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Best management practices to reduce soil erosion and change water balance components in watersheds under grain and dairy production

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International Soil and Water Conservation Research 2024年第1期12卷 121-136页

作者： thais Palumbo Silva Danielle Bressiani Éderson Diniz Ebling Josémiguel Reichert Soil Science of Federal University of Santa maria Roraima Avenuenumber 1000CEP:97.105-900Santa MariaRio Grande do SulBrazil technological Development Center Federal University of PelotasGomes Carneiro Streetnumber 1CEP:96010-610PelotasRio Grande do SulBrazil Department of Soil Federal University of Santa MariaCampus Universitário s/nCEP 97.105-900Santa MariaRio Grande do SulBrazil

Soil erosion and sedimentation are among the most serious global environmental *** and water conservation measures have been proven effective ways to reduce soil *** objective of this study was to evaluate the impact of three approaches of soil and water conservation measures(soil management,vegetative measures,and structural practices)on soil erosion and water balance of two paired agricultural watersheds located in Southern *** and sediment monitoring was carried out from 2016 to 2019 in the two small paired agricultural watersheds;called North watershed(NW)and South watershed(SW).modeling using Soil&Water Assessment tool(SWAt)was performed to simulate individual(nine scenarios)and combined(four scenarios)best management practices(BmPs),by including the three *** the nine individual BmP scenarios,the most effective in reducing soil erosion was crop rotation and cover crop(sediment yield,SY,reduction of 38.4 for NW,and 28.8%for SW).Among the four combined scenarios,the association of all conservation approaches was the most effective in reducing soil erosion(SY reduction of 46 for NW,and 41.5%for SW),followed by the vegetative measures scenario(SY reduction of 43.5 and 34.1%for NW and SW).All combined scenarios increased infiltration and subsurface water components,and decreased surface *** findings of this study can help farmers and policymakers choosing appropriate BmPs to reduce current soil erosion problems and promote water and soil conservation.

关键词： Agricultural hydrology Conservation measures SWAt Subtropical watersheds

microRNAs in inflammatory bowel disease:What do we know and what can we expect?

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World Journal of Gastroenterology 2024年第16期30卷 2184-2190页

作者： Ellen Cristina Souza de Oliveira Ana Elisa Valencise Quaglio thais Gagno Grillo Luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

microRNAs(miRNAs),small non-coding RNAs composed of 18–24 nucleotides,are potent regulators of gene expression,contributing to the regulation of more than 30%of protein-coding *** that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells,there is an interest in exploring their importance in inflammatory bowel disease(IBD).IBD is a chronic and multifactorial disease of the gastrointestinal tract;the main forms are Crohn's disease and ulcerative *** studies have investigated the dysregulated expression of miRNAs in IBD,demonstrating their important roles as regulators and potential biomarkers of this *** editorial presents what is known and what is expected regarding miRNAs in *** the important regulatory roles of miRNAs in IBD are clearly established,biomarkers for IBD that can be applied in clinical practice are lacking,emphasizing the importance of further *** regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.

关键词： microRNAs Inflammatory bowel disease Crohn’s disease Ulcerative colitis Biomarker therapy

Unsuccessful tuberculosis treatment outcomes across Brazil's geographical landscape before and during the COVID-19 pandemic:are we truly advancing toward the sustainable development/end tB goal?

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Infectious Diseases of Poverty 2024年第1期13卷 105-106页

作者： Reginaldo Bazon Vaz tavares thais Zamboni Berra Yan mathias Alves marcela Antunes Paschoal Popolin Antonio Carlos Vieira Ramos Ariela Fehr tartaro Clara Ferreira de Souza Ricardo Alexandre Arcencic Department of maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of Nursing (USP/RPCN) Ribeirão Preto São Paulo Brazil Federal University of tocantins Palmas Campus (FUT) Palmas Brazil State University of minas Gerais Passos Campus (SUMG) Passos Brazil

Background tuberculosis is one of the most significant infectious diseases for global public *** reallocation of healthcare resources and the restrictions imposed by the COVID-19 pandemic have hindered access to tB diag-nosis and *** in unfavorable outcomes of the disease have been observed in *** objective of this study was to analyze the spatial distribution of unfavorable tB treatment outcomes in Brazil before and during the *** An ecological study with spatial analysis was conducted with all 5569 municipalities in *** reported cases of tuberculosis between January 2010 and December 2021,as well as reported cases of COVID-19 from Febru-ary 2020 to December 2021,were *** outcomes studied encompass loss to follow-up,drug-resistant tuber-culosis,and *** Getis Ord GI*technique was employed to assess spatial association,and the Kernel density estimator was used to identify areas with concentrated increases or decreases in *** Local moran's/was used to examine the spatial association between outcomes and cOVID-19 *** study was approved by the Research Ethics Committee of Ribeirao Preto Nursing School,University of Sao *** there were 134,394 cases of loss to follow-up,10,270 cases of drug resistance,and 37,863 *** of high and low values were identified for all three outcomes,indicating significant changes in the spatial distribu-tion *** in concentrations were observed for lost to follow-up cases in the Southeast,while reductions occurred in the Northeast,South,and ***-resistant tuberculosis experienced an increase in the Southern and Southeastern regions and a decrease in the Northeast and ***-related deaths showed notable concentra-tions in the midwest,Northeast,South,and *** was an increase in high occurrence clusters for deaths after 2020 and 2021 in the *** the pandemic has brought additional chal

关键词： tuberculosis COVID-19 Spatial analysis Ecological studies

the Use of Insulin Negatively Impacts the mortality of Severe COVID-19 in Patients with type 2 Diabetes—A Systematic Review

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Journal of Diabetes mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti marcela R. Simoes thais P. Prado milena monfort-Pires Licio A. Velloso Obesity and Comorbidities Research Center Campinas Brazil turku PEt Centre University of Turku Turku Finland National Institute of Science and technology on Neuroimmunomodulation Campinas Brazil

Obesity and type 2 diabetes are among the most important risk factors for severe coronavirus disease-19. Some studies have suggested that the use of insulin as a therapeutic agent to treat hyperglycemia and the metabolic abnormalities associated with type 2 diabetes during the acute phase of severe coronavirus disease-19 could have a negative impact on the disease’s progression;however, there is no consensus on this issue. Here, we performed a systematic review in an attempt to answer this important question. We included 29 articles published from December 2019 to August 2023, which reported the outcomes of 3,070,657 patients with severe coronavirus disease-19 that had the diagnosis of diabetes and were treated with either insulin or other glucose-reducing agents. the results show that using insulin as a pharmacological intervention to treat type 2 diabetes in patients with severe coronavirus disease-19 increases the likelihood of mortality by 193%.

关键词： SARS-CoV2 Obesity Inflammation metabolism Glucose

Artemisia vulgaris Induces tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli michele Rosana maia Santos Adolfo Garcia Erustes Vanessa marques meccatti thais Cristine Pereira Soraya S Smaili maria Cristina marcucci Carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective to evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(mCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3t3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FItC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPtA-Am)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of mCF-7,SKBR-3 and K562 cells(Pthe viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(Ptreatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FItC/7-AAD(Pthe use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(Pmainly from lysosomes in K562 cells(Pthermore,BAPtA-Am,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(Ptotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).these effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira monteiro da Silva Abreu taysse Holanda Joice Farias do Nascimento Henety Nascimento Pinheiro Rachel menezes Castelo Hélcio Silva dos Santos thais Benincá Patrícia da Silva malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle maria madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNm)and Benzyl4-amino(B4Am)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4Am nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNm increased the antimicrobial activity in comparison with B4Am,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

Operation Strategies for Coordinating Battery Energy Storage with Wind Power Generation and their Effects on System Reliability

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Journal of modern Power Systems and Clean Energy 2021年第1期9卷 190-198页

作者： thais P.teixeira Carmen L.t.Borges the Federal University of Rio de Janeiro Rio de JaneiroBrazil

the variability of wind power generation requires the allocation of a flexible energy reserve which is capable of compensating for possible imbalances between the load and generation. to reduce the variability of wind power generation and loss of load in generation deficit, we propose operation strategies for coordinating battery energy storage with wind power generation. the effects of the operation strategies on system reliability are evaluated by the developed computation model that represents the main aspects and operation limitations of the batteries. the performance evaluation of the power system is based on the composite reliability indices of loss of load probability(LOLP) and expected energy not supplied(EENS), which is calculated through sequential monte Carlo simulation. tests are performed by the developed model with a tutorial system consisting of five busbars and the IEEE RtS system. the results show that the use of large-scale batteries is an alternative to physically guarantee the wind power plants and to act as an operation reserve to reduce the risk of loss of load.

关键词： Energy storage wind power generation power system reliability monte Carlo simulation

Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis thais Branquinho de Araujo Carmen tzanno-martins Fernanda Silveira tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria marra da motta Vilalva mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil the Human Performance mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of mL/min/1.73 m2).the RE+BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:these results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

Response to Commentary by Dr. matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis thais Branquinho de Araújo Carmen tzanno-martins Fernanda Silveira tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória marra da motta Vilalva mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil the Human Performance mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow