Hypolipidemic,antioxidant and anti-atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet-induced hypercholesterolemic rats

作     者：Fidele Ntchapda Kakesse Maguirgue Hamadjida Adjia Paul Faustin Seke Etet Théophile Dimo 

作者机构：Department of Biological SciencesFaculty of ScienceUniversity of Ngaoundéré Department of neuroscienceFaculty of Medicine.University of Montreal Department of Basic Health SciencesCollege of Applied Medical SciencesQassim University Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaoundé 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2015年第8卷第5期

页      面：359-365页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Zanthoxylum heitzii Plant extract Antioxidant Anti-atherosclerogenic Hypocholesterolemic Hypolipidemic 

摘      要：Objective:To evaluate anti-dyslipidemic,antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat.a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular ***:Normocholeslerolemic(NC) male rats were divided into six groups(n=10) and fed a high-cholesterol(HC) diet for 30 days(5 groups),or normal rat chow(normal control group).Rats given a HC diet also received distilled water(disease control),the potent hypocholcsterolcmic agent with antiatherosclerotic activity atorvastatin(2 mg/kg,positive control),or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested(225,300 and 375 mg/kg) concomitantly for four *** of general toxicity,body temperature and weight,and water and food intake were monitored in live *** sacrifice,lipid profiles and oxidative stress markers were assessed in the blood and liver,aorta,and feces,and histopathological analysis of aorta was ***:Plant extract prevented the elevation of aortic total cholesterol and triglycerides,and hepatic low density lipoprotein,very low density lipoprotein,and total *** peroxidation(TBARS) was decreased and aortic atherosclerotic plaque formation ***:These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties,at least partly mediated by antioxidant and hypolipidemic effects.