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The impact of iodinated X-ray contrast agents on formation and toxicity of disinfection by-products in drinking water

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Journal of Environmental Sciences 2017年第8期29卷 173-182页

作者： Clara H.Jeong Edward J.Machek Morteza Shakeri Stephen E.duirk thomas A.Ternes Susan d.Richardson Elizabeth d.Wagner Michael J.Plewa Molecular and Environmental Toxicology Center School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA department of Civil Engineering University of Akron Akron OH USA department of Water Chemistry Federal Institute of Hydrology Koblenz Germany department of Chemistry and Biochemistry University of South Carolina Columbia SC USA department of Crop Sciences and the Safe Global Water Institute University of Illinois at Urbana-Champaign Urbana IL USA

The presence of iodinated X-ray contrast media（ICM） in source waters is of high concern to public health because of their potential to generate highly toxic disinfection by-products（dBPs）. The objective of this study was to determine the impact of ICM in source waters and the type of disinfectant on the overall toxicity of dBP mixtures and to determine which ICM and reaction conditions give rise to toxic by-products. Source waters collected from Akron,OH were treated with five different ICMs, including iopamidol, iopromide, iohexol,diatrizoate and iomeprol, with or without chlorine or chloramine disinfection. The reaction product mixtures were concentrated with XAd resins and the mammalian cell cytotoxicity and genotoxicity of the reaction mixture concentrates was measured. Water containing iopamidol generated an enhanced level of mammalian cell cytotoxicity and genotoxicity after disinfection. While chlorine disinfection with iopamidol resulted in the highest cytotoxicity overall, the relative iopamidol-mediated increase in toxicity was greater when chloramine was used as the disinfectant compared with chlorine. Four other ICMs（iopromide, iohexol, diatrizoate, and iomeprol） expressed some cytotoxicity over the control without any disinfection, and induced higher cytotoxicity when chlorinated. Only iohexol enhanced genotoxicity compared to the chlorinated source water.

关键词： disinfection by-products Iodo-dBPs Iodinated X-ray contrast media

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Adsorption/desorption of Low-density Lipoprotein on a Heparinized Surface of Gold Sensors

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Chemical Research in Chinese Universities 2012年第2期28卷 323-328页

作者： LAN Ping JI Jing HUANG Xiao-Jun GUdURU deepak GROTH thomas VIENKEN Jorg d1NG Hui College of Materials and Textiles Jiaxing UniversityJiaxing 314001P.R.China Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027P.R.China Biomedical Materials Group Department of Pharmaceutics and BiopharmaeeuticsInstitute of PharmacyMartin Luther University Halle-WittenbergHalle(Saale)06120Germany Fresenius Medical Care of deutschland GmbH BioSciences DepartmentBad Homburg 61352Germany College of Mathematics Physics and Information Engineering Jiaxing UniversityJiaxing 314001P.R.China

Heparin has been considered to be a potentially useful ligand for low-density lipoprotein（LdL） detection and analysis in a clinical *** order to construct an affinity surface for preferential adsorption of LdL,heparin-modified gold surface（GS-Hep） was fabricated by a self-assembling method and hydrophobic-modified gold surfaces（GS-Hydro） was used as a *** morphologies of the modified gold surfaces were investigated by atomic force microscopy（AFM） and the quantity of heparin bound to gold surface was assayed by the toluidine blue（TB） colorimetric *** contact angles were determined to investigate wettability on GS-Hep and *** plasmon resonance（SPR） technique was used subsequently to detect the selective binding of LdL with *** the investigation on the effect of pH on LdL adsorption suggests that lower pH lead to higher quantities of LdL adsorption on *** with GS-Hydro,GS-Hep is selective for LdL from both single and binary protein ***,adsorbed LdL on GS-Hep could be washed off by injecting elution solution,such as NaCl solution,for the purpose of the regeneration of GS-Hep for further LdL adsorption.

关键词： Adsorption/desorption Low-density lipoprotein(LdL) Heparinized surface Surface plasmon resonance

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Thermal response of steel framing members in open car park fires

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Frontiers of Structural and Civil Engineering 2022年第9期16卷 1071-1088页

作者： Xia YAN Marion CHARLIER thomas GERNAY department of Civil and Systems Engineering Johns Hopkins UniversityBaltimoreMD 21218USA ArcelorMittal Steligence Esch-sur-Alzette 4221Luxembourg

For open car park structures,adopting a performance-based structural fire design is often justified and allowed because the fire does not reach ***,this design approach requires an accurate assessment of temperatures in structural members exposed to car *** paper describes a numerical study on the thermal exposure on steel framing members in open car park *** temperatures are computed by the coupling of computational fluid dynamics and finite element modeling,and by analytical models from the *** addition,the influence of galvanization on the steel temperature evolution is *** show that temperatures in unprotected beams and columns are influenced by the section geometry,car fire scenario,modeling approach,and use of *** slightly delays and reduces peak *** the different models,CFd-FEM(CFd:computational fluid dynamics,FEM:finite-element method)coupled models predict lower temperatures than the Hasemi model,because the latter conservatively assumes that the fire flame continuously touches the ***,the Hasemi model cannot account for the effect of reduced emissivity from galvanization on the absorbed heat *** temperature distributions obtained in the steel members can be used to complete efficient structural fire designs based on the member sections,structure layout,and use of galvanization.

关键词： open car park localized fire steel frame numerical modeling computational fluid dynamics

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Clinical and Bacteriological Profile of Infections in Sickle Cell Children in Two Referral Hospitals in Niamey, Niger

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Open Journal of Pediatrics 2024年第1期14卷 36-42页

作者： Kamaye Moumouni Samaila Aboubacar Garba Moumouni Georges thomas Ibrahim Mamoudou Abdou djafar Mamane Halima Hamadou Ibrahim Hamani Issaka djibrilla Almoustapha Amadou Yacouba Abdourahamane Marou Soumana Boubacar Moussa Saley Sahada Bade Malam Abdou Soumana Alido Service de Pédiatrie A H&#244pital National de Niamey Niamey Niger Faculté des Sciences de la Santé Université Abdou Moumouni de Niamey Niamey Niger Service de Pédiatrie H&#244pital national Amirou Boubacar Diallo Niamey Niger Service d’Onco-Hématologie H&#244pital national de Niamey Niamey Niger Service de Biologie Médicale H&#244pital national Amirou Boubacar Diallo Niamey Niger

Introduction: Infections are significant causes of mortality in sickle cell children in resource-limited countries. This study aimed to determine the clinical profile and bacterial ecology of infections in children with sickle-cell disease in two referral hospitals in Niamey. Patients and methods: A retrospective descriptive study was conducted from January 2018 to July 2020 in two referral hospitals in Niamey. All children aged one (1) to 15 years with sickle cell disease admitted for suspected infection, including at least one bacterial culture, were studied. Bacteriological analysis was performed using the appropriate culture media, using BactAlert (Reference 4700003 BTA3d60 BioMérieux). Results: Over 36-months, 350 children with a mean age of 10.9 months were admitted. The sex ratio was 1.2. The SS electrophoretic profile was the most common (93.4%). Immunization status was up to date in 66% of patients. Fever was the common reason for consultation (55.1%). Infection was confirmed in 62 patients (17.7%). The primary diagnoses were bacterial gastroenteritis (24.2%) and urinary tract infection (19.4%). Blood cultures were isolated from Salmonella typhi (13.0%) and Escherichia coli (8.7%). Klebsiella spp (7.1%) and Escherichia coli (5.0%) were detected in cytobacteriological examination of urine. Salmonella typhi (23.5%) and Escherichia coli (5.9%) were isolated on coproculture. Conclusion: Bacterial ecology appears not different from that usually observed in sickle-cell children. Salmonella and Escherichia coli were predominant.

关键词： Sickle Cell disease Child Infection Niger

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Acousto-optically driven lensless single-shot ultrafast optical imaging

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Light(Science & Applications) 2022年第4期11卷 628-643页

作者： Mohamed Touil Said Idlahcen Rezki Becheker denis Lebrun Claude Roze Ammar Hideur thomas Godin ORIA CNRS UMR6614-University de Rouen Normandie-INSA Rouen76800 Saint Etienne du RouvrayFrance

driven by many applications in a wide span of scientifc fields,a myriad of advanced ultrafast imaging techniques have emerged in the last decade,featuring record-high imaging speeds above a trllion-frame-per-second with long sequence *** bringing remarkable insights into various ultrafast phenomena,their application out of a laboratory environment is however limited in most cases,either by the cost,complexity of the operation or by heavy data *** then report a versatile single-shot imaging technique combining sequentially timed lloptical mapping photography(STAMP)with acousto-optics programmable dispersive fhItering(AOPdF)and digital in-line holography(dIH).On the one hand,a high degree of simplicity is reached through the AOPdF,which enables full control over the acquisition parameters via an electrically driven phase and amplitude spectro-temporal tailoring of the imaging ***,contrary to most single-shot techniques,the frame rate,exposure time,and frame intensities can be independently adjusted in a wide range of pulse durations and chirp values without resorting to complex shaping stages,making the system remarkably agile and *** the other hand,the use of dIH,which does not require any reference beam,allows to achieve an even higher technical simplicity by allowing its lensless operation but also for reconstructing the object on a wide depth of field,contrary to classical techniques that only provide images in a single *** imaging speed of the system as well as its flexibility are demonstrated by visualizing ultrashort events on both the picosecond and nanosecond *** virtues and limitations as welll as the potential improvements of this on-demand ultrafast imaging method are critically discussed.

关键词： simplicity resort bringing

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Identification and Characterization of Reduced Epicuticular Wax Mutants in Rice

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Rice science 2015年第4期22卷 171-179页

作者： thomas H.TAI United States department of Agriculture-Agricultural Research Service Crops Pathology and Genetics Research UnitDepartment of Plant SciencesMail Stop 1University of California

Epicuticular wax forms the outermost protective barrier of the aerial surfaces of land plants, working in concert with other components of the plant cuticle to prevent uncontrolled loss of water and to provide protection against an array of external environmental stress. In this study, chemically- mutagenized populations of rice （Oryza sativa L.） derived from approximately 4 750 M2 families were screened for adhesion of water droplets resulting in a wet leaf/glossy （wig） phenotype. Mutants were identified in 11 independently-derived M2 families. Scanning electron microscopy analysis confirmed the association of the wig phenotype with changes in the epicuticular wax crystals of these plants. The phenotypes of five mutants （7-17A, 26.1, 524.2, 680.2, and 843.1） were confirmed to be the result of single recessive gene mutation. Evaluation of mutants from 3 （6-1A, 7-17A, and 11-39A） of 11 M2 families revealed significant reductions （〉 50%） in surface wax content and increases in cuticle membrane permeability.

关键词： chemical mutagenesis cuticle wax forward genetics membrane permeability rice scanning electron microscopy

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Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis

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World Journal of Gastroenterology 2019年第41期25卷 6238-6247页

作者： Colin Markus Kruger Ulrich Adam thomas Adam Axel Kramer Claus d Heidecke Frank Makowiec Hartwig Riediger department of Surgery Immanuel Hospital RüdersdorfBerlin 15562Germany department of General Surgery Vivantes-Humboldt hospitalBerlin 13503Germany department of Microbiology Labor Berlin GmbHBerlin 13353Germany Institute of Hygiene and Environmental Medicine University Medicine GreifswaldGreifswald 17495Mecklenburg VorpommernGermany department of Surgery Clinic of GeneralVisceralVascular and Thoracic SurgeryUniversity Medicine GreifswaldGreifswald 17475Mecklenburg VorpommernGermany Section of clinical risk assessment University hospital of FreiburgFreiburg 79106Baden-WürttembergGermany

BACKGROUNd Jaundice or preoperative cholestasis(PC)are typical symptoms of pancreatic *** 50%of patients undergo preoperative biliary drainage(PBd)*** is a common cause of bacterobilia(BB)and is a known surgical site infection risk *** adjustment of preoperative antibiotic prophylaxis(PAP)may be reasonable according to the profile of *** this,we examined the microbiological findings in routine series of *** To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head *** In the period from January 2009 to december 2015,285 consecutive pancreatic head resections were *** for surgery were malignancy(71%),chronic pancreatitis(18%),and others(11%).A PBd was in 51%and PC was in 42%.The standard PAP was ampicillin/***,a smear was taken from the hepatic *** analysis of the isolated species and resistograms was *** were categorized according to the presence or absence of PC(PC+/PC-)and PBd(PBd+/PBd-)into four *** efficiency was analyzed for standard PAP and possible *** BB was present in 150 patients(53%).BB was significantly more frequent in PBd+(n=120)than in PBd-(n=30),Pd without PC:(PBd-/PC-:18%,PBd-/PC+:30%,PBd+/PC-:88%,PBd+/PC+:80%).BB was more frequent in malignancy(56%)than in chronic pancreatitis(45%).PBd,however,was the only independent risk factor in multivariate *** total,357 pathogens(342 bacteria and 15 fungi)were *** five most common groups(n=256,74.8%)were Enterococcus spp.(28.4%),Streptococcus spp.(16.9%),Klebsiella spp.(12.6%),Escherichia coli(10.5%),and Enterobacter spp.(6.4%).A polymicrobial BB(PBd+:77% vs PBd-:40%,Pd a more frequent detection of Enterococcus(Pd with PBd+.In PBd+,the efficiency of imipenem and piperacillin/tazobactam was significantl

关键词： Pancreatic surgery Bacteriobilia Antibiotic prophylaxis Cholestasis Cholangiopancreatography Endoscopic retrograde

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Non-leaving-face property for marked surfaces

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Frontiers of Mathematics in China 2019年第3期14卷 521-534页

作者： thomas BRUSTLE Jie ZHANG departement de Mathematiques Universite de Sherbrooke Sherbrooke J1K 2R1 Canada School of Mathematics and Statistics Beijing Institute of Technology Beijing 100081 China

Abstract We consider the polytope arising from a marked surface by flips of triangulations. d. d. Sleator, R. E. Tarjan, and W. P. Thurston [J. Amer. Math. Soc., 1988, 1(3): 647 681] studied the diameter of the associahedron, which is the polytope arising from a marked disc by flips of triangulations. They showed that every shortest path between two vertices in a face does not leave that face. We give a new method, which is different from the one used by V. disarlo and H. Parlier [arXiv: 1411.4285] to establish the same non-leaving-face property for all unpunctured marked surfaces.

关键词： Marked surface non-leaving-face property exchange graph

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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'donnell Anthony O'Connor Sinead Smith deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUNd Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HdAdT)can be considered,subject to evidence for local *** this study we assess efficacy of HdAdT therapy for *** eradication in an Irish *** To assess the efficacy of HdAdT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HdAdT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HdAdT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HdAdT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic dopamine d2 (-dRd2/ANKK (Taq1A)), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANdAS/CANS: Positive Clinical Outcome with Precision-Guided dNA Testing and Pro-dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman david Han Colin Hanna david Baron Ashim Gupta Shan Kazmi Jag Khalsa debasis Bagchi thomas McLaughlin Rajendra d. Badgaiyan Edward J. Modestino drew Edwards Catherine A. dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA division of Personalized Interventions Peak Logic Del Mar CA USA division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA department of Psychiatry Harvard School of Medicine Cambridge MA USA department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA department of Family Medicine Jefferson Health Northeast Philadelphia PA USA departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANdAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward deficiency Syndrome (RdS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANdAS, especially those with known dNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine d2 (-dRd2/ANKK (Taq1A), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research Id-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided dNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANdAS CANS Genetic Addiction Risk Testing (GARS) Pro-dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

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