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Cardiac Structure and Function in Men with Prostate Cancer receiving Androgen-Deprivation Therapy and the Effects of recreational Small-Sided Football Training:A randomized Controlled Trial

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World Journal of Cardiovascular Diseases 2017年第9期7卷 308-322页

作者： Jakob Friis Schmidt Lars Juel Andersen Jacob Uth therese Hornstrup Jesper Christensen Julie Midtgaard Klaus Brasso Peter Krustrup Mikael rorth Peter riis Hansen Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Nutrition Exercise and SportsCentre for Team Sport and HealthUniversity of CopenhagenCopenhagenDenmark Department of Cardiology Roskilde HospitalRoskildeDenmark The University Hospitals Centre for Health Care research(UCSF) Copenhagen University HospitalRigshospitaletDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Copenhagen Prostate Cancer Center Department of UrologyCopenhagen University HospitalRigshospitaletDenmark Sport and Health Sciences University of ExeterExeterGreat Britain Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdenseDenmark Department of Oncology Copenhagen University HospitalRigshospitaletDenmark

Purpose: Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer (PCa) management that prolongs PCa-free and overall survival, but effects of ADT on human cardiac function have not been investigated. We used echocardiography to examine cardiac structure and function in patients with prostate cancer receiving ADT and to determine whether an exercise intervention can elicit cardiac adaptations in these subjects. Methods: Forty-three patients with prostate cancer receiving ADT were randomized to 12 weeks football training (ST group;n = 20) or usual care (control [CO] group;n = 23). Cardiac function was assessed at baseline and after 12 weeks by comprehensive echocardiography. Peak oxygen consumption, blood pressure and peripheral microvascular function was also measured. results: At baseline, no considerable echocardiographic abnormalities were observed. In the ST group, increases in left ventricular diastolic function variables including E/A ratio (P = 0.03), E’ (P = 0.016), E’TDIcolor (P = 0.040) and in left atrial diameter (P = 0.001) were observed after 12 weeks. In addition, diastolic blood pressure (P = 0.027) and resting heart rate (P 0.001) were reduced after ST. In the CO group, no significant changes were observed in the examined variables after 12 weeks. Despite within group changes in the ST group, no significant differences were observed after 12 weeks between groups in echocardiographic variables, peak oxygen consumption, blood pressure and peripheral microvascular function. Conclusion: In men with prostate cancer receiving ADT, echocardiography showed no abnormalities in cardiac structure and function. Twelve weeks of ST failed to elicit significant cardiovascular adaptations and ADT may blunt cardiovascular adaptations to short-term exercise training.

关键词： Prostate Cancer Exercise rehabilitation Cardiovascular

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恶劣暴风雨事件后森林土壤中汞和甲基汞的活动化

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AMBIO－人类环境杂志 2007年第1期36卷 106-108页

作者： John Munthe Sofie Hellsten therese Zetterberg 周群芳（译） IVL Swedish Environmental research Institute PO Box 5302 SE-400 14 Gothenburg Sweden 不详

汞是空气、土壤、水和生物体中参与复杂生物地球化学循环的元素；由天然和人为因素引入。虽然汞是天然存在的元素，但是人类活动使全球环境中汞水平增加了1个数量级。人体通过工业、人为淘金、银汞合金和食用鱼类的途径暴露于汞。环境... 详细信息

汞是空气、土壤、水和生物体中参与复杂生物地球化学循环的元素；由天然和人为因素引入。虽然汞是天然存在的元素，但是人类活动使全球环境中汞水平增加了1个数量级。人体通过工业、人为淘金、银汞合金和食用鱼类的途径暴露于汞。环境中汞的主要问题在于由于甲基汞的在淡水鱼中的生物富集效应导致鱼体中甲基汞浓度升高，达到了对人体健康有害的水平。

关键词：甲基汞森林土壤生物地球化学循环暴风雨事件全球环境淡水鱼人为因素

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Electrocardiographic Changes in Patients with Type 2 Diabetes Multicenttic Cross Sectional and Descriptive Study in Dakar

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Open Journal of Internal Medicine 2017年第3期7卷 64-73页

作者： Michel Assane Ndour Leye Abdoulaye Fall Biram Codou Leye Yakham Mohamed Ndiaye Nafy Diack Ngoné Diaba Fall Aichetou Mbaye Alassane Diao Maboury Diop Moreira therese Department of Internal Medicine/Endocrinology National Pikine Hospital Center Dakar Senegal Department of Cardiology Center Hospital Aristide le Dantec Dakar Senegal Department of Cardiology National Hospital Center of Grand Yoff Dakar Senegal Department of Internal Medicine Center Hospital Aristide le Dantec Dakar Senegal Faculty of Medicine of Cheikh Anta Diop University of Dakar Dakar Senegal

Introduction: The resting electrocardiogram is generally called upon in the evaluation of cardiovascular risk in diabetics. Thus we proposed in this work to evaluate electrocardiographic changes in patients with type 2 diabetes. Methods: This was a cross-sectional and descriptive observation that took place from 1 January 2014 to 1 October 2014 in the Internal Medicine/Endocrinology Departments of Pikine National Hospital and Cardiology National Hospital of Grand-Yoff. results: One hundred (100) patients consisted of 43 male and 57 female diabetics. The sex ration male/female ratio was 0.7. The average age was 58.3 years. Men were twice as likely to be active as women. rhythm disorders were noted in 20% of patients, 13% of whom were women. right atrial hypertrophy was found in 11% of patients and left hypertrophy in both men and women (25%). Wolf-Parkinson White syndrome was present in 2% of patients. A complete right bundle block was present in 11% of patients. Primary repolarization disorders were noted in 17% of patients and secondary in 18% of patients, postero-diaphragmatic necrosis in 14% of patients, real posterior necrosis in 2% of patients, extensive anterior necrosis in 15% of patients. The QT interval was lengthened in 21% of patients including 14 women. Left ventricular hypertrophy was present in 33% of patients and right ventricular hypertrophy was found in 10% of patients. The bivariate analysis showed that electrocardiographic abnormalities were more correlated with the association of certain risk factors such as hypertension and dyslipidemia, the feminine gender, but also the poor glycemic balance. On the other hand, physical activity and treatment had a protective effect. Conclusion: The ECG is certainly insufficient for an exhaustive exploration of the heart of the diabetic patient, but still very useful in our conditions of exercise to improve the care of our patients.

关键词： Diabetes ECG Heart Dakar Cardiovascular Disease

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细胞色素C电化学反应的静电作用模型

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分析测试通报 1992年第5期11卷 24-27页

作者：陆天虹周成立叶淑玉于秀娟董绍俊 therese M.Cotton 中国科学院长春应用化学研究所 Department of Chemistry Iowa State UniversityAmesIowa 50011U.S.A.

首次发现,简单的阴离子Ⅰ^-是细胞色素c电化学反应的良好促进剂。在碘离子修饰的金电极上能观察到细胞色素c的准可逆电化学反应。根据细胞色素c的结构特点和碘离子的吸附特性,提出了一个以静电作用为基础的细胞色素c的电化学反应的模型。

关键词：碘离子细胞色素C 静电作用

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中国高龄老人健康状况和死亡率变动趋势

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人口学 2017年第6期 22-32页

作者：曾毅冯秋石 therese Hesketh Kaare Christensen James W.Vaupel

文章对“中国老年健康影响因素跟踪调查”近两万名80～105岁高龄老人的数据分析发现，社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被“救”存活率提高，使2008... 详细信息

文章对“中国老年健康影响因素跟踪调查”近两万名80～105岁高龄老人的数据分析发现，社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被“救”存活率提高，使2008年高龄老人客观量测的躯体功能和认知功能比10年前显著下降；这给社会和亿万家庭带来严峻挑战。研究表明，经济社会发展和人类寿命提高带来效益的同时，也会产生一定成本；但它不是以往不少国际文献解释这一现象时所称的“胜利的失败”，所以没有必要为此恐慌，而需要全社会积极应对，努力实现人口健康老龄化。

关键词：高龄老人生活自理能力躯体功能认知功能健康老龄化 oldest old activities of daily living physical performance cognitive function healthy aging

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SWISS LIGHT SHED ON EMBrYOS FrOM THE EDIACArAN AND CAMBrIAN

SWISS LIGHT SHED ON EMBRYOS FROM THE EDIACARAN AND CAMBRIAN

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第二届国际古生物学大会

作者： Philip C.J.DONOGHUE Stefan BENGTSON Neil J.GOSTLING therese HULDTGrEN Maria PAWLOWSKA Ceri-Wyn THOMAS Marco staMPANONI Department of Earth Sciences University of BristolBristol BS8 1RJUK Department of Palaeozoology Swedish Museum of Natural HistoryStockholmSweden Department of Earth Sciences University of BristolBristol BS8 1RJUK Department of Palaeozoology Swedish Museum of Natural HistoryStockholmSweden Department of Earth Sciences University of BristolBristol BS8 1RJUK Department of Earth Sciences University of BristolBristol BS8 1RJUK Swiss Light Source Paul Scherrer InstitutVilligenZürichSwitzerland

＜正＞The discovery of fossilised embryos in rocks laid down contemporaneously with the Cambrian explosion has begun to provide unforeseen insights into the role of embryology in the emergence of metazoan phyla, challenging cherished and long-held assumptions, such as the role of life history evolution in early metazoan evolution. realizing the full potential of these fossils, has however, been limited by traditional analytical techniques. Scanning electron microscopy provides only data on surface features, and while this may be overcome by thin sectioning, it is destructive and provides only a single two-dimensional window onto internal structure that may be difficult to interpret.

关键词： Ediacaran Cambrian fossilised embryos Synchrotron radiation X-ray Tomographic Microscopy

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Investigating Maternal Mortality at regina Pacis Hospital Mutengene and the Government Health Centre Mutengene, South West region, Cameroon

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Journal of Biosciences and Medicines 2020年第5期8卷 163-176页

作者： Ngwa Fabrice Ambe Tanyi Pride Bobga Mohamed Isah Ateh stanislas Ketum Carlson Babila Sama Acha Anwi therese Ngouateu Chrysal Beuadou Ebanja Silva Elonge Gabriel Thierry Pechap Ayafor Department of Medical Laboratory Sciences Faculty Health Sciences University of Buea Buea Cameroon Department of Microbiology and Parasitology Faculty of Science University of Buea Buea Cameroon Saint Louis Institute of Medical Sciences Douala Cameroon Department of Public Health and Hygiene Faculty Health Sciences University of Buea Buea Cameroon Department of Medicine Faculty Health Sciences University of Buea Buea Cameroon Western Sussex NHS Foundation Trust and School of Population Health Sciences Department of Global Health University College London London UK Department of International Public Health Liverpool School of Tropical Medicine Liverpool UK Tuberculosis reference Laboratory Bamenda Cameroon University of Alabama Birmingham USA

Background: One target under sustainable Development Goal 3 is to reduce the global maternal mortality ratio to less than 70 per 100,000 births, with no country having a maternal mortality rate of more than twice the global average. So there is a need to identify ways to reduce maternal mortality which is a top priority in development of the management of pregnant women and invention of equipment in procedures (caesarian section) to provide a maternal health and increase life survival. Objective: This study aimed to investigate the prevalence and causes of maternal mortality at regina Pacis Hospital and Government Health Center Mutengene. Method: This study was a retrospective study, where Data from 2007 to 2017 were collected from the hospital files using a checklist, descriptive and inferential statistics were used to analyse the data. Conclusion: From the finding, maternal mortality is at a pace of increase in the regina Pacis Hospital and Government Health Centre Mutengene and these health facilitiesmay fail to achieve the target of SDG3 by the end of 2030. Since, the overall prevalence of maternal mortality at both study sites was 240 per 100,000 live births at regina Pacis Hospital and Government Health Center Mutengene from 2007 to 2017, increase education of women of reproductive age on pregnancy care and training of hospital staff in obstetric management and health records documentation.

关键词： Maternal Mortality South West region Cameroon Pregnancy and Hemorrhage

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Assessment of HrP2-Based rDT in Diagnosing Malaria Cases

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Journal of Life Sciences 2012年第6期6卷 602-607页

作者： Yemou Dieng Doudou Sow therese Dieng Abdourahmane Sow Babacar Faye Jean Louis Ndiaye Daouda Ndiaye roger Cl6ment Tine Khadime Sylla Oumar Faye Oumar Ndir Oumar Gaye Department of Parasitology-Mycology Dakar Universite Cheikh Anta Diop Dakar Fann 5005 Senegal Department of Parasitology-Mycology Dakar Centre HospitaIier Universitaire National de Farm Dakar 5035 Senegal

Background： HrP2-based rapid Diagnostic Tests （rDTs） for malaria ensure a rational use of artemisinin-based combination therapy （ACT）. The HrP2 antigen can go through the cerebrospinal fluid （CSF）. Purpose： To assess the HrP2-based rDT in malaria and detect the HrP2 in CSF. Methods： From November 2006 to May 2007, all patients under 15 years showing clinical symptoms of malaria were included. rDT was performed on the CSF and peripheral blood. results： Out of the 951 patients included, 131 （13.7%） were confirmed through rDT and 130 （13.6%） through thick blood smear. Sensitivity and specificity stood at 96.96% and 99.71% respectively, for uncomplicated cases and at 100% and 99.13% for severe cases. Tests to detect HrP2 in the CSF of 52 cases were negative. Conclusion： Tests to detect HrP2 in the CSF could make it possible to diagnose severe malaria cases when peripheral parasitemia would be below the detection threshold.

关键词： Malaria rapid diagnostic test paediatrics HrP2 antigen cerebrospinal fluid

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Management of Post-Operative Pain after Gyneco-Obstetrical Surgery: Practice of Transversus Abdominis Plane Bloc (Tap Block) Echoguide at the Ignace Deen National Hospital

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Open Journal of Anesthesiology 2021年第10期11卷 316-324页

作者： Donamou Joseph Bangoura Almamy Touré Abdoulaye Camara Amadou Yalla Traoré Abdourahamane Dine Camara M’Mah Lamine Camara M’Mah Lamine Dramé Boubacar Atigou Camara Mariama Mohamed Orou Yerima therese Touré Aboubacar Anesthesia-Intensive Care Unit Donka National Hospital Conakry Guinea Anesthesia-Intensive Care Unit National Ignace Deen Hospital Conakry Guinea Medico-Surgical Emergency Department Donka National Hospital Conakry Guinea General and Visceral Surgery Department Ignace Deen National Hospital Conakry Guinea

Objectives: To describe the practice of ultrasound-guided TAP in the management of postoperative pain after gyneco-obstetric surgery. Methods: This was a descriptive prospective study carried out at the Gynecology-Obstetrics department of the Ignace Deen National Hospital over a period of three (03) months from February 01, 2020 to April 31, 2020. results: In total, we collected 95 patients. These patients had a mean age of 30 ± 9.5 years. The ASA I class was the most represented with 76% of the cases and the cesarean was the most performed intervention. regarding the assessment of the pain score by the simple verbal scale (SVE) postoperatively at rest, the mean SLE scores at H6 were 0.17 ± 0.38;at H12 of 1.15 ± 0.62;at H24 of 0.84 ± 0.51;at H36 0.45 ± 0.52 and at H48 0.09 ± 0.29. On mobilization, the mean pain scores were 0.77 ± 0.51 at H6, at H12 1.89 ± 0.61;at H24 of 1.53 ± 0.56;at H36 of 1 ± 0.29 and at H48 of 0.82 ± 0.44. The majority of our patients (66.3%) had a mobilization time of less than 24 hours. The mean length of stay was 3.1 ± 1.3 days and most patients (82%) were satisfied with the management of their pain by ultrasound-guided TAP block. Conclusion: Ultrasound-guided TAP is an effective technique for the management of postoperative pain in gyneco-obstetrics surgery. Its integration in a context of multimodal analgesia could improve the management of postoperative pain in gynecological obstetrics.

关键词： Postoperative Pain TAP Block Ultrasound Guidance Gyneco-Obstetrics

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Prevalence of hepatitis B infection and factors associated in children of Ivorian HBsAg carrier subjects

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Open Journal of Gastroenterology 2013年第4期3卷 237-240页

作者： Koffi Alain Attia Ya Henriette Kissi stanislas Doffou Demba Bangoura roseline Flora Wilson Georges Bougha Fulgence Yao Bathaix Kouame Alassan Mahassadi Mohamed Sayegh therese N’dri-Yoman Department of General Medicine and Hepato-Gastroenterology Teaching Hospital of Yopougon Abidjan Cote d’Ivoire Medical Private hospital of Danga Cocody Abidjan Cote d’Ivoire

Aims of the Study: 1) Determine the Prevalence of Hepatitis B virus (HBV) infection in children (contact subjects) of chronic Hepatitis B surface antigen (HBsAg) carrier subjects (index subjects);2) Search for factors associated with HBV infection in these children. Patients and Methods: retrospective-crosssectional study (January 5th, 2006 through December 31st, 2012). Studied parameters: biological and clinical characteristics of index subjects;Prevalence of HBsAg and Hepatitis B core antibody (HBcAb) in their children. Search for the HBV infection associated factors in the children (univariate analyses through Chi-square or Fisher’s exact test;multivariate analysis through a backward logistic regression). results: Our 44 subjects’ median age was 43.1 ± 7.49 years and 88.6% of them lived with a spouse. Average number of children per index subjects was 2.3 ± 1.1. Our 92 children’s median age was 9.3 ± 4.55 (ranging from 1 to 15 years), and 43 (44.8%) were vaccinated against HBV. HBV infection prevalence was 24% (23/96 of which, 4 were HBsAg positive and 19 HBcAb positive subjects without HBsAg). Independent factors associated with HBV infection in children of index subjects were HBV DNA for index subjects >2000 IU/ml (Or = 11.5;p = 0.001), existence of HBV in two parents (Or = 7.9;p = 0.03) and absence of HBV vaccination in the children (Or = 30.9;p = 0.003). Conclusion: Immunization coverage for children of index subjects was insufficient, especially before the introduction of HBV vaccine into the enlarged vaccination program. Outside vertical transmission, those children were more exposed to HBV intrafamilial transmission risk when they were not immunized against HBV, when both parents were infected and when HBV viremia in index subjects was higher than 2000 IU/ml.

关键词： Hepatitis B Infection Intrafamilial Transmission Screening

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