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Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets

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Journal of Pharmaceutical Analysis 2022年第3期12卷 365-379页

作者： Divya S.Parimi Yamini Gupta Sreekar Marpu Chandra S.Bhatt tharun k.bollu Anil k.Suresh Bionanotechnology&Sustainable Laboratory Department of Biological SciencesSchool of Engineering and Applied SciencesSri Ramaswamy Memorial(SRM)UniversityAmaravati522503India Department of Chemistry University of North TexasDentonTX76201USA Department of Biotechnology Faculty of Science and HumanitiesSri Ramaswamy Memorial(SRM)Institute of Science and TechnologyChennai603203India

Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification,monitoring,targeting,and post-treatment response *** of superparamagnetic iron oxide nanoparticles(SPION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility *** addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic ***-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are *** parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are *** also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bioentities,and elimination of ***,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is *** summary,these discussions spotlight the versatility and integration of multitasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.

关键词： Nanomagnets Biomimetics Utrasmall-SPIONs Magnetization Core-fusion Cancer theragnostics

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