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Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects

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Acta Pharmacologica Sinica 2006年第3期27卷 259-272页

作者： Irena MANOV Helen MOTANIS Idan FRUMIN theodore c IANcU Pediatric Research and Electron Microscopy Unit.Ruth and Baruch Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa Israel

With the increasing incidence of drug-induced liver disease,attempts are beingmade to better understand the mechanisms behind these frequently life-endan-gering *** and anti-inflammatory drugs are a major group ex-hibiting *** review research relating to these reactions,focusingon ultrastructural findings,which may contribute to the comprehension and pos-sible avoidance of drug-induced liver *** also present some originalobservations on clinical material and cultured cells exposed to acetaminophenalone or in combination with the antioxidant N-acetylcysteine or the P-glycopro-tein inhibitor verapamil.

关键词： non-steroidal anti-inflammatory agents drug toxicity liver aspirin acetaminophen cultured cells electron microscopy apoptosis P-glycoprotein acetylcysteine

On resolution to Wu's conjecture on cauchy function's exterior singularities

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Acta Mechanica Sinica 2011年第3期27卷 309-317页

作者： theodore Yaotsu Wu california Institute of Technology

This is a series of studies on Wu＇s conjecture and on its resolution to be presented herein. Both are devoted to expound all the comprehensive properties of cauchy＇s function f（z）（z = x ＋ iy） and its integral J[f（z）]≡（2πi）-∮cf（t）（t-z）-1dt taken along the unit circle as contour c,inside which（the open domain D＋） f（z） is regular but has singularities distributed in open domain Doutside c. Resolution is given to the inverse problem that the singularities of f（z） can be determined in analytical form in terms of the values f（t） of f（z） numerically prescribed on c（｜t｜ = 1） ,as so enunciated by Wu＇s conjecture. The case of a single singularity is solved using complex algebra and analysis to acquire the solution structure for a standard reference. Multiple singularities are resolved by reducing them to a single one by elimination in principle,for which purpose a general asymptotic method is developed here for resolution to the conjecture by induction,and essential singularities are treated with employing the generalized Hilbert transforms. These new methods are applicable to relevant problems in mathematics,engineering and technology in analogy with resolving the inverse problem presented here.

关键词： Keywords cauchy function. Singularity distribution . Wu's conjecture - Resolution by induction

On the generalized cauchy function and new conjecture on its exterior singularities

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Acta Mechanica Sinica 2011年第2期27卷 135-151页

作者： theodore Yaotsu Wu california Institute of Technology Pasadena CA 91125 USA

This article studies on cauchy’s function f （z） and its integral, （2πi）J[ f （z）] ≡ ■c f （t）dt/（t z） taken along a closed simple contour c, in regard to their comprehensive properties over the entire z = x ＋ iy plane consisted of the simply connected open domain D ＋ bounded by c and the open domain D outside c. （1） With f （z） assumed to be c n （n ∞-times continuously differentiable） z ∈ D ＋ and in a neighborhood of c, f （z） and its derivatives f （n）（z） are proved uniformly continuous in the closed domain D ＋ = [D ＋＋ c]. （2） cauchy’s integral formulas and their derivatives z ∈ D ＋（or z ∈ D ） are proved to converge uniformly in D ＋（or in D = [D ＋c]）, respectively, thereby rendering the integral formulas valid over the entire z-plane. （3） The same claims （as for f （z） and J[ f （z）]） are shown extended to hold for the complement function F（z）, defined to be c n z ∈ D and about c. （4） The uniform convergence theorems for f （z） and F（z） shown for arbitrary contour c are adapted to find special domains in the upper or lower half z-planes and those inside and outside the unit circle ｜z｜ = 1 such that the four general- ized Hilbert-type integral transforms are proved. （5） Further, the singularity distribution of f （z） in D is elucidated by considering the direct problem exemplified with several typ- ical singularities prescribed in D . （6） A comparative study is made between generalized integral formulas and Plemelj’s formulas on their differing basic properties. （7） Physical sig- nificances of these formulas are illustrated with applicationsto nonlinear airfoil theory. （8） Finally, an unsolved inverse problem to determine all the singularities of cauchy function f （z） in domain D , based on the continuous numerical value of f （z） z ∈ D ＋ = [D ＋＋ c], is presented for resolution as a conjecture.

关键词： Uniform continuity of cauchy’s function · Uni- form convergence of cauchy’s integral formula · Generalized Hilbert-type integral transforms · Functional properties and singularity distributions

Virtual endoscopy of the urinary tract

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Asian Journal of Andrology 2006年第1期8卷 31-38页

作者： George c.Kagadis Dimitrios Siablis Evangelos N.Liatsikos theodore Petsas George c. Nikiforidis Department of Medical Physics Department of Radiology Department of Urology School of MedicineUniversity of PatrasGR 26500 RionGreece Department of Radiology Department of Medical Physics

Technological breakthroughs have advanced the temporal and spatial resolutions of diagnostic imaging, and 3 dimensional （3-D） reconstruction techniques have been introduced into everyday clinical practice. Virtual endoscopy （VE） is a non-invasive technique that amplifies the perception of cross-sectional images in the 3-D space, providing precise spatial relationships of pathological regions and their surrounding structures. A variety of computer algorithms can be used to generate 3-D images, taking advantage of the information inherent in either spiral computed tomography or magnetic resonance imaging （MRI）. VE images enable endoluminal navigation through hollow organs, thus simulating conventional endoscopy. Several clinical studies have validated the diagnostic utility of virtual cystoscopy, which has high sensitivity and specificity rates in the detection of bladder tumor. Published experience in the virtual exploration of the renal pelvis, ureter and urethra is encouraging but still scarce. VE is a safe, non-invasive method that could be applied in the long-term follow-up of patients with ureteropelvic junction obstruction, urinary bladder tumors and ureteral and/or urethral strictures. Its principal limitations are the inability to provide biopsy tissue specimens for histopathologic examination and the associated ionizing radiation hazards （unless MR/is used）. However, in the case of endoluminal stenosis or obstruction, VE permits virtual endoluminal navigation both cephalad and caudal to the stenotic segment. To conclude, VE provides a less invasive method of evaluating the urinary tract, especially for clinicians who are less familiar with cross-sectional imaging than radiologists. （Asian J Androl 2006 Jan; 8： 31-38）

关键词： computed tomography three-dimensional imaging virtual endoscopy urethral stricture

Sleep,immunity and inflammation in gastrointestinal disorders

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World Journal of Gastroenterology 2013年第48期19卷 9231-9239页

作者： Tauseef Ali James choe Ahmed Awab theodore L Wagener William c Orr Inflammatory Bowel Disease center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Department of Medicine University of Oklahoma Health Science Center Oklahoma City OK 73104 United States Department of Medicine Section of Pulmonary and Critical Care Oklahoma City OK 73104 United States Department of Pediatrics University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Lynn Health Science Institute Oklahoma City OK 73112 United States

Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research *** estimated 70 million Americans suffer from some form of sleep *** sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance *** research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause *** research studies support the associations among sleep,immune function and ***,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal *** physiologic processes including immune system and inflammatory cytokines help regulate the *** inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep *** the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory *** in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal *** turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal *** of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients.

关键词： Sleep Immune function Immunity Irritable bowel syndrome Inflammatory bowel disease Gastroesophageal reflux disease Liver disorders colon cancer circadian rhythm

New insights on premature ejaculation： a review of ：lefinition, classification, prevalence and treatmeni

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Asian Journal of Andrology 2012年第6期14卷 822-829页

作者： Ege c Serefoglu theodore R Saitz Tulane University School of Medicine Department of Urology New Orleans LA 70112 USA

There are ongoing debates about the definition, classification and prevalence of premature ejaculation （PE）. The first evidence-based definition of PE was limited to heterosexual men with lifelong PE who engage in vaginal intercourse. Unfortunately, many patients with the complaint of PE do not meet these criteria. However, these men can be diagnosed as one of the PE subtypes, namely acquired PE, natural variable PE or premature-like ejaculatory dysfunction. Nevertheless, the validity of these subtypes has not yet been supported by evidence. The absence of a universally accepted PE definition and lack of standards for data acquisition have resulted in prevalence studies that have reported conflicting rates. The very high prevalence of 20%-30% is probably due to the vague terminology used in the definitions at the time when such surveys were conducted. Although many men may complain of PE when questioned for a population-based prevalence study, only a few of them will actively seek treatment for their complaint, even though most of these patients would define symptoms congruent with PE. The complaints of acquired PE patients may be more severe, whereas complaints of patients experiencing premature-like ejaculatory dysfunction seem to be least severe among men with various forms of PE. Although numerous treatment modalities have been proposed for management of PE, only antidepressants and topical anaesthetic creams have currently been proven to be effective. However, as none of the treatment modalities have been approved by the regulatory agencies, further studies must be carried to develop a beneficial treatment strategy for PE.

关键词： definition ejaculatory disorders epidemiology premature ejaculation sexual dysfunction treatment

Transthoracic echo: A sensitive tool for detecting cardiac extension of renal cell carcinoma?

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World Journal of clinical cases 2014年第8期2卷 377-379页

作者： Michelle Bejarano Yara L cameron theodore c Koutlas Assad Movahed Department of cardiovascular Sciences East Carolina Heart Institute and Brody School of MedicineGreenvilleNC 27834United States

Renal cell carcinoma is a common urological malignancy with the unique ability to invade the inferior vena cava(IVc) and to extend into the right atrium of the heart. Of those with Renal cell carcinoma only 4%-25% are found to have IVc invasion and of those only 2%-10% extend into the right atrium. If treated surgically, extension of tumor thrombus is not a determinant of survival; therefore it is imperative to determine the presence and extent of tumor thrombus in order to determine surgical approach and tumor resection. To date this has been primarily accomplished by magnetic resonance imaging and computed tomography. We present a case of 61 years old African American woman in which transthoracic echocardiography provided a more accurate determination/characterization of the presence and degree of tumor thrombus and extension.

关键词： Renal cell carcinoma Tumor thrombus cardiac extension Right atrial mass

Excited electronic states and internal conversion in cyanocobalamin

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chinese chemical Letters 2015年第4期26卷 439-443页

作者： theodore E.Wiley Brenden c.Arruda Nicholas A.Miller Michael Lenard Roseanne J.Sension Department of chemistry University of Michigan

cyanocobalamin （cNcbl） is a paradigm system for the study of excited electronic states and biological cofactors including the B12 vitamers, The photophysics of cNcbl has been thoroughly investigated using both ultrafast spectroscopy and time dependent density functional theory （TD-DFT）. Here we review the spectroscopic and theoretical investigations of cNcbl with emphasis on the nature of S1, the lowest excited electronic state, and extend the spectroscopic measurements to include the ultraviolet region of the spectrum. Ultrafast transient absorption measurements in the visible αβ band region and in the mid- infrared led to assignment of the S1 state to a ligand-to-metal charge transfer （LMcT） with lengthened axial bonds and a ~3 kcal/mol harrier for internal conversion to the ground state. The present measurements encompassing the y band region of the spectrum provide further support for the assignment of the S1 state. The experiments are in good agreement with the results of TD-DFT calculations which confirm the expected lengthening of the axial bonds in S1 and account for the observed barrier for internal conversion back to the ground state,

关键词： cyanocobalaminExcited electronic statesUltrafast spectroscopyTime dependent density functional theoryLigand-to-metal charge transfer

Numerical Blow-up for a Nonlinear Heat Equation

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Acta Mathematica Sinica,English Series 2011年第5期27卷 845-862页

作者： Firmin K. N'GOHISSE theodore K. BONI Universite d'Abobo-Adjame UFR-SFA Departement de Mathematiques et Informatique 01 BP 1003 Abidjan 01 Cdte d'Ivoire Institut National Polytechnique Houphouet-Boigny de Yamoussoukro BP 1093 Yamoussoukro Cote d'Ivoire

This paper concerns the study of the numerical approximation for the following initialboundary value problem{ut-uzx=f（u）,t∈（0,1）,t∈（0,T） u（0,t）=0,t∈（0,1）,t∈（0,T） u（x,0）=u0（x）,x∈（0,1）where f（s） is a positive, increasing, c1 convex function for the nonnegative values of s, f（0）〉0, f∞ds/f（s）〈∞, u0∈c1（[0, 1]）, u0（0） = 0, u＇0（1）=0. We find some conditions under which the solution of a semidiscrete form of the above problem blows up in a finite time and estimate its semidiserete blow-up time. We also prove the convergence of the semidiscrete blow-up time to the theoretical one. A similar study has been also undertaken for a discrete form of the above problem. Finally, we give some numerical results to illustrate our analysis.

关键词： Semidiscretization blow-up numerical blow-up time nonlinear heat equations