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Childhood sleep:assessments,risk factors,and potential mechanisms

World Journal of Pediatrics 2024年第2期20卷 105-121页

作者： Jianghong Liu Xiaopeng Ji Elizabeth Rovit Susannah Pitt terri Lipman School of Nursing University of Pennsylvania418 Curie Blvd.Room 426Claire M.Fagin HallPhiladelphiaPA 19104USA School of Nursing College of Health SciencesUniversity of DelawareNewarkDE 19716USA Geisinger Commonwealth School of Medicine ScrantonPA 18510USA

Background Sleep problem is a highly prevalent health issue among pediatric populations across the *** this review,we aimed to identify risk factors contributing to sleep deficiency and poor sleep hygiene in *** biological,psychosocial,and environmental mechanisms as well as research gaps in the literature are also *** sources A comprehensive search for relevant English language full-text,peer-reviewed publications was performed focusing on pediatric sleep studies from prenatal to childhood and adolescence in a variety of indexes in PubMed,SCOPUS,and Psych *** relevant data based and systematic reviews are *** This paper summarizes many risk factors for childhood sleep problems,including biological(e.g.,genetics,gender,age and puberty,prenatal factors,postnatal factors);nutritional(e.g.,macronutrients,micronutrients,omega-3 fatty acids,obesity);environmental(e.g.,heavy metals,noise,light,air pollution);interpersonal(e.g.,family,exposure to violence,screen media use,physical injury);and community/socioeconomic variables(e.g.,racial/ethnicity and cultural factors,neighborhood conditions and socioeconomic status,school factors,public health disasters/emergencies),to better understand the development of sleep problems in *** Poor childhood sleep is a multifactorial issue affected by a wide range of prenatal and early-life biological,environmental,and psychosocial risk factors and contributors.A better understanding of these risk factors and their mechanisms is an important first step to develop future research and prevention programs focusing on pediatric sleep problems.

关键词： Child sleep Pediatrics Risk factor Mechanisms

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Childhood sleep:physical,cognitive,and behavioral consequences and implications

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World Journal of Pediatrics 2024年第2期20卷 122-132页

作者： Jianghong Liu Xiaopeng Ji Susannah Pitt Guanghai Wang Elizabeth Rovit terri Lipman Fan Jiang School of Nursing University of Pennsylvania418 Curie Blvd.Room 424Claire M.Fagin HallPhiladelphiaPA 19104USA College of Health Sciences University of DelawareNewarkDE 19716USA Geisinger Commonwealth School of Medicine ScrantonPA 18510USA Pediatric Translational Medicine Institute Department of Developmental and Behavioral PediatricsSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Sleep problems in children have been increasingly recognized as a major public health *** research has extensively studied and presented many risk factors and potential mechanisms for children’s sleep *** this paper,we aimed to identify and summarize the consequences and implications of child sleep *** sources A comprehensive search for relevant English language full-text,peer-reviewed publications was performed focusing on pediatric sleep studies from prenatal to childhood and adolescence in a variety of indexes in PubMed,SCOPUS,and Psych Info published in the past two *** relevant data-based articles and systematic reviews are *** Many adverse consequences are associated with child sleep deficiency and other sleep problems,including physical outcomes(e.g.,obesity),neurocognitive outcomes(e.g.,memory and attention,intelligence,academic performance),and emotional and behavioral outcomes(e.g.,internalizing/externalizing behaviors,behavioral disorders).Current prevention and intervention approaches to address childhood sleep problems include nutrition,exercise,cognitive–behavioral therapy for insomnia,aromatherapy,acupressure,and *** interventions may be particularly important in the context of coronavirus disease *** research and policy strategies can target the risk factors of child sleep as well as the efficacy and accessibility of *** Given the increasing prevalence of child sleep problems,which have been shown to affect children’s physical and neurobehavioral wellbeing,understanding the multi-aspect consequences and intervention programs for childhood sleep is important to inform future research direction as well as a public health practice for sleep screening and intervention,thus improving sleep-related child development and health.

关键词： Behavior Child sleep Consequences Implications Neurocognitive Physical Prevention/intervention

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0—10数字评分量表是否可作为临床疼痛测量工具用于患儿？

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麻醉与镇痛 2012年第4期8卷 78-85页

作者： terri voepel-lewis Constance N. Burke Nieole Jeffreys Shobha Malviya Alan R. Tait 曹俊(译) 彭丽桦(译) University of Michigan Health Systems Ann Arbor Michigan 不详

背景自我疼痛评分已广泛应用于临床和科研，但目前在患儿中的应用情况我们仍知之甚少。本前瞻性、观察性研究对比了0—10分数字评分量表（numericalratingscale，NRS）这-L童手术后疼痛测量方法，与其他疼痛自评指标，如主观镇痛药需求... 详细信息

背景自我疼痛评分已广泛应用于临床和科研，但目前在患儿中的应用情况我们仍知之甚少。本前瞻性、观察性研究对比了0—10分数字评分量表（numericalratingscale，NRS）这-L童手术后疼痛测量方法，与其他疼痛自评指标，如主观镇痛药需求（perceivedneedformedicine，PNM）、疼痛缓解度（painreliel,PR）及手术后镇痛治疗满意度（perceivedsatisfaction，PS）间的相关性。方法本研究纳入了7-16岁伴有术后疼痛的患儿，在术后1。24小时内使用1—4个自评工具对患儿疼痛进行测量。每次测量中，要求患儿使用NRS量表评估疼痛强度，并记录主观镇痛药需求和疼痛治疗满意度。每1—2小时重复测量上述指标，并评估与前次测量相比，PR是无变化、有改善抑或加重。绘制受试者工作特征曲线（receiveroperatorcharacteristic，ROC）并测量NRS在PNM、PS上的潜在截点；结合隙计算疼痛评分的最低临床显著性差异（minimumclinicallysignificantdifference，MCSD）。结果本研究共纳入了113例患儿，共记录了397项测量结果（包括189项配对资料）。自述有镇痛药需求患儿的NRS评分显著高于“无镇痛药需求”患儿（中位数分别是6分和3分，P〈0．001）。NRS评分〉4分判定为需要PNM的敏感性（0．81）和特异性（0．70）较高，但假阳性率和假阴性率（如NRS评分〉4分的患儿42％无需镇痛治疗）也较高。与感觉“好一点”或“差一点”对应的疼痛评分MCSD分别为-1（95％可信区间-0．5—1）和＋1（95％可信区间0．5—2．7）（P〈0．001）。NRS〉6分判定治疗不满意的敏感性为0．82，特异性为0．76，46％的NRS评分〉6分患儿对镇痛勉强满意，24％的患儿对镇痛十分满意。结论本研究为证实NRS用于评估患儿疼痛的临床实用性提供了重要的参考信息。在患儿手术后急性疼痛期，NRS评分作为一种有效的测量疼痛强度的方法，与PNM、PR和Ps有良好的相关性。然而，该评分与其他具有临床意义指标相关性的变异度较大，表明使用NRS截点决定患儿镇痛治疗方案是不恰当的。

关键词：临床实用性测量工具评分量表疼痛评分中位数患儿受试者工作特征曲线手术后镇痛

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小儿术中知晓的发生率：儿童知晓与回忆评估

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麻醉与镇痛 2011年第5期7卷 75-82页

作者： Shobha Malviya, MD Jeffrey L. Galinkin, MD, FAAP Carolyn F. Bannister, MD, FAAP Constance Burke, BSN, RN Jeannie Zuk, PhD, RN Mark Popenhagen, PsyD Samatha Brown, RN terri voepel-lewis, MSN, RN 胥亮（译） Department of Anesthesiology at University of Michigan Health Systems Ann Arbor Michigan University of Colorado Denver Colorado Emory University Atlanta Georgia 不详

背景小儿麻醉中知晓发生率的报道有很大差异（0．2％-2．7％）。在本次前瞻性观察队列研究中，我们做了以下评估：（D三种情况下小儿全麻知晓发生率；（爹知晓的相关因素；③知晓的短期心理影响。方法纳入标准为：5-15岁、行全身麻醉的... 详细信息

背景小儿麻醉中知晓发生率的报道有很大差异（0．2％-2．7％）。在本次前瞻性观察队列研究中，我们做了以下评估：（D三种情况下小儿全麻知晓发生率；（爹知晓的相关因素；③知晓的短期心理影响。方法纳入标准为：5-15岁、行全身麻醉的儿童，详细记录包括麻醉用药在内的围术期资料。使用半结构化问卷于术后对小儿进行3次随访。所有可能或疑似知晓的病例，均需和小儿的医护人员充分讨论以证实或排除所述记忆。不同中心的研究人员内部需要达成一致，而这些病例及随机选出的其他部分病例再交由3个研究之外人员审核。根据此研究的目的，可能僚似知晓定义为内部研究者一致同意，3个外部审核者至少2个认同。结果1，784例儿童完成了至少一次的随访。有32例被至少1位研究人员（中心内部研究人员或一位外部审核者）评估为可能或疑似知晓。其中14例符合可能／疑似知晓的定义标准，知晓率为0．8％。14例知晓儿童中有6例（43％）回忆起手术中感到恐惧，3例（21％）述感觉疼痛。知晓组中有2例（14％）表示如果再次手术会感觉更差，这与无知晓组小儿的比例（15％）无明显差异。知晓患儿无需进一步心理干预。内镜手术是知晓发生的高风险因素（相对危险度为4．5，可信区间1．5—13．6）。结论尽管本研究中有0．8％的患儿出现了可能／疑似知晓，但没有病例出现短期的心理应激状态。

关键词：知晓发生率小儿麻醉儿童评估术中知晓回忆研究人员心理应激状态

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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao terri L.Blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(p<0.05).Light activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

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Reactive oxygen species in the progression and treatment of malignant mesothelioma

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 210-220页

作者： Ava Cote terri Messier Brian Cunniff Department of Pathology and Laboratory Medicine Redox Biology ProgramUniversity of Vermont Larner College of MedicineBurlingtonVT 05405USA University of Vermont Cancer Center University of Vermont Larner College of MedicineBurlingtonVT 05405USA

Malignant mesothelioma(MM)is an aggressive cancer that affects the pleural and peritoneal mesothelial lining of the lungs and *** rates for patients with MM remain extremely low and effective treatments are *** tumors harbor both genotypic and phenotypic features that indicate MM tumor cells are under increased oxidative stress,similar to other aggressive *** increased oxidative stress in MM cells supports aggressive growth while providing a therapeutic vulnerability exploitable by redox-modulating *** tumor cells also exhibit altered mitochondrial structure and function that contribute to the disease through perturbations in metabolism and reactive oxygen species(ROS)production and *** the altered redox status in cancer through increasing cellular ROS levels directly or inhibiting cellular antioxidant pathways and disrupting ROS scavenging mechanisms has become an exciting area for therapeutic *** review discusses ROS sources and signaling,mitochondrial structure and function and targeting mitochondria ROS as a therapeutic approach for the treatment of MM.

关键词： Malignant mesothelioma targeting cellular redox status pro-oxidant therapy

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Pharmacological evaluation of NSAID-induced gastropathy as a “Translatable” model of referred visceral sensitivity

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World Journal of Gastroenterology 2017年第33期23卷 6065-6076页

作者： Michele Hummel terri Knappenberger Meghan Reilly Garth T Whiteside Purdue Pharma L.P. Discovery Research

AIM To evaluate whether non-steroidal anti-inflammatory drugs(NSAIDs)-induced gastropathy is a clinically predictive model of referred visceral *** Gastric ulcer pain was induced by the oral administration of indomethacin to male,CD1 mice(n = 10/group) and then assessed by measuring referred abdominal hypersensitivity to tactile application. A diverse range of pharmacological mechanisms contributing to the pain were subsequently investigated. These mechanisms included: transient receptor potential(TRP),sodium and acid-sensing ion channels(ASICs) as well as opioid receptors and guanylate cyclase C(GC-C). RESULTS Results showed that two opioids and a GC-C agonist,morphine,asimadoline and linaclotide,respectively,the TRP antagonists,AMG9810 and HC-030031 and the sodium channel blocker,carbamazepine,elicited a dose-and/or time-dependent attenuation of referred visceral hypersensitivity,while the ASIC blocker,amiloride,was ineffective at all doses tested. CONCLUSION Together,these findings implicate opioid receptors,GC-C,and sodium and TRP channel activation as possible mechanisms associated with visceral hypersensitivity. More importantly,these findings also validate NSAID-induced gastropathy as a sensitive and clinically predictive mouse model suitable for assessing novel molecules with potential pain-attenuating properties.

关键词： Visceral hypersensitivity Pain Translation Guanylate cyclase C Non-steroidal anti-inflammatory drugs Transient receptor potential channel

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Bullous Pemphigoid: Readability, Quality, and Treatments of Online Health Resources

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International Journal of Dermatology and Venereology 2022年第1期5卷 59-60页

作者： terri Shih Natalie Villa Jennifer L.Hsiao Vivian Y.Shi David Geffen School of Medicine University of California Los AngelesLos AngelesCA 90095USA Department of Dermatology Dartmouth-Hitchcock Medical CenterLebanonNH 03766USA Department of Dermatology University of Southern CaliforniaLos AngelesCA 90007USA Dermatology of Dermatology University of Arkansas for Medical SciencesLittle RockAR 72205USA

Dear Editor,Bullous pemphigoid(BP)is an autoimmune blistering disease that disproportionately affects the elderly,1 a population in which limited health literacy is a known barrier to health *** 2003 National Assessment of Adult Literacy survey found that among patients older than 65,59%had“basic”or“below basic”literacy,and only 3%were“proficient.”2 Despite increased utilization of the internet to seek health information,including among the elderly,3 the accessibility of online BP resources remain ***,we examine the readability and quality of online resources on BP.

关键词： autoimmune spite elderly

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