Antiobesity and antihyperlipidemic effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats: An approach to evaluate asymmetrical temperature distribution analysis using thermography

作     者：Sidhra Syed Zameer Ahmed Syed Zameer Ahmed Khader Krishnaveni Radhakrishnan Vanmathi Marimuthu Muniraj Chinnusamy Venkatesan Thangavel Karamchand Ravi Manimaran Vetrivel 

作者机构：Department of BiotechnologyK.S.Rangasamy College of TechnologyTiruchengodeTamil Nadu 637215India Department of Electrical and Electronics EngineeringK.S.Rangasamy College of TechnologyTiruchengodeTamil Nadu 637215India 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2019年第11卷第3期

页      面：326-331页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：DBT-FIST DBT-STAR 

主　　题：anti-oxidant hyperlipidemia Ixora coccinea Curtis obesity thermography Triton X-100 

摘      要：Objective: Obesity and hyperlipidemia is the major cause of many pathological diseases with an increase side effects using allopathic drugs. The present study focuses on the effect of Ixora coccinea on Triton X-100 induced hyperlipidemia in rats and associated ***: In vitro radical scavenging activity of I. coccinea was assessed using DPPH, FRAP and hydrogen peroxide. In vivo antiobesity and antihyperlipidimic activity of I. coccinea was tested in Triton X-100 induced hyperlipidemic rats and assessed for its biochemical parameters in blood and tissue *** relationship between physiological responses and regulation of body temperature was investigated by using animal surface temperature images captured with infrared ***: The results of mineral analysis, antioxidant, total flavonoid and phenolic content represented high amount of mineral and had the potential to scavenge free radicals tested with DPPH, FRAP and hydrogen peroxide radicals with dose dependent activity. The highest activity was observed in aqueous extract, DPPH with 71.5% inhibition, FRAP with 56.8%, H2 O2 with 33% activity at 100 μg/mL *** X-100 induced hyperlipidemic rats when treated with I. coccinea aqueous extract showed significant activity by regulating the biochemical parameters and maintaining the lipid profile by decreasing TC,LDL-C, VLDL-C, TG and improving HDL-C levels. Similarly, the elevated levels of creatinine, urea, uric acid,AST, ALT, ALP due to induction of hyperlipidemia, were brought back to near normal levels after treatment with I. coccinea. The levels of tissue anti-oxidants enzymes like SOD and CAT were also found to be improved in treated I. coccinea groups. The whole body asymmetrical temperature distribution analysis showed that significant decreases in temperature was observed in obesity induced groups but a gradual increase in temperature(2%–5%) was observed after ***: Thus, the results indicated that