检索结果-南通市图书馆

Hypolipidemic,antioxidant and anti-atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet-induced hypercholesterolemic rats

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2015年第5期8卷 359-365页

作者： Fidele Ntchapda Kakesse Maguirgue Hamadjida Adjia Paul Faustin Seke Etet théophile Dimo Department of Biological Sciences Faculty of ScienceUniversity of Ngaoundéré Department of neuroscience Faculty of Medicine.University of Montreal Department of Basic Health Sciences College of Applied Medical SciencesQassim University Department of Animal Biology and Physiology Faculty of ScienceUniversity of Yaoundé

Objective:To evaluate anti-dyslipidemic,antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat.a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular ***:Normocholeslerolemic(NC) male rats were divided into six groups(n=10) and fed a high-cholesterol(HC) diet for 30 days(5 groups),or normal rat chow(normal control group).Rats given a HC diet also received distilled water(disease control),the potent hypocholcsterolcmic agent with antiatherosclerotic activity atorvastatin(2 mg/kg,positive control),or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested(225,300 and 375 mg/kg) concomitantly for four *** of general toxicity,body temperature and weight,and water and food intake were monitored in live *** sacrifice,lipid profiles and oxidative stress markers were assessed in the blood and liver,aorta,and feces,and histopathological analysis of aorta was ***:Plant extract prevented the elevation of aortic total cholesterol and triglycerides,and hepatic low density lipoprotein,very low density lipoprotein,and total *** peroxidation(TBARS) was decreased and aortic atherosclerotic plaque formation ***:these observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties,at least partly mediated by antioxidant and hypolipidemic effects.

关键词： Zanthoxylum heitzii Plant extract Antioxidant Anti-atherosclerogenic Hypocholesterolemic Hypolipidemic

Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第7期21卷 2214-2219页

作者： Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse 1~(st) Deparment of Medicine University Medical Center Hamburg-Eppendorf

Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic *** recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is *** HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily ***,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis *** wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters.

关键词： Acute liver failure Hepatitis B virus Prednisolone

JAK3 mediates c-myc gene expression induced by interleukin-2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1998年第4期43卷 308-311页

作者： Zhu Jinfang Lu Linrong Ji Hongbin Zheng Zhongcheng J. thèze Liu Xinyuan Chinese Acad Sci Shanghai Inst Biochem Shanghai 200031 Peoples R China Inst Pasteur Paris France

C myc gene expression can be rapidly induced by IL 2 through intracellular signal transduction which is triggered by the interaction between IL 2 and its receptor （IL 2R）. JAK3 which associates to the intracellular domain of IL2R γ may play a critical role in this process. To reveal the action of JAK3 in c myc induction, a chimeric receptor gene IL2R α/γ/Δ NJAK3 is constructed which consists of extracellular domain derived from IL 2R α subunit （IL2R α）, the transmembrane sequence derived from IL2R γ and the cytoplasmic domain derived from the catalytic domain of JAK3 （Δ NJAK3）, and then transfected this chimeric gene into mouse fibroblast cell line L929 β which had been transfected with IL2R β gene and stably expressed IL2R β in high level. In the transfectants coexpressing IL2R β and α/γ/Δ NJAK3, the stimulation of IL2 could intensively induce c myc gene expression. Because the whole cytoplasmic domain of IL2R γ which could recruit signaling molecules was replaced by JAK3 and the c myc could be still induced by IL2 in this situation, the results here gave the direct evidence demonstrating that JAK3 plays an important role in c myc gene expression induced by IL2.

关键词： interleukin 2(IL 2) JAK3(Janus Kinase 3) c myc gene signal transduction.

Assessing decontamination practices at a medical microbiology research laboratory

在线全文

学校读者我要写书评

暂无评论

Journal of Biosafety and Biosecurity 2022年第2期4卷 124-129页

作者： Merna M.Alfy Sherine B.el Sayed Mona el-Shokry Medical microbiology and Immunology Department Faculty of MedicineAin Shams UniversityCairoEgypt

To our knowledge,this is the first study to conduct an objective assessment of the routine decontamination practices at a medical microbiology research laboratory(MRL)a year after a biosafety training was provided to all laboratory *** March 28th and June 28th,2021,unobtrusive observations were carried out to identify-three high-touch surfaces at the MRL during different working *** was used to evaluate the effectiveness of the disinfectant used in the *** three high-touch surfaces were sampled before and after decontamination with 200 ppm of 5%sodium hypochlorite(household bleach)to quantify the microbial load and identify the types of organisms residing on the laboratory surfaces.A higher concentration(500 ppm)of 5%sodium hypochlorite was employed after refresher training was provided to housekeeping staff,and resampling of the three surfaces was carried out during a 4-week follow-up period using the same *** three high-touch surfaces identified were the two sides of the workbench(22%–24%)and the front surface of one incubator(14%).Anthracoid bacilli and Staphylococcus aureus were the most commonly found organisms on laboratory surfaces preintervention(100%and 89%,respectively)and post-intervention(56%and 44%,respectively).Other microorganisms detected included Salmonella spp.(27.7%),Proteus spp.(5.6%),Escherichia coli(5.6%),and Klebsiella spp.(33.3%).Employing a higher concentration(500 ppm)of sodium hypochlorite significantly(pthe total aerobic colony count from an average of 15–250 cfu/cm2 to 10–60 cfu/cm^(2).this study demonstrated suboptimal decontamination practices at the MRL and the need to apply a higher concentration(500 ppm)of sodium hypochlorite to reduce the overall microbial *** also demonstrated the importance of quantitative assessment to monitor decontamination practices and ensure staff *** studies are needed to identify bacterial communities within the laboratory,which will

关键词： Biosafety Laboratory-acquired infection Sodium hypochlorite Environmental decontamination Bacterial contamination Egypt

Estimation of radiation hazard indices from natural radioactivity of some rocks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2006年第2期17卷 118-122页

作者： A.ABBADY N.K.AHMED A.M.el-ARABI R.micHel A.H.el-KAMel A.G.E.ABBADY Physics Department Faculty of Science Qena South Valley University Egypt Institute of the Radiation Protection and Radioecology Hannover University Germany Physics Department Faculty of Science Assiut University Egypt

Different samples of igneous and metamorphic rocks from Egypt and Germany have been considered to measure γ-ray activity concentrations due to naturally occurring, potentially hazardous radonuclides 226Ra, 232th and 40K. the radiation hazard parameters including radiation equivalent activity, gamma-absorbed dose rate, and exter- nal and internal hazard indices have been estimated. the gamma-absorbed dose rates in air of rocks in Egypt range from 4.2 to 128.5 nGy·h-1 with a mean value of 55.3 nGy·h-1. For igneous and metamorphic rocks from Germany, the values of absorbed dose rates fluctuate from 5.1 to 148.6 nGy·h-1, with a mean value of 60.9 nGy·h-1. Generally, it is found that the radiation hazard indices in common igneous rocks are distinctly higher in acidic than in ultrabasic rocks. the results are discussed and compared with the corresponding published data.

关键词：自然放射性岩石变质岩环境放射学

Predicting groundwater level of wells in the Diyala River Basin in eastern Iraq using artificial neural network

在线全文

学校读者我要写书评

暂无评论

Journal of Groundwater Science and Engineering 2020年第1期8卷 87-96页

作者： Abdulrahman th Mohammad Qassem H Jalut Nadia L Abbas Baqubah Technical Institute Middle Technical University(MTU)BaghdadIraq Department of Civil Engineering College of EngineeringUniversity of DiyalaDiyalaIraq.

Al-Mansourieh zone is a part of Al-Khalis City within the province of Diyala and located in the Diyala River Basin in eastern Iraq with a total area about 830 *** is the main water source for agriculture in this *** well drilling without geological and hydraulic information has led the most of these wells to dry up ***,it is necessary to estimate the levels of groundwater in wells through observed *** this study,Alyuda NeroIntelligance 2.1 software was applied to predict the groundwater levels in 244 wells using sets of measured *** data included the coordinates of wells(x,y),elevations,well depth,discharge and groundwater *** ANN structures(5-3-3-1,5-10-10-1 and 5-11-11-1)were used to predict the groundwater levels and to acquire the best matching between the measured and ANN predicted *** coefficient of correlation,coefficient determination(R2)and sum-square error(SSE)were used to evaluate the performance of the ANN *** to the ANN results,the model with the three structures has a good predictability and proves more effective for determining groundwater level in *** best predictor was achieved in the structure 5-3-3-1,with R2 about 0.92,0.89,0.84 and 0.91 in training,validation,testing and all processes *** minimum average error in the best predictor is achieved in validation and testing processes at about 0.130 and 0.171 *** the other hand,the results indicated that the model has the potential to determine the appropriate places for drilling the wells to obtain the highest level of groundwater.

关键词： Groundwater Well ANN Diyala River

Clinical analysis of bone scanning in solitary lesion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2002年第2期13卷 72-78页

作者： ZHU Jun, ZHU Rui-Sen, ZHU Ji-Fang (the 6th People’s Hospital, Shanghai 200233) Shanghai the 6th People's Hospital 上海 200233

A rational analysis procedure for solitary lesions on whole bone scan-ning was offered. this study was undertaken to analyze retrospectively solitary le-sions which obtained final diagnose through the following aspects: (1) diagnosis ofbone metastasis, (2) the incidence of bone metastasis in different tumor, (3) the mostpossible lesion sites indicating bone metastasis, (4) morphological analysis of solitarylesions. the results are: (1) the incidence of solitary lesions in 2465 cases on wholebone scanning is 15.3%. (2) the rate of bone metastasis is 24.8% in 282 patientswith primary malignancy. the rate of bone metastasis is 6.3% in 64 patients withoutprimary malignancy, and the total diagnostic rate of bone metastasis is 21.4% in 346patients. (3) In patients with primary malignancy, the incidence of bone metastasis ofsolitary lesions is as follows respectively: bronchi cancer 36.1%(22/61); breast cancer23.8%(20/84); prostate gland 17.2%(5/29); other urinary system cancer 22.2%(4/18):G.I. system cancer 16.9%(10/59); others 29.0%(9/31). there is no significant differ-ence in different cancer. (4) In patients without primary malignancy, 93.7%(60/64) ofsolitary lesions are benign. (5) From anatomical point of view, we found the diagnos-tic rate of bone metastasis is as follow: 30% in spine; 34.2% in pelvis; 36.4% in skull;10.8% in other bones. there are significant differences in four groups. It is concludedthat: (1) the diagnostic rate of bone metastasis in solitary lesions is 21.4%. (2) themost possible solitary lesions indicating osseous tumor spread are at spine, pelvic andskull. (3) Special attention to "cold" and streak like lesions should be paid. (4) Aclinical analysis procedure for diagnosis of solitary lesions has been summarized outhere.

关键词：骨瘤临床分析辐射造影

Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第10期22卷 2931-2948页

作者： Enas A Abd el-Haleim Ashraf K Bahgat Samira Saleh Department of Pharmacology and Toxicology Faculty of PharmacyCairo University Currently Faculty of Pharmaceutical Sciences and Pharmaceutical Industries Future University in Egypt

AIM: To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in ***: Giving a fructose-enriched diet (FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats (150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate (FENO) (100 mg/kg), resveratrol (RES) (70 mg/kg) and combined treatment (FENO + RES) (half the doses). All treatments were given orally from the 9th week till the end of experimental period. Body weight, oral glucose tolerance test (OGTT), liver index, glucose, insulin, insulin resistance (HOMA), serum and liver triglycerides (TGs), oxidative stress (liver MDA, GSH and SOD), serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α (TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3 (SOCS-3), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), malonyl CoA decarboxylase (MCD), transforming growth factor-β1 (TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were ***: Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, oxidative stress and dyslipidemia. As for gene expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis (NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, MDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance (OGTT, HOMA), serum and liver TGs, hepatic MDA, serum AST, AST/ALT rat

关键词： Fructose Nonalcoholic steatohepatitis Suppressor of cytokine signaling-3 Sterol regulatory element binding protein-1c Fatty acid synthase Malonyl CoA decarboxylase Leptin Adiponectin Transforming growth factor-β Tumor necrosis factor-α

electron paramagnetic resonance characterization of aluminum ion implantation-induced defects in 4H-SiC

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanotechnology and Precision Engineering 2019年第4期2卷 157-162页

作者： Xiuhong Wang Zongwei Xua Mathias Rommel Bing Dong Le Song Clarence Augustine th Tee Fengzhou Fang State Key Laboratory of Precision Measuring Technology&Instruments Tianjin UniversityTianjin 300072China Fraunhofer Institute for Integrated Systems and Device Technology(IISB) Schottkystrasse 10Erlangen 91058Germany Department of electrical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Centre of Advanced Research Enabler Facility Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia

Deep-level defects in silicon carbide(SiC)are critical to the control of the performance of SiC electron *** this paper,deep-level defects in aluminumion-implanted 4H-SiC after high-temperature annealingwere studied using electron paramagnetic resonance(EPR)spectroscopy at temperatures of 77 K and 123 K under different illumination *** showed that the main defect in aluminum ion-implanted 4H-SiC was the positively charged carbon vacancy(VC+),and the higher the doping concentration was,the higher was the concentration of VC+.Itwas found that the type of material defectwas independent of the doping concentration,although more VC+defects were detected during photoexcitation and at lower *** results should be helpful in the fundamental research of p-type 4H-SiC fabrication in accordance with functional device development.

关键词： electron paramagnetic resonance Silicon carbide Defects Carbon vacancy