检索结果-南通市图书馆

Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy

引用

Cellular & Molecular Immunology 2012年第1期9卷 45-53页

作者： thanh-nhan nguyen-pham Deok-Hwan Yang Truc-Anh Thi nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National University Hwasun HospitalJeollanamdoKorea Vaxcell-Bio Therapeutics JeollanamdoKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea

Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer *** require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 *** play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of *** investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions *** that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce *** cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte *** data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy.

关键词： cancer immunotherapy dendritic cells natural killer cells signal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

引用

Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： thanh-nhan nguyen-pham Mi-Seon Lim Truc Anh Thi nguyen Youn-Kyung Lee Chun-Ji Jin Hyun Ju Lee Cheol Yi Hong Jae-Sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comparative study on kinetics and dynamics of two dump truck lifting mechanisms using MATLAB simscape

引用

Theoretical & Applied Mechanics Letters 2024年第2期14卷 146-156页

作者： Thong Duc Hong Minh Quang pham Son Cong Tran Lam Quang Tran Truong thanh nguyen Faculty of Transportation Engineering Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam Vietnam National University Ho Chi Minh City(VNU-HCM) Ho Chi Minh City 700000Vietnam Industrial Maintenance Training Center Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam

In this paper,two lifting mechanism models with opposing placements,which use the same hydraulic hoist model and have the same angle of 50°,have been *** mechanical and hydraulic simulation models are established using MATLAB Simscape to analyze their kinetics and dynamics in the lifting and holding *** simulation findings are compared to the analytical calculation results in the steady state,and both methods show good *** the early lifting stage,Model 1 produces greater force and discharges goods in the container faster than Model ***,Model 2 reaches a higher force and ejects goods from the container cleaner than its counterpart at the end lifting *** established simulation models can consider the effects of dynamic loads due to inertial moments and forces generated during the system *** is crucial in studying,designing,and optimizing the structure of hydraulic-mechanical systems.

关键词： Dump truck Lifting mechanism Hydraulic MATLAB Simscape Kinetic dynamic analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,Thua Thien Hue,Vietnam

引用

Soil Ecology Letters 2024年第1期6卷 131-140页

作者： Khoa Phuc nguyen Tan Trong Tran Huy Dinh Le Phuong Thuy nguyen Hien Thao Thi pham Dien thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,Thua Thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exact solution for thermal vibration of multi-directional functionally graded porous plates submerged in fluid medium

引用

Defence Technology（防务技术） 2024年第5期35卷 77-99页

作者： Quoc-Hoa pham Van Ke Tran Phu-Cuong nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh CityViet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiViet Nam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh CityViet Nam

An analytical method for analyzing the thermal vibration of multi-directional functionally graded porous rectangular plates in fluid media with novel porosity patterns is developed in this *** properties of MFG porous plates change according to the length,width,and thickness directions for various materials and the porosity distribution which can be widely applied in many fields of engineering and defence ***,new porous rules that depend on spatial coordinates and grading indexes are proposed in the present *** Hamilton's principle and the refined higher-order shear deformation plate theory,the governing equation of motion of an MFG porous rectangular plate in a fluid medium(the fluid-plate system)is *** fluid velocity potential is derived from the boundary conditions of the fluid-plate system and is used to compute the extra *** GalerkinVlasov solution is used to solve and give natural frequencies of MFG porous plates with various boundary conditions in a fluid *** validity and reliability of the suggested method are confirmed by comparing numerical results of the present work with those from available works in the *** effects of different parameters on the thermal vibration response of MFG porous rectangular plates are studied in *** findings demonstrate that the behavior of the structure within a liquid medium differs significantly from that within a vacuum ***,they offer appropriate operational approaches for the structure when employed in various mediums.

关键词： Plate-fluid contact Galerkin Vlasov's method Multi-directional functionally graded plate Novel porosity Thermal vibration Refined higher-order shear deformation theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An isogeometric approach to static and transient analysis of fluid-infiltrated porous metal foam piezoelectric nanoplates with flexoelectric effects and variable nonlocal parameters

引用

Frontiers of Structural and Civil Engineering 2024年第3期18卷 461-489页

作者： Quoc-Hoa pham Van Ke Tran Phu-Cuong nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh City 700000Vietnam

In this work,a novel refined higher-order shear deformation plate theory is integrated with nonlocal elasticity theory for analyzing the free vibration,bending,and transient behaviors of fluid-infiltrated porous metal foam piezoelectric nanoplates resting on Pasternak elastic foundation with flexoelectric *** analysis(IGA)and the Navier solution are applied to the *** innovation in the present study is that the influence of the in-plane variation of the nonlocal parameter on the free and forced vibration of the piezoelectric nanoplates is investigated for the first *** nonlocal parameter and material characteristics are assumed to be material-dependent and vary gradually over the thickness of *** on Hamilton’s principle,equations of motion are built,then the IGA approach combined with the Navier solution is used to analyze the static and dynamic response of the ***,we investigate the effects of the porosity coefficients,flexoelectric parameters,elastic stiffness,thickness,and variation of the nonlocal parameters on the mechanical behaviors of the rectangular and elliptical piezoelectric nanoplates.

关键词： isogeometric analysis fluid-infiltrated porous piezoelectric nanoplates static and transient analysis flexoelectric effect variable nonlocal parameters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forecasting measured responses of structures using temporal deep learning and dual attention

引用

Frontiers of Structural and Civil Engineering 2024年第6期18卷 832-850页

作者： Viet-Hung DANG Trong-Phu nguyen Thi-Lien pham Huan X.nguyen Department of Structural Mechanics Hanoi University of Civil EngineeringHanoi 11600Vietnam Faculty of Applied Science University of Economics-Technology for IndustriesHanoi 11600Vietnam London Digital Twin Research Centre Faculty of Science and TechnologyMiddlesex UniversityLondon NW44BTUK International School Vietnam National UniversityHanoi 11600Vietnam

The objective of this study is to develop a novel and efficient model for forecasting the nonlinear behavior of structures in response to time-varying random *** key idea is to design a deep learning architecture to leverage the relationships,between external excitations and structure's vibration signals,and between historical values and future values,within multiple time-series *** proposed method consists of two main steps:the first step applies a global attention mechanism to combine multiple-measured time series and time-varying excitation into a weighted time series before feeding it to a temporal architecture;the second step utilizes a self-attention mechanism followed by a fully connected layer to predict multi-step future *** viability of the proposed method is demonstrated via two case studies involving synthetic data from a three-dimensional(3D)reinforced concrete structure and experimental data from an 18-story steel ***,comparison and robustness studies are carried out,showing that the proposed method outperforms conventional methods and maintains high performance in the presence of noise with an amplitude of less than 10%.

关键词： structural dynamic time-varying excitation deep learning signal processing response forecasting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of novel HLA-A 0201-restricted epitopes from anterior gradient-2 as a tumor-associated antigen against colorectal cancer

引用

Cellular & Molecular Immunology 2012年第2期9卷 175-183页

作者： Hyun Ju Lee Cheol Yi Hong Chun-Ji Jin Mi-Hyun Kim Youn-Kyung Lee thanh-nhan nguyen-pham Hyunah Lee Byoung Chul Park Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital Hwasun Jeollanamdo Korea Department of Hematology-Oncology Chonnam National University Gwangju Korea VaxcelI-Bio Therapeutics Hwasun Jeollanamdo Korea Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Korea Research Institute of Bioscience and Biotechnology （KRIBB） Daejeon Korea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Gwangiu Korea

Anterior gradient-2 （AGR2） promotes tumor growth, cell migration and cellular transformation and its enhanced expression is almost completely restricted to malignant tissues, thus making AGR2 an interesting target for the development of immunotherapeutic strategies. We investigated whether the AGR2 molecule comprises human leukocyte antigen （HLA）-A 0201-binding epitopes recognized by human cytotoxic T lymphocytes （CTLs）, which could be targeted in dendritic cell （DC）-based cancer immunotherapy against colorectal cancer （CRC）. We reviewed the sequence of AGR2 for peptides that could potentially bind to HLA-A 0201 with the aid of a computer-based program. Five candidate peptides with different binding scores were synthesized and tested. These peptides were then assessed for their immunogenicity to elicit specific immune responses mediated by CTLs in vitro by means of enzyme-linked immunospot assays and CTL assays. AGR2 was highly expressed in several CRC cell lines, including DK01, DLD1, KM 12C, HCT-8 and HT-29. DCs pulsed with AGR2-P2 （aa 11-19; LLVALSYTL） or AGR2-P4 （aa 127-135; RIMFVDPSL） generated potent CTLs that could lyse T2 cells pulsed with AGR2-P2 or AGR2-P4 and HLA-A0201＋ AGR2-positive CRC cell lines in a strong dose-dependent and HLA-A 0201-restricted manner. In conclusion, these novel epitopes derived from AGR2 protein may be attractive candidates for DC-based immunotherapy for CRC.

关键词： AGR2 colorectal cancer dendritic cell tumor-associated antigen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An isogeometric approach for nonlocal bending and free oscillation of magneto-electro-elastic functionally graded nanobeam with elastic constraints

引用

Frontiers of Structural and Civil Engineering 2024年第9期18卷 1401-1423页

作者： Thu Huong nguyen THI Van Ke TRAN Quoc Hoa pham School of Mechanical and Automotive Engineering Hanoi University of IndustryHanoi 100000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam

This work uses isogeometric analysis(IGA),which is based on nonlocal hypothesis and higher-order shear beam hypothesis,to investigate the static bending and free oscillation of a magneto-electro-elastic functionally graded(MEE-FG)nanobeam subject to elastic boundary constraints(BCs).The magneto-electric boundary condition and the Maxwell equation are used to calculate the variation of electric and magnetic potentials along the thickness direction of the *** study is innovative since it does not use the conventional boundary ***,an elastic system of straight and torsion springs with controllable stiffness is used to support nanobeams’beginning and end positions,creating customizable *** governing equations of motion of nanobeams are established by applying Hamilton’s principle and IGA is used to determine deflections and natural frequency *** studies were performed to evaluate the convergence and accuracy of the proposed *** from this,the impact of the input parameters on the static bending and free oscillation of the MEE-FG nanobeam is examined in *** findings could be valuable for analyzing and designing innovative structures constructed of functionally graded MEE materials.

关键词： elastic boundary conditions isogeometric analysis nanobeam via nonlocal theory grading of magneto-electro-elastic functions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts

引用

Open Journal of Animal Sciences 2024年第3期14卷 194-203页

作者： Van Khanh nguyen Huong Thu Thi Vu Au Thi Hoang Yen Kim Thi pham Giang Thi thanh nhan Hung Phu Lai Lan Doan pham Key Laboratory of Animal Cell Biotechnology National Institute of Animal Science Hanoi Vietnam

This study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference in the percentage of nucleated fibroblasts in the G0/G1 stage between serum concentrations of 0.3% and 0.4% (83.89% and 82.69%, respectively, P > 0.05) as well as between serum concentrations of 0.2% and 0.5% (76.95% and 75.46%, respectively, P > 0.05). The percentage of nucleated fibroblasts in the G0/G1 stage was highest at the concentration of 0.3% and lowest in the control group (83.89% vs. 62.67%, P 0.05). The beneficial effect of high confluence was confirmed by the large percentage of nucleated fibroblasts at the G0/G1 stage. The 60% confluency was significantly lower than the 80% and 100% confluency (73.44%, 86.63%, and 87.17%, respectively, P < 0.05). The results indicate that the goat fibroblast cycle synchronization is the most effective at the serum concentration of 0.3%, 72 hours of synchronization and 100% confluency.

关键词： Goat Fibroblast Cycle Synchronisation Serum Concentration Synchronization Time Confluence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：