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制作无牙颌种植即刻负载临时修复体的新型开窗式印模技术

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中国口腔医学继续教育杂志 2015年第5期18卷 258-263页

作者： Takahiro Kaneko Kiyoshi Yamagishi Norio Horie tetsuo shimoyama 华泽乾汤春波不详北京瑞尔齿科北京市朝阳区酒仙桥路18号颐堤港LG100 100621 南京医科大学附属口腔医院种植修复科南京市汉中路136号210005

目的：评估一种用于无牙颌患者种植即刻负载临时修复体制作的新型开窗式印模技术的临床疗效。材料与方法：在本回顾性研究中评估一种新型的开窗式印模技术．选择2006年3月到2009年10月之间接受治疗的患者。术前使用诊断义齿．并在该修... 详细信息

目的：评估一种用于无牙颌患者种植即刻负载临时修复体制作的新型开窗式印模技术的临床疗效。材料与方法：在本回顾性研究中评估一种新型的开窗式印模技术．选择2006年3月到2009年10月之间接受治疗的患者。术前使用诊断义齿．并在该修复体上制作新型开窗式托盘．种植体植入后，使用该托盘同时进行印模和咬合记录，手术当天戴入由技工室制作的螺丝固位的丙烯酸树脂临时修复体．自种植术后到最终修复体戴八期间对该临时修复体进行评估。结果：本研究中21位患者（平均年龄645岁），总共植入125颗种植体．其中104颗种植体即刻负载．所有患者的临时修复体适合性良好，修复体最少由4颗种植体支持。一例患者在术后30d发生临时修复体第一磨牙位置的牙尖断裂．但是．修复体支架无大的断裂或修复体功能不良．术后随访无种植体失败。结论：该治疗方法由于在正中咬合下制取印模．而且能够重建出与诊断性修复体相同的咬合，故而能够制作出适合性良好的种植体即刻负载的丙烯酸树脂临时修复体。

关键词：口腔种植无牙颌即刻负载临时修复体

Basic Research on the Burden of Dropping off and Picking up Children: Differences by Employment Type and Gender in the Tokyo Metropolitan Area

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Journal of Transportation Technologies 2024年第3期14卷 445-461页

作者： Jun Morio Koshi Isono Masahiko Kikuchi tetsuo Morita The Institute of Behavioral Sciences (IBS) Tokyo Japan City Bureau Ministry of Land Infrastructure Transport and Tourism Tokyo Japan Maebashi Institute of Technology Maebashi Japan

There is a need to reduce the burden of child drop-off and pick-up for child-rearing generations, but most studies on the actual situation in Japan are based on survey results. In this study, we analyzed differences in child drop-off and pick-up by employment type and gender, utilizing the “Metropolitan Area Person Trip Survey,” which is a statistical data set. The study targeted households in which both spouses were between 30 and 49 years old, had children under the age of 6, and included the following three groups. 1) Dual-income Group 1 (both spouses employed/on contract/temporary);2) Dual-income Group 2 (husband employed/on contract/temporary, wife part-time);3) Full-time housewife group (husband employed, wife unemployed). The analysis revealed that a) wives are almost always responsible for dropping off and picking up their children;b) husbands drop off and pick up their children less frequently in dual-income households;and c) households with children raising within 10 to 30 km of Tokyo Station have longer commuting times and need to reduce the burden of dropping off and picking up their children.

关键词： Drop-Off and Pick-Up Employment Type Gender Dual-Income Households Tokyo Metropolitan Area

Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

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Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yokoyama Takako Yamada tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

日本东京的极化与分化——基于新自由主义城市政策的分析

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国际城市规划 2024年第2期39卷 40-46页

作者：魏阳城所哲夫西南交通大学东京大学都市工学系

自1970年代以来,新自由主义伴随着全球化的进程从欧美向全球蔓延,日本的城市政策也深受其影响。本文首先提出一个假说,即日本新自由主义的城市政策造成了东京的极化与分化现象。通过国土尺度的分析,笔者观察到自2000年新自由主义成为日... 详细信息

自1970年代以来,新自由主义伴随着全球化的进程从欧美向全球蔓延,日本的城市政策也深受其影响。本文首先提出一个假说,即日本新自由主义的城市政策造成了东京的极化与分化现象。通过国土尺度的分析,笔者观察到自2000年新自由主义成为日本主流城市政策后,东京的单极化趋势明显加速;城市尺度的空间与政策分析结果则反映了东京内部的城市分化日益显著。本文的分析检验并支撑了本文所提假说的有效性,同时证明了东京都政府和各区政府的城市政策与区域绅士化之间存在很强的相关性。本文呼吁,城市规划相关政策应从新自由主义式转向区域协作型,并从大规模城市再开发导向转变为渐进式城市更新导向。在后新自由主义的当下,本文为中国规划理论的范式转型提供了一种路径思考。

关键词：新自由主义单极化城市分化城市政策东京

Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

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World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido tetsuo Ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

Assessment of physical stress during the perioperative period of endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第32期28卷 4508-4515页

作者： Daisuke Chinda Tadashi shimoyama Department of Gastroenterology Hirosaki University Graduate School of MedicineHirosaki 036-8562Japan Division of Endoscopy Hirosaki University HospitalHirosaki 036-8563Japan Department of Internal Medicine Aomori General Health Examination CenterAomori 030-0962Japan

The advantage of endoscopic submucosal dissection(ESD)is that it is less invasive than *** is one of the best treatments for older patients as surgery in this age group of patients is ***,it is unclear how much lower the physical stress of ESD is compared with that of ***,objective methods are required to assess physical stress in patients who have undergone *** current review of ESD aimed to summarize the recent advancements in the assessment of physical stress during the perioperative period,focusing on changes in energy metabolism and serum opsonic activity(SOA).Based on metabolic changes,resting energy expenditure(REE)was measured using an indirect *** stress factor calculated from the REE and the basal energy expenditure computed using the Harris-Benedict equation can be used to assess physical *** was assessed using the chemiluminescence method,wherein the use of chemiluminescent probes(i.e.,lucigenin and luminol)allowed quantification of reactive oxygen species generated by *** an auto luminescence analyzer,the results were evaluated based on the maximum light emission and area under the emission *** quantifiable results revealed the minimal invasiveness of ESD.

关键词： Physical stress Endoscopic submucosal dissection Indirect calorimeter Resting energy expenditure Chemiluminescence Serum opsonic activity

Impact of Helicobacter pylori infection on gut microbiota

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World Journal of Gastroenterology 2021年第37期27卷 6224-6230页

作者： Chikara Iino Tadashi shimoyama Department of Gastroenterology Hirosaki University Graduate School of MedicineHirosaki 036-8562Japan Department of Internal Medicine Aomori General Health Examination CenterAomori 030-0962Japan

A number of studies have revealed the association between Helicobacter pylori(***)infection and the gut *** than half of the investigations on the impact of *** on the gut microbiota have been the sub-analyses of the influence of eradication *** was observed that *** eradication altered gut microbiota within a short period after eradication,and majority of the alterations took a long period of time to reverse back to the *** in the gut microbiota within a short period after eradication may be attributed to antibiotics and proton pump *** of gastric acidity in the stomach caused by a long-term *** infection alters the gut *** of the gut microbiota should be conducted in a large population,adjusting for considerable biases associated with the composition of the gut microbiota,such as age,sex,body mass index,diet and the virulence of ***.

关键词： Helicobacter pylori Gut microbiota Atrophic gastritis Eradication Proton pump inhibitor

Controlling the aggregation and assembly of boron-containing molecular and polymeric materials

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Aggregate

Aggregate 2022年第2期3卷 50-59页

作者： Daisuke shimoyama Frieder Jäkle Department of Chemistry Rutgers University-NewarkNewarkNew JerseyUSA

Boron-containing molecules and polymers are attractive as powerful tunable Lewis acids for small molecule activation and catalysis,as luminescent materials for organic electronic device and(bio)imaging applications,and as smart chemical *** the characteristics of the boron-containing building blocks are attractive in and of themselves,their assembly into higher order supramolecular materials offers access to unique properties and emerging ***,we highlight recent achievements in the field of aggregated organoboron *** discuss how supramolecular interactions can be exploited to precisely control the structure of the assemblies and impact their functions as luminescent materials,recyclable and smart catalyst systems,chemical sensors,stimuli-responsive and self-healing materials.

关键词： boron luminescent materials nanostructure self-assembly supramolecular polymers

Trajectories of endoscopic Barrett esophagus: Chronological changes in a community-based cohort

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World Journal of Gastroenterology 2016年第35期22卷 8060-8066页

作者： Shouji shimoyama Toshihisa Ogawa Toshiyuki Toma Gastrointestinal Unit Settlement Clinic

AIM To elucidate longitudinal changes of an endoscopic Barrett esophagus(BE), especially of short segment endoscopic BE(SSBE). METHODS This study comprised 779 patients who underwent two or more endoscopies between January 2009 and December 2015. The intervals between the first and the last endoscopy were at least 6 mo. The diagnosis of endoscopic BE was based on the criteria proposed by the Japan Esophageal Society and was classified as long segment(LSBE) and SSBE, the latter being further divided into partial and circumferential types. The potential background factors that were deemed to affect BE change included age, gender, antacid therapy use, gastroesophageal reflux disease-suggested symptoms, esophagitis, and hiatus hernia. Time trends of a new appearance and complete regression were investigated by Kaplan-Meier curves. The factors that may affect appearance and complete regression were investigated by χ~2 and Student-t tests, and multivariable Cox regression analysis. RESULTS Incidences of SSBE and LSBE were respectively 21.7% and 0%, with a mean age of 68 years. Complete regression of SSBE was observed in 61.5% of initial SSBE patients, while 12.1% of initially disease free patients experienced an appearance of SSBE. Complete regressions and appearances of BE occurred constantly over time, accounting for 80% and 17% of 5-year cumulative rates. No LSBE development from SSBE was observed. A hiatus hernia was the only significant factor that facilitated BE development(P = 0.03) or hampered(P = 0.007) BE regression. CONCLUSION Both appearances and complete regressions of SSBE occurred over time. A hiatus hernia was the only significant factor affecting the BE story.

关键词： Barrett esophagus Longitudinal vessels Progression Regression Hiatus hernia