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ccS chemistry 2021年第7期3卷 1921-1928页

作者： Qunchao Zhao Patrick G.Isenegger thomas c.wilson Jeroen BISap Florian Guibbal Long Lu Véronique Gouverneur Qilong Shen Key Laboratory of Organofluorine chemistry center for Excellence in Molecular Synthesis Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032 chemistry Research Laboratory University of OxfordOxford OX13TA Shanghai Institute of Organic chemistry Chinese Academy of SciencesShanghai 200032

Herein,we report a mild and practical protocol for the copper-catalyzed chlorofluoromethylthiolation of(hetero)aryl boronic acids with the novel reagent *** resulting products are amenable to halogen-exchange^(18)F-fluorination with cyclotronproduced[^(18)F]fluoride affording[^(18)F]*** process highlights the combined value of reagent development and(hetero)aryl boron precursors for radiochemistry by adding the[^(18)F]ScF2H group to the list of^(18)F-motifs within reach for positron emission tomography studies.

关键词： chlorofluoromethylthiolation boron reagent PET fluorine radiolabeling

α-cumyl bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]arylScF3

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α-Cumyl bromodifluoromethanesulfenate: Application to the R...

Thrombolysis for ischaemic stroke despite direct oral anticoagulation

中国化学会第十五届全国氟化学会议

作者： Qunchao Zhao Jiang Wu thomas c.wilson Stefan Verhoog Long Lu Véronique Gouverneur Qilong Shen Key Laboratory of Organofluorine chemistry Shanghai Institute of Organic Chemistry University of Oxford OxfordChemistry Research Laboratory Shanghai Institute of Organic chemistry Chinese Academy of Sciences

Positron Emission Tomography(PET) is a leading noninvasive imaging modality enabling the study of physiological processes in vivo. The trifluoromethylthiol group(-ScF) has gained much attention in the context of medicinal chemistry due to its beneficial effects on pharmacokinetic and physicochemical properties including metabolic stability and lipophilicity.

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Stroke & Vascular Neurology 2024年第5期9卷 464-466页

作者： Jan c.Purrucker thomas R.Meine Duncan wilson Ying Xian Teddy Y.Wu David J.Seiffge Department of Neurology Heidelberg University HospitalHeidelbergGermany Department of Neurology and Stroke Research center Bern Inselspital BernUniversity of BernBernSwitzerland New Zealand Brain Research Institute ChristchurchNew Zealand The University of Texas Southwestern Medical center DallasTexasUSA Department of Neurology Christchurch HospitalChristchurchNew Zealand

Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants(DOAcs)and a recent intake within the last 48hours in US and European ***,three observational studies now suggest safety of thrombolysis in patients with recent intake of DOAcs,and thus support previous experimental *** this perspective,the current evidence and practical consequences are discussed.

关键词： intake patients consequences

Post-processing of biochars to enhance plant growth responses:a review and meta-analysis

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Biochar 2021年第4期3卷 437-455页

作者： Sean c.thomas Institute of Forestry and conservation University of Toronto33 Willcocks St.TorontoON M5S 3B3Canada

A number of processes for post-production treatment of“raw”biochars,including leaching,aeration,grinding or sieving to reduce particle size,and chemical or steam activation,have been suggested as means to enhance biochar effectiveness in agriculture,forestry,and environmental ***,I review studies on post-production processing methods and their effects on biochar physio-chemical properties and present a meta-analysis of plant growth and yield responses to post-processed vs.“raw”*** from 23 studies provide a total of 112 comparisons of responses to processed *** biochars,and 103 comparisons allowing assessment of effects relative to biochar particle size;additional 8 published studies involving 32 comparisons provide data on effects of biochar ***,post-processed biochars resulted in significantly increased average plant growth responses 14%above those observed with unprocessed *** overall effect was driven by plant growth responses to reduced biochar particle size,and heating/aeration *** assessment of biochar effects by particle size indicates a peak at a particle size of 0.5-1.0 *** leachate treatments showed very high heterogeneity among studies and no average growth benefit.I conclude that physiochemical post-processing of biochar offers substantial additional agronomic benefits compared to the use of unprocessed *** research on post-production treatments effects will be important for biochar utilization to maximize benefits to carbon sequestration and system productivity in agriculture,forestry,and environmental restoration.

关键词： Activation Granulation Leachates Particle size Pelletization Post-processing

Modern imaging techniques for preoperative detection of distant metastases in gastric cancer

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World Journal of Gastroenterology 2015年第37期21卷 10502-10509页

作者： Robert M Kwee thomas c Kwee Department of Radiology Maastricht University Medical Center Department of Radiology University Medical Center Utrecht

A substantial portion of patients with newly diagnosed gastric cancer has distant metastases(M1 disease).These patients have a very poor prognosis and it is generally accepted that they should be treated with noncurative intent. Because it dramatically changes prognosis and treatment plans, it is very important to diagnose distant metastases. In this article, the definition, pathways, incidence and sites of distant metastases in gastric cancer are ***, the current performance of imaging in detecting distant metastases in newly diagnosed gastric cancer is outlined and future prospects are discussed.

关键词： Gastric cancer Ultrasonography Distant metastases

Successful aspiration and ethanol sclerosis of a large,symptomatic, simple liver cyst:case presentation and review of the literature

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World Journal of Gastroenterology 2006年第18期12卷 2949-2954页

作者： Wojciech c Blonski Mical S campbell thomas Faust David c Metz Division of Gastroenterology University of PennsylvaniaPhiladelphiaPAUnited States and Department of Gastroenterology and HepatologyWroclaw Medical UniversityPoland Division of Gastroenterology University of PennsylvaniaPhiladelphiaPAUnited States

Simple liver cysts are congenital with a prevalence of 2.5%-4.25%. Imaging, whether by US, cT or MRI, is accurate in distinguishing simple cysts from other etiologies, including parasitic, neoplastic, duct-related, and traumatic cysts. Symptomatic simple liver cysts are rare, and the true frequency of symptoms is not known. Symptomatic simple liver cysts are predominantly large （〉 4 cm）, right-sided, and more common in women and older patients. The vast majority of simple hepatic cysts require no treatment or follow-up, though large cysts （〉 4 cm） may be followed initially with serial imaging to ensure stability. Attribution of symptoms to a large simple cyst should be undertaken with caution, after alternative diagnoses have been excluded. Aspiration may be performed to test whether symptoms are due to the cyst; however, cyst recurrence should be expected. Limited experience with both laparoscopic deroofing and aspiration, followed by instillation of a sclerosing agent has demonstrated promising results for the treatment of symptomatic cysts. Here, we describe a patient with a large, symptomatic, simple liver cyst who experienced complete resolution of symptoms following cyst drainage and alcohol ablation, and we present a comprehensive review of the literature.

关键词： Simple hepatic cyst Alcohol sclerosis Laparoscopic deroofing

Pyogenic liver abscess:An audit of 10 years’experience

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World Journal of Gastroenterology 2011年第12期17卷 1622-1630页

作者： Tony cY Pang thomas Fung Jaswinder Samra thomas J Hugh Ross c Smith Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt Leonards NSW 2065Australia

AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous ***:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were *** and hydatid abscesses were ***,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were ***:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) *** 59%of patients were febrile at presentation;however,the serum c-reactive protein was elevated in all 47 in whom it was *** function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) *** organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial *** initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their *** hypoalbuminaemia[mean (95%cI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate ***:PLA is a diagnostic challenge,because the presentation of this condition is *** antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage.

关键词： Pyogenic liver abscess Image guided drainage Surgical drainage c-reactive protein Hypoalbuminaemia

Third degree atrioventricular block associated with treatment with rivastigmine transdermal patch

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Journal of Geriatric cardiology 2013年第1期10卷 113-115页

作者： Fredrikke c. Knudtzen thomas B. christophersen Department of Internal Medicine OUH Svendborg Hospital Valdemarsgade 53 5700 Svendborg Denmark

Rivastigmine transdermal patch is indicated for patientswithAlzheimer’s disease and dementia with Parkinson’s disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. This report presents two cases of patients presenting with 3rd degree atrioventricular block. Both patients were treated with the acetylcholinesterase inhibitor, rivastigmine. In one case, the patient reverted to normal sinus rhythm following the discontinuation of rivastigmine, and the atrioventricular block reappeared after rivastigmine was reinstated. In the other case, the atrioventricular block did not revert and the patient required a permanent pacemaker. Both bradycardia and syncope have previously been reported as adverse events in patients treated with acetylcholinesterase inhibitors. However, the type of bradycardia and the etiology of the syncope are rarely specified. Rivastigmine, and other acetylcholinesterase inhibitors, are widely used in the pharmacological treatment of Alzheimer��s disease. We recommend that physicians are vigilant of possible warning signs, such as dizziness, syncope and bradycardia.

关键词： Acetylcholinesterase inhibitors Alzheimer's disease Atrioventricular block Rivastigmine

Hepatocellular carcinoma,human immunodeficiency virus and viral hepatitis in the HAART era

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World Journal of Gastroenterology 2008年第11期14卷 1657-1663页

作者： Douglas c Macdonald Mark Nelson Mark Bower thomas Powles chelsea and Westminster hospital LondonUnited Kingdom St Bartholomew’s Hospital LondonUnited Kingdom

The incidence of hepatocellular carcinoma(Hcc)in patients with human immunodeficiency virus(HIV) is *** in HIV almost invariably occurs in the context of hepatitis c virus(HcV)or hepatitis B virus (HBV)co-infection and,on account of shared modes of transmission,this occurs in more than 33% and 10% of patients with HIV worldwide *** has yet to be clearly established whether HIV directly accelerates Hcc pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy(HAART)era,wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to *** this question will have implications for Hcc surveillance and the timing of HcV/HBV therapy,which in HIV co-infection presents unique *** Hcc develops,there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies,including liver transplantation.

关键词： Hepatocellular carcinoma Human immunodeficiency virus hepatitis Hepatitis B virus Hepatitis c virus co-infection Incidence Transplant Pathogenesis

comparing crystal structures with symmetry and geometry

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npj computational Materials 2021年第1期7卷 1491-1501页

作者： John c.thomas Anirudh Raju Natarajan Anton Van der Ven Materials Department University of CaliforniaSanta BarbaraCAUSA

Measuring the similarity between two arbitrary crystal structures is a common challenge in crystallography and materials *** there are an infinite number of ways to mathematically relate two crystal structures,only a few are physically *** we introduce both a geometry-based and a symmetry-adapted similarity metric to compare crystal *** crystal symmetry and combinatorial optimization we describe an algorithm to arrive at the structural relationship that minimizes these similarity metrics across all possible maps between any pair of crystal *** approach makes it possible to(i)identify pairs of crystal structures that are identical,(ii)quantitatively measure the similarity between crystal structures,and(iii)find and rank structural transformation pathways between any pair of crystal *** discuss the advantages of using the symmetryadapted cost metric over the geometric ***,we show that all known structural transformation pathways between common crystal structures are recovered with the mapping *** methodology presented in this study will be of value to efforts that seek to catalogue crystal structures,identify structural transformation pathways or prune large first-principles datasets used to parameterize on-lattice Hamiltonians.

关键词： crystal symmetry similarity