检索结果-南通市图书馆

Metastasis to Paranasal sinuses as the First Presenting sign of Renal Cell Carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2012年第1期2卷 28-31页

作者： Gustavo Ruschi Bechara José Anacleto Dutra Resende Júnior Hélio Assuncao Gouveia thom.s Accioly de souza Department of Urology Hospital Federal da Lagoa Rio de Janeiro Brazil

The clear cell carcinoma is a relatively rare tumor, represented approximately 85% by renal cell carcinoma (RCC), but has a characteristic of early metastatic, which sometimes spread to unusual places. Metastatic tumors in the paranasal sinuses are very rare. This case report a 65 years-old patient who presented sinusitis and epitaxis as a first sign of renal cell carcinoma with metastasis to the right maxillary sinus, which was opereted at Lagoa Hospital—RJ and strengthen the inclusion of this disease in the differential diagnosis of sinus disease. The renal cell carcinoma is a relatively rare tumor, representing approximately 3% of malignant tumors. About a third of patients with renal cell carcinoma have metastasis at diagnosis. The sinuses are a rare location of metastasis. The maxillary sinuses and the paranasal sinuses are most commonly affected by metastatic tumors to the sinuses region. The most frequent primary tumor to metastasis to paranasal sinuses is the renal cell carcinoma. This report highlights the rarity of the case and the importance in the differential diagnosis of sinus disease.

关键词： Renal Cell Carcinoma Metastasis sinuses Epistaxis

An updated isoerodent map of the conterminous United states

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International soil and Water Conservation Research 2022年第1期10卷 1-16页

作者： Ryan P.McGehee Dennis C.Flanagan Puneet srivastava bernard A.Engel Chi-Hua Huang Mark A.Nearing Purdue University Agricultural and Biological Engineering225 South University StreetWest LafayetteIN47907USA United states Department of Agriculture-Agricultural Research service National Soil Erosion Research Laboratory275 S Russell StWest LafayetteIN47907USA University of Maryland Agricultural Experiment StationSymons Hall7998 Regents DriveCollege ParkMD20742-3131USA Purdue University Agricultural Administration Building615 West State StreetWest LafayetteIN47907-2053USAUnited States Department of Agriculture-Agricultural Research ServiceNational Soil Erosion Research Laboratory275 S Russell StWest LafayetteIN47907USA United states Department of Agriculture-Agricultural Research service Southwest Watershed Research Center2000 E Allen RdTucsonAZ85719USA

Maps of erosivity,which are also commonly referred to as isoerodent maps,have played a critical role in soil conservation efforts in the United states and around the *** available erosivity maps for the United states are either outdated,conflict with erosivity benchmarking studies,or utilized less advanced spatial mapping ***,it is possible that the same underlying issues with Us maps are impacting global maps as *** this study,we used more than 340015-min,fixed-interval precipitation gauges to update the isoerodent map of the conterminous United *** values were interpolated using universal kriging under several spatial model configurations and *** optimal spatial model was selected based on which result had the lowest sample variogram ***,erosivity,and erosivity density maps were compared to existing *** average annual and annual erosivity results were compared to high-quality erosivity benchmarking *** values from both RUsLE2 and Panagos et al.(2017)were generally lower in the eastern United states and mixed in the western United states compared to our *** effects resulted in much greater erosivity differences in this study as compared to prior *** comparisons revealed that erosivity maps from this study and others were lower than the benchmark by 14%or more(up to 38%).These findings suggest current practices of storm omission and intensity dampening correction need to be revisited,especially in locations with relatively low-to-moderate rainfall erosivity such as the Midwest or Northeast United states,for example.

关键词： Erosion index Erosivity United states UsLE RUsLE2 soil loss

The influence of land use change on the spatial–temporal variability of habitat quality between 1990 and 2010 in Northeast China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2019年第6期30卷 2227-2236页

作者： Limin Dai shanlin Li bernard J.Lewis Jian Wu Dapao Yu Wangming Zhou Li Zhou shengnan Wu Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of sciences Beijing 100049People’s Republic of China

Land use changes are a direct consequence of interactions between humans and *** the spatial and temporal changes in habitat quality brought about by land use change can provide a scientific basis for ecological protection and land *** on the analysis of land use change from 1990 to 2010 in Northeast China,we used the InVEsT(integrated valuation of ecosystem services and trade-offs)module to evaluate habitat quality based on watershed *** results show that:(1)the main land use changes from 1990 to 2010 were the transition from grasslands and forest lands to agricultural lands,which led to a decrease in connectivity of landscape and an increase in fragmentation;(2)areas of high habitat quality were distributed north of the Greater Khingan Mountains,the region of the Lesser Khingan Mountains and east of the Changbai Mountains,while the central plain had low habitat quality;(3)agricultural lands had the largest effect on habitat degradation among all habitat *** these 2 decades,the contribution of agricultural lands to habitat degradation were 43.4%in 1990,44.6%in 2000 and 43.9%in 2010;and,(4)at a landscape scale,patch density and splitting index present noticeable negative correlations with habitat quality *** quality was significantly affected by landscape fragmentation and decreased connectivity.

关键词： InVEsT model Habitat quality Land use change Landscape pattern

Chitinase 6 is required for procuticle thickening and organ shape in Drosophila wing

在线全文

学校读者我要写书评

暂无评论

Insect science 2023年第2期30卷 268-278页

作者： Wei Dong Justin Flaven-Pouchon Ying-Hao Gao Chen-Yang song Abeer El Wakil Jian-Zhen Zhang bernard Moussian Institute of Applied Biology Shanxi UniversityTaiyuanChina Interfaculty Institute of Cell Biology University of TübingenTübingenGermany College of Life science Shanxi UniversityTaiyuanChina Faculty of Education Department of Biological and Geological SciencesAlexandria UniversityAlexandriaEgypt INRAE CNRSUniversitéCote d’AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

The polysaccharide chitin is a major scaffolding molecule in the insect *** order to be functional,both chitin amounts and chitin organization have been shown to be important *** great advances in the past decade,the molecular mechanisms of chitin synthesis and organization are not fully ***,we have characterized the function of the Chitinase 6(Cht6)in the formation of the wing,which is a simple flat cuticle organ,in the fruit fly Drosophila *** of Cht6 function by RNA interference during wing development does not affect chitin organization,but entails a thinner cuticle suggesting reduced chitin *** phenotype is opposed to the one reported recently to be caused by reduction of Cht10 *** as a consequence,cuticle permeability to xenobiotics is enhanced in Cht6-less *** also observed massive deformation of these *** addition,the shape of the abdomen is markedly changed upon abdominal suppression of ***,we found that suppression of Cht6 transcript levels influences the expression of genes coding for enzymes of the chitin biosynthesis *** finding indicates that wing epidermal cells respond to activity changes of Cht6 probably trying to adjust chitin ***,in a working model,we propose that Cht6-introduced modifications of chitin are needed for chitin synthesis to proceed *** thickness,according to our hypothesis,is in turn required for correct organ or body part *** molecular mechanisms of this processes shall be characterized in the future.

关键词： abdomen chitin Cht6 Drosophila melanogaster procuticle wing

Monoclonal antibodies to the exon 18 encoded moiety of NCAM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2019年第7期4卷 50-55页

作者： Ann Vander Borght Mieke Duysinx Monique Ummelen bernard AMvan der Zeijst Department of Genetics and Cell Biology and GROW school for Oncology and Developmental Biology Maastricht UniversityMaastrichtPO Box 6166200 MDThe Netherlands MUbio Products B.V. Maastricht6200 EVThe Netherlands Catherinn B.V. Manuel de Fallapad 1Rotterdam3069 MRThe Netherlands

Aim: Exon 18 expression of NCAM has been recognized as a biomarker for small cell lung cancer (sCLC). To use this finding for an improved diagnosis of sCLC and personalized treatment of patients, techniques to identify and quantitate E18, the exon 18 encoded protein moiety of NCAM, are needed. We developed three monoclonal antibodies for this purpose. Methods: The his-tagged E18 antigen was expressed in E. coli and, after purification, used to immunize mice. Hybridoma's were isolated by standard procedures and tested for their reaction with E18. Results: Three monoclonal antibodies, MUM-1, MUM-4 and MUM-6 were obtained. They reacted with E18 in western blots, with sCLC cell line NCI-H82, but not with unrelated his-tagged proteins. Only permeabilized NCI-H82 cells stained with the antibodies, confirming the intracellular position of E18. Next an enzyme-linked immunosorbent assay was developed using the earlier isolated monoclonal antibody MUMi-21B2, coated on the surface of microtiter wells as capture antibody and biotinylated MUM-6 as second antibody. Using streptavidin conjugated to horse radish peroxidase a linear dose response curve to his-tagged E18 antigen was obtained between 0 and 5 μg/mL with a sensitivity of at least 0.5 μg/mL or 50 ng/well. Conclusion: Four monoclonal antibodies are available to be used in assays for the identification and quantification of sCLC biomarker E18. This will enable the development of liquid biopsies to follow the tumor load in patients.

关键词： small cell lung cancer tumor biomarker monoclonal antibodies NCAM exon 18

Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2014年第1期12卷 19-30页

作者： Wang-Xia Wang Robert J.Danaher Craig s.Miller Joseph R.Berger Vega G.Nubia bernard s.Wilfred Janna H.Neltner Christopher M.Norris Peter T.Nelson sanders-Brown Center on Aging University of KentuckyLexingtonKY 40536USA College of Dentistry University of KentuckyLexingtonKY 40536USA Department of Neurology University of KentuckyLexingtonKY 40536USA Department of Pathology University of KentuckyLexingtonKY 40536USA Department of Molecular and Biomedical Pharmacology University of KentuckyLexingtonKY 40536USA

The miR-15/107 family comprises a group of 10 paralogous microRNAs （miRNAs）,sharing a 5＇ AGCAGC *** miRNAs have overlapping *** order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal ***-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain *** also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations （enriched for cortical neurons,astrocytes and microglia,respectively）.In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system （CNs）.In addition to mature miRNAs,we also examined the expression of precursors （pri-miRNAs）.Our data suggested a generally poor correlation between the expression of mature miRNAs and their *** summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

关键词： miR-16 miR-424 miR-503 miR-15 Normalization Target prediction

The Grammars of Mystical Experience in Christian Theological Dialogue

在线全文

学校读者我要写书评

暂无评论

Journal of Philosophy study 2018年第4期8卷 151-168页

作者： Marc Jean-bernard University of Puerto Rico

The philosophical horizon of this essay is theoretically comparative and hermeneutically dialogic. Its main philosophical and theological tonality expresses, in first person and through three discursive moments, the differentiated fusion of horizons between phenomenological and grammatical description and understanding of experience. After a philosophical overture-outlining the ethos of the dialogic problematic and situating it within the contemporary diverse and dialogic dynamic of phenomenology-I will expose the consistent, possible modalities of convergence between Husserlian phenomenology and Wittgensteinian grammar of the mystical shapes of experience. The tense, responsorial dialogue among Husserl, Heidegger, Levinas, and Wittgenstein＇s styles of thinking, far from being anymore limited to the debates between the analytical and phenomenological, will be considered from the crossed categorial spaces of Austrian philosophy and German culture in general. In a second section, I will show how the styles of phenomenology today are advancing into a cautious micro-logical grammar of comparative inquiry. This thematization will first consider some precise semantic clarifications： Experience, the mystical, extasis, evidence, and truth; in a second section, the theoretical levels of grammar and phenomenology of mystical experience are heralded in the context of the Christian theological dialogue, where I emphasize the rebirth of French theological thinking and dialogic transcendence, beginning with Maritain and de Chardin to Marcel, de Lubac, Levinas, and Marion. Finally, I consider the aesthetic expressions of mystical experience, both from the visual and musical dimensions. I will conclude this talk by highlighting theological perspectives drawn from my research in musico-philosophical problematics, through an awakening to the resonance of Being and the Divine in sonic and musical life. Through a theology of the musical λογοζ, the grammar of mystical experience reveals

关键词： phenomenology grammar mysticism theology ontology dialogue music silence

Forest Carbon storage and Tree Carbon Pool Dynamics under Natural Forest Protection Program in Northeastern China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical science 2014年第4期24卷 397-405页

作者： WEI Yawei YU Dapao bernard Joseph LEWIs ZHOU Li ZHOU Wangming FANG Xiangmin ZHAO Wei WU shengnan DAI Limin state Key Laboratory of Forest and soil Ecology Institute of Applied Ecology Chinese Academy of Sciences shenyang Agriculture University

The Natural Forest Protection(NFP) program is one of the six Key Forestry Projects which were adopted by the Chinese Government since the 1980s to address important natural issues in China. It advanced to protecting and restoring the structures and functions of the natural forests through sustainable forest management. However, the role of forest carbon storage and tree carbon pool dynamics since the adoption of the NFP remains unknown. To address this knowledge gap, this study calculated forest carbon storage(tree, understory, forest floor and soil) in the forest region of northeastern(NE) China based on National Forest Inventory databases and field investigated databases. For tree biomass, this study utilized an improved method for biomass estimation that converts timber volume to total forest biomass; while for understory, forest floor and soil carbon storage, this study utilized forest type-specific mean carbon densities multiplied by their areas in the region. Results showed that the tree carbon pool under the NFP in NE China functioned as a carbon sink from 1998 to 2008, with an increase of 6.3 Tg C/yr, which was mainly sequestrated by natural forests(5.1 Tg C/yr). At the same time, plantations also acted as a carbon sink, reflecting an increase of 1.2 Tg C/yr. In 2008, total carbon storage in forests covered by the NFP in NE China was 4603.8 Tg C, of which 4393.3 Tg C was stored in natural forests and 210.5 Tg C in planted forests. soil was the largest carbon storage component, contributing 69.5%–77.8% of total carbon storage; followed by tree and forest floor, accounting for 16.3%–23.0% and 5.0%–6.5% of total carbon storage, respectively. Understory carbon pool ranged from 1.9 to 42.7 Tg C, accounting for only 0.9% of total carbon storage.

关键词： biomass-volume linear regression models mean carbon density method national forest inventory Key Forestry Projects northeastern China

Effects of Logging Intensity on structure and Composition of a Broadleaf-Korean Pine Mixed Forest on Changbai Mountains,Northeast China

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical science 2016年第1期26卷 59-67页

作者： WU Zhijun sU Dongkai NIU Lijun bernard Joseph LEWIs YU Dapao ZHOU Li ZHOU Wangming WU shengnan DAI Limin state Key Laboratory of Forest and soil Ecology Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Liaoning Technical University Fuxin 123000China University of Chinese Academy of sciences Beijing 100049China Jilin Forest Industry Group Limited Liability Company Changchun 130021China Changbai Mountains Academy of sciences Antu 133613China

In order to identify a harvesting model which is beneficial for broadleaf-Korean pine mixed forest （BKF） sustainability, we investigated four types of harvested stands which have been logged with intensities of 0 （T0, control）, 15% （T1, low intensity）, 35% （T2, moderate intensity）, and 100% （T3, clear-cutting）, and examined the impacts of logging intensity on composition and structure of these stands. Results showed that there were no significant differences between To and T1 for all structural characteristics, except for density of seeding and large trees. The mean diameter at breast height （DBH, 1.3 m above the ground）, stem density and basal area of large trees in T2 were significantly lower than in To, while the density of seedlings and saplings were significantly higher in T2 than in To. structural characteristics in T3 were entirely different from To. Dominant tree species in primary BKF comprised 93%, 85%, 45% and 10% of the total basal area in T0, T1, T2 and T3, respectively. Three community similarity indices, the Jaccard＇s similarity coefficient （Cj）; the Morisita-Hom index （CMH）; and the Bray-Curtis index （CN）, were the highest for T0 and T1, followed by T0 and T2, and T0 and T3, in generally. These results suggest that effects of harvesting on forest composition and structure are related to logging intensities. Low intensity harvesting is conductive to preserving forest structure and composition, allowing it to recover in a short time period. The regime characterized by low logging intensity and short rotations appears to be a sustainable harvesting method for BKF on the Changbai Mountains.

关键词： broadleaf-Korean pine mixed forest forest structure species composition logging intensity Changbai Mountains