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Patient selection essential in optimizing the benefit of radical prostatectomy for patients with organ-confined prostate cancer

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Asian journal of Andrology 2011年第6期13卷 789-790页

作者： Matthew j resnick thomas j Guzzo The Division of Urology The Hospital of the University of Pennsylvania Philadelphia PA 19104 USA

P rostate cancer is the most common noncutaneous malignancy in the United States and is a highly prevalent disease worldwide in industrialized nations.1 Prostate cancer is also a leading cause of cancer related mortality in the United States with an estimated 32 050 deaths in 2010. If one were to simply look at the raw mortality data,

关键词： Prostate cancer noncutaneous appropriate treatment decisions

Neuromodulator interactions and spinal cord injury in lamprey

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Neural regeneration research 2018年第4期13卷 643-644页

作者： David Parker thomas j.McClelland Department of Physiology Neuroscience and DevelopmentUniversity of Cambridge

Neuromodulation is mediated by neurotransmitters that typically act on G-protein-coupled *** can confer behavioural flexibility by modifying the functional properties of anatomically hard-wired neural *** neuromodulators generally have divergent cellular and synaptic effects（Harris-Warrick and johnson,2010）,and different modulators,

关键词： Figure Neuromodulator interactions and spinal cord injury in lamprey

Visually Modelling Collaborative research into Innovative Community Disaster resilience Practice,Strategy,and Governance

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International journal of Disaster risk Science 2015年第3期6卷 282-294页

作者： thomas j.Huggins robin Peace Stephen r.Hill David M.johnston Alicia Cuevas Muniz joint Centre for Disaster research School of PsychologyMassey University School of Psychology Massey University School of Psychology Massey University Joint Centre of Disaster ResearchMassey University Faculty of Science University of Colima

In 2013 a new collaborative center was established in Wellington, New Zealand to focus on integrating resilience research with the region’s community disaster resilience strategy. An earlier study with parties to this center had indicated that researcher and practitioner groups were divided by attention to their own immediate knowledge and skills, but agreed there was a need to maximize community resilience benefits amongst a regional population. An action research workshop of researchers and practitioners used a visual logic model to focus on the pragmatic benefits of improving community resilience. The visual logic model was used to design research activities that would improve the regional community resilience strategy, which was still in an early implementation *** of 14 workshop participants were interviewed following the workshop. Statistical content analysis of interview data highlighted certain strengths of the action research process: visual monitoring and evaluation planning was a catalyst for complicated conversations between two very different groups of professionals; and researchers became more focused on practical issues as a result. Other findings suggested that in future collaborative researchgovernance would benefit from wider cycles of strategic intelligence, enhanced research contributions, and the use of different information formats for different *** formats for different purposes should also be considered when developing and implementing large-scale disaster risk reduction policies and strategies.

关键词： Collaborative research Community resilience Content analysis Emergency management Visual communication

A-posteriori error estimation for second order mechanical systems

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Acta Mechanica Sinica 2012年第3期28卷 854-862页

作者： thomas ruiner jrg Fehr Bernard Haasdonk Peter Eberhard Institute of Engineering and Computational Mechanics University of StuttgartPfaffenwaldring 970569 StuttgartGermany Institute of Applied Analysis and Numerical Simulation University of StuttgartPfaffenwaldring 5770569 StuttgartGermany

One important issue for the simulation of flexible multibody systems is the reduction of the flexible bodies de- grees of freedom. As far as safety questions are concerned knowledge about the error introduced by the reduction of the flexible degrees of freedom is helpful and very important. In this work, an a-posteriori error estimator for linear first order systems is extended for error estimation of me- chanical second order systems. Due to the special second order structure of mechanical systems, an improvement of the a-posteriori error estimator is achieved. A major advan- tage of the a-posteriori error estimator is that the estimator is independent of the used reduction technique. Therefore, it can be used for moment-matching based, Gramian matrices based or modal based model reduction techniques. The capability of the proposed technique is demon- strated by the a-posteriori error estimation of a mechanical system, and a sensitivity analysis of the parameters involved in the error estimation process is conducted.

关键词： A-posteriori error estimator. Flexible multibodysystems Model reduction

Pyogenic liver abscess:An audit of 10 years’experience

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World journal of Gastroenterology 2011年第12期17卷 1622-1630页

作者： Tony CY Pang thomas Fung jaswinder Samra thomas j Hugh ross C Smith Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt Leonards NSW 2065Australia

AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous ***:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were *** and hydatid abscesses were ***,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were ***:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQr) of 7(5-14) *** 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was *** function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQr) diameter of 6.3(4-9) *** organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial *** initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their *** hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate ***:PLA is a diagnostic challenge,because the presentation of this condition is *** antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage.

关键词： Pyogenic liver abscess Image guided drainage Surgical drainage C-reactive protein Hypoalbuminaemia

A Fast Accurate Boundary IntegralMethod for Potentials on Closely Packed Cells

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Communications in Computational Physics 2013年第9期14卷 1073-1093页

作者： Wenjun Ying j.thomas Beale Shanghai jiao Tong University Department of Mathematics and Institute of Natural SciencesMinhangShanghai 200240P.R.China Duke University Department of MathematicsDurhamNC 27708-0320USA

Boundary integral methods are naturally suited for the computation of harmonic functions on a region having inclusions or cells with different material ***,accuracy deteriorates when the cell boundaries are close to each *** present a boundary integralmethod in two dimensions which is specially designed tomaintain second order accuracy even if boundaries are arbitrarily *** uses a regularization of the integral kernel which admits analytically determined corrections to maintain *** boundaries with many components we use the fast multipolemethod for efficient *** compute electric potentials on a domain with cells whose conductivity differs from that of the surrounding *** first solve an integral equation for a source term on the cell interfaces and then find values of the potential near the interfaces via *** we use a Poisson solver to extend the potential to a regular grid covering the entire region.A number of examples are *** demonstrate that increased refinement is not needed to maintain accuracy as interfaces become very close.

关键词： Laplace equation boundary integral method fast multipole method

Nearly Singular Integrals in 3D Stokes Flow

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Communications in Computational Physics 2013年第10期14卷 1207-1227页

作者： Svetlana Tlupova j.thomas Beale Department of Mathematics University of MichiganAnn ArborMI 48109-1043USA Department of Mathematics Duke UniversityDurhamNC 27708-0320USA

A straightforward method is presented for computing three-dimensional Stokes flow,due to forces on a surface,with high accuracy at points near the *** flowquantities arewritten as boundary integrals using the free-spaceGreen’s *** evaluate the integrals near the boundary,the singular kernels are regularized and a simple quadrature is applied in coordinate *** order accuracy is obtained by adding special corrections for the regularization and discretization errors,derived here using local asymptotic *** tests demonstrate the uniform convergence rates of the method.

关键词： Stokes equations boundary integral equation method nearly singular integrals

Early developmental exposure to inorganic mercury does not alter affiliative behavior of adult prairie voles(Microtus ochrogaster)

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Integrative Zoology 2018年第6期13卷 761-768页

作者： Yue CHEN robert LEWIS j.thomas CUrTIS Department of Pharmacology and Physiology Oklahoma State University Center for Health SciencesTulsaOklahomaUK

Mercury chloride exposure through drinking water in adult male prairie voles(Microtus ochrogaster)has been shown to alter their social ***,we examined the potential disruption of adult social behavior in prairie voles that were exposed to 60 ppm mercury during early *** used a cross-fostering approach to test the effects of mercury exposure:(1)from conception until birth;(ii)from birth until weaning;and(iii)from conception until weaning,on adult affiliative *** and mercury-treated voles were given the option of remaining in an empty cage or affiliating with a same-sex conspecific in a 3-h choice *** found that early developmental mercury exposure had little if any effect on the reproductive success of breeder pairs or on affiliative behavior by either sex when subjects were tested as *** results suggest that,at least in the context of the behavior tested,the effects of early developmental exposure to mercury do not permanently alter adult prairie vole affiliative behavior,or do so in a way that is too subtle to be detected using the current testing paradigm.

关键词： behavioral testing metals toxicity social behavior prairie vole

Positron imaging systems for studying particulate, granular and multiphase flows

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Particuology 2012年第2期10卷 146-153页

作者： thomas W.Leadbeater David j.Parker joseph Gargiuli Positron Imaging Centre University of BirminghamEdgbastonBirmingham B152TTUKa

The University of Birmingham has pioneered and adapted the use of the medical imaging technique known as positron emission tomography （PET） to the study of particulate, granular and multiphase flows in industrial and physical processes, This paper provides a review of the PET and complimentary positron emission particle tracking （PEPT） techniques and details their application to the study of particulate sys- tems, The current state of the art, recent developments and example results from many of the applications to which these techniques have been applied are highlighted.

关键词： Positron emission particle tracking (PEPT)Particle dynamicsMulti-phase flow measurement