Chitinase 6 is required for procuticle thickening and organ shape in Drosophila wing
作者机构：Institute of Applied BiologyShanxi UniversityTaiyuanChina Interfaculty Institute of Cell BiologyUniversity of TübingenTübingenGermany College of Life ScienceShanxi UniversityTaiyuanChina Faculty of EducationDepartment of Biological and Geological SciencesAlexandria UniversityAlexandriaEgypt INRAECNRSUniversitéCote d’AzurInstitut Sophia AgrobiotechSophia AntipolisFrance
出 版 物：《Insect Science》 (昆虫科学（英文版）)
年 卷 期：2023年第30卷第2期
页 面：268-278页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the National Natural Science Foundation of China(Grant No.32170505,32170526) the NSFC-DFG(Grant No.31761133021) Natural Science Foundation of Shanxi Province(Grant No.20210302123473) Research Project Supported by Shanxi Scholarship Council of China(HGKY2019011) the Fund for Shanxi“1331 Project.”BM’s contribution was supported by the German Research Foundation(DFG grant MO1714/10-1)
主 题：abdomen chitin Cht6 Drosophila melanogaster procuticle wing
摘 要：The polysaccharide chitin is a major scaffolding molecule in the insect *** order to be functional,both chitin amounts and chitin organization have been shown to be important *** great advances in the past decade,the molecular mechanisms of chitin synthesis and organization are not fully ***,we have characterized the function of the Chitinase 6(Cht6)in the formation of the wing,which is a simple flat cuticle organ,in the fruit fly Drosophila *** of Cht6 function by RNA interference during wing development does not affect chitin organization,but entails a thinner cuticle suggesting reduced chitin *** phenotype is opposed to the one reported recently to be caused by reduction of Cht10 *** as a consequence,cuticle permeability to xenobiotics is enhanced in Cht6-less *** also observed massive deformation of these *** addition,the shape of the abdomen is markedly changed upon abdominal suppression of ***,we found that suppression of Cht6 transcript levels influences the expression of genes coding for enzymes of the chitin biosynthesis *** finding indicates that wing epidermal cells respond to activity changes of Cht6 probably trying to adjust chitin ***,in a working model,we propose that Cht6-introduced modifications of chitin are needed for chitin synthesis to proceed *** thickness,according to our hypothesis,is in turn required for correct organ or body part *** molecular mechanisms of this processes shall be characterized in the future.
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