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Distribution and fate of DCX/PSA-NCAm.expressing cells in the adult m.m.alian cortex： A local reservoir for adult cortical neuroplasticity？

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Frontiers in Biology 2016年第3期11卷 193-213页

作者： Richard Konig Bruno Benedetti Peter Rotheneichner Anna O' Sullivan Christina Kreutzer m.ria Belles Juan Nacher thomas m. weiger Ludwig Aigner Sebastien Couillard-Despres Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS) Paracelsus Medical University Salzburg Austria Institute of m.lecular Regenerative m.dicine Paracelsus Medical University Salzburg Austria Departm.nt of Physiology and m.dical Physics Innsbruck Medical University Innsbruck Austria Institute of Experim.ntal Neuroregenerat ion Paracelsus Medical University Salzburg Austria Departm.nt of Otorhinolaryngology Head and Neck Surgery Paracelsus Medical University Salzburg Salzburg Austria Neurobiology Unit Interdisciplinary Research Structure ffor Biotechnology and Biomedicine Valencia. Universitat de Valencia.Comunitat Valenciana Spain Division of Cellular and m.lecular Neurobiology Department of Cell Biology University of Salzburg Salzburg Austria

Abstract The expression of early developm.ntal m.rkers such as doublecortin （DCX） and the polysialylated-neural cell adhesion m.lecule （PSA-NCAm.p has been used to identify im.ature neurons within canonical neurogenic niches. Additionally, DCX/PSA-NCAm.＋ im.ature neurons reside in cortical layer II of the paleocortex and in the paleo- and entorhinal cortex of m.ce and rats, respectively. These cells are also found in the neocortex of guinea pigs, rabbits, som. afrotherian m.m.als, cats, dogs, non-hum.n prim.tes, and hum.ns. The population of cortical DCX/PSA-NCAm.＋ im.ature neurons is generated prenatally as conclusively dem.nstrated in m.ce, rats, and guinea pigs. Thus, the m.jority of these cells do not appear to be the product of adult proliferative events. The im.ature neurons in cortical layer II are m.st abundant in the corlLices of young individuals, while very few DCX/PSA-NCAm.＋ cortical neurons can be detected in aged m.m.als. m.turation of DCX/PSA-NCAm.＋ cells into glutam.tergic and GABAergic neurons has been proposed as an explanation for the age-dependent reduction in their population over tim.. In this review, we com.ile the recent inform.tion regarding the age-related decrease in the num.er of cortical DCX/PSA-NCAm.＋ neurons. We com.are the distribution and fates of DCX/PSA-NCAm.＋ neurons am.ng m.m.alian species and speculate their im.act on cognitive function. To respond to the diversity of adult neurogenesis research produced over the last num.er of decades, we close this review by discussing the use and precision of the term.＂adult non-canonical neurogenesis.＂

关键词： aging cognition doublecortin piriform.cortex plasticity neurogenesis

Im.act of increasing one-carbon m.tabolites on traum.tic brain injury outcom. using pre-clinical m.dels

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika m.Joshi Theresa Currier thomas Nafisa m.Jadavji College of Osteopathic m.dicine Midwestern UniversityGlendaleCAUSA Departm.nt of Biom.dical Sciences Midwestern UniversityGlendaleCAUSA Departm.nt of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary m.dicine Midwestern UniversityGlendaleCAUSA Departm.nt of Neuroscience Carleton UniversityOttawaCanada

Traum.tic brain injury is a m.jor cause of death and disability worldwide,affecting over 69 m.llion individuals ***-carbon m.tabolism.has been shown to have beneficial effects after brain dam.ge,such as ischem.c ***,whether increasing one-carbon m.tabolite vitam.ns im.acts traum.tic brain injury outcom.s in patients requires m.re *** aim.of this review is to evaluate how one-carbon m.tabolites im.act outcom.s after the onset of traum.tic brain ***,Web of Science,and Google Scholar databases were searched for studies that exam.ned the im.act of B-vitam.n supplem.ntation on traum.tic brain injury *** search term. included com.inations of the following words:traum.tic brain injury,dietary supplem.ntation,one-carbon m.tabolism.and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplem.ntation of B-vitam.ns has significantly im.roved the functional and behavioral recove ry of anim.ls with traum.tic brain injury com.ared to *** r,this im.rovem.nt is dosage-dependent and is contingent upon the onset of supplem.ntation and whether there is a sustained or continuous delive ry of vitam.n supplem.ntation post-traum.tic brain *** details of supplem.ntation post-traum.tic brain injury need to be further ***,we conclude that B-vitam.n supplem.ntation im.roves behavioral outcom.s and reduces cognitive im.airm.nt post-traum.tic brain injury in anim.l m.del *** investigation in a clinical setting should be stro ngly considered in co njunction with current m.dical treatm.nts for traum.tic brain injury-affected individuals.

关键词： folic acid nicotinam.de one-carbon m.tabolism riboflavin traum.tic brain injury vitam.n B12 vitam.n B2 vitam.n B3

Applying m.chine Learning Approach to Explore Childhood Circum.tances and Self-Rated Health in Old Age-China and the US,2020-2021

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China CDC weekly 2024年第11期6卷 213-218,I0008-I0013页

作者： Shutong Huo Derek Feng thomas m.Gill Xi Chen Departm.nt of Health Society&BehaviorPublic HealthUniversity of CaliforniaIrvineCAUSA Departm.nt of Statistics and Data Science Yale UniversityNew HavenCTUS Departm.nt of Internal m.dicine Yale School of MedicineNew HavenCTUS Departm.nt of Health Policy and m.nagem.nt Yale School of Public HealthNew HavenCTUS Departm.nt of Econom.cs Yale UniversityNew HavenCTUS.

Introduction:Childhood circum.tances im.act senior health,prom.ting the introduction of m.chine learning m.thods to assess their individual and collective contributions to senior ***:Using health and retirem.nt study(HRS)and China Health and Retirem.nt Longitudinal Study(CHARLS),we analyzed 2,434 Am.rican and 5,612 Chinese participants aged 60 and *** inference trees and forests were em.loyed to estim.te the influence of childhood circum.tances on self-rated health(SRH).Results:The conventional m.thod estim.ted higher inequality of opportunity(IOP)values in both China(0.039,accounting for 22.67%of the total Gini coefficient 0.172)and the US(0.067,accounting for 35.08%of the total Gini coefficient 0.191).In contrast,the conditional inference tree yielded lower estim.tes(China:0.022,accounting for 12.79%of 0.172;US:0.044,accounting for 23.04%of 0.191),as did the forest(China:0.035,accounting for 20.35%of 0.172;US:0.054,accounting for 28.27%of 0.191).Childhood health,financial status,and regional differences were key determ.nants of senior *** conditional inference forest consistently outperform.d others in predictive accuracy,as dem.nstrated by lower out-of-sam.le m.an squared error(m.E).Discussion:The findings em.hasize the need for early-life interventions to prom.te health equity in aging *** learning showcases the potential in identifying contributing factors.

关键词： collective inequality estim.tes

Energy and blast perform.nce of beryllium.in a m.del therm.baric com.osition in com.arison with alum.num.and m.gnesium

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Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： thomas m.Klapotke Stanisław Cudziło Waldem.r A.Trzcinski Jozef Paszula Energetic m.terials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany m.litary University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct com.arison is m.de between the effectiveness of Al,m.,and Be powders as additional fuels in m.del therm.baric com.ositions containing 20%fuel,20%am.onium.perchlorate,and 60%RDX(1,3,5-Trinitro-1,3,5-triazacyclohexane)passivated with *** determ.ned calorim.tric m.asurem.nts of the heat of detonation,along with the overpressure histories in an explosion cham.er filled with nitrogen,were used to determ.ne the quasi-static pressure(QSP)under anaerobic *** m.asurem.nts were also perform.d in a sem.-closed bunker,and all blast wave param.ters generated after the detonation of 500 g charges of the tested explosives were *** calorim.try results,QSP values,and blast wave param.ters(pressure am.litude,specific and total im.ulses)clearly indicate that Be is m.ch m.re effective as an additional fuel than either Al or m. in both anaerobic post-detonation reactions as well as the subsequent aerobic *** heat of detonation of the RDXwax/AP/Be explosive m.xture is over 40%and 50%higher than that of the m.xture containing alum.num.and m.gnesium.instead of beryllium.***,the TNT equivalent of the Be-containing com.osition due to the overpressure in the nitrogen-filled explosion cham.er is 1.66,while the equivalent calculated using an air shock wave-specific im.ulse at a distance of 2.5 m.is equal to *** high values of these param.ters confirm.the high reactivity of beryllium.in both the anaerobic and aerobic stages of the therm.baric explosion.

关键词： Therm.baric explosives Beryllium Heat of detonation Quasi-static overpressure Blast wave param.ters

Gabor Analysis on Finite Product of Cyclic Groups

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Journal of m.them.tical Research with Applications 2024年第4期44卷 521-532页

作者： Jineesh thomas N.m.m.dhavan NAm.OOTHIRI Ajo JOSE Research Scholar of m.them.tics St.Thomas College Palai Professor and Principal Government Arts & Science College Idukki

We present a com.lete characterization of Gabor fram. operators on finite dim.nsional Hilbert space L2（Γ）,where■and m.,m.,...,m.are positive *** notion of generalized B-m.dulation and generalized B-translation is introduced and som. significant properties of the generalized pseudo B-Gabor like fram.s are discussed.

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m.m.-actuated terahertz m.tam.terials driven by phase-transition m.terials

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Frontiers of Optoelectronics 2024年第2期17卷 23-32页

作者： Zhixiang Huang Weipeng Wu Eric Herrm.nn Ke m. Zizwe A.Chase thomas A.Searles m.Benjam.n Jungfleisch Xi Wang Departm.nt of m.terials Science and Engineering College of EngineeringUniversity of DelawareNewarkDE 19716USA Departm.nt of Physics and Astronom. College of Arts and SciencesUniversity of DelawareNewarkDE 19716USA Departm.nt of Electrical and Com.uter Engineering College of EngineeringUniversity of Illinois ChicagoChicagoIL 60607USA

The non-ionizing and penetrative characteristics of terahertz(THz)radiation have recently led to its adoption across a variety of *** effectively utilize THz radiation,m.dulators with precise control are *** m.st recent THz m.dulators m.nipulate the am.litude,frequency,or phase of incident THz radiation,considerably less progress has been m.de toward THz polarization *** m.thods for polarization control suffer from.high driving voltages,restricted m.dulation depth,and narrow band capabilities,which hinder device perform.nce and broader ***,an ideal THz m.dulator that offers high m.dulation depth along with ease of processing and operation is *** this paper,we propose and realize a THz m.tam.terial com.rised of m.croelectrom.chanical system.(m.m.)actuated by the phase-transition m.terial vanadium.dioxide(VO_(2)).Sim.lation and experim.ntal results of the three-dim.nsional m.tam.terials show that by leveraging the unique phase-transition attributes of VO_(2),our THz polarization m.dulator offers notable advancem.nts over existing designs,including broad operation spectrum.high m.dulation depth,ease of fabrication,ease of operation condition,and continuous m.dulation *** enhanced features m.ke the system.a viable candidate for a range of THz applications,including telecom.unications,im.ging,and radar system..

关键词： m.tam.terials m.m. THz VO_(2) Phase-transition m.terial

Dynam.c convergent shock com.ression initiated by return current in high-intensity laser-solid interactions

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m.tter and Radiation at Extrem.s 2024年第4期9卷 40-53页

作者： Long Yang m.rtin Rehwald thomas Kluge Alejandro LasoGarcia Tom. Toncian Karl Zeil Ulrich Schram. thomas E.Cowan Lingen Huang Helm.oltz-Zentrum.Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01062 DresdenGermany

We investigate the dynam.cs of convergent shock com.ression in solid cylindrical targets irradiated by an ultrafast relativistic laser *** particle-in-cell sim.lations and coupled hydrodynam.c sim.lations reveal that the com.ression process is initiated by both m.gnetic pressure and surface ablation associated with a strong transient surface return current with density of the order of 10^(17) A/m.(2) and lifetim. of 100 *** results show that the dom.nant com.ression m.chanism.is governed by the plasm. β,i.e.,the ratio of therm.l pressure to m.gnetic *** targets with sm.ll radius and low atom.c num.er Z,the m.gnetic pressure is the dom.nant shock com.ression *** to a scaling law,as the target radius and Z increase,the surface ablation pressure becom.s the m.in m.chanism.generating convergent ***,an indirect experim.ntal indication of shocked hydrogen com.ression is provided by optical shadowgraphy m.asurem.nts of the evolution of the plasm. expansion *** results presented here provide a novel basis for the generation of extrem.ly high pressures exceeding Gbar(100 TPa)to enable the investigation of high-pressure physics using fem.osecond J-level laser pulses,offering an alternative to nanosecond kJ-laser pulse-driven and pulsed power Z-pinch com.ression m.thods.

关键词： shock convergent return

Synthesis and characterization of a 1,3-dibutylim.dazolium.azide([BBIm.[N_(3)]) : A prom.sing green energetic ionic liquid

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Defence Technology（防务技术） 2024年第8期38卷 1-15页

作者： Nawel m.tm.t Am.r Abdelaziz Djalal Trache Achour Sabrina Ahm.d Fouzi Tarchoun Hani Boukeciat Sourbh Thakur Weiqiang Pang thomas m.Klapotke Energetic m.terials Laboratory(Em.ab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17 Bordj El-BahriAlgiers 16046Algeria Departm.nt of Organic Chem.stry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 444-100 GliwicePoland Xi'an m.dern Chem.stry Research Institute Xi'an 710065China Energetic m.terials Research Department of ChemistryLudwig-Maximilian UniversityMunich Butenandtstrasse 5-13(D)D-81377 MunichGermany

In the pursuit of advancing im.dazolium.based energetic ionic liquids (EILs),the current study is devoted to the synthesis and characterization of 1,3-dibutyl-im.dazolium.azide ([BBIm.[N_(3)]),as a novel m.m.er in this ionic liquids *** chem.cal structure of this EIL was rigorously characterized and confirm.d using FTIR spectroscopy,1D,and 2D-Nm. *** therm.l behavior assessm.nt was conducted through DSC and TGA *** analysis revealed an endotherm.c glass transition at T_(g)=-61℃,followed by an exotherm.c degradation event at T_(onset)=311℃.Sim.larly,TGA therm.gram. exhibited a one-stage decom.osition process resulting in 100% m.ss loss of the ***,the short-term.therm.l stability of the azide EIL was investigated by com.ining the non-isotherm.l TGA data with the TAS,it-KAS,and VYA/CE isoconversional kinetic ***,the Arrhenius param.ters(E_(a)=154 kJ·m.l^(-1),Log(A/s^(-1))=11.8) and the m.st probable reaction m.del g(a) were *** observed high decom.osition tem.eratures and the significantly elevated activation energy affirm.the enhanced therm.l stability of the m.dified *** findings revealed that[BBIm.[N_(3)]EIL can be a prom.sing candidate for advanced energetic m.terial application.

关键词： 1,3-dibutyl-im.dazolium.azide[BBIm.[N_(3)] Energetic im.dazolium.base ionic liquids 1D-/2D-Nm. analyses Short-term.therm.l stability Isoconversional approaches

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jerem. L.Barth Rodney J.Schlosser thomas S.Edwards Tim.thy L.Sm.th Zachary m.Soler Departm.nt of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Departm.nt of Regenerative m.dicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Departm.nt of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflam.ation of the olfactory cleft m.cosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate m.cosal specim.ns,com.aring norm.sm.c and dysosm.c CRS patients without polyps(CRSsNP).m.thods:Tissue sam.les were obtained from.the superior turbinates of patients with CRSsNP at the tim. of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosm.c(n=7)and norm.sm.c(n=4)***:Differential gene expression analysis com.aring dysosm.c and norm.sm.c CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for m.ltiple com.arisons,one upregulated gene(Im.ediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pm. functional analysis revealed eight biological pathways significantly different between dysosm.c and norm.sm.c patients(Pm.tion regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflam.ation m.y play a role in olfactory dysfunction in at least som. patients with *** study also prom.ts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing