Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China

作     者：Li Hongying Mendelsohn Emma Zong Chen Zhang Wei Hagan Emily Wang Ning Li Shiyue Yan Hong Huang Huimin Zhu Guangjian Ross Noam Chmura Aleksei Terry Philip Fielder Mark Miller Maureen Shi Zhengli Daszak Peter Li Hongying;Mendelsohn Emma;Zong Chen;Zhang Wei;Hagan Emily;Wang Ning;Li Shiyue;Yan Hong;Huang Huimin;Zhu Guangjian;Ross Noam;Chmura Aleksei;Terry Philip;Fielder Mark;Miller Maureen;Shi Zhengli;Daszak Peter

作者机构：EcoHealth AllianceNew YorkNYUSA School of Education and Human DevelopmentUniversity of Colorado DenverDenverCOUSA Key Laboratory of Special Pathogens and BiosafetyWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China School of Health SciencesWuhan UniversityWuhan 430071China Directorate of ResearchBusiness and InnovationKingston UniversityLondonUK School of Life ScienceEngineering and ComputingKingston UniversityLondonUK Mailman School of Public HealthColumbia UniversityNew YorkNYUSA 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2019年第1卷第2期

页      面：84-90页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 0836[工学-生物工程] 10[医学] 

基　　金：This study was approved by Wuhan University School of Health Sciences Medical Ethics Committee,Institutional Review Board Administration of University of California,Davis(No.804522-6) Hummingbird IRB(No.2014-23) This work was supported by the United States Agency for International Development(USAID)Emerging Pandemic Threats PREDICT project[Cooperative Agreement No.AID-OAA-A-14-00102] the National Institute of Allergy and Infectious Diseases of the National Institutes of Health[Award No.R01AI110964] 

主　　题：Bat coronavirus Human-animal interaction Disease emergence Southern China Rural community 

摘      要：Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses,including many bat-origin viral *** the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined,and the link between specific interactions and spillover risk is poorly *** investigate this phenomenon,we conducted biological-behavioral surveillance among rural residents in Yunnan,Guangxi,and Guangdong districts of Southern China,where we have identified a number of SARS-related coronaviruses in *** samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays(ELISA).Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk.A total of 1,596 residents were enrolled in the study from 2015 to *** participants(0.6%)tested positive for bat coronaviruses.265(17%)participants reported severe acute respiratory infections(SARI)and/or influenza-like illness(ILI)symptoms in the past year,which were associated with poultry,carnivore,rodent/shrew,or bat contact,with variability by family income and district of *** study provides serological evidence of bat coronavirus spillover in rural communities in Southern *** low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare ***,this study highlights associations between human-animal interaction and zoonotic spillover *** findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence.