检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

香港南亚裔小六学生中文辅助教材设计研究

汉语学习 2019年第6期 94-102页

作者：梁慧敏香港理工大学中文及双语学系

为了帮助香港第二语言中文教学逐步完善及规范化,本研究为南亚裔小六学生设计了一套既利于教师教学又方便学生学习的辅助教材,尝试通过教材、教法和教学实际的配合,摸索出适合香港南亚族裔学生的中文教学路子。本文将详细介绍辅助教材... 详细信息

为了帮助香港第二语言中文教学逐步完善及规范化,本研究为南亚裔小六学生设计了一套既利于教师教学又方便学生学习的辅助教材,尝试通过教材、教法和教学实际的配合,摸索出适合香港南亚族裔学生的中文教学路子。本文将详细介绍辅助教材的设计构想、特点,并在此基础上就香港南亚族裔学生中文学习的发展方向提出相应的建议。

关键词：香港南亚族裔辅助教材民族中小学汉语教学共享课程

Gender-Biased Regulation of Human IL-17-Producing Cells <i>in Vitro</i>by Peptides Corresponding to Distinct <i>HLA-DRB</i>1 Allele-Coded Sequences

在线全文

学校读者我要写书评

暂无评论

Journal of Immune Based Therapies, Vaccines and Antimicrobials 2013年第3期2卷 29-38页

作者： Luz P. Blanco Melissa Plegue wai-Ping Fung-leung Joseph Holoshitz Center for Statistical Consultation and Research (CSCAR) University of Michigan Ann Arbor USA Division of Rheumatology Department of Internal Medicine University of Michigan Ann Arbor USA Janssen Research & Development Immunology San Diego USA

Rheumatoid arthritis (RA) is associated with an HLA-DRB1-coded sequence motif called “shared epitope” (SE). To explore potential mechanisms of RA susceptibility, we analyze in vitro effect of peptides bearing different HLA-DR4 sequences on human peripheral blood-derived cells. Three 15-mer peptides were used: 65-79*0401 (HLA-DRB1*04:01- coded sequence SE motif, QKRAA);65-79*0402 (HLA-DRB1*04:02-coded sequence SE-negative motif, DERAA);65-79*0403 (HLA-DRB1*04:03-coded sequence SE-negative motif, QRRAE). We found that CD4 TH17 cells are regulated by peptide treatment with gender bias. In male-derived T cells, all peptide treatments significantly reduced TH17 cell differentiation in vitro when compared to no peptide treatment, and to female samples. TH17 differentiation in samples not treated with peptides, either in the presence or absence of TH17-polarizing cytokines, was higher in males than in females;however, in unfractionated PBMC after treatment with TH17 polarizing cytokines, IL-17A-positive cells were more abundant in females than in males. In addition, SE-positive females showed a significantly higher percentage of IL-17A-positive cells compared to SE-negative females. In conclusion, donor’s SE status and gender may both influence TH17 immune polarization.

关键词： MHC Class II PBMC TH17 Cytokines Immune Polarization Review

Helicobacter pylori associated gastric intestinal metaplasia:Treatment and surveillance

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界胃肠病学杂志：英文版 2016年第3期22卷 1311-1320页

作者： Kevin Sze-Hang Liu Irene Oi-Ling Wong wai K leung Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina

Gastric cancer(GC) is one of the leading causes of cancer related death in the world, particularly in East Asia. According to the Correa's cancer cascade, noncardia GC is usually developed through a series of mucosal changes from non-atrophic gastritis to atrophic gastritis(AG), intestinal metaplasia(IM), dysplasia and adenocarcinoma. Atrophic gastritis and IM are therefore generally considered to be pre-neoplastic gastric lesions. Helicobacter pylori(H. pylori) infection is an important initiating and promoting step of this gastric carcinogenesis cascade. Emerging long-term data showed that eradication of H. pylori reduced the risk of subsequent cancer development. It however remains confusing whether eradication of the bacterium in individuals with pre-neoplastic gastric lesions could regress these changes as well as in preventing cancer. Whilst H. pylori eradication could likely regress AG, the presence of IM may be a point of no return in this cascade. Hence, surveillance by endoscopy may be indicated in those with extensive IM or those with incomplete IM, particularly in populations with high GC risk. The optimal interval and the best tool of surveillance endoscopy remains to be determined in future studies.

关键词： Helicobacter pylori Gastric cancer Intestinalmetaplasia Treatment Surveillance

Extensive contact tracing and screening to control the spread of vancomycin-resistant Enterococcus faecium ST414 in hong Kong

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第19期125卷 3450-3457页

作者： CHENG Vincent Chi-chung TAI Josepha wai-ming NG Modissa Lai-ming CHAN Jasper Fuk-woo WONG Sally Cheuk-ying LI Iris wai-sum CHUNG Hon-ping LO wai-kei YUEN Kwok-yung HO Pak-leung Department of Microbiology Queen Mary Hospital Hong Kong Special Administrative Region China Infection Control Team Queen Mary Hospital Hong Kong Special Administrative Region China Department of Surgery Tung Wah Hospital Hong Kong Special Administrative Region China Infection Control Team Tung Wah Hospital Hong Kong Special Administrative Region China

Background Proactive infection control management is crucial in preventing the introduction of multiple drug resistant organisms in the healthcare setting. In hong Kong, where vancomycin-resistant enterococci （VRE） endemicity is not yet established, contact tracing and screening, together with other infection control measures are essential in limiting intra- and inter-hospital transmission. The objective of this study was to illustrate the control measures used to eradicate a VRE outbreak in a hospital network in hong Kong. Methods We described an outbreak of VRE in a healthcare region in hong Kong, involving a University affiliated hospital and a convalescent hospital of 1600 and 550 beds respectively. Computer-assisted analysis was utilized to facilitate contact tracing, followed by VRE screening using chromogenic agar. Multi-locus sequence typing （MLST） was performed to assess the clonality of the VRE strains isolated. A case-control study was conducted to identify the risk factors for nosocomial acquisition of VRE. Results Between November 26 and December 17, 2011, 11 patients （1 exogenous case and 10 secondary cases） in two hospitals with VRE colonization were detected during our outbreak investigation and screening for 361 contact patients, resulting in a clinical attack rate of 2.8% （10/361）. There were 8 males and 3 females with a median age of 78 years （range, 40-87 years）. MLST confirmed sequence type ST414 in all isolates. Case-control analysis demonstrated that VRE positive cases had a significantly longer cumulative length of stay （P 〈0.001）, a higher proportion with chronic cerebral and cardiopulmonary conditions （P=0.001）, underlying malignancies （P 〈0.001）, and presence of urinary catheter （P 〈0.001）, wound or ulcer （P 〈0.001）, and a greater proportion of these patients were receiving β-lactam/ β-1actamase inhibitors （P=0.009）, carbapenem group （P 〈0.001）, fluoroquinolones （P=0.003）, or vancomycin （P=0.001） when compared with the controls. Conclusion

关键词： vancomycin-resistant Enterococcus faecium ST414 outbreak contact tracing screening

ABC/2 formula for"bedside"postoperative pneumocephalus volume measurement

在线全文

学校读者我要写书评

暂无评论

Chinese Neurosurgical Journal 2022年第4期8卷 284-291页

作者： David Yuen Chung Chan Eric Yuk hong Cheung Ka Ho Hui Cecelia Mei Sze leung Stephanie Chi Ping Ng wai Kit Mak George Kwok Chu Wong Tat Ming Danny Chan wai Sang Poon Division of Neurosurgery Department of SurgeryFaculty of MedicinePrince of Wales HospitalThe Chinese University of Hong KongHong KongSARChina

Background:Postoperative pneumocephalus is associated with a higher risk of recurrence of chronic subdural hematoma(cSDH).However,there is no verified simple way to measure the pneumocephalus volume at the bedside for daily clinical *** ABC/2 method was shown to be a simple and reliable technique to estimate volumes of intracranial lesions,such as intracranial *** study aims to evaluate the accuracy of the ABC/2 formula in estimating volumes of pneumocephalus,as compared to the gold standard with computer-assisted volumetric ***:A total of 141 postoperative computed tomographic(CT)brain scans of cSDH patients with burr-hole drainage were *** volume was measured independently by both the ABC/2 formula and the computer-assisted volumetric *** the computer-assisted measurement,the volume of the air was semiautomatically segmented and calculated by computer *** regression was used to determine the correlation between the ABC/2 method and computer-assisted ***:The postoperative pneumocephalus volume after bilateral burr-hole drainage was significantly larger than that of unilateral burr-hole drainage(29.34 ml versus 12.21 ml,p<0.001).The estimated volumes by the formula ABC/2 significantly correlated to the volumes as measured by the computer-assisted volumetric technique,with r=0.992(p<0.001).The Pearson correlation coefficient is very close to 1,which signifies a very strong positive correlation,and it is statistically ***:An excellent correlation is observed between the ABC/2 method and the computer-assisted *** study verified that the ABC/2 method is an accurate and simple"bedside"technique to estimate pneumocephalus volume.

关键词： ABC/2 Chronic subdural haematoma Burr-hole Pneumocephalus

A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine 2023年第4期14卷 242-254页

作者： Zumeng Xia Hoi Yan leung Hoi Ling Siu Chung wai Chan Kam Ming Ko R&D Center Infinitus China Limited Guangzhou China Division of Life Science Hong Kong University of Science & Technology Hong Kong China

The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.

关键词： Cardiomyopeptin Herbal Extract Chronic Heart Failure Isoproterenol

论香港国际机场起飞着陆滑行区域气象回避路线的识别（英文）

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第3期17卷 171-185页

作者： Manuela SAUER thomas HAUF Ludmila SAKIEW Pak wai CHAN Shuk-Mei TSE Patrick HUPE Institute of Meteorology and Climatology Leibniz Universitet Hannover 30419 Hannover Germany Aviation Weather Services Hong Kong Observatory Kowloon Hong Kong China

空中交通的安全和效率明显受恶劣天气的影响,在机场起飞着陆滑行区域(TMA)尤其如此。在此区域,除了受天气影响之外,潜在的气象回避路线还受到空中交通管制的严格限制。因此气象回避模型DIVMET被开发出来。该模型给出一条建议路线,可以... 详细信息

空中交通的安全和效率明显受恶劣天气的影响,在机场起飞着陆滑行区域(TMA)尤其如此。在此区域,除了受天气影响之外,潜在的气象回避路线还受到空中交通管制的严格限制。因此气象回避模型DIVMET被开发出来。该模型给出一条建议路线,可以通过正在形成雷暴但尚未在里面实施任何空中交通管制的场地。DIVMET被应用到香港国际机场的TMA区域,因为此处的空中交通管制(ATC)单位有兴趣通过模拟回避路线来提高管制员的工作量,尤其是用于管理进场飞机交通。ATC单位对模拟的回避路线进行目视检查,其结果令人满意,但是商定了用实际观察到的路线对模拟情况进行定量验证。本文选择了香港TMA区域内有雷暴且交通严重扭曲时的两种真实恶劣天气情况。但是,进行任何验证之前的主要目标是识别仅仅受到天气影响但并未显示任何管制标志的路线。在飞行位置数据的基础上完成路线选择,选择若干着陆航班,并分析与标准进场路线的偏差。结果显示,272架航班中大多数同时受到天气和管制的影响(60%),这突出表明空中交通管制员在恶劣天气下要安全有效地管理着陆交通是存在挑战的。只有少数受天气影响的航班(7%)未受到管制,可以用于验证。DIVMET模拟路线被传给当地空中交通管制员,证明了这些路线是潜在切实的回避路线。在TMA区域内的DIVMET气象回避路线模拟有一定参考价值,但是进一步的模型开发必须将管制纳入考虑,至少要考虑停候、近道和减速。

关键词：雷暴回避机场起飞着陆滑行区域香港水平环行协同决策

Three-Photon Up-conversion from Polymeric Lanthanide (III) Complexes

在线全文

学校读者我要写书评

暂无评论

Three-Photon Up-conversion from Polymeric Lanthanide (III) C...

Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

第五届全国稀土发光材料学术研讨会

作者： Ka-leung Wong wai-Ming Kwok Wing-Tak Wong David Lee Phillips Kok-wai Cheah Department of Chemistry The University of Hong Kong Pokfulam Road Hong Kong P. R.China Department of Physics Hong Kong Baptist University Kowloon Tong Hong Kong P. R.China

We report the first observation of three-photon up-conversion emission from polymeric organic lanthanide complexes, [N,N’,N”-tris(2–methoxybenzamido)-triethylamine]-lanthanide complexes (Ln = Tb, Eu),

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第9期19卷 705-711页

作者： Danish Iltaf Satti Yan Hiu Athena Lee Keith Sai Kit leung Jeremy Man Ho Hui Thompson Ka Ming Kot Arslan Babar Gauranga Mahalwar Abraham KC wai Tong Liu Leonardo Roever Gary Tse Jeffrey Shi Kai Chan International Health Informatics Study(IHIS)Network Cardiovascular Analytics Group Hong KongChina-UK Collaboration Emergency Medicine Unit Li Ka Shing Fac-ulty of MedicineThe University of Hong KongHong KongChina Aston Medical School Faculty of Health&Life SciencesAston UniversityBirminghamUnited Kingdom Li Ka Shing Faculty of Medicine The University of Hong KongHong KongChina Department of Anaesthesia and Pain Service Princess Margaret HospitalLai Chi KokKowloonHong KongChina Department of Medicine Cleveland Clinic FoundationClevelandUSA Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardi-ologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Clinical Research Federal Uni-versity of UberlândiaUberlândiaBrazil Kent and Medway Medical School CanterburyKentUnited Kingdom 不详

OBJECTIVES To assess the effect of vasopressin,steroid and epinephrine(VSE)combination therapy on return of spontan-eous circulation(ROSC)after in-hospital cardiac arrest(IHCA),and test the conclusiveness of evidence using trial sequential ana-lysis(TSA).METHODS The systematic search included PubMed,EMBASE,Scopus,and Cochrane Central Register of Controlled *** controlled trials(RCTs)that included adult patients with IHCA,with at least one group receiving combined VSE therapy were *** was extracted independently by two *** main outcome of interest was *** out-comes included survival to hospital discharge or survival to 30 and 90 days,with good neurological *** We included a total of three RCTs(n=869).Results showed that VSE combination therapy increased ROSC(risk ra-tio=1.41;95%CI:1.25-1.59)as compared to *** demonstrated that the existing evidence is *** was also validated by the alpha-spending adjusted relative risk(1.32[1.16,1.49],P<0.0001).Other outcomes could not be meta-analysed due to differences in timeframe in the included *** VSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ***-ture trials of VSE therapy should evaluate survival to hospital discharge,neurological function and long-term survival.

关键词： resuscitation analysis return