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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 254-260页

作者： P.W.Shum M.Escursell T.h.wong K.y.li Z.F.Zhou y.G.Shen Advanced Coatings Applied Research Laboratory(ACARL) Department of Manufacturi ng Engineering and Engineering ManagementCity University of Hong KongKowloonHong KongChina

Titanium-aluminium-nitride(Ti_(1-x)Al_(x)N)coatings were deposited by close-field un balanced magnetron sputtering on M42 steel substrates and WC-6wt%Co inserts at 450℃.The tribological behavior was analyzed by sliding against steel and WC-6wt%Co balls,while the turning performance was evaluated by a conventional tu rning machine at high cutting speeds without using *** the tribological tests,the formation of transfer layer and the variations of hardness of the co atings played an important role for sliding against steel *** the coating s sliding against WC-6wt%Co balls,the Ti-Al-N coatings showed a similar frictio n coefficient,but the TiN coating exhibited a lower *** difference could be explained by the tri-oxidation wear *** the turning tests,a super ior cutting performance of the coating was found at x=0.45,which endured 38 min utes before the tool flank wear reached the maximum value of 0.3mm,whereas only 20 minutes were endured for the TiN *** excellent performance of the c oatings in the turning tests could be explained by the enhanced mechanical prope rties and oxidation/diffusion resistance of the coatings.

关键词： hardness Ti-Al-N coating tribology turning test wear test

铜绿假单胞菌对肺血管内皮细胞功能的影响及其机制

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中国医学科学院学报 2024年第1期46卷 1-10页

作者：张雷王俊轶何翔吴敏李国平黄锦伟澳门科技大学中药质量研究国家重点实验室中国澳门999078 成都市第三人民医院呼吸健康研究所过敏与精准医学实验室成都610000 北达科他大学医学与健康科学院生物医学科学系美国北达科他州大福克斯58203 中国科学院大学温州研究院浙江温州325000

目的探究铜绿假单胞菌(PA)感染对肺血管内皮细胞功能的影响,并探讨其加重小鼠肺部炎症反应的可能机制。方法PAO1菌株感染人肺微血管内皮细胞hULEC-5a 2 h后,采用逆转录实时荧光定量PCR(RT-qPCR)检测自噬相关基因5(ATG5)、6-磷酸果糖-2-... 详细信息

目的探究铜绿假单胞菌(PA)感染对肺血管内皮细胞功能的影响,并探讨其加重小鼠肺部炎症反应的可能机制。方法PAO1菌株感染人肺微血管内皮细胞hULEC-5a 2 h后,采用逆转录实时荧光定量PCR(RT-qPCR)检测自噬相关基因5(ATG5)、6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3(PFKFB3)和钙黏蛋白5(CDh5)的mRNA表达,免疫荧光检测ATG5、PFKFB3和血管内皮钙黏蛋白(VE-cadherin)的蛋白表达。采用小干扰RNA(siRNA)分别敲减ATG5、PFKFB3后,RT-qPCR检测ATG5、PFKFB3和CDh5的mRNA表达,免疫荧光检测PFKFB3和VE-cadherin的蛋白表达,并采用乳酸测定试剂盒检测细胞内乳酸的水平。采用PAO1菌株感染小鼠后,肺组织切片病理染色观察小鼠肺部炎症,激光共聚焦显微镜观察并分析荧光标记的内皮细胞PFKFB3和VE-cadherin的表达量。结果与对照组比较,PAO1感染hULEC-5a细胞后,PFKFB3 mRNA和蛋白表达均增加(P均h5 mRNA表达减少(P=0.023),VE-cadherin蛋白表达减少(PhULEC-5a细胞比较,PAO1感染敲减PFKFB3的hULEC-5a细胞后,CDh5 mRNA表达增加(P=0.043),VE-cadherin荧光连续性得到恢复,乳酸含量降低(P=0.047);PAO1感染敲减ATG5的hULEC-5a细胞后,PFKFB3 mRNA(P=0.013)和蛋白表达(P=0.003)均增加,CDh5 mRNA(P=0.020)和VE-cadherin蛋白表达(P=0.001)均减少,乳酸含量升高(P=0.015)。PAO1感染小鼠后,病理hE染色结果显示,肺泡内明显的红细胞渗漏,炎症细胞浸润,肺泡间隔增宽和部分血管内皮细胞脱落。免疫荧光染色结果显示,与正常小鼠比较,PAO1感染小鼠内皮细胞PFKFB3表达增加,VE-cadherin荧光减弱,且不连续。结论PA可能通过AGT5调控PFKFB3通路,破坏肺血管内皮细胞功能,进而加重小鼠肺部炎症反应。

关键词：铜绿假单胞菌肺血管内皮细胞 6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 自噬相关基因5 感染

Estimations of primary production and export production in the South China Sea based on sediment trap experiments

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Chinese Science Bulletin 1998年第7期43卷 583-586页

作者： Jianfang Chen lianfu zheng M. G. Wiesner Ronghua Chen yulong zheng h. K. wong SOA Inst Oceanog 2 Hangzhou 310012 Peoples R China Univ hamburg Inst Biogeochem & Marine Chem D-20146 Hamburg Germany

The results of time series sediment trap experiments in the South China Sea show that particulate organic carbon (POC) fluxes are influenced by the monsoons. The increase of productivity in the northern South China Sea is mainly due to northeast monsoon while in the central South China Sea the influence of southwest monsoon becomes more prominent. The annual primary production and export production calculated based on POC fluxes are 53 0-63 4 and 10 32-12 93 gC·m -2·a -1, respectively. The enhancement of POC flux during monsoon period suggest that higher palaeoproductivity or organic carbon accumulation rate in glacial age in the South China Sea might be the result of strengthening of the monsoons.

关键词： South China Sea POC flux sediment trap primary production export production

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胆道纤维化的发生发展与治疗

中华消化外科杂志 2024年第7期23卷 989-1000页

作者：赵进玉林延延岳平姚佳米宁宁李麻图付文康高龙 Azumi Suzuki Peng F wong Kiyohito Tanaka Rungsun Rerknimitr henrik h Junger Tan T Cheung Emmanuel Melloul Nicolas Demartines Joseph W Leung 袁金秋 hans J Schlitt 孟文勃兰州大学第一临床医学院兰州730030 兰州大学第一医院普通外科兰州730030 浜松医学中心消化科日本浜松432-8002 詹姆斯库克大学医院血管外科英国米德尔斯堡TS43BW 京都第二红十字医院消化科日本京都602-8031 朱拉隆功国王纪念医院胃肠内镜卓越中心泰国曼谷10330 雷根斯堡大学医学中心外科德国雷根斯堡93053 香港大学外科学系中国香港999077 洛桑大学医院内脏外科瑞士洛桑CH-1015 加州大学戴维斯分校医学中心和萨克拉门托退伍军人医学中心胃肠肝病科美国萨克拉门托95817 中山大学附属第七医院临床研究中心深圳518107

胆道纤维化(BF)是病理性胆道损伤修复的结果,主要表现为胆管壁的增厚硬化和管腔的进行性狭窄,最终可能导致胆道梗阻、胆汁性肝硬化、肝衰竭、肝胆恶性肿瘤等严重不良结局。目前的研究将BF描述为某些胆管病的病理特征,对其病因、病理生... 详细信息

胆道纤维化(BF)是病理性胆道损伤修复的结果,主要表现为胆管壁的增厚硬化和管腔的进行性狭窄,最终可能导致胆道梗阻、胆汁性肝硬化、肝衰竭、肝胆恶性肿瘤等严重不良结局。目前的研究将BF描述为某些胆管病的病理特征,对其病因、病理生理、分子机制和治疗缺乏系统总结。BF是胆道系统普遍存在但容易被忽略的疾病状态,可能通过病理性胆道损伤后的异常修复机制促进肝胆疾病的发生和进展,笔者结合国内外最新研究进展,综述BF的概念、临床表现、病因、发病机制和治疗策略,为临床医师提供参考。

关键词：胆道疾病纤维化胆管反应病因信号通路治疗

Generation of Electron Traps at high Field in Silicon Oxide Films

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Chinese Physics Letters 1995年第7期12卷 420-423页

作者： B.L.yang h.wong y.C.Cheng Department of Electronic Engineering City University of Hong KongTat Chee AvenueKowloonHONG KONG

Temperature dependences of the high-field electron trapping in a SiO_(2) thin film for temperature ranging from 100 to 423K are *** is found that in the investigated temperature range,when the temperature decreases the effective surface density of the electron traps in the film decreases;the energy levels of the effective electron traps at high field concentrate at very narrow energy *** thermal generation rate is found to be 1.283x10^(10)/cm^(2).K and its activation energy is *** on these results,a model for the electron traps generated at high field in thin oxide is proposed.

关键词： film Electron energy

The Use of Enzyme-digested Soybean Residue For Feeding Common Carp

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Biomedical and Environmental Sciences 1996年第4期9卷 418-423页

作者： M.h.wong L.y.TANG 等 DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong DepartmentofAppliedBiologyandChem

This experiment was an attempt to use the soybean residue derived from the production of 'soy milk'. The residue contains about 18% protein, 70% caf bohydrates and 7.5% lipid as fish feed for reafing common carp, Cyrinus carpto. There were 4 types of diets: (1)soybean residue, (2 ) soybean residue digested with Papain, (3) soybean residue (64%)mixed with beef liver (34%) and (4) same mixture as (3) but digested with Papain. The results indicate that the percentage increase in weight and length of fish feeding with beef liver supplemented diets was higher than those feeding with soybean residue alone. This was possibly due to the fact that beef liver was able to supplement the nutrient deficiency in soybean. The two types of feeds (2 and 4) digested with Papain also yielded significantly better fish growth in terms of weight and length gains, than their counterparts without digestion. Furthermore, the water turbidity of the tanks added with digested feeds was significantly less, as papain was able to hyrolyse the protein substrates suspended in the water, and thus lowered the turbidity

关键词： In Res The Use of Enzyme-digested Soybean Residue For Feeding Common Carp

Thoracic surgery in 2030

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中华胸部外科电子杂志 2021年第3期8卷 145-152页

作者： Joyce W.y.Chan Rainbow W.h.Lau Aliss T.C.Chang Ivan C.h.Siu teddy.h.y.wong.zheng.li Calvin S.h.Ng Department of Surgery Prince of Wales Hospitalthe Chinese University of Hong KongHong Kong SARChina

Introduction Thoracic surgery has evolved at an exponential pace since the first clinical lung resection in *** first pneumonectomy was performed in 1895,the first lobectomy in 1901,while double lumen endotracheal intubation for pulmonary resection did not occur until *** 1990s saw the development of game-changer video-assisted thoracoscopic surgeries(VATS),while the 2000s gave witness to the explosive boom of robotic *** Abraham lincoln once said,“The best way to predict the future is to create it”,in this article we discuss the current cutting-edge technologies and attempt to predict the future of thoracic surgery in 10 years’time.

关键词： surgery lung clinical

Single crystal growth, structural and transport properties of bad metal RhSb2

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Chinese Physics B 2020年第3期29卷 1-6页

作者： D S Wu y T Qian Z y liu W Wu y J li S h Na y T Shao P zheng G li J G Cheng h M Weng J L Luo Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

We have successfully grown an arsenopyrite marcasite type RhSb2 single crystal, and systematically investigated its crystal structure, electrical transport, magnetic susceptibility, heat capacity, and thermodynamic properties. We found that the temperature-dependent resistivity exhibits a bad metal behavior with a board peak around 200 K. The magnetic susceptibility of RhSb2 shows diamagnetism from 300 K to 2 K. The low-temperature specific heat shows a metallic behavior with a quite small electronic specific-heat coefficient. No phase transition is observed in both specific heat and magnetic susceptibility data. The hall resistivity measurements show that the conduction carriers are dominated by electrons with ne = 8.62 × 10^(18) cm^(-3) at 2 K, and the electron carrier density increases rapidly above 200 K without change sign. Combining with ab-initio band structure calculations, we showed that the unusual peak around 200 K in resistivity is related to the distinct electronic structure of RhSb_2. In addition, a large thermopower S(T) about -140 μV/K is observed around 200 K, which might be useful for future thermoelectric applications.

关键词： single crystal growth ab-initio band calculations susceptibility heat capacity thermodynamic transport properties

Metallated conjugation in small-sized-molecular donors for solution-processed organic solar cells

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Science China Chemistry 2015年第2期58卷 347-356页

作者： Chaohua Cui yunye Zhang Wallace C.h.Choy hua li Wai-yeung wong Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University Department of Electrical and Electronic Engineering The University of Hong Kong College of life and Environmental Sciences & Beijing Engineering Research Center of Food Environment and Public health Minzu University of China hKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

Four metallated conjugated oligothiophenes, S-1, S-2, S-3 and S-4, with platinum（II） aryleneethynylenes as the electron-rich building block were synthesized to investigate their physicochemical and photovoltaic properties. These small molecules possess fairly low-lying hOMO energy levels which match with the LUMO energy level of the electron acceptor PC70BM （[6,6]-phenyl-C71-butyric acid methyl ester）. Using the simple process of spin-coating solution fabrication technique, S-I：PC70BM （1：4, w/w） based organic solar cells exhibiting a high Voc of 0.913 V, with a PCE value of 0.88% were developed. In contrast, the OSC device based on S-2：PC70BM （3：7, w/w） displayed a higher PCE of 1.59% with a higher Jsc value of 5.89 mA cm^-2. The device based on S-4：PCToBM （1：4, w/w） exhibited a PCE value of 1.56%, with a Voc of 0.917 V.

关键词： platinum acetylide photovoltaics organic solar cell oligothiophene

Management of cytomegalovirus corneal endotheliitis

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Eye and Vision 2021年第1期8卷 18-30页

作者： Angela h.y.wong Wee Nie Kua Alvin L.young Kelvin h.Wan Department of Ophthalmology Tuen Mun HospitalHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina

Background:Cytomegalovirus(CMV)can manifest as corneal endotheliitis in immunocompetent *** diagnosis is prudent to prevent endothelial cell loss,which could ultimately lead to corneal *** DNA was first detected in an eye with corneal endotheliitis in 2006;since then,clinical evidence from numerous case reports and case series have *** text:In this narrative review,we identified several drugs,including ganciclovir,valganciclovir,and their combination in oral,intravenous,intravitreal,and topical forms in different concentrations,together with the judicious use of topical steroids,have reported variable *** has yet to be any prospective comparative study evaluating the efficacy and safety of these assorted forms of treatment;clinical evidence is based on case reports and case *** endotheliitis presenting with corneal edema can masquerade as other corneal diseases and thus poses a great challenge especially in post-keratoplasty *** awareness is needed before and after keratoplasty to start prompt prophylaxis and ***:There is no consensus on the management of CMV *** studies are much needed to elucidate the optimal treatment modality,regime,and duration in the treatment and prophylaxis of CMV endotheliitis.

关键词： Cytomegalovirus CMV Endotheliitis Keratoplasty Corneal transplant Cornea