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Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study

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World Journal of Clinical Cases 2022年第24期10卷 8556-8567页

作者： Fabrizio D'Acapito Leonardo Solaini Daniela Di pietrantonio Francesca Tauceri Maria teresa Mirarchi ElenaAntelmi Francesca Flamini Alessio Amato Massimo Framarini Giorgio Ercolani Department of General and Oncologic Surgery Morgagni-Pierantoni HospitalAUSL RomagnaForlì47121Italy Department of Medical and Surgical Sciences University of BolognaBologna 40126Italy

BACKGROUND Incidence of gallstones in those aged≥80 years is as high as 38%-53%.The decision-making process to select those oldest old patients who could benefit from cholecystectomy is *** To assess the risk of morbidity of the“oldest-old”patients treated with cholecystectomy in order to provide useful data that could help surgeons in the decision-making process leading to surgery in this *** A retrospective study was conducted between 2010 and *** variables were collected and compared between patients who had postoperative complications.A model was created and tested to predict severe postoperative *** The 269 patients were included in the study(193 complicated).The 9.7%of complications were grade 3 or 4 according to the Clavien-Dindo *** levels were lower in patients who did not have any postoperative *** Society of Anesthesiologists scale 4 patients,performing a choledocholithotomy and bilirubin levels were associated with Clavien-Dindo>2 complications(pproposed model had a higher net benefit than the treating all/none options between threshold probabilities of 11%and 32%of developing a severe *** patients with American Society of Anesthesiologists scale 4,higher level of bilirubin and need of choledocholithotomy are at the highest risk of a severely complicated postoperative *** endoscopic or percutaneous treatments should be considered in this subgroup of octogenarians.

关键词： Cholecystitis Gallstones Choledocholithotomy Elderly post-operative complications

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Hyperlactatemia in patients with non-acetaminophen-related acute liver failure

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World Journal of Gastroenterology 2006年第12期12卷 1949-1953页

作者： pilar Taurá Graciela Martinez-palli Julia Martinez-Ocon Joan Beltran Gerard Sanchez-Etayo Jaume Balust teresa Anglada Antoni Mas Juan-Carlos Garcia-Valdecasas Department of Anesthesiology Hospital ClinicBarcelonaSpain Department of Hepatology Hospital ClinicBarcelonaSpain Department of Surgery Hospital ClinicBarcelonaSpain

AIM： To characterize hyperlactatemia in patients with non-acetaminophen acute liver failure （ALF） in an attempt to clarify the mechanisms implicated and the role as a prognosis factor. METHODS： In the setting of liver transplantation, 63 consecutive patients with non-acetaminophen acute liver failure were studied in relation to tissue oxygenation, hemodynamic and metabolic parameters. Before and after transplantation, the number of infected patients and outcome were registered. RESULTS： Acute ALF showed higher levels of lactate than subacute ALF （5.4 ± 1 mmol/L versus 2.2 ± 0.6 mmol/L, p= 0.01）. Oxygenation parameters were within the normal range. Lactate levels showed good correlation with respiratory quotient （r=0.759, p〈 0.005）, mean glucose administration （r= 0.664, p= 0.01） and encephalopathy （r= 0.698, p= 0.02）, but not with splanchnic arteriovenous difference in pCO2, pH and the presence of infection （p=0.1）. portal vein lactate was higher （p〈0.05） than arterial and mixed venous lactate, suggesting its production of hyperlactatemia in the intestine and spleen. The presence of infection was an independent predictor of survival. CONCLUSION： Hyperlactatemia is not a prognosis factor due to byproduct of the overall acceleration in glycolysis.

关键词： Hyperlactatemia Non-acetaminophen acuteliver failure Splanchnic hypoperfusion Acute liverfailure

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Biohydrometallurgy applied to exploitation of black shale resources： Overview of Bioshale Fp6 European project

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中国有色金属学会会刊：英文版 2008年第6期18卷 1485-1490页

作者： p. D＇HUGUES p. SpOLAORE Bioshale Consortium BRGM EPI/Eco 3 Avenue C. Guillemin 45060 Orleans Cedex 2 France

Bioshale 工程，由欧洲委员会(Fp6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属... 详细信息

Bioshale 工程，由欧洲委员会(Fp6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属而且有机物的高内容由常规技术的那缺陷金属恢复。三世界级黑人页岩沉积物被选择为 R&D 行动的目标。这些包括在自然条件下面存在的一沉积物(Talvivaara，芬兰) ，一个当前在过程(Lubin，波兰) 并且在采矿以后的(Mansfeld，德国) 。工作计划的主要技术方面能如下被总结：忍受金属的部件的地质的资源和选择的评估；为金属恢复要测试的生物协会的选择；对 bioprocessing 的评价发送，包括为金属恢复处理的 hydrometallurgical；包括社会、环境的影响的新过程的 techno 经济的评估。13 欧洲人获得的主要结果的概述合伙(从 8 个国家) 在这个完成的研究计划包含了在这个工作被给。

关键词：生物技术生物浸取矿石处理黑页岩

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Damaging effects of gliadin on three-dimensional cell culture model

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World Journal of Gastroenterology 2005年第38期11卷 5973-5977页

作者： Ersilia Dolfini Luca Elli Leda Roncoroni Barbara Costa Maria pia Colleoni Vito Lorusso Simona Ramponi paola Braidotti Stefano Ferrero Maria Letizia Falini Maria teresa Bardella Department of Biology and Genetics for Health Sciences Department of Gastroenterology Department of Biotechnology and Bioscience Department of pharmacology Bracco Imaging SpA Department of Medicine Department of Agrifood Molecular Science

AIM： To evaluate the effects of gliadin on the oxidative environment in the “in vivo-like”model of a three-dimensional cell culture system. METHODS： LoVo cell line （intestinal adenocarcinoma） multicellular spheroids were treated with digested gliadin （with albumin used as a control）. Spheroid volumes, cell viability and morphology, lactate dehydrogenase （LDH） release, content of reduced glutathione （GSH） and activity of GSH-related enzymes were examined. The data were statistically analyzed using the Student＇s t-test （p〈0.05）. was considered statistically significant. RESULTS： Gliadin reduced cell viability （from 20% to 60%） and led to morphological alterations characterized by apoptotic findings and cytoskeletal injuries. LDH activity increased. The content of GSH reduced （-20% vscontrols）, and activity of GSH-related enzymes was significantly inhibited. CONCLUSION： Gliadin treatment induces an imbalance in the antioxidative mechanism of cells cultured by the three-dimensional technique. This alteration may explain cell damage directly caused by gliadin and the subsequentmorphological abnormalities.

关键词： Gliadin Celiac disease Cytotoxicity Multicellular spheroids

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Dried fruit pomace inclusion in poultry diet:growth performance, intestinal morphology and physiology

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1100-1116页

作者： Elena Colombino Ilario Ferrocino Ilaria Biasato Luca Simone Cocolin Daniel prieto-Botella Zenon Zduńczyk Jan Jankowski Joanna Milala Monika Kosmala Bartosz Fotschki Maria teresa Capucchio Jerzy Juśkiewicz Department of Veterinary Sciences University of TorinoLargo Paolo Braccini 2Grugliasco10095 TurinItaly Department of Agricultural Forest and Food SciencesUniversity of TorinoTorinoItaly Research Team on Occupational Therapy(InTeO) Department of Surgery and PathologyUniversity Miguel Hernandez of ElcheAlicanteSpain polish Academy of Sciences Institute of Animal Reproduction and Food ResearchOlsztynPoland Department of poultry Science University of Warmia and MazuryOlsztynPoland Institute of Chemical Technology of Food Lodz University of TechnologyLodzPoland.

Background: Fruit pomaces are by-products rich in polyphenol compounds and dietary fiber. They seem to play an important role in regulating the gut microbiota, morphology and physiology. The aim of this study was to assess whether apple(A), blackurrant(B) or strawberry(S) pomaces could be suitable ingredients in broiler diets and their effect on gut health. A total of 480 male broilers were randomly allotted to 8 dietary treatments with lower(3%-L) or higher(6%-H) dietary fiber content: two control groups(CL/CH), two A diets(AL/AH), two B diets(BL/BH), two S diets(SL/SH). Diet and fruit pomaces were chemically analyzed to assess polyphenol concentration and fibre fraction content. After the evaluation of growth performance, 6 birds/group were slaughtered at 35 days of age. Morphometric and histopathological investigations were performed on duodenum, jejunum and *** were collected to perform microbiota evaluation by 16 S DNA sequencing. Weight, viscosity, enzymatic activity, short chain fatty acid(SCFAs) and ammonia concentration were determined in ileum and/or ceca ***: A pomace and A diets showed the lowest polyphenol content and the highest content of soluble fibre fraction. No significant differences were observed for growth performance, gut morphometry and histopathology(p > 0.05). Dietary fruit pomace inclusion increased the weight of ileum and ceca and the ileum digesta viscosity(p ps showed lower bacterial α-glucosidase activity than C groups. Moreover,small intestine SCFAs concentration was higher in fruit pomaces diets(p ps showed lower ammonia concentration and higher SCFAs than C. Dietary treatments also influenced the activity of α-glucosidase, α-galactosidase, β-galactosidase β-glucuronidase and xylase. Regarding microbiota, at phylum level,Firmicutes were differentially abundant across treatment(maximum for C and minimum in S, FDR > 0.05). At genus level, an increase

关键词： Fruit pomace Gut health Morphohistology polyphenols poultry

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Cyclic E2 and p4 on Alzheimer’s Disease pathways

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Advances in Alzheimer's Disease 2017年第1期6卷 32-44页

作者： teresa S. Wiley Jason T. Haraldsen Wiley Compounding Systems Santa Fe New Mexico USA Department of physics University of North Florida Florida USA

In recent years, Alzheimer’s disease has been clearly linked to the degradation of microtubules and microtubule-associated tau (τ) and β-amyloid (βA) proteins. Through an examination and evaluation of current literature, we assess the possible effects of the steroid hormones on τ hyperphosphorylation and the regulation of βA proteins and their influence on Alzheimer’s dementia and memory loss. We present a mechanism by which Alzheimer’s cases may be reduced or perhaps even prevented through the use of non-synthetic, steroid hormones prescribed in a cyclic dosing schedule that mimics the rhythmic, escalating and descending production normally observed in a reproductive female body. Given the ability of estrogen to prevent τ hyperphosphorylation and increase metabolism of the βA precursor protein, we propose the possibility of controlling both protein cycles through the exogenous application of estrogen and progesterone may help those patients with active disease as well as prevent the onset of Alzheimer’s and other neurodegenerative diseases.

关键词： Hormones Estradiol progesterone Bio-Memtic Treatment

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Synchronous and metachronous neoplasms in gastric cancer patients:A 23-year study

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World Journal of Gastroenterology 2014年第23期20卷 7480-7487页

作者： Magorzata Lawniczak Alicja Gawin Halina Jaroszewicz-Heigelmann Wiesawa Rogoza-Mateja Joanna Raszeja-Wyszomirska Andrzej Biaek Katarzyna Karpińska-Kaczmarczyk teresa Starzyńska Department of Gastroenterology Pomeranian Medical University71-252 SzczecinPoland Liver Unit Pomeranian Medical University70-111 SzczecinPoland Department of pathology Pomeranian Medical UniversityUnii Lubelskiej 171-252 SzczecinPoland

AIM: To determine the prevalence and characteristics of additional primary malignancies in gastric cancer (GC) patients.

关键词： Gastric cancer Multiple primary cancers Synchronous Metachronous Blood groups

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Dietary inclusion of a partially defatted black soldier fly(Hermetia illucens)larva meal in low fishmeal-based diets for rainbow trout(Oncorhynchus mykiss)

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1399-1413页

作者： Christian Caimi Ilaria Biasato Giulia Chemello Sara Bellezza Oddon Carola Lussiana Vanda Maria Malfatto Maria teresa Capucchio Elena Colombino Achille Schiavone Francesco Gai Angela Trocino Alberto Brugiapaglia Manuela Renna Laura Gasco Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 210095 GrugliascoTOItaly Department of Veterinary Sciences University of TurinLargo P.Braccini 210095 GrugliascoTOItaly Institute of Science of Food production National Research CouncilLargo P.Braccini 210095 GrugliascoTOItaly Department of Comparative Biomedicine and Food Science University of PaduaViale dell’Università1635020 LegnaroPDItaly

Background:Recent investigations highlighted that Hermetia illucens(BSF)larva meal can be a valuable alternative protein source for aquafeed *** this study,in substitution of fishmeal,we used increasing inclusion levels of a partially defatted BSF larva meal in low fishmeal-based diets for rainbow trout(Oncorhynchus mykiss Walbaum)and we evaluated the related implications in terms of growth performance,physical characteristics,proximate and fatty acid(FA)compositions of the fillets,gut and liver histology,and diet *** a 131-day trial,576 fish(100.1±9.29 g)were randomly allotted to 24 tanks(24 fish/tank,4 replicates/treatment).Six experimental diets were produced to have partial replacement of fishmeal(0,10%,20%,30%,40%and 50%)by increasing levels of BSF meal(0%[BSF0],3%[BSF3],6%[BSF6],9%[BSF9],12%[BSF12]and 15%[BSF15]on as fed basis,respectively).Results:No differences were observed among the treatments for all the considered growth performance *** viscero and hepato-somatic indexes showed significant differences among the treatments,with the highest values observed in the BSF15 *** differences were recorded in terms of fillet’s physical characteristics,dry matter(DM),crude protein(Cp)and ether extract(EE)*** saturated and monounsaturated FA increased,while polyunsaturated FA(particularly n-3 FA)decreased while increasing the HI meal inclusion in the *** of liver and gut was not affected,whereas,in posterior gut,villi were higher in BSF6 and BSF9 compared to BSF3 *** apparent digestibility of DM,Cp,EE and gross energy did not vary among the ***:These results suggest that a partially defatted BSF meal could be included up to 15%in low fishmeal-based diets for rainbow trout with no adverse effects on growth performance,fillet’s physical characteristics,gut and liver health,and diet *** the contrary,the fillet FA composition worsened while increasing the level of BSF

关键词： Apparent digestibility coefficient Chemical and physical characteristics of fillets Fatty acid profile Fishmeal substitution Hermetia illucens meal Histopathology performance

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Impact of HIV Status,CD4 Count and Antiretroviral Treatment on Tuberculosis Treatment Outcomes in a Low-Burden Country

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Journal of Tuberculosis Research 2018年第4期6卷 281-291页

作者： Vera Clérigo teresa Mourato Conceicao Gomes Ana Castro pulmonology Service—Thorax Department North Lisbon Hospital CenterLisbonPortugal pulmonary Diagnostic Center Dr.Ribeiro Sanches LisbonPortugal

Background: Few data is available in low-burden TB-HIV countries on TB treatment outcomes. We evaluated TB patients (pts) characteristics by HIV status and compared treatment outcomes in relation to HIV status, CD4 count and antiretroviral therapy (ART). Methods: We performed a retrospective analysis of 447 adult TB pts who registered and initiated treatment in our center from 2014 to 2015. Results: pts were categorized as HIV-negative (n = 399, 89.3%), HIV-positive on ART (n = 42, 9.4%) and HIV-positive not on ART (n = 6, 1.3%). The proportion of pts with extended TB therapy was higher among HIV-positive pts (p = 0.03). Increased age was associated with higher death rates regarding treatment success (OR 1.08;95% CI 1.01 - 1.17, p = 0.03). Statistically significant higher mortality was found among HIV-positive pts on ART (OR 9.93;95% CI 1.36 - 72.37, p = 0.03) and HIV-positive pts not on ART (OR 397.00;95% CI 44.27 to 3559.91, p ≤ 0.0001) compared to HIV-negative pts. When multivariate analyses were restricted to HIV-positive pts, being not on ART was associated with higher mortality (OR 40.0;95% CI 4.37 - 365.78, p = 0.001). Conclusions: There was significant difference in death rates between HIV-positive and HIV-negative TB pts. HIV-positive pts not on ART had a significantly higher mortality.

关键词： Tuberculosis Treatment Outcomes HIV Infection

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Lovastatin as a supplement to mitigate rumen methanogenesis:an overview

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Journal of Animal Science and Biotechnology 2022年第2期13卷 353-364页

作者： Amaury Ábrego-Gacía Héctor M.poggi-Varaldo Vania Robles-González teresa ponce-Noyola Graciano Calva-Calva Elvira Ríos-Leal Daniel Estrada-Bárcenas Alfredo Mendoza-Vargas Department of Biotechnology and Bioengineering CINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Environmental Biotechnology and Renewable Energies Group CINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Instituto de Hidrología Universidad Tecnológica de la MixtecaOaxaca 69000 Huajuapan de LeónMexico National Collection of Microbial and Cellular Cultures CINVESTAV-IPNP.O.Box17-74007000 Mexico CityMexico Unidad de Secuenciación e Identificación de polimorfismos Instituto Nacional de Medicina Genómica14610 Mexico CityMexico

Methane from enteric fermentation is the gas with the greatest environmental impact emitted by ***(Lv)addition to feedstocks could be a strategy to mitigate rumen methane emissions via decreasing the population of methanogenic archaea(MA).Thus,this paper provides the first overview of the effects of Lv supplementation,focusing on the inhibition of methane production,rumen microbiota,and ruminal *** indicated that Lv treatment had a strong anti-methanogenic effect on pure strains of ***,there are uncertainties from in vitro rumen fermentation trials with complex substrates and rumen ***-state fermentation(SSF)has emerged as a cost-effective option to produce *** this way,SSF of agricultural residues as an Lv-carrier supplement in sheep and goats demonstrated a consistent decrease in ruminal methane *** experimental evidence for in vitro conditions showed that Lv did not affect the volatile fatty acids(VFA).However,in vivo experiments demonstrated that the production of VFA was *** did not negatively affect the digestibility of dry matter during in vitro and in vivo methods,and there is even evidence that it can induce an increase in *** the rumen microbiota,populations of MA were reduced,and no differences were detected in alpha and beta diversity associated with Lv ***,some changes in the relative abundance of the microbiota were *** studies are recommended on:(i)Lv biodegradation products and stability,as well as its adsorption onto the solid matter in the rumen,to gain more insight on the“available”or effective Lv concentration;and(ii)to determine whether the effect of Lv on ruminal fermentation also depends on the feed composition and different ruminants.

关键词： Fermentation Lovastatin Methanogenesis Microbiota Rumen

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