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Immunogenetic factors driving formation of ultralong VH cDR3 in Bos taurus antibodies

cellular & Molecular Immunology 2019年第1期16卷 53-64页

作者： thaddeus c deiss Melissa Vadnais Feng Wang Patricia L chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F criscitiello Vaughn V Smider comparative Immunogenetics Laboratory Department of Veterinary PathobiologyCollege of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843USA Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037USA california Institute for Biomedical Research La JollaCA 92037USA Department of Integrative Structural and computational Biology The Scripps Research InstituteLa JollaCA 92037USA Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS 66506USA IMGT the International ImMunoGeneTics information systemLaboratoire d’ImmunoGénétique MoléculaireInstitut de Génétique HumaineCNRSUniversity of MontpellierMontpellier 34396France Department of Microbial Pathogenesis and Immunology College of MedicineTexas A&M UniversityBryanTX 77807USA Fabrus Inc.La JollaCA 92037USA

The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(cDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV *** unusual cDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding *** genetic components and processes for forming these unusual cattle antibody VH cDR3 are not well *** we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong cDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,*** eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged cDR3.A low amino acid variability was observed in cDR1 and cDR2,suggesting that antigen binding for this subset most likely only depends on the *** a novel,potentially AID mediated,deletional diversification mechanism of the *** VH ultralong cDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in *** deletions serve to further diversify cysteine positions,and thus disulfide bonded ***,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong cDR3 repertoire.

关键词： bovine complementarity determining region 3 repertoire diversification deletions immunoglobulin heavy chain

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Improved Design of a 25 MW Gas Turbine Plant Using combined cycle Application

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Journal of Power and Energy Engineering 2015年第8期3卷 1-14页

作者： Barinaadaa thaddeus Lebele-Alawa Anthony Kpegele Le-ol Department of Mechanical Engineering Rivers State University of Science and Technology Port Harcourt Nigeria

This paper presents the improved design of a 25 MW gas turbine power plant at Omoku in the Niger Delta area of Nigeria, using combined cycle application. It entails retrofitting a steam bottoming plant to the existing 25 MW gas turbine plant by incorporating a heat recovery steam generator. The focus is to improve performance as well as reduction in total emission to the environment. Direct data collection was performed from the HMI monitoring screen, log books and manufacturer’s manual. Employing the application of MATLAB, the thermodynamics equations were modeled and appropriate parameters of the various components of the steam turbine power plant were determined. The results show that the combined cycle system had a total power output of 37.9 MW, made up of 25.0 MW from the gas turbine power plant and 12.9 MW (an increase of about 51%) from the steam turbine plant, having an HRSG, condenser and feed pump capacities of 42.46 MW, 29.61 MW and 1.76 MW respectively. The condenser cooling water parameters include a mass flow of 1180.42 kg/s, inlet and outlet temperatures of 29.8°c and 35.8°c respectively. The cycle efficiency of the dry mode gas turbine was 26.6% whereas, after modification, the combined cycle power plant overall efficiency is 48.8% (about 84% increases). Hence, SIEMENS steam turbine product of MODEL: SST-150 was recommended as the steam bottoming plant. Also the work reveals that a heat flow of about 42.46 MW which was otherwise being wasted in the exhaust gas of the 25 MW gas turbine power plant could be converted to 12.9 MW of electric power, thus reducing the total emission to the environment.

关键词： Gas Turbine Steam Turbine HRSG combined cycle Power Output Overall Efficiency condenser cooling Water

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Long-term immune-modulatory side effects of radiofrequencyablation in patients with liver metastases and hepatocellularcarcinoma

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Hepatoma Research 2015年第1期1卷 92-96页

作者： thaddeus Till Wissniowski Thomas Gress Pietro Di Fazio Division of Gastroenterology Philipps University of MarburgBaldingerstrasse35043 MarburgGermany Department of Visceral Thoracic and Vascular SurgeryPhilipps University of MarburgBaldingerstrasse35043 MarburgGermany

Aim:Used as a palliative therapy for unresectable liver cancer,radiofrequency ablation(RFA)is associated with the induction of immunological ***,we show strong evidence of tumor-specifi c peripheral blood mononuclear cells(PBMcs)12 months after ***:Three patients with colorectal cancer(cRc)metastases to the liver and two patients with primary hepatocellular carcinoma(Hcc)were enrolled in this ***,isolated 12 months after RFA,were stimulated with normal and tumor tissue *** gamma secretion was evaluated by fl ow cytometry and indirectly,by luciferase assay for adenylate kinase activity in PBMc-stimulated lysates of target *** data were detected before RFA and 4 weeks after ***:Two cRc patients and one Hcc patient had recurrence-free *** patient with cRc developed secondary metastases;one patient with Hcc developed a local ***-free patients showed a signifi cantly higher cytolytic activity of PBMc against matched tumor cells 12 months after RFA ***,patients with malignant recurrence showed a decreased cytolytic ***:RFA seems to overcome immune-tolerance toward tumor antigens and/or presents new tumor *** seem to benefi t from a prolonged increase in cytolytic *** immune-modulatory effects of RFA need further investigations in multimodality anticancer therapies.

关键词： Liver cancer radiofrequency ablation immune response interferon gamma peripheral blood mononuclear cells

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多靶点粪便DNA和cT结肠成像对无创性结直肠癌筛查的诊断效能

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国际医学放射学杂志 2020年第6期 739-740页

作者：陈羽琦 P.J.Pickhardt P.M.Graffy B.Weigman N.deiss-Yehiely c.Hassan J.M.Weiss Department of Radiology University of Wisconsin School of Medicine & Public Health

摘要自2014年美国食品和药物管理局(FDA)与医疗保险和医疗补助服务中心(美国医保服务中心,cMS)同时批准以来,多靶点粪便DNA(mt-sDNA)筛查的应用迅速增多,

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Integrated sensing and delivery of oxygen for next- generation smart wound dressings

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Microsystems & Nanoengineering 2020年第1期6卷 991-1006页

作者： Manuel Ochoa Rahim Rahimi Jiawei Zhou Hongjie Jiang chang Keun Yoon Dinesh Maddipatla Binu Baby Narakathu Vaibhav Jain Mark Michael Oscai thaddeus Joseph Morken Rebeca Hannah Oliveira Gonzalo L.campana Oscar W.cummings Michael A.Zieger Rajiv Sood Massood Z.Atashbar Babak Ziaie School of Electrical and computer Engineering Purdue UniversityWest Lafayette 47907 INUSA Birck Nanotechnololgy center 1205W State StreetWest Lafayette 47907 INUSA School of Material Science Engineering Purdue UniversityWest Lafayette 47907 INUSA Electrical and computer Engineering Department Western Michigan University4601 Campus Drive B-236Kalamazoo 49008 MIUSA School of Mechanical Engineering Purdue UniversityWest Lafayette 47907 INUSA Indiana University School of Medicine 980 West Walnut StreetBuilding R3 Room C634Indianapolis 46202 INUSA Department of Pathology and Laboratory Medicine Indiana University School of MedicineIU Health Pathology Laboratory350W 11th StreetRoom 4054IndianapolisIN 46202USA Weldon School of Biomedical Engineering Purdue UniversityWest Lafayette 47907 INUSA Present address:Shenzhen MSU-BIT University ShenzhenChina

chronic wounds affect over 6.5 million Americans and are notoriously difficult to *** oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable ***,we developed a low-cost alternative for continuous O 2 delivery and sensing comprising of an inexpensive,paper-based,biocompatible,flexible platform for locally generating and measuring oxygen in a wound *** platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology,inkjet ***,we demonstrate the functionality of the oxygenation patch,capable of increasing oxygen concentration in a gel substrate by 13%(5ppm)in *** platform is able to sense oxygen in a range of 5–26 *** vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.

关键词： patch smart printing

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Adaptive Immunity Restricts Replication of Novel Murine Astroviruses

Adaptive Immunity Restricts Replication of Novel Murine Astr...

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第九届全国免疫学学术大会

作者： christine c.Yokoyama Joy T.Loh Guoyan Zhao Erning Duan Pamela Freiden Richard J.Heath Stacey Schultz-cherry thaddeus S.Stappenbeck David Wang Henry V.Huang Larissa B.Thackray Herbert W.Virgin Department of Pathology and Immunology Washington Univsersity School of MedicineSt.LouisMissouriUSA Department of Infectious Diseases St.Jude Children's Research HospitalMemphisTennesseeUSA Department of Molecular Microbiology Washington Univsersity School of MedicineSt.LouisMissouriUSA

The mechanisms of astrovirus pathogenesis are largely unknown,in part due to a lack of a small-animal model of *** shotgun sequencing and a custom analysis pipeline,we identified two novel astroviruses capable of infecting research mice,murine astrovirus(MuAstV)STL1 and *** analysis revealed the presence of at least two additional

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