Integrated sensing and delivery of oxygen for next- generation smart wound dressings

作     者：Manuel Ochoa Rahim Rahimi Jiawei Zhou Hongjie Jiang Chang Keun Yoon Dinesh Maddipatla Binu Baby Narakathu Vaibhav Jain Mark Michael Oscai Thaddeus Joseph Morken Rebeca Hannah Oliveira Gonzalo L.Campana Oscar W.Cummings Michael A.Zieger Rajiv Sood Massood Z.Atashbar Babak Ziaie Manuel Ochoa;Rahim Rahimi;Jiawei Zhou;Hongjie Jiang;Chang Keun Moon;Dinesh Maddipatla;Binu Baby Narakathu;Vaibhav Jain;Mark Michael Oscai;Thaddeus Joseph Morken;Rebeca Hannah Oliveira;Gonzalo L.Campana;Oscar W.Cummings;Michael A.Zieger;Rajiv Sood;Massood Z.Atashbar;Babak Ziaie

作者机构：School of Electrical and Computer EngineeringPurdue UniversityWest Lafayette 47907 INUSA Birck Nanotechnololgy Center1205W State StreetWest Lafayette 47907 INUSA School of Material Science EngineeringPurdue UniversityWest Lafayette 47907 INUSA Electrical and Computer Engineering DepartmentWestern Michigan University4601 Campus Drive B-236Kalamazoo 49008 MIUSA School of Mechanical EngineeringPurdue UniversityWest Lafayette 47907 INUSA Indiana University School of Medicine980 West Walnut StreetBuilding R3 Room C634Indianapolis 46202 INUSA Department of Pathology and Laboratory MedicineIndiana University School of MedicineIU Health Pathology Laboratory350W 11th StreetRoom 4054IndianapolisIN 46202USA Weldon School of Biomedical EngineeringPurdue UniversityWest Lafayette 47907 INUSA Present address:Shenzhen MSU-BIT UniversityShenzhenChina 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2020年第6卷第1期

页      面：991-1006页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 0817[工学-化学工程与技术] 08[工学] 080202[工学-机械电子工程] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0836[工学-生物工程] 0811[工学-控制科学与工程] 0702[理学-物理学] 

基　　金：The authors thank the staff of the Birck Nanotechnology Center for their support.Funding for this work was provided by NextFlex under AFRL Cooperative Agreement No.FA8650-15-2-5401 

主　　题：patch smart printing 

摘      要：Chronic wounds affect over 6.5 million Americans and are notoriously difficult to *** oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable ***,we developed a low-cost alternative for continuous O 2 delivery and sensing comprising of an inexpensive,paper-based,biocompatible,flexible platform for locally generating and measuring oxygen in a wound *** platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology,inkjet ***,we demonstrate the functionality of the oxygenation patch,capable of increasing oxygen concentration in a gel substrate by 13%(5ppm)in *** platform is able to sense oxygen in a range of 5–26 *** vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.