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Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients： insights from the Dartmouth Dynamic Registry

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Journal of Geriatric Cardiology 2018年第2期15卷 131-136页

作者： Shawn X Li Hannah I Chaudry Jiyong Lee theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries Dartmouth Geisel School of Medicine Hanover NH USA Department of Internal Medicine Dartmouth-Hitcheock Medical Center Lebanon NH USA Section of Cardiovascular Medicine Dartmouth-Hitchcock Medical Center Lebanon NH USA

Background Very elderly patients （age 〉 85 years） are a rapidly increasing segment of the population. As a group, they experience high rates of in-hospital mortality and bleeding complications following percutaneous coronary intervention （PCI）. However, the relationship between bleeding and mortality in the very elderly is unknown. Methods Retrospective review was performed on 17,378 consecutive PCI procedures from 2000 to 2015 at Dartmouth-Hitchcock Medical Center. Incidence of bleeding during the index PCI admission （bleeding requiring transfusion, access site hematoma 〉 5 cm, pseudoaneurysm, and retroperitoneal bleed） and in-hospital mortality were reported for four age groups （〈 65 years, 65-74 years, 75-84 years, and ≥ 85 years）. The mortality of patients who suffered bleeding complications and those who did not was calculated and multivariate analysis was performed for in-hospital mortality. Lastly, known predictors of bleeding were compared between patients age 〈 85 years and age ≥85 years. Results Of 17,378 patients studied, 1019 （5.9%） experienced bleeding and 369 （2.1%） died in-hospital following PCI. Incidence of bleeding and in-hospital mortality increased monotonically with increasing age （mortality： 0.94%, 2.27%, 4.24% and 4.58%; bleeding： 3.96%, 6.62%, 10.68% and 13.99% for ages 〈 65, 65-4, 75-84 and ≥ 85 years, respectively）. On multivariate analysis, bleeding was associated with increased mortality for all age groups except patients age ≥85 years [odds ratio （95% CI）： age 〈 65 years, 3.65 （1.99-6.74）; age 65-74 years, 2.83 （1.62-4.94）; age 75-84 years, 3.86 （2.56-5.82）, age ≥ 85 years 1.39 （0.49-3.95）]. Conclusions Bleeding and mortality following PCI increase with increasing age. For the very elderly, despite high rates of bleeding, bleeding is no longer predictive of in-hospital mortality following PCI.

关键词： Complications In-hospital mortality Percutaneous coronary intervention The elderly

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The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1361-1369页

作者： Dennis Y.Tse Seong Jae Kim Inyoung Chung Feng He theodore G.Wensel Samuel M.Wu Department of Ophthalmology Baylor College of MedicineHoustonTX 77030USA School of Optometry the Hong Kong Polytechnic UniversityHong KongChina Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju52727Korea Department of Biochemistry and Molecular Biology BaylorCollege of MedicineHoustonTX 77030USA

AIM：To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into ***：Forty-eight 6-8-week-old C57BL/6J mice were used in this *** was intravitreally injected into the right eye of each mouse;the left eye was injected with vehicle and was used as a *** dark-adapted electroretinography（ERG）was performed 1 and 7d following *** was examined using a combination of light,fluorescence and electron *** liquid chromatography（HPLC）was used to determine the decay in the retinal simvastatin ***：ERG revealed no significant changes in the simvastatin-injected eyes compared to *** studies showed normal retinal morphology in eyes injected with simvastatin up to a final vitreal concentration of 200μmol/*** significant changes in the number of photoreceptors,bipolar cells or ganglion cells were *** retinal simvastatin concentration decayed exponentially,with a half-life of ***：Intravitreal injection of up to 200μmol/L simvastatin produced no signs of adverse effects in the mouse *** reaches the retina shortly after intravitreal injectionand has a short half-life.

关键词： simvastatin retina electroretinography highperformance liquid chromatography electron microscopy intravitreal injection

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Multi-strategy engineering greatly enhances provitamin A carotenoid accumulation and stability in Arabidopsis seeds

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aBIOTECH 2021年第3期2卷 191-214页

作者： Tianhu Sun Qinlong Zhu Ziqing Wei Lauren AOwens Tara Fish Hyojin Kim theodore W.Thannhauser Edgar B.Cahoon Li Li Robert W.Holley Center for Agriculture and Health USDA-ARSCornell UniversityIthacaNY 14853USA Plant Breeding and Genetics Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Department of Biochemistry and Center for Plant Science Innovation University of Nebraska-LincolnLincolnNE 68588USA

Staple grains with low levels of provitamin A carotenoids contribute to the global prevalence of vitamin A deficiency and therefore are the main targets for provitamin A ***,carotenoid stability during both seed maturation and postharvest storage is a serious concern for the full benefits of carotenoid biofortified *** this study,we utilized Arabidopsis as a model to establish car-otenoid biofortification strategies in *** discovered that manipulation of carotenoid biosynthetic activity by seed-specific expression of Phytoene synthase(PSY)increases both provitamin A and total carotenoid levels but the increased carotenoids are prone to degradation during seed maturation and storage,consistent with previous studies of provitamin A biofortified *** contrast,stacking with Orange(OR^(His)),a gene that initiates chromopl ast biogenesis,dramatically enhances provitamin A and total carotenoid content and *** to 65-and 10-fold increases of β-carotene and total car-otenoids,res pectively,with provitamin A carotenoids composing over 63%were observed in the seeds containing OR^(His) and ***-expression of Homogen tisate geranylgeranyl transferase(HGGT)with OR^(His) and PSY further increases carotenoid accumulation and stability during seed maturation and ***,knocking-out of B-carotene hydroxylase 2(BCH2)by CRISPR/Cas9 not only potentially facilitates β-carotene accumulation but also minimizes the negative effect of carotenoid over production on seed germi *** findings provide new insights into various processes on carotenoid accu-mulation and stability in seeds and establish a multiplexed strategy to simultaneously target carotenoid biosynthesis,turnover,and stable storage for carotenoid biofortification in crop seeds.

关键词： Carotenoid PSY OR^(His) HGGT BCH2 Seed Metabolic engineering

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Foreign Manufacturing Multinationals and the Transformation of the Chinese Economy

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China's Foreign Trade 2011年第8期 42-45页

作者： theodore H.Moran 不详

1 The argument in brief China became the world＇s largest destination for foreign direct investment （FDI）, almost all of which is FDI in manufacturing and assembly, in 2003, before falling back into a solid second place. These FDI flows have revolutionized Chinas industrial base and shifted the composition of Chinese exports from low-skill intensive to high-skill intensive goods and services.

关键词：外国直接投资制造业中国跨国公司改造技术密集工业基地 FDI

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Retinal imaging and diagnostics

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Annals of Eye Science 2021年第3期 1-2页

作者： R.theodore Smith Department of Ophthalmology Icahn School of Medicine at Mount SinaiNew YorkNYUSA.

This special series is devoted to a broad range of breakthroughs in multimodal retinal imaging that will be of interest to all specialists,and to those in the many other disciplines that increasingly rely on imaging for research,diagnosis and clinical ***,the topics themselves are not broad,but are developed in enough detail to bring a depth of understanding to the most enquiring mind,one that might consider further applications.

关键词： diagnosis clinical breakthrough

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Management of primary retroperitoneal synovial sarcoma: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2019年第1期11卷 27-33页

作者： Aikaterini Mastoraki Dimitrios Schizas Ioannis S Papanikolaou George Bagias Nikolaos Machairas George Agrogiannis theodore Liakakos Nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Surgery National and Kapodistrian University of Athens Laikon Hospital Hannover Medical School Clinic for General Visceral and Transplant Surgery 3rd Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Pathology National and Kapodistrian University of Athens

BACKGROUND Synovial sarcoma(SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the ***, several cases of retroperitoneal SS(RSS) have been described. We herein report a case of RSS presented in our *** SUMMARY A 69-year-old female patient was admitted with a large, palpable, firm mass in the right abdominal space SS. Computerized tomography scan depicted a concentric, sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver. Subsequently, the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm. The final histological diagnosis of the tumour was grade II monophasic *** RSS is encountered in the biphasic type, the monophasic fibrous, and the monophasic epithelial category as well. Relevant clinical manifestations are not always documented at early stages. Therefore, the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis. Therapeutic approach happens often late when metastases at the lungs and the liver are apparent. Thus, 5-year survival rates remain low.

关键词： Retroperitoneal tumours Synovial sarcoma Case report Clinical presentation Diagnostic modalities Therapeutic management

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Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects

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Acta Pharmacologica Sinica 2006年第3期27卷 259-272页

作者： Irena MANOV Helen MOTANIS Idan FRUMIN theodore C IANCU Pediatric Research and Electron Microscopy Unit.Ruth and Baruch Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa Israel

With the increasing incidence of drug-induced liver disease,attempts are beingmade to better understand the mechanisms behind these frequently life-endan-gering *** and anti-inflammatory drugs are a major group ex-hibiting *** review research relating to these reactions,focusingon ultrastructural findings,which may contribute to the comprehension and pos-sible avoidance of drug-induced liver *** also present some originalobservations on clinical material and cultured cells exposed to acetaminophenalone or in combination with the antioxidant N-acetylcysteine or the P-glycopro-tein inhibitor verapamil.

关键词： non-steroidal anti-inflammatory agents drug toxicity liver aspirin acetaminophen cultured cells electron microscopy apoptosis P-glycoprotein acetylcysteine

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Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle

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World Journal of Gastrointestinal Oncology 2022年第5期14卷 959-972页

作者： Christos Liatsos Apostolis Papaefthymiou Nikolaos Kyriakos Michail Galanopoulos Michael Doulberis Marios Giakoumis Evangelia Petridou Christos Mavrogiannis theodore Rokkas Jannis Kountouras Department of Gastroenterology 401 General Military Hospital of AthensAthens 11525Greece Gastroenterology University Hospital of LarissaLarissa 41336Greece Division of Gastroenterology and Hepatology Medical University DepartmentKantonsspital AarauAarau 1234Switzerland Department of Microbiology “Agia Sofia”Paediatric HospitalGoudiAthens 11527Greece Gastrointestinal and Liver Unit Faculty of NursingKifissia General and Oncology HospitalKaliftakiN.Kifisia 14564Greece Gastroenterological Clinic Henry Dunant HospitalAthens 11525Greece Department of Internal Medicine Second Medical ClinicIppokration HospitalAristotle University of ThessalonikiThessaloniki 41336MacedoniaGreece

Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric *** normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(***)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant *** studies indicate that *** has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the *** comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of ***(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains ***-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis *** *** eradication is suggested to restore gastric microbiota,at least in primary *** is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to *** studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by *** as well as on the relationships between the gastric microbiota and gastric carcinogenesis.

关键词： Helicobacter pylori infection Gastric microbiota Gastric cancer Oncogenesis Dysbiosis Helicobacter pylori eradication

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A review: Challenges and opportunities for artificial intelligence and robotics in the offshore wind sector

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能源与人工智能(英文) 2022年第2期8卷 177-212页

作者： Daniel Mitchell Jamie Blanche Sam Harper theodore Lim Ranjeetkumar Gupta Osama Zaki Wenshuo Tang Valentin Robu Simon Watson David Flynn Smart Systems Group Institute of SensorsSignals and SystemsSchool of Engineering and Physical SciencesHeriot-Watt UniversityEdinburghEH144ASUnited Kingdom Centre for Mathematics and Computer Science Intelligent and Autonomous Systems GroupCWIAmsterdam1098 XG Netherlands Algorithms Group Faculty of Electrical EngineeringMathematics and Computer Science(EEMCS)Delft University of Technology(TU Delft)Delft2628 XE Netherlands The University of Manchester Department of Electrical and Electronic EngineeringOxford RoadManchesterM139PL United Kingdom James Watt School of Engineering University of GlasgowG128QQUnited Kingdom

The UK has set plans to increase offshore wind capacity from 22GW to 154GW by 2030. With such tremendous growth, the sector is now looking to Robotics and Artificial Intelligence (RAI) in order to tackle lifecycle service barriers as to support sustainable and profitable offshore wind energy production. Today, RAI applications are predominately being used to support short term objectives in operation and maintenance. However, moving forward, RAI has the potential to play a critical role throughout the full lifecycle of offshore wind infrastructure, from surveying, planning, design, logistics, operational support, training and decommissioning. This paper presents one of the first systematic reviews of RAI for the offshore renewable energy sector. The state-of-the-art in RAI is analyzed with respect to offshore energy requirements, from both industry and academia, in terms of current and future requirements. Our review also includes a detailed evaluation of investment, regulation and skills development required to support the adoption of RAI. The key trends identified through a detailed analysis of patent and academic publication databases provide insights to barriers such as certification of autonomous platforms for safety compliance and reliability, the need for digital architectures for scalability in autonomous fleets, adaptive mission planning for resilient resident operations and optimization of human machine interaction for trusted partnerships between people and autonomous assistants. Our study concludes with identification of technological priorities and outlines their integration into a new ‘symbiotic digital architecture’ to deliver the future of offshore wind farm lifecycle management.

关键词： Artificial intelligence Autonomous systems Digitalization Offshore renewable energy Offshore wind farms Robotics

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基于攻击行为预测的网络防御策略

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浙江大学学报（工学版） 2014年第12期48卷 2144-2151,2229页

作者：任午令赵翠文姜国新 David Maimon theodore Wilson Bertrand Sobesto 浙江工商大学网络信息中心浙江杭州310018 浙江工商大学计算机与信息工程学院浙江杭州310018 马里兰大学克拉克工程学院马里兰州美国md20742

为了有效阻止网络攻击行为,提出一种基于攻击行为预测的网络攻击防御方法.针对入侵者的攻击行为具有强的随机性和不确定性,部署高交互蜜罐网络,采集入侵者攻入主机后的攻击数据,构建攻击状态转移图;利用隐马尔可夫模型(HMM)具有较为精... 详细信息

为了有效阻止网络攻击行为,提出一种基于攻击行为预测的网络攻击防御方法.针对入侵者的攻击行为具有强的随机性和不确定性,部署高交互蜜罐网络,采集入侵者攻入主机后的攻击数据,构建攻击状态转移图;利用隐马尔可夫模型(HMM)具有较为精确的似然度概率计算的特点,设计网络攻击行为预测模型.以攻击行为预测模型为核心,结合常用的入侵防御系统,构建主动防御策略,并开发相应的原型系统,将之部署到真实的网络系统中进行攻击实验.通过累计5个月真实数据的训练和验证,预测模型的准确率达到80%.结果表明该策略具有良好的网络攻击对抗性,可有效地用于预防网络攻击.

关键词：蜜罐网络隐马尔可夫模型入侵防御系统

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