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Chinese Journal of Catalysis 2017年第11期38卷 1888-1898页

作者： Ayako Taketoshi Tamao Ishida Hironori Ohashi tetsuo honma Masatake Haruta Research Center for Gold Chemistry Graduate School of Urban Environmental Sciences Tokyo Metropolitan University 1‐1 Minami‐osawa HachiojiTokyo 192‐0397 Japan Department of Applied Chemistry Graduate School of Urban Environmental Sciences Tokyo Metropolitan University 1‐1 Minami‐osawa Hachioji Tokyo 192‐0397 Japan Faculty of Symbiotic Systems Science Fukushima University 1 Kanayagawa Fukushima Fukushima 960‐1296 Japan Japan Synchrotron Radiation Research Institute (JASRI) 1‐1‐1 Kouto Sayo Hyogo 679‐5198 Japan Gold Catalysis Research Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning China

Gold clusters and small nanoparticles supported on metal oxides could be prepared by deposition‐precipitation followed by microwave irradiation as a drying method and then *** drying method influenced the size of the Au ***(III)was partly reduced during conventional oven drying,resulting in Au *** contrast,Au(III)was preserved during microwave drying owing to rapid and uniform heating,and the Au diameter was minimized to1.4nm on *** method can be applied to several metal oxide supports having different microwave absorption efficiencies,such as MnO2,Al2O3,and *** catalysts exhibited higher catalytic activities for CO oxidation at low temperature and for selective aerobic oxidation of sulfide than those prepared by conventional methods.

关键词： Gold nanoparticles Gold clusters Microwave CO oxidation Aerobic oxidation

X-Ray Absorption Spectroscopy Analysis of Lead Species Adsorbed on Various Oxides from High pH Solution

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Journal of Environmental Protection 2020年第10期11卷 807-820页

作者： Takanori Miyake tetsuo honma Hiroshi Arimatsu Hiroto Fukunishi Huimin Liu Makoto Sano Yuuki Kakutani Mitsumasa Okada Kaori Shimizu Setsuo Yoshida Kazumasa Suetsugu Faculty of Urban and Environmental Engineering Kansai University Suita Osaka Japan Japan Synchrotron Radiation Institute (JASRI) Sayo-cho Hyogo Japan TOSOH Corporation Shunan Yamaguchi Japan

Lead dissolved in water must be removed in order not to cause diseases, especially from high pH aqueous solution. Various oxides having high specific surface area are often applied to remove lead in water media. To improve removal ability for lead species, it is necessary to understand the adsorbed structure of lead species on oxides. At first, the adsorption behavior of lead from high pH solution in the presence of Ca2+ and Na+ was compared. Lead and calcium species were adsorbed up to the monolayer, and the adsorption isotherm was analyzed as Langmuir-type adsorption. In the presence of Ca2+, the amount of removed lead was reduced. To clarify this influence of Ca2+, X-ray absorption spectroscopy was adopted. It was for the first time revealed that lead species at pH > 12 and pH < 10.5 differed, and that lead species adsorbed on various oxides had a similar structure.

关键词： X-Ray Absorption Spectroscopy Water Purification Lead Removal Manganese Oxide Adsorption

FEM analysis for hot rolling process of AM60 alloy

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中国有色金属学会会刊：英文版 2008年第A01期18卷 242-246页

作者：丁汉材 KANAMORI Nao honma Tomoyuki KAMADO Shigeharu KOJIMA Yo Department of Mechanical Engineering Nagaoka University of Technology 1603-1 Kamitomioka Nagaoka Niigata 940-2188 Japan

The rolling of AM60 sheets for 50%reduction was analyzed with DEFORM to investigate the hot deformation process. The simulated results show that the sheet velocities at the entrance(21 mm/s) and at the exit(37 mm/s) are less and larger than roll velocity,*** the entrance to the neutral point,the velocity at the sheet surface is greater than that at the middle point of sheet in thickness,while that from the neutral point to the exit shows the opposite *** effective strain of the sheet increases from the entrance to the exit due to the continuous reduction in *** addition,the effective strain at the sheet surface reaches to 1.0 and is larger than that of 0.8 at the middle point of *** difference of effective strain in thickness direction has a much stronger effect on the recrystallized fraction than on the recrystallized grain *** minimum temperature of 347℃is obtained at the surface contacting directly with roll and the maximum temperature 388℃at the middle point of sheet in thickness.

关键词： AM60镁合金流动性有限元分析 FEM

Antitumor effect of VEGFR2-targeted microbubble destruction with gemcitabine using an endoscopic ultrasound probe:In vivo mouse pancreatic ductal adenocarcinoma model

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 478-485页

作者： Nana Shimamoto Masaki Ito Masafumi Chiba Sadamu honma Hiroo Imazu Kazuki Sumiyama Department of Endoscopy The Jikei University School of Medicine3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Oncology Research Center for Medical Science3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of Medicine30-1 Oyaguchikami-choItabashi-kuTokyo 173-8610Japan

Background:Ultrasound-targeted microbubble destruction(UTMD)induces cellular inflow of drugs at low intensity,while high intensity eradicates tumor *** vascular endothelial growth factor receptor 2(VEGFR2)is highly expressed in pancreatic ductal adenocarcinoma(PDAC),VEGFR2-targeted microbubble(MB)might additionally increase the tissue specificity of drugs and thus improve antitumor *** addition,fixing the dual pulse intensity could maximize MB *** study evaluated the one-off(experiment 1)and cumulative(experiment 2)treatment effect of UTMD by regulating the dual pulse output applied to PDAC using VEGFR2-targeted ***:C57BL/6 mice inoculated with Pan-02 cells were allocated to five groups:VEGFR2-targeted MB+gemcitabine(GEM),VEGFR2-targeted MB,non-targeted MB+GEM,GEM,and control *** injection of GEM or GEM and either VEGFR2-targeted or non-targeted MB,UTMD was applied for several minutes at low intensity followed by high intensity *** experiment 1,mice were treated by the protocol described above and then euthanized immediately or at the tumor diameter doubling time(TDT).In experiment 2,the same protocol was repeated weekly and mice were euthanized at TDT regardless of protocol *** analysis by CD31 and VEGFR2 staining provided microvascular density(MVD)and VEGFR2 expression along vessels(VEGFR2v)or intra/peripheral cells(VEGFR2c).Results:In experiment 1,TDT was significantly longer in the VEGFR2-targeted MB+GEM group compared to the non-targeted MB+GEM,GEM,and control groups,while the VEGFR2-targeted MB group showed no statistical *** and VEGFR2v in the immediate euthanasia was significantly lower in the VEGFR2-targeted MB+GEM and VEGFR2-targeted MB groups than other *** experiment 2,the VEGFR2-targeted MB+GEM group produced significantly longer TDT than the GEM or control groups,whereas the VEGFR2-targeted MB group showed no significant *** revealed sign

关键词： Ultrasound-targeted microbubble destruction VEGFR2-targeted microbubble Pancreatic ductal adenocarcinoma Gemcitabine

Automatic registration of MLS point clouds and SfM meshes of urban area

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Geo-Spatial Information Science 2016年第3期19卷 171-181页

作者： Reiji Yoshimura Hiroaki Date Satoshi Kanai Ryohei honma Kazuo Oda Tatsuya Ikeda Graduate School of Information Science and Technology Hokkaido UniversitySapporoJapan Asia Air Survey Co. LtdKawasakiJapan

Recent advances in 3D scanning technologies allow us to acquire accurate and dense 3D scan data of large-scale environments ***,there are various methods for acquiring largescale 3D scan data,such as Mobile Laser Scanning(MLS),Airborne Laser Scanning,Terrestrial Laser Scanning,photogrammetry and Structure from Motion(SfM).Especially,MLS is useful to acquire dense point clouds of road and road-side objects,and SfM is a powerful technique to reconstruct meshes with textures from a set of digital *** this research,a registration method of point clouds from vehicle-based MLS(MLS point cloud),and textured meshes from the SfM of aerial photographs(SfM mesh),is proposed for creating high-quality surface models of urban areas by combining *** general,SfM mesh has non-scale information;therefore,scale,position,and orientation of the SfM mesh are adjusted in the registration *** our method,first,2D feature points are extracted from both SfM mesh and MLS point *** process consists of ground-and building-plane extraction by region growing,random sample consensus and least square method,vertical edge extraction by detecting intersections between the planes,and feature point extraction by intersection tests between the ground plane and the ***,the corresponding feature points between the MLS point cloud and the SfM mesh are searched efficiently,using similarity invariant features and ***,the coordinate transformation is applied to the SfM mesh so that the ground planes and corresponding feature points are ***,scaling Iterative Closest Point algorithm is applied for accurate *** results for three data-sets show that our method is effective for the registration of SfM mesh and MLS point cloud of urban areas including buildings.

关键词： Registration MLS point clouds SfM mesh urban area hash similarity invariant feature

Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto Shinji Oe Koichiro Miyagawa Yuichi honma Masaru Harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

Hepatitis A complicated with acute renal failure and high hepatocyte growth factor: A case report

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World Journal of Gastroenterology 2015年第32期21卷 9671-9674页

作者： Shinji Oe Michihiko Shibata Koichiro Miyagawa Yuichi honma Masaaki Hiura Shintaro Abe Masaru Harada Department of Internal Medicine School of Medicine University of Occupational and Environmental Health

A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus(HAV) antibodies. He was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth factor(HGF). Therefore, he was diagnosed with severe acute liver failure with acute renal failure(ARF) caused by HAV infection. Prognosis was expected to be poor because of complications by ARF and high serum HGF. However, liver and renal functions both improved rapidly without intensive treatment, and he was subsequently discharged from our hospital on the 21 st hospital day. Although complication with ARF and high levels of serum HGF are both important factors predicting poor prognosis in acute liver failure patients, the present case achieved a favorable outcome. Endogenous HGF might play an important role as a regenerative effector in injured livers and kidneys.

关键词： Acute hepatitis Acute renal failure Hepatitis A vi

Role of targeted therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 642-655页

作者： Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita Department of Medical Oncology Hokkaido University Graduate School of MedicineSapporoHokkaido 060-8638Japan

Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the *** of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two *** biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage ***,ramucirumab,and regorafenib are also used in second-line or salvage *** retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR *** on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and *** aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC.

关键词： Metastatic colorectal cancer Aflibercept Ramucirumab Regorafenib Cetuximab Panitumumab Targeted therapy Bevacizumab

Current Topics in Genetic Toxicology

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Current Topics in Genetic Toxicology

Risk assessment and management of genotoxic impurities in pharmaceuticals

遗传毒理和发育毒理专题研讨会

作者： Masamitsu honma Division of Genetics and Mutagenesis National Institute of Health Sciences

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Risk assessment and management of genotoxic impurities in ph...