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A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

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Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul thierry walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis Humoral response COVID-19 SARS-CoV-2v

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Zebl represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1^(+) T cell development

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Cellular & Molecular Immunology 2021年第9期18卷 2140-2152页

作者： Jiang Zhang Melanie Wencker Quentin Marliac Aurore Berton Uzma Hasan Raphael Schneider Daphne Laubreton Dylan E.Cherrier Anne-Laure Mathieu Amaury Rey Wenzheng Jiang Julie Caramel Laurent Genestier Antoine Margais Jacqueline Marvel Yad Ghavi-Helm thierry walzer CIRI Centre International de Recherche en InfectiologieUniv LyonInsermU1111Universite Claude Bernard Lyon 1CNRSUMR5308ENS de LyonF-69007 LyonFrance Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina lnstitut de Genomique Fonctionnelle de Lyon CNRS UMR 5242Ecole Normale Superieure de LyonUniversity Claude Bernard Lyon 146 allée d'ltalieF-69364 LyonFrance CRCL Centre de Recherche sur le Cancer de LyonINSERM U1052—CNRS UMR5286Centre Léon BerardUniversity Claude Bernard Lyon 1LyonFrance

T cell development proceeds un der the in fluence of a n etwork of transcription factors(TFs).The precise role of Zeb1,a member of this network,remains ***,we report that Zeb1 expression is induced early during T cell development in CD4^(-)CD8^(-)double-negative(DN)stage 2(DN2).Zeb1 expression was further increased in the CD4^(+)CD8^(+)double-positive(DP)stage before decreasing in more mature T cell *** performed an exhaustive characterization of T cells in Cellophane mice that bear Zeb 7 hypomorphic *** Zebl mutation profoundly affected all thymic subsets,especially DN2 and DP ***1 promoted the survival and proliferation of both cell populations in a cell-intrinsic *** the periphery of Cellophane mice,the number of conventional T cells was near normal,but invariant NKT cells,NK1.1^(+)γδ T cells and Ly49^(+)CD8 T cells were virtually *** suggested that Zebl regulates the development of unconventional T cell types from DP progenitors.A transcriptomic analysis of WT and Cellophane DP cells revealed that Zebl regulated the expression of multiple genes involved in the cell cycle and TCR sign aling,which possibly occurred in cooperation with Tcf1 and *** deed,Cellophane DP cells displayed stron ger signaling than WT DP cells upon TCR engagement in terms of the calcium respons巳phosphorylation events,and expression of early ***,Zebl is a key regulator of the cell cycle and TCR signaling during thymic T cell *** propose that thymocyte selection is perturbed in Zeb7-mutated mice in a way that does not allow the survival of unconventional T cell subsets.

关键词： T cell selection TCR signaling Zebl transcription development

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Global public health crisis response:A roundtable discussion with Professor George Fu Gao,Professor Jules A Hoffmann,Professor Chris walzer and Professor Jiahai Lu

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hLife 2023年第2期1卷 63-70页

作者： George Fu Gao Jules A Hoffmann Chris walzer Jiahai Lu Institute of Microbiology Chinese Academy of SciencesBeijingChina University of Strasbourg Institute for Advanced Study StrasbourgFrance Institute of Molecular and Cellular Biology CNRSInsect Models of Innate Immunity(M3IUPR9022)StrasbourgFrance Sino-French Hoffmann Institute School of Basic Medical ScienceGuangzhou Medical UniversityGuangdongChina Wildlife Conservation Society New YorkUSA University of Veterinary Medicine ViennaAustria Sun Yat-sen University GuangdongChina

Four heavyweight guests in the field of public health gathered ***-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris walzer and Professor Jiahai Lu discussed how to deal with global public health crises,such as the recent coronavirus disease 2019(COVID-19)pandemic,as well as the role of international *** concept of“One Health”emerged as the latest approach to disease prevention and *** concept emphasizes the intertwined health of humans,animals and the *** experts shared their thoughts and insights on how humanity can address emerging global public health crises through international cooperation.

关键词： Academician prevention Chris

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一种排放新概念

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车用发动机 1990年第4期 28-32页

作者： Peter walzer I. Geiger 陈卫国

本文介绍了一种排放新概念,其基本思想是使汽油机在运转时减少有害排放物,并在保持最小排放量(HC+NOx)的情况下改善燃油经济性。本文还介绍了为实现这一新概念所采取的平稳运转控制方法以及各缸独立的燃油喷射装置和双循环冷却系统。

关键词：排放排气新概念汽油机汽车

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实施灵活的实时协议

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现代制造 2014年第10期 44-45页

作者： FRANK walzer

在工业通信子系统基础上，原则上支持任意以太网网络通信协议，列举一个Ethercat软件和标准以太网的实例来表述实现这些目标的基本原理及可能性。

关键词：实时协议网络通信协议通信子系统以太网

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实施灵活的实时协议

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现代制造 2013年第48期 40-41页

作者： FRANK walzer

在工业通信子系统基础上，原则上支持任意以太网网络通信协议，列举一个Ethercat软件和标准以太网的实例来表达实现这些目标的基本原理及可能性。

关键词：实时协议网络通信协议通信子系统以太网

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机械增压用——大众汽车公司的G增压器

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车用发动机 1988年第6期 3-13页

作者： Peter walzer ,董复兴

本文从车辆的行驶特性、经济性和环境法等不同的角度阐述了采用机械增压的理由。以较大的篇幅讲述了大众汽车G增压器的工作原理和结构。并以不同的指标对G增压器和其它类型的机械增压器进行比较,进而得出了G增压器具有充气效率高、机械... 详细信息

本文从车辆的行驶特性、经济性和环境法等不同的角度阐述了采用机械增压的理由。以较大的篇幅讲述了大众汽车G增压器的工作原理和结构。并以不同的指标对G增压器和其它类型的机械增压器进行比较,进而得出了G增压器具有充气效率高、机械损失适中、可以设置内压缩,转动惯量小、噪音低以及制造成本低廉等优点的结论。并通过将装有G增压器的机械增压发动机进行装车试验,显示了其性能的优越性。

关键词：发动机涡轮扭矩排量透平大众汽车公司增压器挤压器汽油机机械增压

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