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Probability parametric imaging with DCE-MRI data to identify prostate cancer in the peripheral zone

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Progress in Natural Science:Materials International 2006年第9期16卷 948-953页

作者： HUANG Xinrui, WANG Qiang, XU Yufeng, WANG Xiaoying and BAO Shanglian ( The Key Laboratory of medical Physics and Engineering, peking university, {3. 100871, China the medical school of peking university, {3. 100083. China 3. The First Hospital of peking university, {3. 10003., China) [a]The key Laboratory of medical Physics and Engineering Peking University Beijing China [b]the medical school of peking university Beijing China [c]The First Hospital of peking university Beijing China

To quantitatively analyze prostate dynamic contrast-enhanced magnetic resonance images (DCE-MRI), a retrospective study was carried out to construct a mathematical model to predict whether a lesion is cancerous or not. With known diagnosis of 52 re-gions-of-interest (10 malignant, 26 benign and 16 normal) in peripheral zone (PZ) of prostate from 18 patients undergoing needle biopsy and 8 normal volunteers, we combined feature parameters (k1, k2 and tp) from the linear-slope model with logistic regression to determine the statistical probability model. Prostate cancerous probability maps were derived using the model on each subject to examine the correlation between the model-based prediction and the known diagnosis. Compared the model prediction results of 52 regions-of-interest with the histopathologic results, the total agreement rate was 90.4 % ; the agreement rate was 60 % for the malignant and 97. 6 % for the nonmalignant. The diagnostic results only referencing the probability maps by two radiologists showed a high agreement in tissue characteristics and lesion location with the combining results from other diagnostic techniques such as PSA (prostate specific antigen) level and MRS (magnetic resonance spectroscopy) .

关键词： time-intensity curve prostate DCE-MRI logistic regression probability parametric image.

β2 Adrenergic receptor on T lymphocytes and its clinical implications

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Progress in Natural Science:Materials International 2009年第1期19卷 17-23页

作者： Xuelai Fan a,Yuedan Wang b,a peking university,school of Pharmaceutical Sciences,{3. 100083.China b peking university,school of Basic medical Sciences,{3. 100083.China [a]peking university School of Pharmaceutical Sciences Beijing 100083 China [b]Peking University School of Basic Medical Sciences Beijing 100083 China

Sustained complex cross-talk between the immune system and the nervous system plays a vital role in retaining homeostasis in a healthy *** of the central regulatory mechanisms involved is the existence and functions of β2-adrenergic receptors(β2AR) on T *** article reviews research progress made recently,including the expression of adrenergic receptors on T lymphocytes,the structure and intracellular pathways of β2AR,the activation of β2AR by either endogenous or exogenous agonists,and the effect of β2AR stimulation on T cells which alters T cell proliferation,differentiation,cytokine production and T-helper-mediated antibody ***,we discuss the roles of β2AR played in the pathogenesis and treatment of autoimmune diseases.

关键词： Neuroimmunology β2-adrenergic receptor T cell Autoimmune

Mapping the Antigenic Peptides of Sm26/2 in Glutathione S-Transferases of Schistosoma Mansoni

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Chinese Chemical Letters 1998年第4期9卷 377-379页

作者： Jia Xi XU Meng Shen CAI(College of Chemistry and Molecular Engineering, peking university, beijing 100871 ({3. of Pharmaceutical Sciences, beijing medical university, beijing 100083. peking Univ Coll Chem & Mol Engn Beijing 100871 Peoples R China beijing Med Univ Sch Pharmaceut Sci Beijing 100083 Peoples R China

Six antigenic peptides of Sm26/2 glutathione S-transferase of schistosoma mansoni have been predicted according to their hydrophilicity, flexibility, accessibility, charge distribution and beta-turn in the secondary structure by the determination of its primary structure, and synthesized by solid phase method. Two of them showed good antigenicity by Dot-ELISA. They would be candidate peptides of synthetic anti-schistosomal vaccine.

关键词： schistosoma mansoni glutathione S-transferase antigenic peptide peptide vaccine

Prediction, Synthesis and Antigenicity of the Antigenic Peptides of 26kDa Glutathione S-Transferasc of Schistosoma Japonicum (Sj26)

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Chinese Chemical Letters 1999年第1期10卷 27-28页

作者： Jia Xi XU Meng Shen CAI(College of Chemistry and Molecular Engineering, peking university, beijing 100871)({3. of Pharmaceutical Sciences, beijing medical university. beijing 100083. Coll. of Chem. and Molec. Eng. Peking University Beijing 100871 China school of Pharmaceutical Sciences Beijing Medical University Beijing 100083 China

Six antigenic peptides of 26 kDa glutathione S-transferase of Schistosoma japonicum(Sj26) have been predicted according to their hydrophilicity, flexibility. accessibility. chargedistribution and β -turn in the secondary structure by the determination of its primary structure andsynthesized by solid phase method. All of them showed antigenicity with anti-schistosomajaponicum immunoglobulin polyclonal antibody, anti-Sj-lgG PcAb by Dot-ELISA. Three of themshowed good antigenicity. They would serve as candidates of synthetic anti-schistosomal vaccine.

关键词： SchistosomajQPonicum glutathione S-transferase antigenic peptide peptide vaccine.

Improve Fractal Compression Encoding Speed Using Feature Extraction and Self-organization Network

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Journal of university of Science and Technology beijing 2001年第4期8卷 306-310页

作者： Berthe Kya, Yang Yang Information Engineering school. university of Science and Technology beijing. beijing 100083. China Univ Sci & Technol beijing Informat Engn Sch Beijing 100083 Peoples R China

Image compression consists of two main parts: encoding and decoding. One of the important problems of the fractal theory is the long encoding implementation time, which hindered the acceptance of fractal image compression as a practical method. The long encoding time results from the need to perform a large number of domain-range matches, the total encoding time is the product of the number of matches and the time to perform each match. In order to improve encoding speed, a hybrid method combining features extraction and self-organization network has been provided, which is based on the feature extraction approach the comparison pixels by pixels between the feature of range blocks and domains blocks. The efficiency of the new method was been proved by examples.

关键词： image compression fractal theory features extraction self-organization network fractal encoding

Prediction of Rock Burst with Deep Mining Excavation in Linglong Gold Mine

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Journal of university of Science and Technology beijing 2001年第4期8卷 241-243页

作者： Meifeng Cai, Jinan Wang, Shuanghong Wang Civil and Environmental Engineering school, university of Science and Technology beijing, beijing 100083. China Univ Sci & Technol beijing Sch Civil & Environm Engn Beijing 100083 Peoples R China

To predict rock burst in deep mining excavation in Linglong gold mine, systematical laboratory tests of mechanical properties of rock, in situ stress measurement and 3.D FEM analysis on energy distribution in rock mass surrounding deep mining rooms were carried out. According to various prediction criteria of rock burst, it is concluded that rock burst is liable to occur during deep mining excavation in the mine.

关键词： rock burst prediction deep mining excavation Linglong gold mine

The regular representation and regular covariant representation of crossed products of Woronowicz C^(*)-algebras

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Science China Mathematics 2005年第9期48卷 1245-1259页

作者： ZHANG Xiaoxia~(1,2) & GUO Maozheng~(1,3. 1. school of Mathematical Sciences,peking university,{3. 100871,China 2. Department of Mathematics,Yantai university,Yantai 264005,China 3. LMAM,peking university,{3. 100871,China 1. school of Mathematical Sciences Peking University 100871 Beijing China 2. Department of Mathematics Yantai University 264005 Yantai China 3. LMAM Peking University 100871 Beijing China

In this paper,it is shown that the regular representation and regular covariant representation of the crossed products A×α G correspond to the twisted multiplicative unitary operators,where A is a Woronowicz C~*-algebra acted upon by a discrete group ***,it is also shown that the regular covariant C~*-algebra is the Woronowicz C~*-algebra which corresponds to a multiplicative ***,an explicit description of the multiplicative unitary operator for C(SU_q(2) )×α (?) is given in terms of those of the Woronowicz C~*-algebra C(SU_q(2) ) and the discrete group G.

关键词： multiplicative unitary operator, Woronowicz C*-algebra, crossed product.

Carbon Solubility and Mass Action Concentrations of Fe-Cr-C Melts

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International Journal of Minerals,Metallurgy and Materials 2000年第2期14卷 86-91页

作者： Jtan Zhang(Metallurgy school, university of Science and Technology beijing, beijing 100083. China) Metallurgy school University of Science and Technology Beijing Beijing 100083 China

An empirical equation of carbon solubility in Fe-Cr-C melts is regressed based on the experimental data from references. Acalculating model of mass action concentrations for these melts is formulated on the basis of the coexistence theory of metaIlic melts in-volving compound formation, the phase diagram of Cr-C system as well as thermodynamic data of Fe-Cr-C melts. According to the mod-el, the standard Gibbs free energies of formation of CrC and Cr3.2 are obtained. Satisfactory agreement between the calculated and me-asured values shows that the model can reflect the structural characteristics of Fe-Cr-C melts.

关键词： activity, coexistence theory mass action concentration saturated state

Application of annexation principle to the study of thermodynamic properties of Ag-Bi-In metallic melts

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Journal of university of Science and Technology beijing 2003年第1期10卷 18-20页

作者： Jian ZhangMetallurgy school, university of Science and Technology beijing, beijing 100083. China Metallurgy school University of Science and Technology Beijing Beijing 100083 China

Based on the measured activities, the phase diagrams and the annexation principle, the calculating models of mass action concentrations for Ag-Bi and Ag-Bi-In melts have been formulated. The calculated results agree with practice and obey the mass action law, showing that the models formulated can reflect the structural characteristics of both melts. Meanwhile, it confirms that annexation principle is applicable to the Ag-Bi-In metallic melts. The melts involving eulectic which give rise to phase separation, and in which activities exhibit positive deviation from Raoult's law is the basic cause of melts transforming from homogeneous to heterogeneous ones.

关键词： the mass action law annexation principle two phase melts activity, mass action concentration