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广州市中老年人主动脉弓钙化的现患率及其相关特征

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中华流行病学杂志 2007年第2期28卷 173-176页

作者：江朝强林大庆郑家强殷鹏 thomas g.neil 劳向前张维森刘斌 Paymone Adab 李志斌广州市第十二人民医院 510620 香港大学公共卫生学院 Department of Public Health and Epidemiology University of Birmingham UK

目的研究广州市≥50岁居民主动脉弓钙化（AAC）现患率及其相关特征。方法收集10413名年龄在≥50岁居民的一般资料，体格检查和实验室检查结果；用东芝KSO-15R型X光机拍摄10305名受检者胸部后前位X线平片，由2名高级放射科医师一起进行X... 详细信息

目的研究广州市≥50岁居民主动脉弓钙化（AAC）现患率及其相关特征。方法收集10413名年龄在≥50岁居民的一般资料，体格检查和实验室检查结果；用东芝KSO-15R型X光机拍摄10305名受检者胸部后前位X线平片，由2名高级放射科医师一起进行X线胸片AAC诊断，同时作独立阅片一致性可靠检验（Kappa值）。结果（1）2名高级放射科医师独立阅片对AAC诊断符合率为85．0％，一致性可靠检验Kappa值为0．68（P〈0．001），显示其AAC诊断一致性是可靠的；（2）10305名（男3064，女7349）受检者平均年龄男（640±6．0）岁，女（66．2±5．8）岁，文化程度以中学或以下为主，从事工人和农民职业占一半以上；（3）AAC检出率：为40．6％，女性（41．4％）高于男性（38．6％）；（4）AAC随年龄增加而明显增加（P〈0．001），但与职业无明显相关；（5）AAC主要发生于弓部（98．7％），长度〉10mm（57．6％）、宽度1～4mm（74．0％）占多数，提示≥50岁者AAC程度较为严重。结论广州市≥50岁者AAC检出率为40．6％，明显高于国外相关报道，程度也较严重，其原因及机理正在进一步探讨。

关键词：主动脉弓钙化现患率影像学特征

Protective effects of trilinolein extracted from Panax notoginseng against cardiovascular disease

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Acta Pharmacologica Sinica 2002年第12期23卷 104-109页

作者： Paul CHAN,g.neil thomas,Brian TOMLINSON Division of Cardiovascular Medicine Taipei Medical College Affiliated Taipei Wan Fang Hospital Taipei China Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong SAR China Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong SAR China

Trilinolein is a triacylglycerol purified from a commonly used traditional Chinese medicine Panax notoginseng. Trilinolein has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. Additionally, trilinolein has been reported to be an antioxidant, which can counteract free radical damage associated with atherogenesis, and myocardial damage seen with is-chaemia and reperfusion. These pharmacologic effects may explain the perceived benefits derived from treating circulatory disorders with the herb over the centuries.

关键词： antioxidants cardiovascular system Chinese traditional medicine trilinolein Panax notoginseng

2型糖尿病患者大脑中动脉狭窄的危险因素分析

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中华神经科杂志 2004年第2期37卷 135-138页

作者：林健雯 g.neil thomas 黄如训方燕南黄家星香港中文大学威尔斯亲王医院内科及药物治疗学系中山大学附属第一医院神经科

目的　探讨 2型糖尿病患者大脑中动脉 (MCA)狭窄的危险因素。方法　对 2 2 0 2例 2型糖尿病患者用经颅多普勒 (TCD)筛选 ,MCA狭窄者为病例组 ,其余为对照组 ,行年龄、性别、糖尿病病程的频率配对后分析MCA狭窄的危险因素。结果　MCA狭... 详细信息

目的　探讨 2型糖尿病患者大脑中动脉 (MCA)狭窄的危险因素。方法　对 2 2 0 2例 2型糖尿病患者用经颅多普勒 (TCD)筛选 ,MCA狭窄者为病例组 ,其余为对照组 ,行年龄、性别、糖尿病病程的频率配对后分析MCA狭窄的危险因素。结果　MCA狭窄组与对照组在高血压 (76 8%与5 3 4 % )、抗高血压治疗 (5 1 5 %与 2 6 6 % )、收缩压 [14 7与 138mmHg(1mmHg =0 133kPa) ]、舒张压(81与 84mmHg)、血糖 (8 1与 8 7mmol/L)、白蛋白尿 (4 1 1%与 30 1% )、尿的白蛋白肌酐比 (ACR)(5 9与 3 5mg/mmol)、低密度脂蛋白 (LDL) (3 8与 3 6mmol/L)的分布差异存在显著意义。Logistic回归发现年龄、高血压、LDL 胆固醇是MCA狭窄的独立危险因素。结论　年龄增长、高血压、LDL 胆固醇高是MCA狭窄的危险因素。

关键词： 2型糖尿病大脑中动脉 MCA 危险因素非胰岛素依赖型脑动脉疾病

Comparison of Various Ion Exchange Resins for the Separation of Phenols in a Wood Pyrolysis-Based Biorefinery

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Journal of Renewable Materials 2024年第12期12卷 2135-2152页

作者： Kristine Meile Martins Romanovskis thomas Nicol neil Hindle Aivars Zhurinsh Latvian State Institute of Wood Chemistry RigaLV-1006Latvia University of Latvia RigaLV-1004Latvia Nova Pangaea Technologies Lealholme BuildingWilton InternationalWiltonRedcarTS104RGUK

Fast pyrolysis of pre-treated birch wood in a super-heated steam environment produces a condensate rich in *** the objective to obtain several product streams from this condensate,the possibility of extracting additional chemical species is explored,thus promoting the development of a pyrolysis-based *** this work,the extraction and recovery of pyrolytic phenols from birch wood pyrolysis condensate was studied using ion exchange *** an aim to achieve effective phenol recovery,while obtaining high purity levoglucosan,basic ion exchange resins,both in OH−and Cl−form,as well as polystyrene-divinyl resins without functional groups were *** study characterizes the influence of sorbent matrix type and porosity,functional group and counter ion on the sorption of various aromatic *** was concluded that the counter ion of the ion exchange resins had the most influence on the pyrolytic phenol adsorption,while in the case of unfunctionalized resins smaller pore size improved removal of phenols from the pyrolysis *** the resins tested,the most effective at the removal and recovery of pyrolytic phenols were strongly basic,macroporous,anion exchange resins in OH−*** possibility to reuse the sorbents and solvents is explored to make the over-all process more environmentally friendly and economically feasible.

关键词： Biorefinery birch wood fast pyrolysis levoglucosan ion exchange resins solid phase extraction

Numerical simulation on inclusion transport in continuous casting mold

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Journal of University of Science and Technology Beijing 2006年第4期13卷 293-300页

作者： Lifeng Zhang Brian g thomas Department of Materials Science ＆ Engineering Norwegian University of Science ＆ Technology （NTNU） Alfred Getz vei 2 N-7491 Trondheim Norway University of Illinois at Urbana-Champaign 1206 W. Green St. Urbana IL 61801 USA

Turbulent flow, the transpor＇t of inclusions and bubbles, and inclusion removal by fluid flow, transport and by bubble flotation in the strand of the continuous slab caster are investigated using computational models, and validated through comparison with plant measurements of inclusions. Steady 3-D flow of steel in the liquid pool in the mold and upper strand is simulated with a finitedifference computational model using the standard k-εturbulence rondel. Trajectories of inclusions and bubhles tire calculated by integrating each local velocity, considering its drag and buoyancy forces, A ＂random walk＂ model is used to incorporate the effect of turbulent fluctuations on the particle motion. The attachment probability of inclusions on a bubble surface is investigated based on fundamental fluid flow simulations, incorporating the turbulent inclusion trajectory and sliding time of each individual inclusion along the bubble surface as a function of particle and bubble size. The chunge in inclusion distribution due to removal by bubble transport in the mold is calculated based on the computed attachment probability of inclusions on each bubble and the computed path length of the bubbles. The results indicate that 6%-10% inclusions are removed by fluid flow transport. 10% by bubble flotation, and 4% by entrapment to the submerged entry nozzle （SEN） walls. Smaller bubbles and larger inclusions have larger attachment probabilities. Smaller bubbles are more efficient for inclusion removal by bubble flotation, so Inng as they are not entrapped in the solidifying shell A larger gas flow rate favors inclusion removal by bubble flotation. The optimum bubble size should be 2-4mm.

关键词： inclusion removal fluid flow transport bubble flotation continuous casting mold attachment probability

Robust artificial intelligence and robust human organizations

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Frontiers of Computer Science 2019年第1期13卷 1-3页

作者： thomas g.DIETTERICH Kelley Engineering Center Oregon State UniversityCorvallis OR 97331USA

The more powerful technology becomes,the more it magni- fies design errors and human *** angry man who has only his fists,cannot hurt very many *** the same man with a machine gun can kill hundreds in just a few *** technologies under the name of "artificial intelligence"(AI)are likely to provide many new opportunities to observe this "fault magnification"*** society contemplates deploying AI in self-driving cars,in surgical robots,in police activities,in managing critical infrastructure,and in weapon systems,it is creating situations in which errors committed by human users or errors in the software could have catastrophic consequences. Are these consequences inevitable?In the wake of the Three Mile Island nuclear power plant failure,Perrow [1] published his book "Normal Accidents"in which he argued that in any sufficiently complex system,with sufficiently many feedback loops,catastrophic accidents are "normal"-- that is,they can not be avoided.

关键词： Robust artificial organizations

Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy

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Asian Journal of Andrology 2012年第2期14卷 204-221页

作者： thomas W Storet Renee Miciek thomas g Travison Section of Endocrinology Diabetes and Nutrition Boston University School of Medicine Boston MA 02118 USA

Prostate cancer （PCa） is the most common visceral malignancy in men with androgen deprivation therapy （ADT） the preferred therapy to suppress testosterone production and hence tumor growth. Despite its effectiveness in lowering testosterone, ADT is associated with side effects including loss of muscle mass, diminished muscle strength, decrements in physical performance, earlier fatigue and declining quality of life. This review reports a survey of the literature with a focus on changes in muscle strength, physical function and body composition, due to short-term and long-term ADT. Studies in these areas are sparse, especially well-controlled, prospective randomized trials. Cross-sectional and longitudinal data （up to 2 years） for men with PCa treated with ADT as well as patients with PCa not receiving ADT and age-matched healthy men are presented when available. Based on limited longitudinal data, the adverse effects of ADT on muscle function, physical performance and body composition occur shortly after the onset of ADT and tend to persist and worsen over time. Exercise training is a safe and effective intervention for mitigating these changes and initial guidelines for exercise program design for men with PCa have been published by the American College of Sports Medicine. Disparities in study duration, types of studies and other patient-specific variables such as time since diagnosis, cancer stage and comorbidities may all affect an understanding of the influence of ADT on health, physical performance and mortality.

关键词： androgen deprivation therapy androgen suppression exercise prescription exercise training functional assessment lean body mass older men prostate cancer

Sediment bed destabilization by an isolated vortex:an experimental approach

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Journal of Hydrodynamics 2021年第2期33卷 370-385页

作者： Yann Devaux Lionel thomas Damien Calluaud gérard Pineau Institut Pprime CNRS-Universitéde Poitiers-ISAE-ENSMA-UPR 3346PoitiersFrance

The destabilization of an erodible sediment bed by a reproducible impulsive phenomenon is studied *** this,a specific setup is designed to produce a well-controlled isolated vortex,advected over a uniform sand *** image velocimetry(PIV)measurements are performed to get fluid flow information;suspended particles images are also recorded.A new measurement technique,based on a stereo-correlation method,provides a precise reconstruction of the bedform morphology over *** turbulent structures(namely sweep events)are evidenced in a near-wall region,where particles are mainly *** sediment plume follows the vortex:in particular,the upward velocity inside maintains the suspension ***,the dispersion process seems to be not dependent on the vortex ***,the bed morphology is investigated:a scour hole is dug as the vortex hits the granular *** dynamics is described by a typical scour law,even if the initial perturbation is *** area,where the particles settled,can be observed:it behaves like a ripple,with a logarithmic growth of its *** deposition region has a specific geometry,studied here by a Fourier contour ***,a pickup rate is also derived from the morphological data:it appears independent of the vortex and bedform features.

关键词： Sediment plume isolated vortex stereo-correlation particle image velocimetry(PIV) bedform dynamics

Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease

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World Journal of gastroenterology 2019年第28期25卷 3808-3822页

作者： Nadia Mazen Hijaz thomas Mario Attard Jennifer Marie Colombo neil Joseph Mardis Craig Alan Friesen Division of gastroenterology Hepatology and Nutrition University of Missouri Kansas City Children’s Mercy Hospital Kansas City

BACKgROUND Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn’s disease exacerbation compared to MRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices. AIM To prospectively compare the findings of MRE and WCE and their agreement with PCDAI or histology in children with CD or IC. METHODS Consecutive patients diagnosed with CD and IC were screened for inclusion. After informed consent, patient’s demographic and clinical data was abstracted. The current pediatric disease activity index (PCDAI) and endoscopic findings were included. Patients underwent MRE and WCE including preprocedural patency capsule within a maximum of 7 d of each other. Pathological presence of active small bowel disease in ileal and duodenal biopsies were collected if the endoscopy was performed within 2 mo of the WCE study. Patients who failed to pass the PC were excluded from the study. WCE was read by two different experienced gastroenterologists (Attard TM and Colombo JM) blinded to each other's findings and to the findings on MRE (Mardis NJ). Agreement between WCE reviewers, WCE and MRE findings and concordance between positive PCDAI and SBI based on MRE compared with WCE was computed. RESULTS Forty-five patients were included in the study, 18 withdrew and 27 (20 males and 20 CD), mean age (standard deviation) 13.46 (2.4) years, completed the study protocol. There were no instances of capsule retention. Concordance between gastroenterologist reviewers was excellent for the diagnosis of small intestinal CD with good

关键词： Crohn’s disease Wireless capsule endoscopy Inflammatory bowel disease Magnetic resonance enterography Small bowel involvement Small bowel disease Indeterminate colitis Pediatric Children