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Sleep,immunity and inflammation in gastrointestinal disorders

World Journal of Gastroenterology 2013年第48期19卷 9231-9239页

作者： Tauseef Ali James Choe Ahmed Awab theodore l wagener William C Orr Inflammatory Bowel Disease Center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Department of Medicine University of Oklahoma Health Science Center Oklahoma City OK 73104 United States Department of Medicine Section of Pulmonary and Critical Care Oklahoma City OK 73104 United States Department of Pediatrics University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States lynn Health Science Institute Oklahoma City OK 73112 United States

Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research *** estimated 70 million Americans suffer from some form of sleep *** sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance *** research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause *** research studies support the associations among sleep,immune function and ***,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal *** physiologic processes including immune system and inflammatory cytokines help regulate the *** inflammatory cytokines such as tumor necrosis factor,interleukin-1(Il-1),and Il-6 have been shown to be a significant contributor of sleep *** the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory *** in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal *** turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal *** of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients.

关键词： Sleep Immune function Immunity Irritable bowel syndrome Inflammatory bowel disease Gastroesophageal reflux disease liver disorders Colon cancer Circadian rhythm

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Ranking academic institutions based on the productivity,impact,and quality of institutional scholars

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Journal of Data and Information Science 2024年第3期9卷 116-154页

作者： Amir Faghri theodore l.Bergman Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical Engineering University of KansasLawrenceKS 66045USA

Purpose:The quantitative rankings of over 55,000 institutions and their institutional programs are based on the individual rankings of approximately 30 million scholars determined by their productivity,impact,and ***/methodology/approach:The institutional ranking process developed here considers all institutions in all countries and regions,thereby including those that are established,as well as those that are emerging in scholarly *** of individual scholars worldwide are first generated using the recently introduced,fully indexed ScholarGPS *** rankings of individual scholars are extended here to determine the lifetime and last-five-year Top 20 rankings of academic institutions over all Fields of scholarly endeavor,in 14 individual Fields,in 177 Disciplines,and in approximately 350,000 unique *** associated with five specific Fields(Medicine,Engineering&Computer Science,life Sciences,Physical Sciences&Mathematics,and Social Sciences),and in two Disciplines(Chemistry,and Electrical&Computer Engineering)are presented as examples,and changes in the rankings over time are ***:For the Fields considered here,the Top 20 institutional rankings in Medicine have undergone the least change(lifetime versus last five years),while the rankings in Engineering&Computer Science have exhibited significant *** evolution of institutional rankings over time is largely attributed to the recent emergence of Chinese academic institutions,although this emergence is shown to be highly Field-and *** implementations:Existing rankings of academic institutions have:(i)often been restricted to pre-selected institutions,clouding the potential discovery of scholarly activity in emerging institutions and countries;(ii)considered only broad areas of research,limiting the ability of university leadership to act on the assessments in a concrete manner,or in contrast;(iii)have considered only a narrow are

关键词： Academic institution ranking Top institutional scholars ScholarGPS

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Deciphering “the language of nature”: A transformer-based language model for deleterious mutations in proteins

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The Innovation 2023年第5期4卷 47-58页

作者： theodore T.Jiang li Fang Kai Wang Raymond G.Perelman Center for Cellular and Molecular Therapeutics Children's Hospital of PhiladelphiaPhiladelphiaPA 19104USA Palisades Charter High School Pacific PalisadesCA 90272USA Massachusetts Institute of Technology CambridgeMA 02139USA Department of Genetics and Biomedical Informatics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Pathology and laboratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Various machine-learning models,including deep neural network models,have already been developed to predict deleteriousness of missense(non-synonymous)*** improvements to the current state of the art,however,may still benefit from a fresh look at the biological problem using more sophisticated self-adaptive machine-learning *** advances in the field of natural language processing show that transformer models—a type of deep neural network—to be particularly powerful at modeling sequence information with context *** this study,we introduce MutFormer,a transformer-based model for the prediction of deleterious missense mutations,which uses reference and mutated protein sequences from the human genome as the primary *** takes advantage of a combination of self-attention layers and convolutional layers to learn both long-range and short-range dependencies between amino acid mutations in a protein *** first pre-trained MutFormer on reference protein sequences and mutated protein sequences resulting from common genetic variants observed in human *** next examined different fine-tuning methods to successfully apply the model to deleteriousness prediction of missense ***,we evaluated MutFormer’s performance on multiple testing datasets.

关键词： delete prediction apply

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Hierarchically Structured Nanocomposites via a“Systems Materials Science”Approach

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Accounts of Materials Research 2022年第12期3卷 1248-1259页

作者： Rebecca l.li Carl J.Thrasher theodore Hueckel Robert J.Macfarlane Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

CONSPECTUS:Nanocomposite materials can achieve desirable characteristics otherwise unavailable to single component systems,making them attractive platforms to precisely modulate a material’s mechanical,electromagnetic,thermal,and optical *** these properties are often dependent on the organization of constituent materials just as much as their relative composition,intentionally programming composite properties requires hierarchical structural control across many length ***,the fundamental forces governing the atomic,molecular,nanoscale,microscale,and macroscale composition and structure of a material are all interlinked,and thus must be manipulated simultaneously to properly create ideal designer materials.

关键词： properties composite composites

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心肌梗塞并发休克的处理现状

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国外医学（心血管疾病分册） 1989年第6期16卷 328-330页

作者： theodore l 刘霞

作者介绍了急性心肌梗塞并发休克的出现率和短期预后,讨论了心源性休克的发病机理,临床表现,应急处理,急诊左心导管检查和治疗效果。

关键词：心肌梗塞休克并发症

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Chemistry-The Central Science 影印

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丛书名：时代教育·国外高校优秀教材精选

2003年

作者： Brown theodore l.

Includes index.

ISBN: (纸本)7111114930

Includes index.

关键词： Chemistry.

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Partial Unlock for COVID-19-like Epidemics Can Save 1 - 3 Million lives Worldwide

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Open Journal of Epidemiology 2020年第3期10卷 283-302页

作者： Robert l. Shuler theodore Koukouvitis Dyske Suematsu Shuler Research Houston USA

Background: A large percentage of deaths in an epidemic or pandemic can be due to overshoot of population (herd) immunity, either from the initial peak or from planned or unplanned exit from lockdown or social distancing conditions. Objectives: We study partial unlock or reopening interaction with seasonal effects in a managed epidemic to quantify overshoot effects on small and large unlock steps and discover robust strategies for reducing overshoot. Methods: We simulate partial unlock of social distancing for epidemics over a range of replication factor, immunity duration and seasonality factor for strategies targeting immunity thresholds using overshoot optimization. Results: Seasonality change must be taken into account as one of the steps in an easing sequence, and a two-step unlock, including seasonal effects, minimizes overshoot and deaths. It may cause undershoot, which causes rebounds and assists survival of the pathogen. Conclusions: Partial easing levels, even low levels for economic relief while waiting on a vaccine, have population immunity thresholds based on the reduced replication rates and may experience overshoot as well. We further find a two-step strategy remains highly sensitive to variations in case ratio, replication factor, seasonality and timing. We demonstrate a three or more step strategy is more robust, and conclude that the best possible approach minimizes deaths under a range of likely actual conditions which include public response.

关键词： Epidemic Partial Unlock Social Distancing Overshoot COVID-19 SARS-CoV-2

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Chemistry: : the central science 8th ed.

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2000年

作者： Brown theodore l

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Data Selection Using Support Vector Regression

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Advances in Atmospheric Sciences 2015年第3期32卷 277-286页

作者： Michael B.RICHMAN lance M.lESlIE theodore B.TRAFAlIS Hicham MANSOURI School of Meteorology and Cooperative Institute for Mesoscale Meteorological Studies University of OklahomaNorman Oklahoma 73072 USA School of Industrial and Systems Engineering University of OklahomaNorman Oklahoma 73019 USA Power Costs Inc. 301 David L.Boren Blvd.Suite 2000 Norman Oklahoma 73072 USA

Geophysical data sets are growing at an ever-increasing rate,requiring computationally efficient data selection （thinning） methods to preserve essential ***,such as WindSat,provide large data sets for assessing the accuracy and computational efficiency of data selection techniques.A new data thinning technique,based on support vector regression （SVR）,is developed and *** manage large on-line satellite data streams,observations from WindSat are formed into subsets by Voronoi tessellation and then each is thinned by SVR （TSVR）.Three experiments are *** first confirms the viability of TSVR for a relatively small sample,comparing it to several commonly used data thinning methods （random selection,averaging and Barnes filtering）,producing a 10％ thinning rate （90％ data reduction）,low mean absolute errors （MAE） and large correlations with the original data.A second experiment,using a larger dataset,shows TSVR retrievals with MAE ＜ 1 m s-1 and correlations ≥ *** was an order of magnitude faster than the commonly used thinning methods.A third experiment applies a two-stage pipeline to TSVR,to accommodate online *** pipeline subsets reconstruct the wind field with the same accuracy as the second experiment,is an order of magnitude faster than the nonpipeline ***,pipeline TSVR is two orders of magnitude faster than commonly used thinning methods that ingest the entire data *** study demonstrates that TSVR pipeline thinning is an accurate and computationally efficient alternative to commonly used data selection techniques.

关键词： data selection data thinning machine learning support vector regression Voronoi tessellation pipeline methods

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A New Control Approach of a Three-Phase Inverter Two levels

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Open Journal of Energy Efficiency 2022年第3期11卷 55-70页

作者： François Yonga Colince Welba theodore louossi Noël Djongyang Department of Renewable Energies National Higher Polytechnic School of Maroua University of Maroua Maroua Cameroon Department of Fundamental Sciences National Advanced School of Mines and Petroleum Industries University of Maroua Maroua Cameroon

In this paper, we present the study, modelling and simulation of the duty cycle modulation (DCM) based on SVPWM control technique using Matlab/Simulink software. It is one of the most advanced control techniques of space vector modulation (SVM), which can be used for controlling static converters or for controlling electrical machines to achieve better dynamic performance. DCSVM is a control technique that generates control signals for the two-level voltage converter as well as for the intermediate times. The main advantage of this control technique is the reduction of the number of calculations, especially for the trigonometric functions and the generation of the reference voltage. In order to reduce the computational effort, we have designed a DCSVM controller that is able to faithfully reproduce the same vectors and output quantities as a classical SVM. In order to test the functionality and validity of the DCSVM control, we have developed different simulations that result in a total harmonic distortion (THD) of the voltage and current of 41.19% and 15.19% respectively with fundamental values of 61.51 V for the voltage and 2.80 A for the current;in contrast to the SVM which gives 47.27 V for the voltage and 2.01 A for the current with THDs of 77.16% for the voltage and 16.00% for the current. This results in an improvement in the distortion rate of around 25.5%. The results obtained are very satisfactory. The DCSVM is a real competitor to the SVM and its various variants.

关键词： Inverter SVM (Space Vector Modulation) DCSVM (Duty Cycle Space Vector Modulation) Harmonic THD (Total Harmonic Distorsion)

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