检索结果-南通市图书馆

Ultra-high Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice

Translational Neurodegeneration 2018年第1期7卷 187-200页

作者： Rodolfo G.Gatto Manish Y.Amin Daniel Deyoung Matthew hey thomas h.mareci Richard L.Magin Department of Anatomy and Cell Biology University of Illinois at Chicago808 S.Wood St.Rm 578 M/C 512ChicagoIL 60612USA Department of Physics University of FloridaGainesvilleFLUSA Department of Applied Physiology and Kinesiology University of FloridaGainesvilleFLUSA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFLUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Background:Amyotrophic lateral sclerosis(ALS)is a disease characterized by a progressive degeneration of motor neurons leading to *** previous MRI diffusion tensor imaging studies detected early white matter changes in the spinal cords of mice carrying the G93A-SOD1 ***,we extend those studies using ultra-high field MRI(17.6 T)and fluorescent microscopy to investigate the appearance of early structural and connectivity changes in the spinal cords of ALS ***:The spinal cords from presymptomatic and symptomatic mice(80 to 120 days of age)were scanned(ex-vivo)using diffusion-weighted *** fractional anisotropy(FA),axial(AD)and radial(RD)diffusivities were calculated for axial slices from the thoracic,cervical and lumbar regions of the spinal *** diffusion parameters were compared with fluorescence microscopy and membrane cellular markers from the same tissue ***:At early stages of the disease(day 80)in the lumbar region,we found,a 19% decrease in FA,a 9% decrease in AD and a 35% increase in *** changes were observed in cervical and thoracic spinal cord *** between control and ALS mice groups at the symptomatic stages(day 120)were *** fluorescence microscopy at 80 days,demonstrated a 22% reduction in axonal area and a 22% increase in axonal *** and quantitative connectome analyses measured by edge weights showed a 52%decrease in the lumbar regions of the spinal cords of this ALS mice group.A significant increase in ADC(23.3%)in the ALS mice group was related to an increase in aquaporin ***:These findings suggest that the combination of ultra-high field diffusion MRI with fluorescent ALS mice reporters is a useful approach to detect and characterize presymptomatic white matter micro-ultrastructural changes and axonal connectivity anomalies in ALS.

关键词： Amyotrophic Lateral Sclerosis Spinal Cord,Ultra-high Field MRI Diffusion Tensor Imaging Yellow Fluorescent Protein G93A-SOD1 mice Axonal Degeneration Tractography Connectomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra-high field MRI and diffusion tensor metrics

引用

Animal Models and Experimental Medicine 2020年第2期3卷 117-129页

作者： Rodolfo G.Gatto Carina Weissmann Manish Amin Ariel Finkielsztein Ronen Sumagin thomas h.mareci Osvaldo D.Uchitel Richard L.Magin Department of Bioengineering University of Illinois at ChicagoChicagoILUSA Instituto de Fisiología Biologia Molecular y Neurociencias-IFIBYNE-CONICET University of Buenos AiresBuenos AiresArgentina Department of Biochemistry National High Magnetic Field LaboratoryUniversity of FloridaGainesvilleFLUSA Department of Pathology School of MedicineNorthwestern UniversityChicagoILUSA

Objective: Cell structural changes are one of the main features observed during the development of amyotrophic lateral sclerosis(ALS). In this work, we propose the use of diffusion tensor imaging(DTI) metrics to assess specific ultrastructural changes in the central nervous system during the early neurodegenerative stages of ***: Ultra-high field MRI and DTI data at 17.6 T were obtained from fixed, excised mouse brains, and spinal cords from ALS(G93 A-SOD1) ***: Changes in fractional anisotropy(FA) and linear, planar, and spherical anisotropy ratios(C_L, C_P, and C_S, respectively) of the diffusion eigenvalues were measured in white matter(WM) and gray matter(GM) areas associated with early axonal degenerative processes(in both the brain and the spinal cord). Specifically, in WM structures(corpus callosum, corticospinal tract, and spinal cord funiculi) as the disease progressed, FA, C_L, and C_P values decreased, whereas C_S values increased. In GM structures(prefrontal cortex, hippocampus, and central spinal cord) FA and C_P decreased, whereas the C_L and C_S values were unchanged or slightly smaller. histological studies of a fluorescent mice model(YFP, G93 A-SOD1 mouse) corroborated the early alterations in neuronal morphology and axonal connectivity measured by ***: Changes in diffusion tensor shape were observed in this animal model at the early, nonsymptomatic stages of ALS. Further studies of C_L, C_P, and C_S as imaging biomarkers should be undertaken to refine this neuroimaging tool for future clinical use in the detection of the early stages of ALS.

关键词： amyotrophic lateral sclerosis animal models diffusion tensor imaging G93A-SOD1 mice ultra-high field MRI

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

引用

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neuroinflammation as a therapeutic target in huntington's disease

引用

Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glial response in the midcingulate cortex in huntington’s disease

引用

Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification and Characterization of Reduced Epicuticular Wax Mutants in Rice

引用

Rice science 2015年第4期22卷 171-179页

作者： thomas h.TAI United States Department of Agriculture-Agricultural Research Service Crops Pathology and Genetics Research UnitDepartment of Plant SciencesMail Stop 1University of California

Epicuticular wax forms the outermost protective barrier of the aerial surfaces of land plants, working in concert with other components of the plant cuticle to prevent uncontrolled loss of water and to provide protection against an array of external environmental stress. In this study, chemically- mutagenized populations of rice （Oryza sativa L.） derived from approximately 4 750 M2 families were screened for adhesion of water droplets resulting in a wet leaf/glossy （wig） phenotype. Mutants were identified in 11 independently-derived M2 families. Scanning electron microscopy analysis confirmed the association of the wig phenotype with changes in the epicuticular wax crystals of these plants. The phenotypes of five mutants （7-17A, 26.1, 524.2, 680.2, and 843.1） were confirmed to be the result of single recessive gene mutation. Evaluation of mutants from 3 （6-1A, 7-17A, and 11-39A） of 11 M2 families revealed significant reductions （〉 50%） in surface wax content and increases in cuticle membrane permeability.

关键词： chemical mutagenesis cuticle wax forward genetics membrane permeability rice scanning electron microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

引用

Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Iron-Catalysed C(sp^(2))-h Borylation with Expanded Functional Group Tolerance

引用

Chinese Journal of Chemistry 2022年第24期40卷 2875-2881页

作者： Luke Britton Jamie h.Docherty Gary S.Nichol Andrew P.Dominey Stephen P.thomas EaStChEM School of Chemistry University of EdinburghEdinburghEH93FJ United Kingdom GSK Medicines Research Centre StevenageSG12NY United Kingdom

Arene C(sp^(2))-h bond borylation offers direct and efficient access to aryl boronic *** in situ catalyst activation and photoirradiation,the iron-catalysed C(sp^(2))-h borylation reaction of carboarenes,pyrroles,and indoles has been developed using only bench-stable pre-catalysts and *** functional group tolerance was observed including those not reported using previous methods(ArNh_(2),ArOh,ArSiR_(3),ArP(O)(O)_(2),ArC(O)NR_(2)).Mechanistic studies revealed iron-catalysed reductive deoxygenation,C—F protodefluorination,and a demethylation of aryl methyl ethers by C—O sigma bond hydroboration.

关键词： Iron Earth-abundant C-h borylation Boron Photochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enamel biomimetics—fiction or future of dentistry?

引用

International Journal of Oral Science 2019年第1期11卷 1-9页

作者： Mirali Pandya thomas G.h.Diekwisch Center for Craniofacial Research and Diagnosis Texas A&M College of Dentistry

Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals configured into decussating enamel rods. In recent years, multiple approaches have been introduced to generate or regenerate this highly attractive biomaterial characterized by great mechanical strength paired with relative resilience and tissue compatibility. In the present review, we discuss five pathways toward enamel tissue engineering,(i) enamel synthesis using physico-chemical means,(ii) protein matrix-guided enamel crystal growth,(iii) enamel surface remineralization,(iv) cell-based enamel engineering, and(v) biological enamel regeneration based on de novo induction of tooth morphogenesis. So far, physical synthesis approaches using extreme environmental conditions such as ph, heat and pressure have resulted in the formation of enamel-like crystal *** methods relying on enamel proteins as templating matrices have aided the growth of elongated calcium phosphate crystals. To illustrate the validity of this biochemical approach we have successfully grown enamel-like apatite crystals organized into decussating enamel rods using an organic enamel protein matrix. Other studies reviewed here have employed amelogeninderived peptides or self-assembling dendrimers to re-mineralize mineral-depleted white lesions on tooth surfaces. So far, cell-based enamel tissue engineering has been hampered by the limitations of presently existing ameloblast cell lines. Going forward, these limitations may be overcome by new cell culture technologies. Finally, whole-tooth regeneration through reactivation of the signaling pathways triggered during natural enamel development represents a biological avenue toward faithful enamel regeneration. In the present review we have summarized the state of the art in enamel tissue engineering and provided novel insights into future opportunities to regenerate this arguably most fascinating of all dental tissues.

关键词： complex mineralized Biochemical methods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

引用

Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：