检索结果-南通市图书馆

Intoxicated Eyewitnesses: The Effects of Alcohol on Eyewitness Recall across Repeated Interviews

Open Journal of Medical Psychology 2013年第3期2卷 107-114页

作者： David La Rooy Annabelle Nicol philip terry Department of Psychology Kingston University London London UK School of Social & Health Sciences University of Abertay Dundee Dundee UK

The study evaluated the usefulness of repeat-interviewing of witnesses to crimes who were intoxicated by alcohol at the time of the incident and their first interview, and then re-interviewed when not intoxicated the following day. Sixty young, social drinkers were divided into three groups. One group was given a “placebo” (alcohol-like) beverage, a second was given a “low dose” of alcohol (0.2 g/kg men;0.17 g/kg women), and a third was given a “high dose” of alcohol (0.6 g/kg men;0.52 g/kg women) over a 15 minute period. Twenty minutes later they viewed a 4-minute video of a crime, and afterwards they were given two opportunities to recall everything that they could remember from the incident;the first opportunity was immediately after the event, and the second was 24 hours later. Analyses of the quantity and accuracy of the details recalled revealed no overall increase in the total amount of information recalled between the first and second recall opportunities. However, on average, 18% of the details recalled by participants in the second test were new and accurate. The incidence of contradictions between the first and second recall opportunities was less than 1%. Surprisingly, none of the effects were influenced by alcohol, even at the highest dose. The results imply that 1) memory for at least some incidents observed under the influence of alcohol is resilient even up to relatively high blood-alcohol levels;and 2) the repeated interviewing of witnesses who were intoxicated at the time of the crime can reveal additional, reliable information that is not present at the initial interview, just as is the case for non-intoxicated witnesses.

关键词： Alcohol Eyewitness Memory Repeated Interviews Reminiscence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China

引用

Biosafety and Health 2019年第2期1卷 84-90页

作者： Li Hongying Mendelsohn Emma Zong Chen Zhang Wei Hagan Emily Wang Ning Li Shiyue Yan Hong Huang Huimin Zhu Guangjian Ross Noam Chmura Aleksei terry philip Fielder Mark Miller Maureen Shi Zhengli Daszak Peter EcoHealth Alliance New YorkNYUSA School of Education and Human Development University of Colorado DenverDenverCOUSA Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China School of Health Sciences Wuhan UniversityWuhan 430071China Directorate of Research Business and InnovationKingston UniversityLondonUK School of Life Science Engineering and ComputingKingston UniversityLondonUK Mailman School of Public Health Columbia UniversityNew YorkNYUSA

Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses,including many bat-origin viral *** the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined,and the link between specific interactions and spillover risk is poorly *** investigate this phenomenon,we conducted biological-behavioral surveillance among rural residents in Yunnan,Guangxi,and Guangdong districts of Southern China,where we have identified a number of SARS-related coronaviruses in *** samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays(ELISA).Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk.A total of 1,596 residents were enrolled in the study from 2015 to *** participants(0.6%)tested positive for bat coronaviruses.265(17%)participants reported severe acute respiratory infections(SARI)and/or influenza-like illness(ILI)symptoms in the past year,which were associated with poultry,carnivore,rodent/shrew,or bat contact,with variability by family income and district of *** study provides serological evidence of bat coronavirus spillover in rural communities in Southern *** low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare ***,this study highlights associations between human-animal interaction and zoonotic spillover *** findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence.

关键词： Bat coronavirus Human-animal interaction Disease emergence Southern China Rural community

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tree Population Dynamics of Three Altitudinal Vegetation Communities on Mount Cameroon(1989-2004)

引用

Journal of Mountain Science 2011年第4期8卷 495-504页

作者： philip F.FORBOSEH terry C.H.SUNDERLAND James A.COMISKEY Michael BALINGA Plan Cameroon P O Box 25236 MessaYaoundéCameroon Centre for International Forestry Research(CIFOR) Inventory and Monitoring Program National Park Service120 Chatham Lane Smithsonian Institution S.Dillon Ripley Center1100 JeffersonDrive SW Washington DC 20560USA Center for International Forestry Research(CIFOR)

Changes in permanent sample plots in the lowland,submontane and montane forests on Mount Cameroon(4,095 m above sea level),an active volcano,are described for 15 years from 1989 to *** the study period,the stocking level of trees with a diameter at breast height(DBH) ≥ 10 cm in the three forests were lower than in pan-tropical stands suggesting a significant impact of volcanic and human-related activities on the vegetation communities on the *** mortality rates in the submontane and montane forests were consistent with those reported for comparable altitudinal ranges in the Blue Mountains of *** annual mortality rate was higher in the lowland forest than other lowland sites *** between recruitment and mortality rates was large suggesting that the three vegetation communities have not reached their *** seven-year difference in half-life of large trees(with a DBH ≥ 50 cm) in the submontane and montane forests suggests an altitudinal effect on turnover of larger trees that in turn contributes to the frequent small stature of high altitude *** was little evidence of an altitudinal effect on species turnover and growth *** finding supports generalizations about the zero effect of growth on the stature of high altitude *** forest dynamics is crucially important in the management of tropical montane environmentsand in this instance particularly so given the recent creation of the Mount Cameroon National Park.

关键词： Growth rates Recruitment Mortality Altitude Half-life Mount Cameroon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microbial communities biostimulated by ethanol during uranium （VI） bioremediation in contaminated sediment as shown by stable isotope probing

引用

Frontiers of Environmental Science & Engineering 2015年第3期9卷 453-464页

作者： Mary Beth LEIGH Wei-Min WU Erick CARDENAS Ondrej UHLIK Sue CARROLL terry GENTRY Terence L. MARSH Jizhong ZHOU philip JARDINE Craig S. CRIDDLE James M. TIEDJE Center for Microbial Ecology Michigan State University East Lansing MI 48824 USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK 99775 USA Department of Civil and Environmental Engineering Center for Sustainable Development & Global Competitiveness Codiga Resource Recovery Center Stanford University Stanford CA 94305-4020 USA Department of Biochemistry and Microbiology Institute of Chemical Technology Prague Technicka 3 166 28 Prague Czech Republic Environmental Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA Department of Crop and Soil Sciences Texas A&M University College Station TX 77843 USA

Stable isotope probing （SIP） was used to identify microbes stimulated by ethanol addition in microcosms containing two sediments collected from the bioremediation test zone at the US Department of Energy Oak Ridge site, TN, USA. One sample was highly bioreduced with ethanol while another was less reduced. Microcosms with the respective sediments were amended with ^13C labeled ethanol and incubated for 7 days for SIP. Ethanol was rapidly converted to acetate within 24h accompanied with the reduction of nitrate and sulfate. The accumulation of acetate persisted beyond the 7 d period. Aqueous U did not decline in the microcosm with the reduced sediment due to desorption of U but continuously declined in the less reduced sample. Microbial growth and concomitant 13C-DNA production was detected when ethanol was exhausted and abundant acetate had accumulated in both microcosms. This coincided with U（VI） reduction in the less reduced sample. I3C originating from ethanol was ultimately utilized for growth, either directly or indirectly, by the dominant microbial community members within 7 days of incubation. The microbial community was comprised predominantly of known denitrifiers, sulfate-reducing bacteria and iron （Ⅲ） reducing bacteria including Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus and others, including the known U（VI）-redueing bacteria Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobac- ter and Desulfosporosinus. The findings suggest that ethanol biostimulates the U（VI）-reducing microbial com- munity by first serving as an electron donor for nitrate, sulfate, iron （IH） and U（VI） reduction, and acetate which then functions as electron donor for U（VI） reduction and carbon source for microbial growth.

关键词： Stable isotope probing (S/P) ethanol acetate uranium reduction sediment bioremediation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dysfunctional stem and progenitor cells impair fracture healing with age

引用

World Journal of Stem Cells 2019年第6期11卷 281-296页

作者： Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M terry Loghmani philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li Department of Mechanical and Energy Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202United States Department of Medicinal Chemistry and Molecular Pharmacology Purdue UniversityWest LafayetteIN 47907United States Department of Physical Therapy Indiana University- Purdue University IndianapolisIndianapolisIN 46202United States Division of Biomedical Science Marian University College of Osteopathic MedicineIndianapolisIN 46222United States Department of Chemistry Purdue UniversityWest LafayetteIN 47907 United States Richard L. Roudebush VA Medical Center IndianapolisIN 46202United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States Department of Biology Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.

关键词： Fracture healing Aging Bone Angiogenesis Mesenchymal stem cells Endothelial progenitor cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development

引用

Molecular Plant 2016年第2期9卷 245-260页

作者： Kamaldeep S. Virdi Yashitola Wamboldt Hardik Kundariya John D. Laurie Ido Keren K.R. Sunil Kumar Anna Block Gilles Basset Steve Luebker Christian Elowsky philip M. Day Johnna L. Roose terry M. Bricker Thomas Elthon Sally A. Mackenzie School of Biological Sciences Department of Agronomy and Horticulture University of Nebraska Lincoln NE 68588 USA Center for Biotechnology University of Nebraska Lincoln NE 68588 USA Department of Biological Sciences Louisiana State University Baton Rouge LA 70803 USA These authors contributed equally to this article

As metabolic centers, plant organelles participate in maintenance, defense, and signaling. MSH1 is a plant- specific protein involved in organeUar genome stability in mitochondria and plastids. Plastid depletion of MSH1 causes heritable, non-genetic changes in development and DNA methylation. We investigated the rash I phenotype using hemi-complementation mutants and transgene-null segregants from RNAi suppres- sion lines to sub-compartmentalize MSH1 effects. We show that MSH1 expression is spatially regulated, specifically localizing to plastids within the epidermis and vascular parenchyma. The protein binds DNA and localizes to plastid and mitochondrial nucleoids, but fractionation and protein-protein interactions data indicate that MSH1 also associates with the thylakoid membrane. Plastid MSH1 depletion results in variegation, abiotic stress tolerance, variable growth rate, and delayed maturity. Depletion from mitochon- dria results in 7%-10% of plants altered in leaf morphology, heat tolerance, and mitochondrlal genome sta- bility. MSH1 does not localize within the nucleus directly, but plastid depletion produces non-genetic changes in flowering time, maturation, and growth rate that are heritable independent of MSH 1. MSH1 deple- tion alters non-photoactive redox behavior in plastids and a sub-set of mitochondrially altered lines. Ectopic expression produces deleterious effects, underlining its strict expression control. Unraveling the complexity of the MSH1 effect offers insight into triggers of plant-specific, transgenerational adaptation behaviors.

关键词： Thylakoid protein Organellar DNA binding MSH1 Epigenetic variation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diversity and Frequencies of HLA Class I and Class II Genes of an East African Population

引用

Open Journal of Genetics 2014年第2期4卷 99-124页

作者： Trevor A. Peterson Thomas Bielawny philip Lacap Rae-Anne Hardie Christina Daniuk Lillian Mendoza Subotheni Thavaneswaran Tony Kariri Joshua Kimani Charles Wachihi Maboku Kimani terry Blake Ball Francis A. Plummer Ma Luo Department of Medical Microbiology University of Manitoba Winnipeg Canada Department of Medical Microbiology University of Nairobi Nairobi Kenya National Microbiology Laboratory Winnipeg Canada

Human Leukocyte Antigens (HLAs) play an important role in host immune responses to infectious pathogens, and influence organ transplantation, cancer and autoimmune diseases. In this study we conducted a high resolution, sequence-based genotyping of HLA class I and class II genes of more than 2000 women from Kenya, eastern Tanzania and southern Uganda around Lake Victoria and analyzed their allele, phenotype and haplotype frequencies. A considerable genetic diversity was observed at both class I and II loci. A total of 79 HLA-A, 113 HLA-B, 53 HLA-C, 25 HLA-DPA1, 60 HLA-DPB1, 15 HLA-DQA1, 44 HLA-DQB1 and 38 HLA-DRB1 alleles have been identified. The most common class I alleles were A * 02:01:01 (10.90%), B * 58:02 (8.79%), and C * 06:02:01 (16.98%). The most common class II alleles were DPA1*01:03:01 (40.60%), DPB1 * 01:01:01 (23.45%), DQA1 * 01:02:01 (31.03%), DQB1 * 03:01:01 (21.79%), DRB1 * 11:01:02 (11.65%), DRB3 * 02:02:01 (31.65%), DRB4 * 01:01:01 (10.50%), and DRB5 * 01:01:01 (10.50%). Higher than expected homozygosity was observed at HLA-B (P = 0.022), DQA1 (P = 0.004), DQB1 (P = 0.023), and DRB1 (P = 0.0006) loci. The allele frequency distribution of this population is very similar to the ones observed in other sub-Saharan populations with the exception of lower frequencies of A * 23 (5.55% versus 11.21%) and DQA1 * 03 (4.79% versus 11.72%), and higher frequencies of DPB1 * 30 (2.26% versus 0.37%) and DRB1 * 11 (21.51% versus 15.89%). The knowledge of the diversity and allele/ phenotype frequencies of the HLA alleles of this east African population, can contribute to the understanding of how host genetic factors influence disease susceptibility and effective anti-retroviral treatment of HIV infections and future vaccine trials.

关键词： HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 HLA Frequencies HLA Class I HLA Class II East African

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症一级预防的环境与职业干预：一个跨部门的政策框架

引用

环境与职业医学 2013年第10期30卷 806-810页

作者： Carolina Espina Miquel Porta Joachim Schüz Ildefonso Hernández Aguado Robert V.Percival Carlos Dora terry Slevin Julietta Rodriguez Guzman Tim Meredith philip J.Landrigan Maria Neira 汪源何蓉金泰廙 Department of Public Health and Environment World Health Organization(WHO)GenevaSwitzerland Section of Environment and Radiation International Agency for Research on Cancer(IARC)LyonFrance Hospital del Mar Institute of Medical Research(IMIM-Hospital del Marprbb) BarcelonaSpain Networking Centre of Biomedical Research in Epidemiology and Public Health(CIBERESP) Spain Universidad Autónoma de Barcelona(UAB) BarcelonaSpain Department of Public Health Facultad de MedicinaUniversidad Miguel HernándezSan Juan de AlicanteSpain Environmental Law Program University of Maryland Carey School of LawBaltimoreMarylandUSA Cancer Council Western Australia PerthWestern AustraliaAustralia Occupational Health Program El Bosque UniversityBogotaColombia Department of Sustainable Development and Environment Pan-American Health Organization/WHOWashington DCUSA Department of Preventive Medicine Mount Sinai School of MedicineNew YorkNew YorkUSA

[背景]每年,全球新发癌症近1300万例,癌症死亡760万例;63%的癌症死亡病例发生在中、低收入国家。有相当比例的癌症是由环境和工作场所中致癌物暴露所致。[目的]为环境和职业性癌症的一级预防制定基于循证的全球愿景和战略。[方法]通过在... 详细信息

[背景]每年,全球新发癌症近1300万例,癌症死亡760万例;63%的癌症死亡病例发生在中、低收入国家。有相当比例的癌症是由环境和工作场所中致癌物暴露所致。[目的]为环境和职业性癌症的一级预防制定基于循证的全球愿景和战略。[方法]通过在PubMed中组合使用"环境的"、"职业的"、"暴露"、"癌症"、"一级预防"和"干预"这些搜索词,确定相关研究。为补充文献综述,于2011年3月17—18日在西班牙阿斯图里斯亚召开了"癌症的环境与职业决定因素:一级预防干预"国际会议,该会议由世界卫生组织主办。[讨论]很多由环境和职业引起的癌症都是可以预防的。一级预防政策通过减少或消除非自愿暴露于确认或潜在致癌物质,可最有效地实现预防目的。根据现有的知识,这些策略直接且经济有效,还具有附带效益,即通过减少共同风险因素的暴露,协同降低其他非传染性疾病的风险。[结论]通过整合环境和职业性致癌物初级干预来重振全球癌症控制政策是可能的。

关键词：癌症环境卫生职业的政策一级预防公共卫生

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

经济全球化及其对卫生事业的影响制造两三架战斗机的费用足以根除某些疾病

引用

英国医学杂志中文版 1998年第3期1卷 107-108页

作者： Nigel Unwin George Alberti terry Aspray Richard Edwards Jean-Claude Mbanya Eugene Sobngwi Ferdinand Mugusi Seif Rashid philip Setel David Whiting 刘智 Newcastle upon Tyne UK c/o Department of MedicineUniversity of Newcastle Medical SchoolNewcastle NE2 4HH Yaounde c/o Department of Medicine University of Newcastle Medical SchoolNewcastle NE2 4HH Cameroon c/o Department of Medicine University of Newcastle Medical SchoolNewcastle NE2 4HH Dar es Salaam Tanzania c/o Department of MedicineUniversity of Newcastle Medical SchoolNewcastle NE2 4HH

世界银行的统计数字把坦桑尼亚列为世界最穷国家之一,然而,其商业中心达累斯萨拉姆却是世界上最为昂贵的城市之一,这是由于领取发达国家水平工资的外企职工助长了高消费。更具讽刺意义的是,在坦桑尼亚及其它众多发展中国家,净剩财富的... 详细信息

世界银行的统计数字把坦桑尼亚列为世界最穷国家之一,然而,其商业中心达累斯萨拉姆却是世界上最为昂贵的城市之一,这是由于领取发达国家水平工资的外企职工助长了高消费。更具讽刺意义的是,在坦桑尼亚及其它众多发展中国家,净剩财富的流向同殖民时期一样,仍是从穷人流向富人。

关键词：经济全球化国家债务统计数字商业中心公共卫生基本卫生服务卫生工作者间接死亡卫生保健阿鲁沙

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：