3 nanoparticles via spontaneous cross-linking to enhance selective hydrogenation of furfural

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Journal of Energy chemistry 2025年第1期100卷 612-620页

作者： Weiwei Yu Xinbao Zhang Hongyu chen Yanan Wang Shaoguo Li Fucun chen Zhenni Liu Xiujie Li Xiangxue Zhu State Key Laboratory of catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Selective hydrogenation of furfural to furfuryl alcohol is a great challenge in the hydrogenation field due to thermodynamic preference for hydrogenation of c=c over c=***,a novel Al2O3/c-u hybrid catalyst,composed of N-modified dendritic carbon networks supporting Al2O3nanoparticles,was successfully prepared via carbonizing the freeze-dried gel from spontaneous cross-linking of alginate,Al3+and *** obtained carbon-supported Al2O3hybrid catalyst has a high ratio （31%） of Al species in pentahedral-coordinated *** introduction of urea enhances the surface N content,the ratio of pyrrolic N,and specific surface area of catalyst,leading to improved adsorption capacity of c=O and the accessibility of active *** the furfural hydrogenation reaction with isopropyl alcohol as hydrogen donor,Al2O3/c-u catalyst achieved a 90%conversion of furfural with 98.0% selectivity to furfuryl alcohol,outperforming that of commercial γ-***,Al2O3/c-u demonstrates excellent catalytic stability in the recycling tests attributed to the synergistic effect of abundant weak Lewis acid sites and the anchoring effect of the carbon network on *** work provides an innovative and facile strategy for fabrication of carbon-supported Al2O3hybrid catalysts with rich AlVspecies,serving as a high selective hydrogenation catalyst through MPV reaction route.

关键词： Selective hydrogenation Furfural Furfuryl alcohol cross-linking MPV route

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A sinusoidal method for time-resolved quantification of dynamic brain extracellular space and diffusion tortuosity

A sinusoidal method for time-resolved quantification of dyna...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Kevin c.chen Multidisciplinary Research center Shantou University

A sinusoidal iontophoresis method was proposed to determine the dynamic modulations of two important parameters for characterizing extracellular diffusion,the brain extracellular volume and diffusion tortuosity,during shortlived pathological *** method improved the commonly used step-release protocol in better characterization of the time-resolved diffusion tortuosity by measuring the phase lags and sinusoidal amplitudes of the sampled tetramethyl ammonium(TMA) concentration *** validate the sinusoidal method,we tested whether the dynamic diffusion properties in the brain extracellular space can be extracted reliably from the TMA sinusoidal waveform through computersimulated *** TMA mass balance equation was first modified to accommodate temporal changes of the brain extracellular space,followed by solving the mass balance equation numerically to model the in vitro and in vivo experimental situations incorporating a sinusoidal TMA point *** showed that the sinusoidal method can accurately capture the dynamic behaviors of the simulated brain extracellular volume and tortuosity both in vitro and in vivo,as long as no abrupt changes of the two parameters were *** sinusoidal method also proved to be more accurate in inferring the relative extracellular volume changes man the traditional method of monitoring the TMA background concentration in vitro,which produced significant TMA undershoot artifacts following pathological events.

关键词： Extracellular Space Diffusion Ion-Selective Microelectrode Spreading Depression

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