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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang Jane lliesveld laura mCalvi Brea Clipe lianping Xing michael WBecker Edward mSchwarz Shu-Chi A.Yeh Center for musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and laboratory medicine University of Rochester Medical CenterRochesterNYUSA Wilmot Cancer Center University of Rochester Medical CenterRochesterNYUSA Department of medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BmmE)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HSCs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BmmE to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BmmE in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

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Speek-TiO2 nanocomposite proton conducting polymeric electrolytes for PEmFCs

Speek-TiO2 nanocomposite proton conducting polymeric electro...

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第九届全国氢能学术会议

作者： m.l.Di Vona S.Tosto E.Sgreccia P.Knauth Università di Roma Tor Vergata ENEA Casaccia Univ.Provence France

＜正＞Composite membranes where inorganic fillers are dispersed in a polymeric matrix are very promising electrolytes for fuel cell *** is however hard to achieve homogeneity at a molecular level,but this target can be reached developing hybrids,where the inorganic component is functionalized with organic moieties.

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NVESTIGATION OF PRODUCTOPN OF FUNCTIONAllY GRADIENT mATERIAl BY ElECTROlESS PlATING

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Acta metallurgica Sinica(English letters) 1999年第4期12卷 678-683页

作者： Z.m.Xu1) ,J.S.Zhen1) ,H.F.liu1) and l.m.Zhang2) 1)Departent of Chemistry , Huazhong University of Science and Technology, Wuhan 430074 ,China 2)Institute of materials Science and Engineering, Wuhan University of Technology, Wuhan 430070 ,China

Thispaper proposed a new methodof producing Ceramic/ metalfunctionally gradient mate rialby electroless platingtechnique. The experimentof producing SiC/ Ni PFGm wascar ried out with self made electroless plating facilities. The results show that the thickness of FGmcoating andthegradientdistribution ofcompositioncanbecontrolled byoptimizingelec trolessplating technology and changing the parameters such as plating time, the additionspeed and concentration of SiCparticles. Analysisdemonstratesthatthereisastrongrelation ship amongthe SiCcontent,the microstructureandthe mechanicalproperty ofthe FGm.

关键词： electrolessplating functionally gradient material SiC/ Ni

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随机建模和地质统计学原理、方法和实例研究

随机建模和地质统计学原理、方法和实例研究

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2000年

作者：（美）Jeffrey m.Yarus （美）Richard l.Chambers 穆龙新陈亮译

本书内容包括：储集层表征中随机模拟方法的回顾、利用地质统计学综合井和地震数据、空间不确定性的可视化等。

关键词：地质统计学学科:建立模型学科:研究建立模型

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Bioavailability of Soy Protein and Corn Zein Films

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Food and Nutrition Sciences 2011年第10期2卷 1105-1113页

作者： laura B. matthews m. Elizabeth Kunkel James C. Acton Amod A. Ogale Paul l. Dawson 不详

The in vivo bioavailability of soy protein isolates and corn zein film material before and after film formation by heat/ pressure was determined. The In vitro digestibility of corn zein before and after film formation was also measured. Films were produced from anhydrous protein with 30% glycerol added using a heat-press method with no use of casting solvents or cross-linking agents. Corn zein raw and film material were ground under liquid nitrogen then digested in two enzyme-acid cocktails with free amino acid analysis before and after digestion. The protein efficiency ratio and net protein ratio were determined for both zein and soy protein using a weanling Sprague-Dawley descended rat feeding study. The In vitro digestibility study indicated that the non-heat pressed corn zein was more digestible than the heat pressed zein. However, the in vivo results indicated that corn and soy protein were equally bioavailable whether they were derived from film mixture prior to or after film formation. Both corn zein and soy protein material had lower protein efficiency ratio than the control diet. Furthermore, soy protein films materials had a higher protein efficiency ratio than corn zein.

关键词： Bioavailability Bio-Based Films Edible Films Protein Digestibility Packaging

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男性性功能障碍患者性欲低下的影响因素分析

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中华男科学杂志 2024年第8期30卷 734-737页

作者：吕秋晨王瑞王祖龙张天标郑涛吕坤龙南永浩河南中医药大学第一附属医院男科河南郑州450000 郑州大学第一附属医院男科河南郑州450000

目的:分析男性性功能障碍患者性欲低下的影响因素,为临床诊治提供依据。方法:回顾性分析2023年6月至2023年9月郑州大学第一附属医院男科门诊111例性功能障碍患者(包括勃起、射精或者性欲障碍),将以性欲低下为主诉或伴随症状的患者分组... 详细信息

目的:分析男性性功能障碍患者性欲低下的影响因素,为临床诊治提供依据。方法:回顾性分析2023年6月至2023年9月郑州大学第一附属医院男科门诊111例性功能障碍患者(包括勃起、射精或者性欲障碍),将以性欲低下为主诉或伴随症状的患者分组至性欲低下组(43例),性欲正常组(68例),所有患者均进行国际勃起功能指数问卷表-5(IIEF-5)、早泄诊断量表(PEDT)、男性13项性欲自评量表、健康问卷抑郁量表(PHQ-9)、广泛性焦虑障碍量表(GAD-7)以及血清相关激素检测(FSH、lH、PRl、T、fT、E2、IGF-1、GH),比较两组基本参数差异,并将差异显著的参数与性欲值进行相关性分析。结果:性欲正常组与性欲低下组相比,IIEF-5评分、PEDT评分、性欲评分和IGF-1值显著增高,GAD-7评分明显降低(PlH、PRl、T、fT、E2、T/E2及GH值两组间无显著差异(P>0.05)。性欲值与IIEF-5(r=0.28,P<0.01)、PEDT(r=0.29,P<0.01)、IGF-1(r=0.23,P<0.05)呈正相关,与GAD-7(r=-0.21,P<0.05)呈负相关。结论:性欲低下是多因素导致的结果,生殖激素并不能完全解释性欲的变化。IGF-1水平越低、ED及焦虑程度越重发生性欲低下风险越高。

关键词：性功能障碍性欲低下胰岛素样生长因子1 生殖激素焦虑

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Effect of Pregnancy on TmJ Nociception in Rats

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口腔医学研究 2018年第3期34卷 332-338页

作者： mikhail Umorin larry l.Bellinger Phillip R.Kramer Texas A&m University College of Dentistry 3302 Gaston Avenue Dallas TX 75246 USA

Objective:Does TmJ nociception,as measured by a behavioral assay,differ during pregnancy,potentially due to the effect of sex steroids?methods:Thirty-two Sprague Dawley rats were randomly allocated to either mid-(E11)or late-(E17)pregnancy *** animals within each group were further allocated to a saline or CFA *** E11 or E17,the animals were injected bilaterally into TmJ with either saline(15μl)or 1μg/μl CFA(15μl).Nociception was measured with a feeding assay(pellet recording)and analyzed by comparing intra-meal rates using a distance-based permutation ***:CFA injection resulted in the animals eating longer in both the mid-pregnant and late-pregnant *** estradiol was higher in the late-pregnant group versus the mid-pregnant ***,the CFA injected late-pregnant group ate for a shorter amount of time(i.e.,shorter meal rate)than the CFA injected rats at ***:The reduced nociceptive response(shorter meal rate)in the CFA injected late-pregnant group may be due to greater estradiol versus the CFA injected mid-pregnancy ***,one potential reason why women report fewer TmJ symptoms during pregnancy is the higher level of circulating estradiol.

关键词：孕妇生理盐水治疗方法保健知识

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THE EVOlUTION OF THERmO-PlASTIC SHEAR BAND

THE EVOLUTION OF THERMO-PLASTIC SHEAR BAND

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作者： Cheng,C.m., Bai,Y.l., Ding Yansheng Institute of mechanics Academia Sinica

1. IntroductionAt high strain rates of steels and certain metals, deformation often tends to localize in narrow regions known as thermo-plastic or adiabatic shear bands.A comprehensive review was given by *** for the ...

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精油在家禽饲料中的应用效果

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饲料工业 2011年第24期32卷 39-43页

作者： Bento m H l Ouwehand A Tiihonen K lahtinen S Nurminen P Saarinen m Schulze H mygind T Fischer J 石学刚丹尼斯克动物营养(英国) 丹尼斯克甜味剂(芬兰) 丹尼斯克(丹麦) 丹尼斯克动物营养(广州)

欧盟已经禁止在家禽饲料中使用抗生素生长促进剂（AGPs），随着对食品安全问题的关注，在美闰，消费者也向政府施加压力要求在动物饲料中禁止使用抗生素生长促进剂。为了满足市场需求，寻找动物饲料中抗生素生长促进剂的替代物，从2004... 详细信息

欧盟已经禁止在家禽饲料中使用抗生素生长促进剂（AGPs），随着对食品安全问题的关注，在美闰，消费者也向政府施加压力要求在动物饲料中禁止使用抗生素生长促进剂。为了满足市场需求，寻找动物饲料中抗生素生长促进剂的替代物，从2004年开始，丹尼斯克便对不同的精油产品进行体外试验，以筛选出具有潜在的抗病原微生物作用；同时，有利于有益微生物的生长繁殖。其主要目的是为了开发出一种精油复合物，能够促进单胃动物生长，并有效控制病原微生物的繁殖。

关键词：家禽饲料精油抗生素生长促进剂病原微生物应用食品安全问题动物饲料生长繁殖

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Performance of inverse fluidized bed bioreactor in treating starch wastewater

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Frontiers of Chemical Science and Engineering 2009年第3期3卷 235-239页

作者： m.RAJASImmAN C.KARTHIKEYAN Environmental Engineering laboratory Department of Chemical EngineeringAnnamalai UniversityAnnamalai Nagar-608002Tamil NaduIndia

Aerobic digestion of starch industry waste-water was carried out in an inverse fluidized bed bioreactor using low-density(870kg/m 3)polypropylene *** were carried out at different initial substrate concentrations of 2250,4475,6730,and 8910mg COD/l and for various hydraulic retention times(HRT)of 40,32,24,16,and *** of organic matter was studied at different organic loading rates(OlR)by varying the HRT and the initial substrate *** the results it was observed that the maximum COD removal of 95.6% occurred at an OlR of 1.35kg COD/(m^(3)·d)and the minimum of 51.8% at an OlR of 26.73kg COD/(m 3$d).The properties of biomass accumulation on the surface of particles were also *** was observed that constant biomass loading was achieved over the entire period of operation.

关键词： inverse fluidization low-density particles polypropylene starch biofilm

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