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From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5270-5302页

作者： Brittany Dewdney Misty RJenkins Sarah ABest Saskia Freytag Krishneel Prasad Jeff Holst Raelene Endersby terrance gjohns Cancer Centre Telethon Kids InstituteNedlandsWA6009Australia Centre For Child Health Research University of Western AustraliaPerthWA6009Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchMelbourne3052Australia Department of Medical Biology University of MelbourneMelbourne3010Australia Personalised Oncology Division The Walter and Eliza Hall Institute of Medical ResearchMelbourne3052Australia School of Biomedical Sciences University of New South WalesSydney2052Australia

Glioblastoma,a rare,and highly lethal form of brain cancer,poses significant challenges in terms of therapeutic resistance,and poor survival rates for both adult and paediatric patients *** advancements in brain cancer research driven by a technological revolution,translating our understanding of glioblastoma pathogenesis into improved clinical outcomes remains a critical unmet *** review emphasises the intricate role of receptor tyrosine kinase signalling pathways,epigenetic mechanisms,and metabolic functions in glioblastoma tumourigenesis and therapeutic *** also discuss the extensive efforts over the past two decades that have explored targeted therapies against these *** therapeutic approaches,such as antibody-toxin conjugates or CAR T cell therapies,offer potential by specifically targeting proteins on the glioblastoma cell *** strategies incorporating protein-targeted therapy and immune-based therapies demonstrate great promise for future clinical ***,gaining insights into the role of cell-of-origin in glioblastoma treatment response holds the potential to advance precision medicine *** these challenges is crucial to improving outcomes for glioblastoma patients and moving towards more effective precision therapies.

关键词： glioblastoma therapies targeted

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The Superior Colliculus:Cell Types,Connectivity,and Behavior

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Neuroscience Bulletin 2022年第12期38卷 1519-1540页

作者： Xue Liu Hongren Huang terrance PSnutch Peng Cao Liping Wang Feng Wang Shenzhen Key Lab of Neuropsychiatric Modulation Guangdong Provincial Key Laboratory of Brain Connectome and BehaviorCAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health University of British ColumbiaVancouver V6T 1Z4Canada National Institute of Biological Sciences Beijing 100049China

The superior colliculus(SC),one of the most well-characterized midbrain sensorimotor structures where visual,auditory,and somatosensory information are integrated to initiate motor commands,is highly conserved across vertebrate ***,cell-type-specific SC neurons integrate afferent signals within local networks to generate defined output related to innate and cognitive *** review focuses on the recent progress in understanding of phenotypic diversity amongst SC neurons and their intrinsic circuits and long-projection *** further describe relevant neural circuits and specific cell types in relation to behavioral outputs and cognitive *** systematic delineation of SC organization,cell types,and neural connections is further put into context across species as these depend upon laminar ***,we focus on SC neural circuitry involving saccadic eye movement,and cognitive and innate ***,the review provides insight into SC functioning and represents a basis for further understanding of the pathology associated with SC dysfunction.

关键词： Superior colliculus Glutamatergic neurons GABAergic neurons Neuronal circuits Innate behaviors

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Laparoscopic reduction and repair of acute traumatic diaphragmatic hernia:A video review

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第1期3卷 22-25页

作者： Adeel Ahmed Shamim Muhammad Maaz Zuberi Daniel Tran terrance Fullum Department of General Surgery Howard University Hospital2041 Georgia Ave NWWashingtonDC20060USA

Traumatic diaphragmatic hernia is one of the sequela of thoraco-abdominal injury,occurring in about 0.5%-5% of patients presenting post major *** vehicle collision is the leading blunt trauma etiology.A high level of suspicion is essential to discover such injuries,as a majority of the patients can be asymptomatic.A case of a successful trans-abdominal laparoscopic reduction and repair of a large acute traumatic diaphragmatic hernia is presented as a video *** were able to evacuate all intrathoracic air,obliviating the need for a chest *** operatively the patient did well with no *** expertise is available,laparoscopic intervention is a feasible option even for large traumatic diaphragmatic hernia preventing the need for a large midline laparotomy incision.

关键词： Laparoscopy Diaphragm Traumatic diaphragmatic hernia Hernia Thoracoabdominal trauma Video

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Modeling of transverse stimulated Raman scattering in KDP/DKDP in large-aperture plates suitable for polarization control

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High Power Laser Science and Engineering 2023年第5期11卷 1-9页

作者： Hu Huang Tanya Z.Kosc terrance J.Kessler Stavros G.Demos Laboratory for Laser Energetics University of RochesterRochesterNYUSA Currently at Khiram Prototype Works LLC RochesterNYUSA

Transverse stimulated Raman scattering(TSRS)in potassium dihydrogen phosphate(KDP)and deuterated potassium dihydrogen phosphate(DKDP)plates for large-aperture,inertial confinement fusion(ICF)-class laser systems is a well-recognized limitation giving rise to parasitic energy conversion and laser-induced *** onset of TSRS is manifested in plates exposed to the ultraviolet section of the *** amplification is a coherent process that grows exponentially and is distributed nonuniformly in the crystal and at the crystal *** understand the growth and spatial distribution of TSRS energy in various configurations,a modeling approach has been developed to simulate the operational conditions relevant to ICF-class laser *** aspects explored in this work include(i)the behavior of TSRS in large-aperture crystal plates suitable for third-harmonic generation and use as wave plates for polarization control in current-generation ICF-class laser system configurations;(ii)methods,and their limitations,of TSRS suppression and(iii)optimal geometries to guide future designs.

关键词： transverse stimulated Raman scattering large-aperture laser systems laser damage KDP DKDP

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Degradation of N-Acyl Homoserine Lactone Quorum Sensing Signals by Bacillus thuringiensis AHL Lactonase

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Advances in Microbiology 2023年第11期13卷 526-538页

作者： Waeel H. Alramadhan Anthony Ejiofor terrance Johnson Department of Biological Sciences Tennessee State University Nashville Tennessee USA

Bacterial cells rely on signaling molecules to communicate with others from the same species and induce certain genes in a process known as quorum sensing (QS). A common molecule is N-acyl homoserine lactone (AHL) which is responsible for the expression of virulence and other factors that allow the organisms to compete in a given environment. On the other hand, other bacteria produce certain enzymes such as AHL-lactonase that break down AHL molecules and prevent gene expression of these factors. The aim of this work was to examine the level of degradation of AHL molecules by AHL-lactonase in 62 Bacillus thuringiensis (Bt) strains isolated from Middle Tennessee, Mississippi, and Alabama. N-hexanoyl-homoserine lactone (C6-HSL) and N-3-oxo-hexanoyl homoserine lactone (3-oxo-C6-HSL), which cause Chromobacterium violaceum (CV026) to produce a purple pigment were tested at different concentrations to view the Bt lactonase activity. In addition, PCR was used to test for the presence of the lactonase gene. The results showed that among the 62 Bt strains, there were 58 that possessed the AHL-lactonase (aiiA) gene and 48 strains were able to degrade C6-HSL. At high concentrations of AHL, only 13 strains were able to completely degrade C6-HSL. In addition, degradation of 3-oxo-C6-HSL was weak compared to C6-HSL. The results also revealed that AHL lactonase was thermostable, and it was concluded that the level of degradation varies in Bt strains. Only 13 of the strains studied have potent inhibitory activity against C6-HSL, which may be good to be used in field applications to control agricultural pest.

关键词： Quorum Sensing Quorum Sensing Inhibitor N-Acyl Homoserine Lactone AHL Lactonase Bacillus thuringiensis CV026

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Synthetic aperture ptychography:coded sensor translation for joint spatial-Fourier bandwidth expansion

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Photonics Research 2022年第7期10卷 1624-1632页

作者： PENGMING SONG SHAOWEI JIANG TIANBO WANG CHENGFEI GUO RUIHAI WANG terrance ZHANG GUOAN ZHENG Department of Biomedical Engineering University of ConnecticutStorrsConnecticut 06269USA

Conventional ptychography translates an object through a localized probe beam to widen the field of view in real *** ptychography translates the object spectrum through a pupil aperture to expand the Fourier bandwidth in reciprocal *** we report an imaging modality,termed synthetic aperture ptychography(SAP),to get the best of both *** SAP,we illuminate a stationary object using an extended plane wave and translate a coded image sensor at the far field for data *** coded layer attached on the sensor modulates the object exit waves and serves as an effective ptychographic probe for phase *** sensor translation process in SAP synthesizes a large complex-valued wavefront at the intermediate aperture *** propagating this wavefront back to the object plane,we can widen the field of view in real space and expand the Fourier bandwidth in reciprocal space *** validate the SAP approach with transmission targets and reflection silicon microchips.A 20-mm aperture was synthesized using a 5-mm sensor,achieving a fourfold gain in resolution and 16-fold gain in field of view for object *** addition,the thin sample requirement in ptychography is no longer required in *** can digitally propagate the recovered exit wave to any axial position for post-acquisition *** SAP scheme offers a solution for far-field sub-diffraction imaging without using *** can be adopted in coherent diffraction imaging setups with radiation sources from visible light,extreme ultraviolet,and X-ray,to electron.

关键词： translate ptychography translation

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微波等离子体原子发射光谱法(MP-AES)测定地质样品中的常量和微量元素

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中国无机分析化学 2015年第1期5卷 41-44页

作者： terrance Hettipathirana Phil Lowenstern 安捷伦科技公司

建立了微波等离子体原子发射光谱法(MP-AES)测定地质样品中的常量和微量元素的方法,四酸(盐酸+硝酸+高氯酸+氢佛酸)消解样品,得出了使用4200 MP-AES仪分析地化认证参考物质中常规金属元素(Ag,Cu,Ni,Pb和Zn)的结果,测定样品结果的相对标... 详细信息

建立了微波等离子体原子发射光谱法(MP-AES)测定地质样品中的常量和微量元素的方法,四酸(盐酸+硝酸+高氯酸+氢佛酸)消解样品,得出了使用4200 MP-AES仪分析地化认证参考物质中常规金属元素(Ag,Cu,Ni,Pb和Zn)的结果,测定样品结果的相对标准偏差落在±10%范围内,另外,IEC和FLIC模型可成功校正光谱干扰。MP-AES仪无需使用乙炔等危险气体,极大提高了实验室安全性并显著降低了运行成本。MP-AES仪已成功应用于地化样品的分析中,结果准确可靠。

关键词： 4200 MP-AES 地化认证参考物质常规金属元素检测

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里弄文化的现代演绎——外滩W酒店

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设计家 2017年第3期 103-107页

作者： terrance McGinnity Ralf Tooten G.A DESIGN G.A.国际设计有限公司

项目地点:上海项目面积:平方米完成时间:2017项目功能:酒店所有项目资料由G.A DESIGN事务所提供横跨上海的黄浦江造成了物理性的鸿沟。这就是为什么上海会是一个真正具有多样性的'熔炉',充满了各种对比。无论在物理层次上,还是在社会层... 详细信息

项目地点:上海项目面积:平方米完成时间:2017项目功能:酒店所有项目资料由G.A DESIGN事务所提供横跨上海的黄浦江造成了物理性的鸿沟。这就是为什么上海会是一个真正具有多样性的'熔炉',充满了各种对比。无论在物理层次上,还是在社会层次上。不过在这些对比中都会伴随着一种潜在的享乐感和魅力元素。外滩W酒店设计理念的重要思路就是被这条河贯穿的。这条河就是这个城市的脉搏,它的活力,联系着,也反映着这城市的多个层面。

关键词：现代演绎

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重褶皱的分析方法

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世界地质 1987年第2期 121-132页

作者： Richard,L Thissen Haviland terrance 扬坤光彭少梅

多期褶皱相互作用便产生复杂的干扰型式即叠加褶皱。构造学家可以直接解释简单构造型式,但较复杂的型式常具有多解性和不确定性。本文提出了不直接需要任何野外构造测量资料的叠加褶皱的分析方法.仅需一系列相互平行的穿过叠加褶皱的剖... 详细信息

多期褶皱相互作用便产生复杂的干扰型式即叠加褶皱。构造学家可以直接解释简单构造型式,但较复杂的型式常具有多解性和不确定性。本文提出了不直接需要任何野外构造测量资料的叠加褶皱的分析方法.仅需一系列相互平行的穿过叠加褶皱的剖面,这可从矿区或从切片的岩石中获得.从平面图可鉴别各个褶皱并可计算枢纽的指向和倾伏角。赤平投影图和横剖面图可以反应褶皱的方向和形态。本方法假定:(1)第一期褶皱是圆柱状的;(2)第二期褶皱作用的运动近似相似褶皱(剪切褶皱). 上述方法被用于华盛顿州Kootenay弧地区的小尺度标本。分析指出,两期褶皱的叠加产生雁列状的共轭褶皱,非圆柱状和非相似型褶皱。本实例表明,这种方法也适用于与上述假设不相等的褶皱的叠加,对地质工作者在其它重褶地区的工作很有价值;同时还可以为矿床研究提供可靠的三维资料。

关键词：褶皱运动枢纽切面赤平投影倾伏造山运动地壳运动产状相似褶皱共轴叠加褶皱分析方法

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Physicians’ Use of Patients’ Daily Reports of Quality of Life to Evaluate Treatment Response in Phase I Cancer Trials

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Journal of Cancer Therapy 2012年第5期3卷 582-588页

作者： Felicity W. K. Harper Elisabeth I. Heath Marci E. J. Gleason Louis Penner Patricia LoRusso Ding Wang terrance L. Albrecht Josephine Ford Cancer Center at Henry Ford Hospital Detroit USA Karmanos Cancer Institute Communication and Behavioral Oncology Program Detroit USA University of Texas Department of Human Ecology Austin USA 4Josephine Ford Cancer Center at Henry Ford Hospital Detroit USA

For cancer patients on Phase I trials, one of the most important physician decisions is whether or not patients are deriving benefit from therapy. With an increasing number of cytostatic treatment agents, the criteria to determine patient response to Phase I treatment has become harder to define. Physicians are increasingly looking to patient-reported outcomes (PROs) such as quality of life (QOL) to help evaluate treatment response. Electronic daily diary (EDD) devices can be used by patients to report their QOL over extended periods of time, thereby providing a more accurate picture of how patients are affected by treatment on a daily basis. However, questions remain about how to integrate this patient-reported information into decisions about Phase I treatment. This study investigated how physicians use patients’ daily QOL reports to evaluate patient response to Phase I treatment. Data were collected over a 4-month period from Phase I patients (N = 30) and physicians (N = 3) in an NCI-designated comprehensive cancer center. Patients completed daily QOL reports using EDD devices and physicians were provided with a summary of patients’ QOL before each visit. After the visit, doctors recorded their treatment decision and also rated the importance of four biomedical factors (Toxicity, Imaging, Labs, and Performance Status) and QOL in their treatment decision for that visit. Although physicians rated QOL as being very important in evaluating treatment response, in practice, when predictors of their decisions were analyzed, results showed they relied exclusively on biomedical data (Toxicity, Imaging) to make Phase I treatment decisions. Questions remain about the utility and effective integration of QOL and biomedical data in clinical decision-making processes in Phase I clinical trials.

关键词： Patient-Reported Outcomes Quality of Life Clinical Trials Treatment Decision-Making

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