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Tuning the inhomogeneous charge transport in ZnO interfaces for ultrahigh on/off ratio top-gated field-effect-transistor arrays

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Nano Research 2020年第11期13卷 3033-3040页

作者： Thanh Luan Phan Dinh Loc Duong Tuan Khanh Chau Sidi Fan Won Tae Kang thi suong le Hyun Yong Song Linfeng Sun Van Tu Vu Min Ji lee Quoc An Vu Young Hee lee Woo Jong Yu Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Center for Integrated Nanostructure Physics(CINAP) Institute for Basic Science(IBS)Suwon16419Republic of Korea Department of Energy Science Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon16419Republic of Korea

The interface between oxide/oxide layers shows an inhomogeneous charge transport behavior,which reveals a high conductivity owing to *** typical example is the hetero-interface between ZnO film and other wide band gap oxides(e.g.,Al_(2)O_(3),TiO_(2),and HfO_(2)).It is thus quite evident that the ZnO/other oxides hetero-interface contains high density electron carriers effectively screening the gate-induced electric ***,an extremely weak gate modulation in ZnO film was showed,resulting in very low on/off ratio of 1.69 in top-gate field-effect-transistor(TG-FET)***,to extend the usage of ZnO TG-FET is not quite possible toward further practical ***,we clarified the correlation of inhomogeneous region in oxide/oxide hetero-junction by systematically *** work suggests that a self-assembly of molecules(SAM)buffer layer is suitable for tuning the inhomogeneous charge transport in ZnO film,which not only reduces the interface trap density,but also effectively enhances the gate electric field modulation at the *** further report the robust fabrication of TG-FET arrays based on ZnO thin film,using an ultra-thin alkylphosphonic acid molecule monolayer as buffer *** device demonstrates a pronounced ultrahigh on/off ratio of≥10^(8),which is 8-order of magnitude higher than that of a device without buffer *** the highly reliable arrays,our device exhibits a high yield of over 93%with an average on/off ratio of^10^(7) across the entire wafer scale,mobility(18.5 cm^(2)/(V·s)),an extended bias-stressing(~2,000 s)and long-stability(~150 days)under ambient conditions.

关键词： zinc oxides thin-film field-effect-transistor self-assembly molecule inhomogeneous charge transport interface engineering

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Acute-on-chronic liver failure: Controversies and consensus

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World Journal of Gastroenterology 2023年第2期29卷 232-240页

作者： Natalie L Y Ngu Eliza Flanagan Sally Bell suong T le Department of Gastroenterology and Hepatology Monash HealthClayton 3168VictoriaAustralia Faculty of Medicine Nursingand Health SciencesMonash UniversityClayton 3800VictoriaAustralia Department of Gastroenterology and Hepatology Alfred HealthMelbourne 3004VictoriaAustralia Monash digital Therapeutics and Innovation Laboratory(MoTILa) Monash UniversityClayton 3168VictoriaAustralia

Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver *** include high short-term morbidity,mortality,and healthcare resource *** encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ *** precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is *** definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology *** can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease *** transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care *** review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps.

关键词： Acute-on-chronic liver failure Liver cirrhosis End stage liver disease Epidemiology Mortality

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Survival outcomes and predictors of mortality,re-bleeding and complications for acute severe variceal bleeding requiring balloon tamponade

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World Journal of Hepatology 2022年第8期14卷 1584-1597页

作者： Charlotte Y Keung Aparna Morgan suong T le Marcus Robertson Paul Urquhart Michael P Swan Department of Gastroenterology Monash HealthMelbourne 3168VictoriaAustralia Department of Gastroenterology Eastern HealthMelbourne 3128VictoriaAustralia Department of Medicine Monash UniversityMelbourne 3168VictoriaAustralia Monash Digital Therapeutics and Innovation Laboratory Monash UniversityMelbourne 3168VictoriaAustralia

BACKGROUND Acute severe variceal bleeding(AVB)refractory to medical and endoscopic therapy is infrequent but associated with high *** cohort studies from 1970-1980s no longer represent the current population as balloon tamponade is no longer first-line therapy for variceal bleeding;treatments including vasoactive therapies,intravenous antibiotics,endoscopic variceal band ligation are routinely used,and there is improved access to definitive treatments including transjugular intrahepatic portosystemic ***,only a few studies from the current era exist to describe the practice of balloon tamponade,its outcomes,and predictors with a requirement for further updated *** To describe current management of AVB requiring balloon tamponade and identify the outcomes and predictors of mortality,re-bleeding and *** A retrospective multi-centre cohort study of 80 adult patients across two large tertiary health networks from 2008 to 2019 in Australia who underwent balloon tamponade using a Sengstaken-Blakemore tube(SBT)were included for *** were identified using coding for balloon *** primary outcome of this study was all-cause mortality at 6 wk after the index *** outcomes included re-bleeding during hospitalisation and complications of balloon *** of these outcomes were determined using univariate and multivariate binomial *** The all-cause mortality rates during admission and at 6-,26-and 52 wk were 48.8%,51.2%and 53.8%,*** haemostasis was achieved in 91.3%and re-bleeding during hospitalisation occurred in 34.2%.Independent predictors of 6 wk mortality on multivariate analysis included the Model for Endstage Liver disease(MELD)score(OR 1.21,95%CI 1.06-1.41,P=0.006),advanced hepatocellular carcinoma(OR 11.51,95%CI 1.61-82.20,P=0.015)and re-bleeding(OR 13.06,95%CI 3.06-55.71,Plevant predictors of re-bleeding but a larg

关键词： Balloon tamponade Acute variceal bleeding Sengstaken-Blakemore tube Mortality Complications Haemostasis

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