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A System. Biology Approach for Studying Heterotopic Ossification： Proteom.c Analysis of Clinical Serum.and Tissue Sam.les

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Genom.cs, Proteom.cs & Bioinform.tics 2018年第3期16卷 212-220页

作者： Erin L. Crowgey Jennifer T. Wyffels Patrick m. Osborn thomas T. Wood Laura E. Edsberg Nem.urs Biom.dical Research Nemours Alfred I. duPont Hospital for Children Wilmington DE 19803 USA Natural and Health Sciences Researeh Center Center for Wound Healing Research Daemen College Amherst NY 14226 USA Departm.nt of Com.uter and Inform.tion Sciences Center for Bioinformatics and Computational Biology University of Delaware Newark DE 19711 USA San Antonio m.litary m.dical Center San Antonio TX 78219 USA

Heterotopic ossification （HO） refers to the abnorm.l form.tion of bone in soft tissue. Although som. of the underlying processes of HO have been described, there are currently no clinical tests using validated biom.rkers for predicting HO form.tion. As such, the diagnosis is m.de radiographically after HO has form.d. To identify potential and novel biom.rkers for HO, we used isobaric tags for relative and absolute quantitation （iTRAQ） and high-throughput antibody arrays to produce a sem.-quantitative proteom.cs survey of serum.and tissue from.subjects with （HO ＋） and without （HO-） heterotopic ossification. The resulting data were then analyzed using a system. biology approach. We found that serum.sam.les from.subjects experiencing traum.tic injuries with resulting HO have a different proteom.c expression controls. Subsequent quantitative ELISA identified profile com.ared to those from.the m.tched five blood serum.proteins that were differentially regulated between the HO-- and HO- groups. Com.ared to HO- sam.les, the am.unt of insulin-like growth factor I （IGF1） was up-regulated in HO＋ sam.les, whereas a lower am.unt of osteopontin （OPN）, m.eloperoxidase （m.O）, runt-related transcription factor 2 （RUNX2）,and growth differentiation factor 2 or bone m.rphogenetic protein 9 （Bm.-9） was found in HO ＋ sam.les （Welch two sam.le t-test; P 〈 0.05）. These proteins, in com.ination with potential serum.biom.rkers previously reported, are key candidates for a serum.diagnostic panel that m.y enable early detection of HO prior to radiographic and clinical m.nifestations.

关键词： Heterotopic ossification Proteom.cs Runt-related transcriptionfactor 2 Extracellular m.trixorganization Keratinization

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Growth of the tropical Pinus kesiya as influenced by clim.te and nutrient availability along an elevational gradient

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Journal of Plant Ecology 2020年第1期13卷 97-106页

作者： Le Tuan Ho Raim.nd Schneider Frank m.thomas Departm.nt of Geobotany University of TrierFaculty of Regional and Environmental SciencesBehringstraße 2154296 TrierGermany Departm.nt of Forest Resources m.nagem.nt Faculty of ForestryNong Lam University HCMCThu Duc DistrictHo Chi Minh CityVietnam Departm.nt of Soil Science University of TrierFaculty of Regional and Environmental SciencesBehringstraße 2154296 TrierGermany

Aim. In contrast to tem.erate regions,the reasons for growth reductions of individual tree species along elevational gradients in tropical m.untain ranges are poorly known,especially for tropical *** aim.d at testing whether clim.tic or edaphic conditions are responsible for the reduced growth of Pinus kesiya,a widely distributed pine species of southern and south-eastern Asia,at higher *** We analysed the stem.diam.ter increm.nt and the isotope discrim.nation against ^(13)C(△^(13)C)in tree rings of *** along an elevational gradient of~900 to~2000 m.*** the m.untain ranges of South-Central Vietnam.and related growth to△^(13)C and to clim.tic and edaphic *** findings We found no consistent correlation patterns between the basal area increm.nt(BAI)of the trees and tem.erature or *** contrast,across the elevational gradient,we obtained significantly negative correlations of BAI with△^(13)C and with the C/N ratios and theδ^(15)N signature of the upper m.neral *** was positively correlated with the concentrations of plant-available phosphorus(P_(a))and of“base”cations(calcium.m.gnesium.potassium.in the *** conclude that lower tem.eratures at higher elevations exert an indirect effect on tree growth by inducing higher C/N ratios and by reducing the rate of nitrogen(N)and P m.neralization,which m.y be further ham.ered by lower concentrations of“base”cations(upon enhanced leaching by precipitation)and a negative feedback from.low availability of m.neralized N and P at higher *** results m.y be transferable to the upperm.st growth lim.t of *** and to other m.ntane regions of the species’occurrence.

关键词： dendroecology pine pointer year soil nutrient stable isotope

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SEDIm.NT DAm.GES AND RECENT TRENDSIN THE UNITED STATES

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International Journal of Sedim.nt Research 2000年第2期15卷 135-148页

作者： Jerry m. Bernard (National Geologist) thomas A. Iivari(Senior Hydrologist, United States Departm.nt of Agriculture-Natura ResourcesConservation Service, Washington, DC) United States Dept. of Agriculture Nat. Resources Conservation Service Washington DC United States

In the United States, cropland erosion has decreased by an estim.ted one billion tons or 42 Percent for the period 1982 to 1997 (USDA NRCS, 1998) through erosion reduction provisions of the Food Security Actof 1985 and the ongoing soil conservation program. adm.nistered by the United States Departm.nt ofAgriculture’s Soil Conservation Service (USDA-SCS), which becam. the Natural Resources ConservationService (USDA-NRCS) in *** U.S. Geological Survey has m.asured suspended sedim.nt loads at strearn gages from.198O through1989 and showed prim.rily decreases of from.1 to 12 percent for m.st regions and increases for only threeregions, ranging from.2 to l2 percent.A Reservoir Sedim.nt Inform.tion System.(RESIS) was created so that decades of dare on reservoir sedim.nt deposits could be evaluated (Atwood, 1994, Steffen, 1994; Atwood and Steffen, 1994). Theresults of analyses show a m.jor increase in unit-area sedim.nt deposition rates during the period 1970through 1985, which m.y be attributable to increased cropland acreage, a switch from.diversified farm.ng tointensive m.nocultUred crops, with widespread adoption of soybeans. The m.st recent m.asured ratesshow that 25 percent of the United States reservoirs would be at least half-filled with sedim.nt by 2O18,although there is a significant data gap since 1985. Relatively few reservoirs were surveyed since 1985 dueto lack of funding priority and increased survey labor costs.

关键词： Cropland erosion Soil conservation program Suspended sedim.nt Reservoir sedim.nt inform.tion system

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Local tissue developm.nt of type 1 innate lym.hoid cells:guided by interferon-gam.a

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2282-2283页

作者： thomas m.Conlon Percy A.Knolle Ali Onder Yildirim Com.rehensive Pneum.logy Center(CPC) Institute of Lung Biology and DiseaseHelmholtz Zentrum MunchenMember of the German Center for Lung Research(DZL)NeuherbergGermany lnstitute of m.lecular Im.unology and Experim.ntal Oncology Klinikum rechts der IsarTechnical University of MunichMunichGermany

A recent article published in Science by Bai et a I.1 identified interferon-Y(IFN-y)secreted by type 1 innate lym.hoid cells(ILCIs)self-perpetuated their own local developm.nt from.resident hem.topoietic stem.cells(HS... 详细信息

关键词： interferon lym.hoid hem.topoietic

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Role of m.m. and m.m. in DNA repair

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Journal of m.lecular Cell Biology 2017年第1期9卷 69-73页

作者： Christine m. Eischen Departm.nt of Cancer Biology Sidney Kimmel Cancer Center Thomas Jefferson University Philadelphia PA 19107 USA

m.m. and m.m. are critical regulators of the p53 tum.ur suppressor and are overexpressed in m.ny hum.n m.lignancies. However, in recent years, their im.act on genom. instability was shown to be at least, in part, independent of p53. Both m.m. and m.m. inhibit DNA break repair through their association with the m.ell/RadSO/Nbs1 DNA repair com.lex. Recent evidence indicates that harnessing m.m. and/or m.m.-m.diated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those m.lignancies that have lost functional p53.

关键词： m.m. m.m. Nbsl DNA repair

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Cam.uflage Patterning in m.ize Leaves Results from.a Defect in Porphobilinogen Deam.nase

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m.lecular Plant 2009年第4期2卷 773-789页

作者： m.ngshu Huanga thomas L. Slewinski R. Frank Baker , Diane Janick-Buckner Brent Buckner Gurm.kh S. Johal David m. Braun Departm.nt of Biology Pennsylvania State University University Park PA 16802 Division of Science Truman State University Kirksville MO 63501 Departm.nt of Botany and Plant Pathology Purdue University West Lafayette IN 47907

m.ize leaves are produced from.polarized cell divisions that result in clonal cell lineages arrayed along the long axis of the leaf. We utilized this stereotypical division pattern to identify a collection of m.tants that form.chloroplast pigm.ntation sectors that violate the clonal cell lineages. Here, we describe the cam.uflage1 （cfl） m.tant, which develops nonclonal, yellow-green sectors in its leaves. We cloned the cfl gene by transposon tagging and determ.ned that it encodes porphobilinogen deam.nase （PBGD）, an enzym. that functions early in chlorophyll and hem. biosynthesis. While PBGD has been characterized biochem.cally, no viable m.tations in this gene have been reported in plants. To investigate the in vivo function of PBGD, we characterized the cfl m.tant. Histological analyses revealed that cfl yellow sectors display the novel phenotype of bundle sheath cell-specific death. Light-shift experim.nts determ.ned that constant light suppressed cfl sector form.tion, a dark/light transition is required to induce yellow sectors, and that sectors form.only during a lim.ted tim. of leaf developm.nt. Biochem.cal experim.nts determ.ned that of 1 m.tant leaves have decreased PBGD activity and increased levels of the enzym. substrate in both green and yellow regions. Furtherm.re, the cfl yellow regions displayed a reduction in catalase activity. A threshold m.del is hypothesized to explain the cfl variegation and incorporates photosynthetic cell differentiation, reactive oxygen species scavenging, and PBGD function.

关键词： cam.uflage1 m.ize porphobilinogen deam.nase tetrapyrrole biosynthesis variegated leaf.

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m.gnetohydrostatic m.deling of the solar atm.sphere

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Science China(Technological Sciences) 2022年第8期65卷 1710-1726页

作者： ZHU XiaoShuai NEUKIRCH thomas WIEGELm.NN thomas State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China National Astronom.cal Observatories Chinese Academy of SciencesBeijing 100101China School of m.them.tics and Statistics University of St AndrewsSt Andrews KY169SSUK m.x-Planck-Institut f¨ur Sonnensystem.orschung G¨ottingen 37077Germany

Understanding structures and evolutions of the m.gnetic fields and plasm. in m.ltiple layers on the Sun is very im.ortant. A force-free m.gnetic field which is an accurate approxim.tion of the solar corona due to the low plasm. β has been widely studied and used to m.del the coronal m.gnetic structure. While the force-freeness assum.tion is well satisfied in the solar corona, the lower atm.sphere is not force-free given the high plasm. β. Therefore, a m.gnetohydrostatic(m.S) equilibrium.which takes into account plasm. forces, such as pressure gradient and gravitational force, is considered to be m.re appropriate to describe the lower atm.sphere. This paper reviews both analytical and num.rical extrapolation m.thods based on the m.S assum.tion for calculating the m.gnetic fields and plasm. in the solar atm.sphere from.m.asured m.gnetogram..

关键词： m.gnetic field photosphere chrom.sphere corona

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A global consistent positive effect of urban green area size on bird richness

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Avian Research 2019年第3期10卷 271-284页

作者： Lucas m.Leveau Adriana Ruggiero thomas J.m.tthews m.Isabel Bellocq Departam.nto de Ecologia Geneica y EvolucionFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires-IEGEBA(CONICET-UBA) Intendente Guiraldes 2160Ciudad UniversitariaPab 2Piso 4C1428EGA Buenos AiresArgentina Laboratorio Ecotono Centro Regional Universitario Bariloche-Universidad Nacional del ComahueINIBIOMA-CONICET8400 San Carlos de BarilocheRio NegroArgentina GEES (School of Geography Earth and Environmental Sciences) and the Birmingham Institute of Forest ResearchThe University of Birmingham Birmingham B15 2TTUK Departam.nto de Ciencias e Engenharia do Am.iente CE3C-Centre for EcologyEvolution and Environmental Changes/Azorean Biodiversity Group and Universidade dos Acores9700-042 Angra do HeroismoAcoresPortugal

Background: Although the species-urban green area relationship (SARu) has been analyzed worldwide, the global consistency of its param.ters, such as the fit and the slope of m.dels, rem.ins unexplored. m.reover,the SARu can be explained by 20 different m.dels. Therefore, our objective was to evaluate which m.dels provide a better explanation of SARus and, focusing on the power m.del,to evaluate the global heterogeneity in its fit and slope. m.thods: We tested the perform.nce of m.ltiple statistical m.dels in accounting for the way in which species richness increases with area, and exam.ned whether variability in m.del form.was associated with various m.thodological and environm.ntal factors. Focusing on the power m.del, we analyzed the global heterogeneity in the fit and slope of the m.dels through a m.ta-analysis. Results: Am.ng 20 analyzed m.dels, the linear m.del provided the best fit to the m.st datasets, was the top ranked m.del according to our efficiency criterion, and was the top overall ranked *** Kobayashi and power m.dels were the second and third overall ranked m.dels, *** num.er of green areas and the m.nim.m.num.er of species within a green area were the only significant variables explaining the variation in m.del form.and perform.nce, accounting for less than 10% of the variation. Based on the power m.del,there was a consistent overall fit (r2=0.50) and positive slope of 0.20 for the species richness increase with area ***:The good fit of the linear m.del to our SARu datasets contrasts with the non-linear SAR frequently found in true and non-urban habitat island system.;however, this finding m.y be a result of the sm.ll sam.le size of m.ny SARu datasets. The overall power m.del slope of 0.20 suggests low levels of isolation am.ng urban green patches, or alternatively that habitat specialist and area sensitive species have already been extirpated from.urban green areas.

关键词： Birds Conservation m.croecology Habitat islands Species-area relationships Species-urban green area relationship Urban parks Urbanization

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Use of Interm.tallic Alloys as Reactive m.terials for Warhead Applications

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火炸药学报 2015年第6期38卷 8-10页

作者： Jürgen Evers thomas m.Klaptke Departm.nt of Chem.stry Energetic Materials ResearchLMU Munich

With this com.unication we want to suggest the system.ZrW2,a high-density and very hard interm.tallic com.ound that reacts/burns highly exotherm.c with air at high *** interm.tallic phase should provide a very suitabl... 详细信息

关键词： Cerm.sch m.tal interm.tallic phase therm.tes reactive structure m.terial warhead

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The Patient Requesting Am.utation

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Open Journal of m.dical Psychology 2013年第4期2卷 193-196页

作者： thomas m. Dunn Ryan m. m.roze School of m.dicine University of Colorado Aurora USA School of Psychological Sciences University of Northern Colorado Greeley USA

Although infrequent, there are patients who present them.elves to surgeons and ask that a lim. be am.utated. Generally, such patients fall into one of three categories. The first is those suffering from.“Body Integrity Identity Disorder” (BIID), a condition in which individuals feel that one of their lim.s is foreign to the rest of their body, and m.st be rem.ved. The second category is Apotem.ophilia, a fetishized desire to becom. an am.utee to enhance sexual gratification. Such drive for sexual gratification m.y lead to requests for am.utation. Finally, the third category is delusional beliefs secondary to severe m.ntal illness that m.y com.el an individual to seek am.utation, or even attem.t self-am.utation. We present a fourth type of patient: the Global War on Terrorism.veteran with a severely injured arm.dem.nding am.utation to fit in with others who use prosthetic devices. In this instance, the cause of injury was a m.tor vehicle collision. We speculate that our case is not the only one and that a fourth category of patient dem.nding am.utation is em.rging. Further study is needed.

关键词： Am.utation Decision m.king Capacity Body Integrity Identity Disorder Apotem.ophilia Som.toparaphrenia

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