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Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies

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World Journal of Gastroenterology 2021年第15期27卷 1630-1642页

作者： thiruvengadam muniraj Harry R Aslanian Loren Laine Priya A Jamidar James F Farrell Kisha A Mitchell Ronald R Salem Section of Digestive Diseases Department of MedicineYale University School of MedicineNew HavenCT 06510United States Department of Pathology Yale University School of MedicineNew HavenCT 06510United States Department of Surgery Yale University School of MedicineNew HavenCT 06510United States

BACKGROUND Recurrent acute pancreatitis(RAP)may be a presenting feature of and an indication for resection of pancreatic cysts,including intra-ductal papillary mucinous neoplasm(IPMN).Few data are available regarding the prevalence of malignancy and post-operative RAP in this *** To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for *** This retrospective study assessed 172 patients who underwent surgical resection of pancreatic cystic neoplasms at a university hospital between 2002 and *** prevalence of preoperative high-risk cyst features,and of neoplasia was compared between patients with and without *** identify the cause of pancreatitis,all the patients had a detailed history of alcohol,smoking,medications obtained,and had cross-sectional imaging(contrast-enhanced computed tomography/magnetic resonance imaging)and endoscopic ultrasound to look for gallstone etiology and other structural causes for *** incidence of RAP post-resection was the primary *** IPMN accounted for 101 cases(58.7%){[branch duct(BD)59(34.3%),main duct(MD)42](24.4%)}.Twenty-nine(16.9%)presented with RAP(mean 2.2 episodes):15 had BD-IPMN,8 MD-IPMN,5 mucinous cystic neoplasm and 1 serous cystic *** was similar among those with vs without RAP for all patients[6/29(20.7%)vs 24/143(16.8%)]and IPMN patients[6/23(26.1%)vs 23/78(29.5%)],although tended to be higher with RAP in BD-IPMN,[5/15(33.3%)vs 3/44(6.8%),P=0.04].At mean follow-up of 7.2 years,1(3.4%)RAP patient had post-resection *** mean episodes of acute pancreatitis before vs after surgery were 3.4 vs 0.02(P<0.0001).CONCLUSION Malignancy was not increased in patients with pancreatic cystic neoplasms who have RAP compared to those without *** addition,specific cyst characteristics were not clearly associated with *** incidence of RAP was markedly decreased in almost all patients following cyst resect

关键词： Pancreatic cyst Pancreatic neoplasm Pancreatitis Malignancies

Alternative uses of lumen apposing metal stents

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World Journal of Gastroenterology 2020年第21期26卷 2715-2728页

作者： Prabin Sharma Thomas R McCarty Ankit Chhoda Antonio Costantino Caroline Loeser thiruvengadam muniraj Marvin Ryou Christopher C Thompson Department of Gastroenterology and Hepatology Yale-New Haven Health-Bridgeport HospitalBridgeportCT 06610United States Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Department of Internal Medicine Yale-New Haven Health-Bridgeport HospitalBridgeportCT 06708United States Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

The advent of lumen apposing metal stents(LAMS)has revolutionized the management of many complex gastroenterological conditions that previously required surgical or radiological *** procedures have garnered popularity due to their minimally invasive nature,higher technical and clinical success rate and lower rate of adverse *** virtue of their unique design,LAMS provide more efficient drainage,serve as conduit for endoscopic access,are associated with lower rates of leakage and are easy to be *** used for drainage of pancreatic fluid collections,the use of LAMS has been extended to gallbladder and biliary drainage,treatment of luminal strictures,creation of gastrointestinal fistulae,pancreaticobiliary drainage,improved access for surgically altered anatomy,and drainage of intra-abdominal and pelvic abscesses as well as post-surgical fluid *** new indications of endosonographic techniques and LAMS continue to evolve,this review summarizes the current role of LAMS in the management of these various complex conditions and also highlights clinical pearls to guide successful placement of LAMS.

关键词： Lumen apposing metal stents Walled off necrosis Gallbladder drainage Biliary drainage Gastric access temporary for endoscopy Gastric outlet obstruction Therapeutic endoscopy

Micro Calcification Detection in Mammogram Images Using Contiguous Convolutional Neural Network Algorithm

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Computer Systems Science & Engineering 2023年第5期45卷 1887-1899页

作者： P.Gomathi C.muniraj P.S.Periasamy Selvam College of Technology Namakkal637003Tamil NaduIndia Knowledge Institute of Technology Kakapalayam637504Tamil NaduIndia KSR College of Engineering Tiruchengode637215NamakkalIndia

The mortality rate decreases as the early detection of Breast Cancer(BC)methods are emerging very fast,and when the starting stage of BC is detected,it is *** early detection of the disease depends on the image processing techniques,and it is used to identify the disease easily and accurately,especially the micro calcifications are visible on mammography when they are 0.1 mm or bigger,and cancer cells are about 0.03 mm,which is crucial for identifying in the BC *** achieve this micro calcification in the BC images,it is necessary to focus on the four main steps presented in this *** are three significant stages of the process assigned to find the BC using a thermal image;the image processing procedures are described *** the first stage of the process,the Gaussian filter technique is implemented to magnify the screening *** the second stage,BC detection is separated from the pre-processed *** Proposed Versatile K-means clustering(VKC)algorithm with segmentation is used to identify the BC detection form of the screening *** centroids are then recalculated using proposed VKC,which takes the mean of all data points allocated to that centroid’s cluster,lowering the overall intracluster variance in comparison to the prior ***“means”in K-means refers to the process of averaging the data and determining a new *** process eliminates unnecessary areas of ***,the mammogram screening image information is taken from the patient and begins with the Contiguous Convolutional Neural Network(CCNN)*** proposed CCNN is used to classify the Micro calcification in the BC spot using the feature values is the fourth stage of the *** assess the presence of high-definition digital infrared thermography technology and knowledge base and suggests that future diagnostic and treatment services in breast cancer imaging will be *** use of sophisticated CCNN techniques in thermography is being developed

关键词： Contiguous Convolutional Neural Network(CCNN) Gaussian filter Versatile K-Means Clustering(VKC)algorithm mammogram cancer detection

Alternate paradigms on Zika virus-related complications:An analytical review

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Asian Pacific Journal of Tropical Medicine 2017年第7期10卷 701-704页

作者： Baburajan Radha Gnanaraj muniraj MVK Hospital-Hitech Diagnostic Laboratory Tanjavur-02Tamil NaduIndia Department of Plant Morphology and Algology School of Biological SciencesMadurai Kamaraj UniversityMadurai-21Tamil NaduIndia

The proportion of the reported cases of Zika virus(ZIKV) infection reached the status of a pandemic. Numerous studies are being conducted on the isolation of ZIKV strains from various epidemics, diagnosis of the infections, various animal models and cell culture designs to study the pathogenesis of ZIKV in the attempts to find an effective ZIKV vaccine. This review focuses upon the 'Off-Spectrum' body of studies which analyses the epidemiology, pathogenesis and other attributes of ZIKV in the light of various dissident hypotheses.

关键词： Zika Virus Microcephaly Neurotropism Koch’s postulates Placenta Vaccines

A SVM Based Condition Monitoring of Transmission Line Insulators Using PMU for Smart Grid Environment

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Journal of Power and Energy Engineering 2016年第3期4卷 47-60页

作者： Kailasam Saranya Chinnusamy muniraj Electrical and Electronics Engineering K.S. Rangasamy College of Technology Thiruchengode India

A new methodology for the detection and identification of insulator arc faults for the smart grid environment based on phasor angle measurements is presented in this study and the real time phase angle data are collected using Phasor Measurement Units (PMU). Detection of insulator arcing faults is based on feature extraction and frequency component analysis. The proposed methodology pertains to the identification of various stages of insulator arcing faults in transmission lines network based on leakage current, frequency characteristics and synchronous phasor measurements of voltage. The methodology is evaluated for IEEE 14 standard bus system by modeling the PMU and insulator arc faults using MATLAB/Simulink. The classification of insulator arcs is done using Support Vector Machine (SVM) technique to avoid empirical risk. The proposed methodology using phasor angle measurements employing PMU is used for fault detection/classification of insulator arcing which further helps in efficient protection of the system and its stable operation. In addition, the methodology is suitable for wide area condition monitoring of smart grid rather than end to end transmission lines.

关键词： Phasor Measurement Units Insulator Arc Feature Extraction Synchronous Phasor Measurements Leakage Current Support Vector Machine

Antiobesity and antihyperlipidemic effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats: An approach to evaluate asymmetrical temperature distribution analysis using thermography

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Chinese Herbal Medicines 2019年第3期11卷 326-331页

作者： Sidhra Syed Zameer Ahmed Syed Zameer Ahmed Khader Krishnaveni Radhakrishnan Vanmathi Marimuthu muniraj Chinnusamy Venkatesan Thangavel Karamchand Ravi Manimaran Vetrivel Department of Biotechnology K.S.Rangasamy College of TechnologyTiruchengodeTamil Nadu 637215India Department of Electrical and Electronics Engineering K.S.Rangasamy College of TechnologyTiruchengodeTamil Nadu 637215India

Objective: Obesity and hyperlipidemia is the major cause of many pathological diseases with an increase side effects using allopathic drugs. The present study focuses on the effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats and associated ***: In vitro radical scavenging activity of I. coccinea was assessed using DPPH, FRAP and hydrogen peroxide. In vivo antiobesity and antihyperlipidimic activity of I. coccinea was tested in Triton X-100 induced hyperlipidemic rats and assessed for its biochemical parameters in blood and tissue *** relationship between physiological responses and regulation of body temperature was investigated by using animal surface temperature images captured with infrared ***: The results of mineral analysis, antioxidant, total flavonoid and phenolic content represented high amount of mineral and had the potential to scavenge free radicals tested with DPPH, FRAP and hydrogen peroxide radicals with dose dependent activity. The highest activity was observed in aqueous extract, DPPH with 71.5% inhibition, FRAP with 56.8%, H2 O2 with 33% activity at 100 μg/mL *** X-100 induced hyperlipidemic rats when treated with I. coccinea aqueous extract showed significant activity by regulating the biochemical parameters and maintaining the lipid profile by decreasing TC,LDL-C, VLDL-C, TG and improving HDL-C levels. Similarly, the elevated levels of creatinine, urea, uric acid,AST, ALT, ALP due to induction of hyperlipidemia, were brought back to near normal levels after treatment with I. coccinea. The levels of tissue anti-oxidants enzymes like SOD and CAT were also found to be improved in treated I. coccinea groups. The whole body asymmetrical temperature distribution analysis showed that significant decreases in temperature was observed in obesity induced groups but a gradual increase in temperature(2%–5%) was observed after ***: Thus, the results indicated that

关键词： anti-oxidant hyperlipidemia Ixora coccinea Curtis obesity thermography Triton X-100