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G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2493-2549页

作者： thian-Sze Wong Guangzhi Li Shiliang Li Wei Gao Geng Chen Shiyi Gan Manzhan Zhan Honglin Li song Wu Yang Du Kobilka Institute of Innovative Drug Discovery Shenzhen Key Laboratory of Steroid Drug Discovery and DevelopmentSchool of MedicineThe Chinese University of Hong Kong518172ShenzhenGuangdongChina School of Medicine Tsinghua University100084BeijingChina Institute of Urology The Affiliated Luohu Hospital of Shenzhen UniversityShenzhen University518000ShenzhenGuangdongChina Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and Technology200237ShanghaiChina Innovation Center for AI and Drug Discovery East China Normal University200062ShanghaiChina Department of Urology South China HospitalHealth Science CenterShenzhen University518116ShenzhenGuangdongChina

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological *** treatment targets is challenging because the diseases are resulting from heterogeneous biological,genetic,and environmental ***,the increasing understanding of G protein-coupled receptor(GPCR)opens a new possibility in drug *** our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective *** review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric ***,we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

关键词： psychiatric disorders diseases

Pulse oximeter as a home assessment tool:Knowledge and user experience among the community in Malaysia during the COVID-19 pandemic

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Asian Pacific Journal of Tropical Medicine 2022年第5期15卷 213-219页

作者： Siew-Keah Lee Jin Wei Ma Khai Ying Chan Yi song Cheong Wan Ting Hong Regine Chew Yi ong Wei Cheng Tay Ang-Lim Chua Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia

Objective:To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in ***:A cross-sectional survey was conducted in November *** questionnaire assessed the knowledge in using pulse oximeters,user experience and opinions in using pulse oximeter as a home assessment tool during the ***:A total of 504 respondents were included in the study,and the mean score in knowledge related to application of pulse oximetry was 73.00%,while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%.A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult,while 69.4% recognised the definition of silent *** addition,the majority of the respondents agreed that factors such as poor blood circulation(71.2%),excessive movements(69.8%),and hand position(60.7%)affected oximetry ***,61.7%,81.7%,77.2% and 76.8% of the respondents could not identify nail polish,skin colour,skin thickness and tattoos as factors that may affect oximetry readings ***:The respondents showed a satisfactory level of knowledge related to application of pulse oximetry,but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in *** efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress.

关键词： COVID-19 Pulse oximetry SpO2 Home assessment tool Silent hypoxia

Toward real-time digital pulse process algorithms for CsI(Tl)detector array at external target facility in HIRFL-CSR

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Nuclear Science and Techniques 2023年第9期34卷 8-20页

作者： Tao Liu Hai-Sheng song Yu-Hong Yu Duo Yan Zhi-Yu Sun Shu-Wen Tang Fen-Hua Lu Shi-Tao Wang Xue-Heng Zhang Xian-Qin Li Hai-Bo Yang Fang Fang Yong-Jie Zhang Shao-Bo Ma Hooi-Jin ong Cheng-Xin Zhao Northwest Normal University Lanzhou 730070China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

A fully digital data acquisition system based on a field-programmable gate array(FPGA) was developed for a CsI(Tl) array at the external target facility(ETF) in the Heavy Ion Research Facility in Lanzhou(HIRFL). To process the CsI(Tl) signals generated by γ-rays and light-charged ions, a scheme for digital pulse processing algorithms is proposed. Every step in the algorithms was benchmarked using standard γ and α sources. The scheme, which included a moving average filter, baseline restoration, leading-edge discrimination, moving window deconvolution, and digital charge comparison, was subsequently implemented on the FPGA. A good energy resolution of 5.7% for 1.33-MeV γ-rays and excellent α-γ identification using the digital charge comparison method were achieved, which satisfies CsI(Tl) array performance requirements.

关键词： CsI(Tl)array On-line digital algorithms Moving average filter Moving window deconvolution On-line particle identification algorithms

Embolic Effects of Bletilla striata Microspheres in Renal Artery and Transplanted VX2 Liver Tumor Model in Rabbits

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Chinese Journal of Integrative Medicine 2019年第6期25卷 431-438页

作者： LUO Shi-hua song song-lin ZHENG Chuan-sheng LI Wei-yong WANG Yong XIA Xiang-wen FENG Gan-sheng Department of Radiology Union Hospital Tongji Medical College Huazh ong University of Science and Tech no logy Wuhan (430022) China Department of Pharmacy Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan (430022) China

Objective: To evaluate the characteristics of Bletilla striata microspheres(BSMs) and its effects as an embolic agent in a rabbit model. Methods: BSMs were prepared with an emulsi?cation-cool condensation-chemical cross-linking method. The characteristics of BSMs in vitro were observed. Embolization experiments were performed in renal artery of rabbit and in a rabbit liver VX2 carcinoma model. Seventy-two New Zealand rabbits were divided into 2 groups, and the right renal artery was embolized with BSMs(200 μm in diameter) in the experimental group and with polyvinyl alcohol(PVA) of the same size in the control group. The pathological findings were examined with hematoxylin-eosin and Masson stainings. Liver and renal functions were tested before and after ***2 tumor was transplanted in 15 New Zealand rabbits, which were randomly divided into 3 groups(n=5). Group A were treated with saline, group B with a mixture of doxorubicin and lipiodol, and group C with hepatic arterial infusion of BSMs(200 μm in diameter). Tumor growth rate was evaluated by magnetic resonance imaging ***-related factors(bax, bcl-2) and tumor vascular endothelial cell growth factor(VEGF) were evaluated through immunohistochemical staining. Results: The characteristics of BSMs in vitro were in full compliance with the requirements for use in interventional procedures. In the renal artery embolization experiment, after BSMs intervention, it was more dif?cult to form collateral circulation than that with PVAs, and the kidney manifested atrophy and calci?cation. There were no signi?cant difference of liver and renal functions in rabbits between groups. In the liver VX2 carcinoma embolization experiment, compared with group A, the growth rate of VX2 liver tumor and Bcl-2 levels was reduced, while apoptosis index, Bax, and VEGF were increased in group B(P0.05). Conclusions: The characteristics of BSMs in vitro a

关键词： Bletilla striata Chinese medicine microsphere characteristic embolization

Nitrogen, phosphorus co-doped carbon cloth as self-standing electrode for lithium-iodine batteries

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Nano Research 2019年第3期12卷 549-555页

作者： Kang Li song Chen Si Chen Xien Liu Wei Pan Jintao Zhang Key Laboratory for Colloid and Interface Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China State Key Laboratory Base of Eco-chemical Engineering College of Chemistry and Molecular Engineering Qingdao University of Science & Technology Qingdao 266042 China College of Chemistry Chemical Engineering and Materials Science Shandong Normal University Jinan 250014 China

Rechargeable lithium-iodine (Li-I2) battery is a promising energy storage system because of the high energy and power density. However, the shuttle effects of iodine species and the unstable features of l2 block the practical applications of Li-I2 batteries. Herein, a dual heteroatom doped porous carbon cloth is fabricated as the host material for lithium iodide (Lil). Specifically, the self-standing nitrogen, phosphorus co-doped carb on cloth with high Lil loading exhibits a large specific capacity (221 mAh·g^-1 at 1 C), excelle nt rate capability (95.8% capacity rete ntion at 5 C) and superior I ong cycli ng stability (2,000 cycles with a capacity rete ntion of 96%). Electrochemical kin etic an alysis con firms the domi nant contribution of capacitive effects at high sean rates, which is responsible for the good high-rate performance. The improved electrochemical performance mainly stems from two unique features of nitrogen, phosphorus co-doped porous carbon cloth. Heteroatom doping provides extra active sites for strong adsorption of iodine species while the highly porous structure with large surface area favors the capacitive effects at high rates. This work provides a facile yet efficient approach to regulating both redox reaction and capacitive effects via adjusting surface composition and pore structure of carbon materials for en hanced battery performance.

关键词： iodine heteroatom doping self-standing capacitive effect porous carbon

基于有效期望质量度量的图像混合丢包保护方法

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西安电子科技大学学报 2006年第5期33卷 696-699,744页

作者：杨亚东吴成柯肖嵩杜建超西安电子科技大学综合业务网理论与关键技术国家重点实验室

针对现有基于交织器结构的不等丢包保护方案通常以端到端期望质量度量系统性能,而没有考虑最小质量要求的问题,提出了以有效期望质量度量系统性能的新判据.有效期望质量定义为扣除传输失败情况后接收端得到的期望质量.基于此新判据,提... 详细信息

针对现有基于交织器结构的不等丢包保护方案通常以端到端期望质量度量系统性能,而没有考虑最小质量要求的问题,提出了以有效期望质量度量系统性能的新判据.有效期望质量定义为扣除传输失败情况后接收端得到的期望质量.基于此新判据,提出了一种双向局部搜索的信源/信道码率分配算法.采用双状态马尔可夫网络模型,通过对SPIHT和JPEG2000编码器产生的码流数据进行仿真实验,结果表明,新算法与基于端到端期望质量度量的原算法相比能显著提高有效期望质量,降低传输失败事件发生的概率,同时计算复杂度也明显减小.

关键词：图像传输联合信源/信道编码不等保护 QoS JPEG2000

Efficacy of small-volume simethicone given at least 30 min before gastroscopy

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 572-578页

作者： Mingjun song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang Department of Gastroenterology and Hepatology Changi General Hospital

AIMTo evaluate the efficacy of 5 mL simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy. METHODSThis was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior surgical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score (TMVS) which was evaluated using McNally score. The sample size was calculated to be 24 per group (SD 2.4, 80% power, P t test). RESULTSFifty-four patients were randomised to receive either simethicone [1 mL liquid simethicone (100 mg) in 5 mL of water] or placebo (5 mL of water) at least 30 min before their gastroscopy. Six accredited consultants conducted the gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo (5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P CONCLUSIONWith a premedication time of at least 30 min, 5 mL simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time.

关键词： Simethicone Premedication Gastroscopy Gastric foam

2020 Roadmap on two-dimensional nanomaterials for environmental catalysis

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Chinese Chemical Letters 2019年第12期30卷 2065-2088页

作者： Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma School of Physics and Electronics Hunan UniversityChangsha 410082China School of the Environment and Safety Engineering Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China College of Chemistry Jilin UniversityChangchun 130012China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and TechnologyJilin UniversityChangchun 130012China Key Laboratory for Powder Metallurgy Central South UniversityChangsha 410083China Multidisciplinary Platform of Advanced Engineering Chemical Engineering DisciplineSchool of EngineeringMonash UniversityJalan Lagoon SelatanBandar SunwaySelangor 47500Malaysia University of Palermo Department of EngineeringPalermo 90128Italy University of Trento Department of Industrial EngineeringTrento 38123Italy School of Materials Science and Engineering Shaanxi University of Science&TechnologyXi'an 710021China College of Bioresources Chemistry and Materials Engineering Shaanxi University of Science&TechnologyXi'an 710021China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China School of Chemistry Faculty of Basic SciencesShoolini UniversitySolanHP 173229India Himalayan Centre for Excellence in Nanotechnology Shoolini UniversitySolanmHP 173229India School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China Nanomaterials and Nanotechnology Department Advanced Materials DivisionCentral Metallurgical R&D Institute(CMRDI)Cairo 11421Egypt Key Laboratory for Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical Engineering Shandong UniversityJi'nan 250100China National Laboratory for Molecular Science(BNLMS) CAS Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence i

Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical *** and electrocatalysis play important roles in these *** can decompose and remove organic pollutants from the aqueous environment,and prepare some fine ***,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted *** recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural *** progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and *** content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental *** hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions.

关键词： Two-dimensional materials Graphene Black phosphorus C3N4 Metal organic frameworks MXenes

软X射线光发射电子显微镜光束线聚焦用KB镜系统

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光学精密工程 2017年第11期25卷 2810-2816页

作者：陈家华龚学鹏薛松卢启鹏彭忠琦宋源王依中国科学院上海应用物理研究所上海201800 中国科学院大学北京100049 中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室吉林长春130033

研制了光发射电子显微镜(PEEM)高精度微聚焦系统,以实现上海光源软X射线PEEM光束线的高质量聚焦。根据上海光源PEEM光束线的概况,给出微聚焦系统光学元件的基本参数。基于Kirkpatrick-Baez(KB镜)两镜方案,设计了PEEM线微聚焦系统。介绍... 详细信息

研制了光发射电子显微镜(PEEM)高精度微聚焦系统,以实现上海光源软X射线PEEM光束线的高质量聚焦。根据上海光源PEEM光束线的概况,给出微聚焦系统光学元件的基本参数。基于Kirkpatrick-Baez(KB镜)两镜方案,设计了PEEM线微聚焦系统。介绍了KB镜姿态调整机构的设计方案,即利用三垂直线性驱动装置和两水平线性驱动装置相结合来实现五维调节,分析了姿态调节机构的原理与工作过程,给出了微聚焦系统的整体设计方案。测试了KB镜系统的机械性能,给出水平调节机构以及第一面镜子Pitch运动的测试结果,结果显示:水平调节机构分辨率为0.6μm,重复精度为0.85μm,Pitch角度分辨率为0.4″,重复精度为0.5″,优于指标要求。其它参数的测试结果亦均优于指标要求。实验表明,微聚焦系统机械指标的实现保证了PEEM线光斑的高质量聚焦。

关键词：同步辐射光发射电子显微镜(PEEM) X射线显微镜 KB镜结构设计