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晚期头颈鳞癌（n3）的治疗效果

中国口腔颌面外科杂志 2005年第3期3卷 270-270页

作者： Carvalho AL Kowalski LP Agra im

该文旨在研究头颈部鳞癌晚期颈淋巴转移的远期治疗效果。作者对1981—1996年间在其癌症中心治疗的224例头颈鳞癌患者进行回顾研究，所有患者此前未接受任何治疗，并且颈部转移之淋巴结直径均大于6cm。54例（24．1％）接受颈淋巴清扫术，... 详细信息

该文旨在研究头颈部鳞癌晚期颈淋巴转移的远期治疗效果。作者对1981—1996年间在其癌症中心治疗的224例头颈鳞癌患者进行回顾研究，所有患者此前未接受任何治疗，并且颈部转移之淋巴结直径均大于6cm。54例（24．1％）接受颈淋巴清扫术，137例（61．2％）仅行放疗，33例（14．7％）仅接受支持疗法。治疗组颈部转移灶的总控制率为24．1％，其中手术组控制率为51．9％，放疗组为13．1％（P〈0．001），

关键词：治疗效果头颈鳞癌晚期颈部转移灶颈淋巴清扫术颈淋巴转移头颈部鳞癌中心治疗支持疗法

Inspirations from the scientific discovery of the anammox bacteria: A classic example of how scientific principles can guide discovery and development

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Science China Earth Sciences 2016年第1期59卷 449-455页

作者： DAnG Hong Yue HUAnG Rong Fang JIAO nian Zhi State Key Laboratory of Marine Environmental Science College of Ocean and Earth Sciences Xiamen University

Anaerobic ammonium oxidation(anammox) is a relatively new pathway within the n cycle discovered in the late 1990 s. This eminent discovery not only modified the classical theory of biological metabolism and matter cycling, but also profoundly influenced our understanding of the energy sources for life. A new member of chemolithoautotrophic microorganisms capable of carbon fixation was found in the vast deep dark ocean. If the discovery of the chemosynthetic ecosystems in the deep-sea hydrothermal vent environments once challenged the old dogma "all living things depend on the sun for growth," the discovery of anammox bacteria that are widespread in anoxic environments fortifies the victory over this dogma. Anammox bacteria catalyze the oxidization of nH_4^+ by using nO_2^- as the terminal electron acceptor to produce n_2. Similar to the denitrifying microorganisms, anammox bacteria play a biogeochemical role of inorganic n removal from the environment. However, unlike heterotrophic denitrifying bacteria, anammox bacteria are chemolithoautotrophs that can generate transmembrane proton motive force, synthesize ATP molecules and further carry out CO_2 fixation through metabolic energy harvested from the anammox process. Although anammox bacteria and the subsequently found ammonia-oxidizing archaea(AOA), another very important group of n cycling microorganisms are both chemolithoautotrophs, AOA use ammonia rather than ammonium as the electron donor and O_2 as the terminal electron acceptor in their energy metabolism. Therefore, the ecological process of AOA mainly takes place in oxic seawater and sediments, while anammox bacteria are widely distributed in anoxic water and sediments, and even in some typical extreme marine environments such as the deep-sea hydrothermal vents and methane seeps. Studies have shown that the anammox process may be responsible for 30%–70% n_2 production in the ocean. In environmental engineering related to nitrogenous wastewater treatment, an

关键词： Anaerobic ammonium oxidation Marine nitrogen cycle Chemolithoautotrophy Wastewater treatment Scientific inspiration

The <i>Helicobacter pylori</i>Eradication Rate in a High Prevalence Area (West Africa): Three Triple Therapy Comparative Study

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Open Journal of Gastroenterology 2015年第12期5卷 200-206页

作者： Adjéka Stanislas Doffou Koffi Alain Attia Mamert Fulgence Yao Bathaix Aboubacar Demba Bangoura Ya Henriette Kissy-Anzouan Hartrydt Dimitri Kouamé Kouamé Alassan Mahassadi Kouamé Justin n’Da Mohamed Kouyaté Constant Assi Aya Thérèse n’dri-Yoman Department of Hepatology and Gastroenterology Centre Hospitalier Universitaire de Yopougon (CHU-Y) Abidjan Cote d’Ivoire Anatomopathology Laboratory of the Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire Department of Hepatology and Gastroenterology Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire

In Western countries, the current trend is to use sequential quadruple therapy or bismuth-based instead of triple therapy for the eradication of Helicobacter pylori (H. pylori). In sub-Saharan Africa, high prevalence area of the H. pylori infection, the effectiveness of these triple therapies widely used in routine has been little evaluated. The purpose of this study was to evaluate and compare the effectiveness of three patterns of first-line triple therapy based on combining a proton pump inhibitors (PPI), and 3 types of antibiotics: omeprazole (O), amoxicillin (A), clarythromycin (C) and metronidazole (M). Patients and Methods: This is a randomized clinical trial opened on 3 parallel arms: OAM (group 1 or G1), OAC (group 2 or G2) or OCM (group 3 or G3). The primary endpoint was H. pylori eradication rate after seven days triple therapy. H. pylori diagnosis infection was based on bacterium detection on the histological examination of the gastric biopsies. Histological control was performed 4 weeks after the end of treatment to assess H. pylori eradication rate. Results: The average age of our 153 patients included in the study (86 men) was 44.33 ± 11.72 years. The main reason of the endoscopy was the dyspeptic syndrome (75.16%). The gastroscopy was normal in 28.76%. A Gastric or duodenal peptic ulcer was found in 17% of cases and gastropathy in 45.75%. Histologically, the GC was active in 90.9% of cases, follicular in 35.3% of cases, atrophic in 22.5% of cases and was associated with intestinal metaplasia (im) in 5.2% of cases. Patients of these three groups (n = 64 for G1, n = 56 for G2 and n = 33 for G3) were comparable for age, gender, endoscopy indications, alcohol consumption history or smoking, and anti-inflammatory drugs taking. Approximately 23% of patients experienced adverse reactions. The overall H. pylori eradication rate was 22.3%. There was no significant difference H. pylori eradication rate depending on the treatment used (28.1%, 21.4% and 15.1% fo

关键词： Helicobacter pylori Triple Therapy Eradication West Africa

Spanish Initiative for the Automation in Urban Transport: AutoMOST

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Journal of Transportation Technologies 2018年第1期8卷 1-10页

作者： Jesús Murgoitio Rafael Durbán Joshué M. Pérez Antonio García Jose A. Moreno Ray A. Lattarulo Industry & Transport Division Tecnalia Derio Spain Grupo Avanza Madrid Spain

The progressive automation of transport will imply a new paradigm in mobility, which will profoundly affect people, logistics of goods, as well as other sectors dependent on transport. It is precise within this automation where the development of new driving technologies is going to cause a great impact on the mobility of the near future, and that will have an effect on the economic, natural and social environment. It is therefore a primary issue at the global level, as it is reflected in the work programs of the European Commission in relation to the road transport [1] [2]. Thus, the size impact is caused by the following novelties and advantages: 1) Safety: Accidents reduction caused by human error;2) Efficiency increase in transportation, both in energy consumption and time;3) Comfort for users and professionals who will increase their operational availability to execute other more valuable tasks, both for them and enterprises;4) Social Inclusion: enabling mobility easily for everybody during more time;5) Accessibility, to get to city centers and other difficult reach places. It should be noted that the economic impact projected for automated driving for the years to come ranges up to €71 bn in 2030, when estimated global market for automated vehicles is 44 million vehicles, as is reflected in document Automated Driving Roadmap by ERTRAC [3], European Road Transport Research Advisory Council (http://***/uploads/documentsearch/id38/ERTRAC_***). As background that already anticipates these im-provements, the Advance Driver Assistance System (ADAs) have already showed the safety increase in the last ten years, but always maintain a leading role for the driver. Related to the efficiency increase, automated driving offers great opportunities for those companies where mobility is a key factor in operating costs, and affects the whole value chain. The project opportunity is consistent with ERTRAC vision, especially in applications focus

关键词： Urban Transport Automated Vehicles Dual Mode

基于模糊逻辑异步电动机间接矢量控制传动系统及其性能分析

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变流技术与电力牵引 2003年第6期 10-14,19页

作者： M.n.Uddin 倪觉生孟加拉

文章提出了一种新颖的采用模糊逻辑控制的异步电动机(im)转速控制方法.模糊逻辑控制器(FLC)是基于间接矢量控制系统设计的.模糊逻辑转速控制器用于外层回路.针对实验室1 hp鼠笼式im采用DS-1102数字信号处理器插件板,对基于FLC的im矢量... 详细信息

文章提出了一种新颖的采用模糊逻辑控制的异步电动机(im)转速控制方法.模糊逻辑控制器(FLC)是基于间接矢量控制系统设计的.模糊逻辑转速控制器用于外层回路.针对实验室1 hp鼠笼式im采用DS-1102数字信号处理器插件板,对基于FLC的im矢量控制传动系统进行了实验研究.对文章提出的基于FLC的im传动性能进行了研究,从理论和实验两个方面,在诸如指令转速突变、负载阶跃变化等不同的动态工作条件下,与基于传统的比例积分(PI)控制器的传动系统作了比较,结果表明使用FLC更优越.因此该方法适用于高性能工业传动系统,以取代传统PI控制器的方法.

关键词：数字信号处理器模糊逻辑控制器异步电动机比例积分控制器实时实现转速控制

行业协会参与食品安全“共治”困境及对策研究——以浙江省金华市为例

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浙江师范大学学报（社会科学版） 2017年第6期42卷 100-105页

作者：刘根华郑文钟李铭熙金华职业技术学院旅游与酒店管理学院浙江金华321007 浙江大学生物系统工程与食品科学学院浙江杭州310058 金华市食品安全办公室督查处浙江金华321000

为改变当今国内食品安全以政府治理为主的现状,文章界定了食品安全共治和行业协会参与共治的内涵,并选取27家浙江省金华市的食品行业相关协会进行调研。结果显示:行业协会参与食品行业安全共治存在能力不强、平台不足、机制不完善、模... 详细信息

为改变当今国内食品安全以政府治理为主的现状,文章界定了食品安全共治和行业协会参与共治的内涵,并选取27家浙江省金华市的食品行业相关协会进行调研。结果显示:行业协会参与食品行业安全共治存在能力不强、平台不足、机制不完善、模式单一等问题,这些也是造成目前食品安全治理效果不佳的主要因素。有鉴于此,文章提出了前移政府职能,提升"三项能力";重构共治平台,建立"组织之家";完善参与机制,实现"五方联动";固化共治模式,推行"协同共治"等对策,以提高食品安全治理水平。

关键词：食品安全社会共治行业协会

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酵母菌细胞自溶突变株的研究

微生物学报 2003年第2期43卷 283-287页

作者：何秀萍刘增然刘春秀张博润中国科学院微生物研究所北京100080

Saccharomyces cerevisiae osmotic fragile mutants were obtained from parental strain SH208 15 by n methyl n’ nitro n nitrosoguanidine(nTG) treatments. Three mutants, HF2, HF7 and HF9 showed high degree of release of the intracellular components into medium under hypo osmotic condition and were studied in details. They showed some similar phenotypes to the previously reported fragile mutants, including hypo osmolarity sensitivity, temperature sensitivity and sensitivity to zymolyase indicating the existence of cell wall integrity defect. However, the three mutants differ from the reported mutants in some respects. Firstly, The temperature sensitivity of the isolated three mutants could not be complemented by osmotic stabilizer, while that of the PKC1 pathway mutants could be restored. Secondly, the degree of glycosylation of invertase in HF2, HF7 and HF9 did not decrease as that of srb1/vig9 mutants when compared with invertase in wild type strain respectively. In addition, the three mutants differ from each other. Hence, the three mutants are putative novel fragile mutants defect in cell wall. They can be used to further study the metabolism of yeast cell wall in biochemical and genetic levels and have the potential value to release intracellular heterologous proteins in high yield.

关键词：酵母菌低渗透敏感自溶突变株

Preoperative Intra-Aortic Balloon Counterpulsation in Coronary Artery Bypass Graft Patients with Severe Left Ventricular Dysfunction

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World Journal of Cardiovascular Diseases 2016年第10期6卷 321-328页

作者： Andrea Cristina Oliveira Freitas Danilo B. Gurian Wladmir F. Saporito Leandro n. Machado Louise Horiuti Adilson C. Pires Rua Dr. Henrique Calderazzo Sao Paulo Brazil

Background: The intra-aortic balloon pumping (IABP) is the most used ventricular mechanical assist device. In recent years, the preoperative use in patients with severe ventricular dysfunction presents itself as a great benefic strategy to the postoperative recovery. This paper aim is to evaluate the IABP post-operative benefit in patients with severe ventricular dysfunction. Methods: From January 2011 to March 2016, 125 patients underwent a coronary artery bypass graft (CABG) with cardiopulmonary bypass and preoperative IABP in Teaching Hospital of the ABC Medical School and Hospital Estadual Mario Covas. The inclusion criteria were the presence of severe ischemic cardiomyopathy with left ventricular ejection fraction (LVEF) less than or equal to 40%, estimated by Doppler echocardiography using the Simpson method. The preoperative LVEF was 30.25% ± 8.53% and the diastolic diameter of the left ventricle (LVDD) 67.75 ± 16.37 mm. IABP was installed approximately 15 hours before the surgery. Results: The patients required the IABP for 2.4 ± 1.58 days, and vasoactive drugs, 4.8 ± 2.12 days. We performed 3.2 ± 1.9 grafts per patient and the total length of stay was 07 ± 5.52 days. Cardiopulmonary bypass time was 67 ± 10.95 minutes and anoxia time, 46.4 ± 10.06 minutes. Twelve patients (9.6%) had pneumonia and four (3.2%), atrial fibrillation. We observed a LVDD reduction to 63 ± 16.26 (p = 0.068) and LVEF enhancement to 36.50 ± 16.86 (p = 0.144). The data were analyzed statistically according to the Wilcoxon test. There were no deaths. Conclusion: The initial experience of the authors with the preoperative IABP in patients with severe left ventricular dysfunction suggests great benefit in post-operative recovery with im-provement of LVEF and reduction of LVDD.

关键词： Intra-Aortic Balloon Pumping Left Ventricular Dysfunction Coronary Artery Bypass Graft

接受新辅助化疗乳腺癌病人的生存结果分析:通过联系计算机辅助评价的动态对比增强MR成像

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国际医学放射学杂志 2013年第6期 570-570页

作者： A.Yi n.Cho S.A.im J.M.Chang S.J.Kim H.G.Moon 赵阳 Seoul national University Hospital Seoul Republic of Korea

摘要目的采用计算机辅助评价程序回顾性评估动态对比增强(DCE)MRI的相关参数,以探讨其结果是否与接受新辅助化疗(nAC)的乳腺癌病人无复发生存以及整体生存

关键词：新辅助化疗乳腺癌乳腺肿瘤动态对比增强生存计算机辅助评价病人 MR